Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C2CD4B Gene

Aliases for C2CD4B Gene

  • C2 Calcium-Dependent Domain Containing 4B 2 3
  • NLF2 3 4 6
  • Family With Sequence Similarity 148, Member B 2 3
  • Nuclear Localized Factor 2 2 3
  • Nuclear-Localized Factor 2 3 4
  • FAM148B 3 4
  • C2 Calcium-Dependent Domain-Containing Protein 4B 3
  • Protein FAM148B 4

External Ids for C2CD4B Gene

Previous HGNC Symbols for C2CD4B Gene

  • FAM148B

Previous GeneCards Identifiers for C2CD4B Gene

  • GC15M060245
  • GC15M062456
  • GC15M039278

Summaries for C2CD4B Gene

GeneCards Summary for C2CD4B Gene

C2CD4B (C2 Calcium-Dependent Domain Containing 4B) is a Protein Coding gene. An important paralog of this gene is C2CD4A.

UniProtKB/Swiss-Prot for C2CD4B Gene

  • May be involved in inflammatory process. May regulate cell architecture and adhesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2CD4B Gene

Genomics for C2CD4B Gene

Genomic Location for C2CD4B Gene

Start:
62,163,535 bp from pter
End:
62,165,283 bp from pter
Size:
1,749 bases
Orientation:
Minus strand

Genomic View for C2CD4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2CD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD4B Gene

No data available for Regulatory Elements for C2CD4B Gene

Proteins for C2CD4B Gene

  • Protein details for C2CD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLJ0-C2C4B_HUMAN
    Recommended name:
    C2 calcium-dependent domain-containing protein 4B
    Protein Accession:
    A6NLJ0
    Secondary Accessions:

    Protein attributes for C2CD4B Gene

    Size:
    364 amino acids
    Molecular mass:
    38769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2CD4B Gene

Proteomics data for C2CD4B Gene at MOPED

Post-translational modifications for C2CD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2CD4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2CD4B Gene

Domains for C2CD4B Gene

Protein Domains for C2CD4B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2CD4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLJ0

UniProtKB/Swiss-Prot:

C2C4B_HUMAN :
  • A6NLJ0
Domain:
  • Contains 1 C2 domain.
Family:
  • Belongs to the C2CD4 family.
genes like me logo Genes that share domains with C2CD4B: view

No data available for Gene Families for C2CD4B Gene

Function for C2CD4B Gene

Molecular function for C2CD4B Gene

UniProtKB/Swiss-Prot Function: May be involved in inflammatory process. May regulate cell architecture and adhesion.
UniProtKB/Swiss-Prot Induction: Up-regulated by pro-inflammatory cytokines.

Gene Ontology (GO) - Molecular Function for C2CD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 NOT syntaxin binding IBA --
GO:0030276 NOT clathrin binding IBA --
genes like me logo Genes that share ontologies with C2CD4B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C2CD4B Gene

Localization for C2CD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2CD4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2CD4B Gene COMPARTMENTS Subcellular localization image for C2CD4B gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C2CD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005886 plasma membrane IBA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with C2CD4B: view

Pathways for C2CD4B Gene

SuperPathways for C2CD4B Gene

No Data Available

Interacting Proteins for C2CD4B Gene

Gene Ontology (GO) - Biological Process for C2CD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 NOT vesicle fusion IBA --
GO:0016079 NOT synaptic vesicle exocytosis IBA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 NOT calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with C2CD4B: view

No data available for Pathways by source for C2CD4B Gene

Transcripts for C2CD4B Gene

mRNA/cDNA for C2CD4B Gene

(124) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2CD4B Gene

C2 calcium-dependent domain containing 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD4B Gene

No ASD Table

Relevant External Links for C2CD4B Gene

GeneLoc Exon Structure for
C2CD4B
ECgene alternative splicing isoforms for
C2CD4B

Expression for C2CD4B Gene

mRNA expression in normal human tissues for C2CD4B Gene

mRNA differential expression in normal tissues according to GTEx for C2CD4B Gene

This gene is overexpressed in Pancreas (16.0), Stomach (4.8), and Adipose - Visceral (Omentum) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C2CD4B Gene

SOURCE GeneReport for Unigene cluster for C2CD4B Gene Hs.144372

mRNA Expression by UniProt/SwissProt for C2CD4B Gene

A6NLJ0-C2C4B_HUMAN
Tissue specificity: Specifically expressed in endothelial cells.
genes like me logo Genes that share expressions with C2CD4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C2CD4B Gene

Orthologs for C2CD4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2CD4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2CD4B 35
  • 96.61 (n)
  • 94.29 (a)
C2CD4B 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
ManyToMany
C2CD4A 36
  • 63 (a)
ManyToMany
LOC529849 35
  • 77.78 (n)
  • 69.35 (a)
dog
(Canis familiaris)
Mammalia LOC100688626 35
  • 78.07 (n)
  • 67.53 (a)
mouse
(Mus musculus)
Mammalia C2cd4a 36
  • 53 (a)
ManyToMany
C2cd4b 35
  • 73.15 (n)
  • 66.46 (a)
C2cd4b 16
C2cd4b 36
  • 60 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia C2cd4b 35
  • 71.25 (n)
  • 65 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii C2CD4A 36
  • 25 (a)
OneToMany
Species with no ortholog for C2CD4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2CD4B Gene

ENSEMBL:
Gene Tree for C2CD4B (if available)
TreeFam:
Gene Tree for C2CD4B (if available)

Paralogs for C2CD4B Gene

Paralogs for C2CD4B Gene

Selected SIMAP similar genes for C2CD4B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C2CD4B: view

Variants for C2CD4B Gene

Sequence variations from dbSNP and Humsavar for C2CD4B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs8555 -- 62,163,743(+) ACCAA(C/T)AGACG utr-variant-3-prime
rs1055090 - 62,163,947(+) CCCCG(A/C)TCCCG missense, reference
rs1133660 -- 62,163,965(+) CCCTC(A/G)TCCCG synonymous-codon, reference
rs1133662 -- 62,163,980(+) TTGAC(G/T)CGAAC synonymous-codon, reference
rs1133665 -- 62,164,001(+) CGCAC(C/T)TCGTC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for C2CD4B Gene

Variant ID Type Subtype PubMed ID
nsv457176 CNV Gain 19166990
nsv471247 CNV Gain 18288195
dgv2397n71 CNV Loss 21882294

Relevant External Links for C2CD4B Gene

HapMap Linkage Disequilibrium report
C2CD4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2CD4B Gene

Disorders for C2CD4B Gene

Relevant External Links for C2CD4B

Genetic Association Database (GAD)
C2CD4B
Human Genome Epidemiology (HuGE) Navigator
C2CD4B
genes like me logo Genes that share disorders with C2CD4B: view

No data available for UniProtKB/Swiss-Prot for C2CD4B Gene

Publications for C2CD4B Gene

  1. A novel gene family induced by acute inflammation in endothelial cells. (PMID: 15527968) Warton K. … Stanley K.K. (Gene 2004) 3 4
  2. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J. … Barroso I. (Nat. Genet. 2010) 3 48
  3. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. (PMID: 20419449) Boesgaard T.W. … Pedersen O. (Diabetologia 2010) 3 48
  4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 48
  5. Identification of new genetic risk variants for type 2 diabetes. (PMID: 20862305) Shu X.O. … Hu F.B. (PLoS Genet. 2010) 3

Products for C2CD4B Gene

Sources for C2CD4B Gene

Back to Top

Content