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C2CD3 Gene

protein-coding   GIFtS: 46
GCID: GC11M073724

C2 Calcium-Dependent Domain Containing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C2 Calcium-Dependent Domain Containing 31 2
C2 Domain-Containing Protein 32

External Ids:    HGNC: 245641   Entrez Gene: 260052   Ensembl: ENSG000001680147   UniProtKB: Q4AC943   

Export aliases for C2CD3 gene to outside databases

Previous GC identifers: GC11M073424 GC11M070041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C2CD3 Gene:
C2CD3 (C2 calcium-dependent domain containing 3) is a protein-coding gene.

UniProtKB/Swiss-Prot: C2CD3_HUMAN, Q4AC94
Function: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for proteolytic processing of GLI3
(By similarity). Required for distal end centriole biogenesis and primary cilium formation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the C2CD3 gene promoter:
         SREBP-1c   E2F-2   Gfi-1   SREBP-1b   E2F-1   POU2F1   SREBP-1a   E2F   POU2F1a   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC2CD3 promoter sequence
   Search Chromatin IP Primers for C2CD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C2CD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

C2CD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C2CD3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073724:  view genomic region     (about GC identifiers)

Start:
73,723,763 bp from pter      End:
73,882,255 bp from pter
Size:
158,493 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: C2CD3_HUMAN, Q4AC94 (See protein sequence)
Recommended Name: C2 domain-containing protein 3  
Size: 2353 amino acids; 260389 Da
Sequence caution: Sequence=BAC03654.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC86334.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C9JR55 E2QRD1 Q2NLE1 Q3C1U9 Q6ZU92 Q8IYM4 Q8NB87 Q8NDH7 Q9Y4M2
Alternative splicing: 5 isoforms:  Q4AC94-5   Q4AC94-1   Q4AC94-2   Q4AC94-3   Q4AC94-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C2CD3: NX_Q4AC94

Explore proteomics data for C2CD3 at MOPED

Post-translational modifications: 

  • Was found to be N-glycosylated on Asn-1543 (PubMed:16335952). However, since it is probably cytoplasmic,
    N-glycosylation is highly unsure1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C2CD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273506.1  NP_056346.3  

    ENSEMBL proteins: 
     ENSP00000404577   ENSP00000323339   ENSP00000388750   ENSP00000441742   ENSP00000445933  
     ENSP00000439343   ENSP00000334379  

    C2CD3 Human Recombinant Protein Products:

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    antibodies-online antibodies for C2CD3 (4 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q4AC94

    ProtoNet protein and cluster: Q4AC94

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: C2CD3_HUMAN, Q4AC94
    Similarity: Contains 2 C2 domains


    Find genes that share domains with C2CD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C2CD3_HUMAN, Q4AC94
    Function: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for proteolytic processing of GLI3
    (By similarity). Required for distal end centriole biogenesis and primary cilium formation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with C2CD3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for C2CD3:
     Decreased TP53 protein express 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for C2cd3):
     cardiovascular system  embryogenesis  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system 

    Find genes that share phenotypes with C2CD3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C2CD3

    miRNA
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    miRTarBase miRNAs that target C2CD3:
    hsa-mir-335-5p (MIRT019082)

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    4 qRT-PCR Assays for microRNAs that regulate C2CD3:
    hsa-miR-920 hsa-miR-4300 hsa-miR-767-3p hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidC2CD3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C2CD3_HUMAN, Q4AC94: Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in
    interphase and mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005814centriole IDA--
    GO:0042995cell projection IEA--

    Find genes that share ontologies with C2CD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C2CD3
    Interactions:

        Search GeneGlobe Interaction Network for C2CD3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for C2CD3 (ENSP000003233394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP4ENSP000003134224STRING: ENSP00000313422
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001947heart looping IEA--
    GO:0007389pattern specification process ----
    GO:0007420brain development IEA--
    GO:0008589regulation of smoothened signaling pathway IEA--

    Find genes that share ontologies with C2CD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C2CD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C2CD3 gene (2 alternative transcripts): 
    NM_001286577.1  NM_015531.5  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000442398(uc001out.3) ENST00000542452 ENST00000538625 ENST00000540452
    ENST00000313663(uc001ouu.2) ENST00000414160 ENST00000538361 ENST00000542484
    ENST00000535645 ENST00000540057 ENST00000537285 ENST00000366334 ENST00000415191(uc001ouv.2)
    ENST00000539061 ENST00000436679 ENST00000541922 ENST00000535954 ENST00000544293

    miRNA
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    hsa-miR-920 hsa-miR-4300 hsa-miR-767-3p hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidC2CD3 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat C2CD3

    Selected AceView cDNA sequences (see all 115):

    AA242936 BM128517 BM725210 AA135304 BM680157 AI362471 CD742766 AI222449 
    AL833903 AI332933 AI683978 AI089268 BF439272 CD369754 AA905559 AA744799 
    AL043744 BM724927 H06851 AA932820 BX101408 AA252221 CD359943 CA436899 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C2CD3 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ·
    SP1:                                            -                             -                                   -                                             
    SP2:                                                                          -                                   -                                             
    SP3:                                            -                             -                                   -                                             
    SP4:                                                                          -                                   -                                             
    SP5:                                                                                                                                                            

    ExUns: 20c ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                          -                                                   
    SP2:        -                 -     -     -     -                       -         
    SP3:                                                                              
    SP4:                          -     -                                             
    SP5:        -     -                                                               


    ECgene alternative splicing isoforms for C2CD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C2CD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGACAAA
    C2CD3 Expression
    About this image

    C2CD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C2CD3 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for C2CD3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C2cd31 , 5 C2 calcium-dependent domain containing 31, 5 83.47(n)1
    77.1(a)1
      7 (54.35 cM)5
    2779391  NM_001017985.21  NP_001017985.21 
     1003722335 
    chicken
    (Gallus gallus)
    Aves C2CD31 C2 calcium-dependent domain containing 3 60.36(n)
    54(a)
      419059  XM_417250.4  XP_417250.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    33(a)
    many → 1
    many → 1
    GL344267.1(14679-51971)
    GL343978.1(1040-39794)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia c2cd31 C2 calcium-dependent domain containing 3 54.86(n)
    49.8(a)
      780184  NM_001079259.1  NP_001072727.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-149e23.11 si:ch211-149e23.1 54.13(n)
    46.75(a)
      797081  XM_001337498.5  XP_001337534.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG324256
    --
    21(a)
    1 ↔ 1
    3L(20490423-20507207)


    ENSEMBL Gene Tree for C2CD3 (if available)
    TreeFam Gene Tree for C2CD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C2CD3 gene
    1 SIMAP similar gene for C2CD3 using alignment to 6 protein entries:     C2CD3_HUMAN (see all proteins):
    MS4A4E

    Find genes that share paralogs with C2CD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C2CD3 (see all 2822)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498182781,2
    C--73744980(+) ATCTCA/CTTTAA 1 -- int11Minor allele frequency- C:0.00EU 589
    rs802203431,2
    C--73745044(+) CTGCCC/TCAGTG 1 -- int10--------
    rs1457650351,2
    C,F--73745083(+) GTACTG/ACATGC 1 -- int11Minor allele frequency- A:0.01EU 591
    rs1406031981,2
    --73745110(+) GCATTC/TTTCCT 1 -- int10--------
    rs8260711,2
    C,F,A,H--73745147(-) CCCCAC/TCACCC 1 -- int118Minor allele frequency- A:0.01MN NS EA NA WA CSA EU 1721
    rs1134484141,2
    F--73745353(+) TATTAC/TAAGGT 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1465399091,2
    --73745359(+) AAGGTA/CGGGCC 1 -- int10--------
    rs171326101,2
    C,F,H--73745395(+) AGCCTT/CTAGCT 1 -- int124Minor allele frequency- C:0.15NA NS EA WA CSA 2352
    rs1887995801,2
    --73745537(+) ATCTAC/TAGTTG 1 -- ut310--------
    rs10551781,2
    C,F--73745544(-) GTATCC/TACAAC 1 -- ut315Minor allele frequency- T:0.03NA CSA WA 246

    HapMap Linkage Disequilibrium report for C2CD3 (73723763 - 73882255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for C2CD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668510CNV Deletion23128226
    esv2662605CNV Deletion23128226
    esv2744773CNV Deletion23290073
    nsv392CNV Insertion18451855
    esv34979CNV Gain17911159
    dgv397e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): C2CD3
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases from the University of Copenhagen DISEASES database for C2CD3:
    Nephronophthisis     Bardet-Biedl syndrome

    Find genes that share disorders with C2CD3           About GenesLikeMe

    Genetic Association Database (GAD): C2CD3

    Export disorders for C2CD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C2CD3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with C2CD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. (PubMed id 23769972)2 Balestra F.R.... Gonczy P. (Dev. Cell 2013)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)
    7. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26005 HGNC: 24564 AceView: DKFZP586P0123 Ensembl:ENSG00000168014 euGenes: HUgn26005
    ECgene: C2CD3 H-InvDB: C2CD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C2CD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C2CD3 gene:
    Search GeneIP for patents involving C2CD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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