C2CD4C Gene
protein-coding GIFtS: 37
GCID: GC19M000363
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C2 calcium-dependent domain containing 4C(Previous names: KIAA1957, family with sequence similarity 148, member C...)
(Previous symbols: KIAA1957, FAM148C)
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Aliases
for C2CD4C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C2 Calcium-Dependent Domain Containing 4C1 2 | | Nuclear-Localized Factor 32 3 | | KIAA19571 2 3 5 | | C2 Calcium-Dependent Domain-Containing Protein 4C2 | | NLF31 2 3 5 | | Nuclear Localized Factor 32 | | FAM148C1 2 3 | | Protein FAM148C3 | | Family With Sequence Similarity 148, Member C1 2 | | |
Export aliases for C2CD4C gene to outside databasesPrevious GC identifer: GC19M000177 |
Summaries
for C2CD4C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C2CD4C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for C2CD4C
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2CD4C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2CD4C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3C2CD4C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M000363: view genomic region
(about GC identifiers)
Start:
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405,443 bp from pter |
End:
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409,170 bp from pter |
Size:
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3,728 bases |
Orientation:
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minus strand |
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Proteins
for C2CD4C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C2C4C_HUMAN, Q8TF44 (See
protein sequence)Recommended Name: C2 calcium-dependent domain-containing protein 4C Size: 421 amino acids; 44576 Da
Sequence caution: Sequence=BAB85543.1; Type=Erroneous initiation;
Secondary accessions: Q8N3H7Explore the universe of human proteins at neXtProt for C2CD4C: NX_Q8TF44
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TF44
C2CD4C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001129735.1
ENSEMBL proteins: ENSP00000328677
Human Recombinant Protein Products:
C2CD4C Antibody Products:
Assay Products for C2CD4C: |
Protein
Domains /
Families
for C2CD4C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C2CD4C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TF44ProtoNet protein and cluster: Q8TF44 1 Blocks protein family: IPB000008 C2 domain
UniProtKB/Swiss-Prot: C2C4C_HUMAN, Q8TF44Similarity: Belongs to the C2CD4 familySimilarity: Contains 1 C2 domain |
Function
for C2CD4C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for C2CD4C | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C2CD4C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD4C |
|
Pathways & Interactions
for C2CD4C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2CD4C
|
Drugs & Compounds
for C2CD4C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2CD4C
Search CenterWatch for drugs/clinical trials and news about C2CD4C / C2C4C
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Transcripts
for C2CD4C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2CD4C gene: NM_001136263.1 Unigene Cluster for C2CD4C: C2 calcium-dependent domain containing 4C Hs.223770 [show with all ESTs]Unigene Representative Sequence: NM_0011362631 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332235(uc002loo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C2CD4C (NM_001136263) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2CD4C | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C2CD4C |
Additional cDNA sequence: AB075837.1 AL834341.1 2 DOTS entries: DT.91732470 DT.97835024 23 AceView cDNA sequences: CR609064 CR616939 CA432780 CD514709 BM450741 AL566954 AL834341 AL537714 AW613736 BF057159 BX433270 BE552013 AI653135 BX433271 BX452338 AI989838 AB075837 AL557025 AW291099 AI962291 AL579128 BM930056 AI039029
GeneLoc Exon Structure
|
Expression
for C2CD4C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2CD4C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGAGACG
About this image
See C2CD4C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2CD4C
SOURCE GeneReport for Unigene cluster: Hs.223770
SABiosciences Custom PCR Arrays for C2CD4C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD4C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C2CD4C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2CD4C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2CD4C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD4C |
Orthologs
for C2CD4C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C2CD4C gene from 5/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
C2cd4c1 , 5 |
C2 calcium-dependent domain containing 4C1, 5 |
84.13(n)1
91.39(a)1 |
|
10 (39.72 cM)5
2373971 NM_001168624.11 NP_001162095.11
796068575 |
chicken
(Gallus gallus) |
Aves |
C2CD4C1 |
C2 calcium-dependent domain containing 4C |
71.96(n)
69.02(a) |
|
428334 XM_425894.2 XP_425894.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C2CD4C6 |
-- |
64(a) |
1 ↔ 1 |
AAWZ02037909(7553-8839) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.134202 |
Transcribed sequence with weak similarity to protein more |
78.93(n) |
|
BX731430.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5687541 |
c2 calcium-dependent domain-containing protein 4C-like |
61.61(n)
59.7(a) |
|
568754 XM_692105.2 XP_697197.2 |
ENSEMBL Gene Tree for C2CD4C (if available)
TreeFam Gene Tree for C2CD4C (if available) |
Paralogs
for C2CD4C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C2CD4C gene
- C2CD4D2 C2CD4B2 C2CD4A2
C2CD4C for paralogs About GeneDecksing
|
Genomic Variants
for C2CD4C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C2CD4C (405443 - 409170 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C2CD4C
2 CNVs: 30050 10540 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2CD4C |
|
Disorders
/ Diseases
for C2CD4C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C2CD4C for disorders About MalaCards
C2CD4C for disorders About GeneDecksing
OMIM gene information: 610336
OMIM disorders: --
Export disorders for C2CD4C gene to outside databases
|
Publications
for C2CD4C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2CD4C gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2CD4C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- A novel gene family induced by acute inflammation in endothelial cells. (PubMed id 15527968)1, 2 Warton K.... Stanley K.K. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
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External Searches for C2CD4C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C2CD4C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2CD4C gene
(According to HUGE)
About This Section
| |
Specialized Databases showing C2CD4C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2CD4C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C2CD4C gene:
Search GeneIP for patents involving C2CD4C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2CD4C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2CD4C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2CD4C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD4C | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C2CD4C | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for C2CD4C |
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 | | | C2CD4C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD4C |
|  |  |  | | | | Search ThermoFisher Antibodies for C2CD4C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C2CD4C |
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