Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C2CD4A Gene

Aliases for C2CD4A Gene

  • C2 Calcium-Dependent Domain Containing 4A 2 3
  • NLF1 3 4 6
  • Family With Sequence Similarity 148, Member A 2 3
  • Nuclear Localized Factor 1 2 3
  • Nuclear-Localized Factor 1 3 4
  • FAM148A 3 4
  • C2 Calcium-Dependent Domain-Containing Protein 4A 3
  • Protein FAM148A 4

External Ids for C2CD4A Gene

Previous HGNC Symbols for C2CD4A Gene

  • FAM148A

Previous GeneCards Identifiers for C2CD4A Gene

  • GC15P060148
  • GC15P062360
  • GC15P039181

Summaries for C2CD4A Gene

GeneCards Summary for C2CD4A Gene

C2CD4A (C2 Calcium-Dependent Domain Containing 4A) is a Protein Coding gene. An important paralog of this gene is C2CD4C.

UniProtKB/Swiss-Prot for C2CD4A Gene

  • May be involved in inflammatory process. May regulate cell architecture and adhesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2CD4A Gene

Genomics for C2CD4A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C2CD4A Gene

Start:
62,066,977 bp from pter
End:
62,070,917 bp from pter
Size:
3,941 bases
Orientation:
Plus strand

Genomic View for C2CD4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2CD4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD4A Gene

No data available for Regulatory Elements for C2CD4A Gene

Proteins for C2CD4A Gene

  • Protein details for C2CD4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCU7-C2C4A_HUMAN
    Recommended name:
    C2 calcium-dependent domain-containing protein 4A
    Protein Accession:
    Q8NCU7
    Secondary Accessions:

    Protein attributes for C2CD4A Gene

    Size:
    369 amino acids
    Molecular mass:
    39744 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2CD4A Gene

Proteomics data for C2CD4A Gene at MOPED

Post-translational modifications for C2CD4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2CD4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2CD4A Gene

Domains for C2CD4A Gene

Protein Domains for C2CD4A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2CD4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCU7

UniProtKB/Swiss-Prot:

C2C4A_HUMAN :
  • Q8NCU7
Domain:
  • Contains 1 C2 domain.
Family:
  • Belongs to the C2CD4 family.
genes like me logo Genes that share domains with C2CD4A: view

No data available for Gene Families for C2CD4A Gene

Function for C2CD4A Gene

Molecular function for C2CD4A Gene

UniProtKB/Swiss-Prot Function: May be involved in inflammatory process. May regulate cell architecture and adhesion.
UniProtKB/Swiss-Prot Induction: Up-regulated by pro-inflammatory cytokines.

Gene Ontology (GO) - Molecular Function for C2CD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 NOT syntaxin binding IBA --
GO:0030276 NOT clathrin binding IBA --
genes like me logo Genes that share ontologies with C2CD4A: view

Phenotypes for C2CD4A Gene

GenomeRNAi human phenotypes for C2CD4A:
genes like me logo Genes that share phenotypes with C2CD4A: view

Animal Model Products

CRISPR Products

miRNA for C2CD4A Gene

miRTarBase miRNAs that target C2CD4A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C2CD4A Gene

Localization for C2CD4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2CD4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2CD4A Gene COMPARTMENTS Subcellular localization image for C2CD4A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for C2CD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with C2CD4A: view

Pathways for C2CD4A Gene

SuperPathways for C2CD4A Gene

No Data Available

Interacting Proteins for C2CD4A Gene

Gene Ontology (GO) - Biological Process for C2CD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 NOT vesicle fusion IBA --
GO:0016079 NOT synaptic vesicle exocytosis IBA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 NOT calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with C2CD4A: view

No data available for Pathways by source for C2CD4A Gene

Transcripts for C2CD4A Gene

mRNA/cDNA for C2CD4A Gene

(72) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2CD4A Gene

C2 calcium-dependent domain containing 4A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2CD4A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C2CD4A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD4A Gene

No ASD Table

Relevant External Links for C2CD4A Gene

GeneLoc Exon Structure for
C2CD4A
ECgene alternative splicing isoforms for
C2CD4A

Expression for C2CD4A Gene

mRNA expression in normal human tissues for C2CD4A Gene

mRNA differential expression in normal tissues according to GTEx for C2CD4A Gene

This gene is overexpressed in Pituitary (20.1), Liver (8.1), Pancreas (4.7), and Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C2CD4A Gene

SOURCE GeneReport for Unigene cluster for C2CD4A Gene Hs.202656

mRNA Expression by UniProt/SwissProt for C2CD4A Gene

Q8NCU7-C2C4A_HUMAN
Tissue specificity: Specifically expressed in endothelial cells.
genes like me logo Genes that share expressions with C2CD4A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C2CD4A Gene

Orthologs for C2CD4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2CD4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2CD4A 35
  • 97.59 (n)
  • 96.67 (a)
C2CD4A 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
ManyToMany
C2CD4A 36
  • 59 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia C2cd4a 35
  • 74.24 (n)
  • 67.53 (a)
C2cd4a 16
C2cd4a 36
  • 59 (a)
ManyToMany
C2cd4b 36
  • 57 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia C2cd4a 35
  • 74.95 (n)
  • 67.52 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii C2CD4A 36
  • 26 (a)
OneToMany
Species with no ortholog for C2CD4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2CD4A Gene

ENSEMBL:
Gene Tree for C2CD4A (if available)
TreeFam:
Gene Tree for C2CD4A (if available)

Paralogs for C2CD4A Gene

Paralogs for C2CD4A Gene

Selected SIMAP similar genes for C2CD4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C2CD4A: view

Variants for C2CD4A Gene

Sequence variations from dbSNP and Humsavar for C2CD4A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1436961 -- 62,069,851(-) GGAAT(A/G)CAAGT utr-variant-3-prime
rs1436966 -- 62,066,483(-) TTTCA(C/T)GTCTT upstream-variant-2KB
rs1534542 -- 62,070,640(+) TGACC(A/G)TTGAA utr-variant-3-prime
rs4489988 -- 62,069,760(+) GGTAA(C/T)ACCAC utr-variant-3-prime
rs4775456 -- 62,069,996(+) GAAAT(A/G)GGTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C2CD4A Gene

Variant ID Type Subtype PubMed ID
nsv457176 CNV Gain 19166990
nsv471247 CNV Gain 18288195
nsv457178 CNV Loss 19166990
nsv1560 CNV Loss 18451855

Relevant External Links for C2CD4A Gene

HapMap Linkage Disequilibrium report
C2CD4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2CD4A Gene

Disorders for C2CD4A Gene

Relevant External Links for C2CD4A

Genetic Association Database (GAD)
C2CD4A
Human Genome Epidemiology (HuGE) Navigator
C2CD4A
genes like me logo Genes that share disorders with C2CD4A: view

No data available for UniProtKB/Swiss-Prot for C2CD4A Gene

Publications for C2CD4A Gene

  1. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 48
  2. A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. (PMID: 21799836) Cui B. … Ning G. (PLoS ONE 2011) 3 48
  3. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PMID: 21873549) Strawbridge R.J. … Florez J.C. (Diabetes 2011) 3 48
  4. A novel gene family induced by acute inflammation in endothelial cells. (PMID: 15527968) Warton K. … Stanley K.K. (Gene 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for C2CD4A Gene

Sources for C2CD4A Gene

Back to Top

Content