C2CD4A Gene
protein-coding GIFtS: 39
GCID: GC15P062360
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C2 calcium-dependent domain containing 4A(Previous names: family with sequence similarity 148, member A )
(Previous symbol: FAM148A)
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Aliases
for C2CD4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C2 Calcium-Dependent Domain Containing 4A1 2 | | Nuclear-Localized Factor 12 3 | | NLF11 2 3 5 | | C2 Calcium-Dependent Domain-Containing Protein 4A2 | | FAM148A1 2 3 | | Nuclear Localized Factor 12 | | Family With Sequence Similarity 148, Member A1 2 | | Protein FAM148A3 |
Export aliases for C2CD4A gene to outside databasesPrevious GC identifers: GC15P060148 GC15P039181 |
Summaries
for C2CD4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: C2C4A_HUMAN, Q8NCU7Function: May be involved in inflammatory process. May regulate cell architecture and adhesion
|
Genomic Views
for C2CD4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for C2CD4A
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2CD4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2CD4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.2 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q22.2C2CD4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P062360: view genomic region
(about GC identifiers)
Start:
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62,359,176 bp from pter |
End:
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62,363,116 bp from pter |
Size:
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3,941 bases |
Orientation:
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plus strand |
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Proteins
for C2CD4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C2C4A_HUMAN, Q8NCU7 (See
protein sequence)Recommended Name: C2 calcium-dependent domain-containing protein 4A Size: 369 amino acids; 39744 Da
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for C2CD4A: NX_Q8NCU7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCU7
C2CD4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997205.2
ENSEMBL proteins: ENSP00000347712
Human Recombinant Protein Products for C2CD4A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
C2CD4A for ontologies About GeneDecksing
C2CD4A Antibody Products:
Assay Products for C2CD4A: |
Protein
Domains /
Families
for C2CD4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NCU7 UniProtKB/Swiss-Prot: C2C4A_HUMAN, Q8NCU7Similarity: Belongs to the C2CD4 familySimilarity: Contains 1 C2 domain |
Function
for C2CD4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: C2C4A_HUMAN, Q8NCU7Function: May be involved in inflammatory process. May regulate cell architecture and adhesionInduction: Up-regulated by pro-inflammatory cytokinesPhenotypes:
1 GenomeRNAi human phenotype for C2CD4A:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD4A |
|
Pathways & Interactions
for C2CD4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2CD4A
|
Drugs & Compounds
for C2CD4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2CD4A
Search CenterWatch for drugs/clinical trials and news about C2CD4A / C2C4A
|
Transcripts
for C2CD4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2CD4A gene: NM_207322.2 Unigene Cluster for C2CD4A: C2 calcium-dependent domain containing 4A Hs.202656 [show with all ESTs]Unigene Representative Sequence: NM_2073221 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000355522(uc002ahf.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C2CD4A (NM_207322) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2CD4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2CD4A |
Additional cDNA sequence: AF504646.1 BX648578.1 1 DOTS entry: DT.97842125 24/72 AceView cDNA sequences (see all 72): BM128587 AI341395 AW139874 BM068855 AW197466 BM772827 AI832148 BM766044 CK906221 BM742013 CK906222 BM783372 BU948771 BM772844 BE467405 AI656199 AW593828 BM829924 CK818870 BE218239 AW001393 AA931812 AI913984 AW015108
GeneLoc Exon Structure
|
Expression
for C2CD4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2CD4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCATTAAAA
About this image
See C2CD4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2CD4A
SOURCE GeneReport for Unigene cluster: Hs.202656
UniProtKB/Swiss-Prot: C2C4A_HUMAN, Q8NCU7Tissue specificity: Specifically expressed in endothelial cells
SABiosciences Custom PCR Arrays for C2CD4A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD4A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C2CD4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2CD4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2CD4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD4A |
Orthologs
for C2CD4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C2CD4A gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
28(a) |
1 → many |
10(5374160-5375969) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
29(a) |
1 → many |
AAWZ02041427(2107-3525) |
ENSEMBL Gene Tree for C2CD4A (if available)
TreeFam Gene Tree for C2CD4A (if available) |
Paralogs
for C2CD4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C2CD4A gene
- C2CD4D2 C2CD4B2 C2CD4C2
1 SIMAP similar gene for C2CD4A using alignment to 2 protein entries: C2C4A_HUMAN (see all proteins):C2CD4B
C2CD4A for paralogs About GeneDecksing
|
Genomic Variants
for C2CD4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C2CD4A (62359176 - 62363116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C2CD4A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2CD4A |
|
Disorders
/ Diseases
for C2CD4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C2CD4A for disorders About MalaCards
C2CD4A for disorders About GeneDecksing
OMIM gene information: 610343
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: C2CD4A (3 documents)
Export disorders for C2CD4A gene to outside databases
|
Publications
for C2CD4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2CD4A gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2CD4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene family induced by acute inflammation in endothelial cells. (PubMed id 15527968)1, 2 Warton K.... Stanley K.K. (2004)
- Genome-wide association identifies nine common variant s associated with fasting proinsulin levels and provides new insights into the p athophysiology of type 2 diabetes. (PubMed id 21873549)1 Strawbridge R.J....Florez J.C. (2011)
- A genome-wide association study confirms previously re ported loci for type 2 diabetes in Han Chinese. (PubMed id 21799836)1 Cui B....Ning G. (2011)
- A genome-wide association study in the Japanese popul ation identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C 2CD4B. (PubMed id 20818381)1 Yamauchi T....SandbA (2010)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for C2CD4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C2CD4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2CD4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C2CD4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2CD4A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C2CD4A gene:
Search GeneIP for patents involving C2CD4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2CD4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2CD4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2CD4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD4A | | | OriGene Protein Over-expression Lysate for C2CD4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C2CD4A | | OriGene 3'-UTR Clone for C2CD4A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C2CD4A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2CD4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2CD4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2CD4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2CD4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2CD4A |
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 | | | C2CD4A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD4A |
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