C2CD2L Gene
protein-coding GIFtS: 44
GCID: GC11P118978
|
|
C2CD2-like(Previous name: transmembrane protein 24 )
(Previous symbol: TMEM24)
| |
Aliases
for C2CD2L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C2CD2-Like1 | | Transmembrane Protein 241 2 3 | | TMEM241 2 3 | | KIAA02851 3 | | C2 Domain-Containing Protein 2-Like2 |
Export aliases for C2CD2L gene to outside databasesPrevious GC identifers: GC11P118484 GC11P114917 |
Summaries
for C2CD2L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C2CD2L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C2CD2L gene promoter:
c-Fos GATA-3 p53 AP-1 GATA-2 GATA-1 YY1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2CD2L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2CD2L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3C2CD2L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P118978: view genomic region
(about GC identifiers)
Start:
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118,972,908 bp from pter |
End:
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118,989,252 bp from pter |
Size:
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16,345 bases |
Orientation:
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plus strand |
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Proteins
for C2CD2L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C2C2L_HUMAN, O14523 (See
protein sequence)Recommended Name: C2 domain-containing protein 2-like Size: 706 amino acids; 76181 Da
Subcellular location: Membrane; Single-pass membrane protein (By similarity)
Sequence caution: Sequence=AAH10071.2; Type=Erroneous initiation; Sequence=AAH21254.2; Type=Erroneous initiation;
Secondary accessions: Q86UT7 Q86V04 Q8N522 Q8TBN4 Q96G10Alternative splicing: 2 isoforms: O14523-1 O14523-2 Explore the universe of human proteins at neXtProt for C2CD2L: NX_O14523
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14523
C2CD2L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055622.3
ENSEMBL proteins: ENSP00000338885 ENSP00000433600
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
C2CD2L for ontologies About GeneDecksing
C2CD2L Antibody Products:
Assay Products for C2CD2L: |
Protein
Domains /
Families
for C2CD2L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C2CD2L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O14523ProtoNet protein and cluster: O14523 |
Function
for C2CD2L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C2CD2L (NM_014807) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD2L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C2CD2L for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C2CD2L:
|
Pathways & Interactions
for C2CD2L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2CD2L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C2CD2L (O145233 ENSP000003388854) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C2CD2L for ontologies About GeneDecksing
|
Drugs & Compounds
for C2CD2L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2CD2L
Search CenterWatch for drugs/clinical trials and news about C2CD2L / C2C2L
|
Transcripts
for C2CD2L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2CD2L gene: NM_014807.3 Unigene Cluster for C2CD2L: C2CD2-like Hs.26899 [show with all ESTs]Unigene Representative Sequence: NM_01480710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534024 ENST00000528271 ENST00000529600 ENST00000529885 ENST00000527854
ENST00000336702(uc001pvn.3 uc001pvo.3) ENST00000529874 ENST00000525598
ENST00000528586 ENST00000533458
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C2CD2L (NM_014807) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2CD2L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2CD2L |
Additional cDNA sequence: AB006623.2 AB094094.1 AK025223.1 BC003598.1 BC010071.2 BC021254.2 BC022219.1 BC033083.1 BC040131.1 BC052246.1 BC075832.1 10 DOTS entries: DT.95200692 DT.455487 DT.100845813 DT.101982557 DT.120710433 DT.92426179 DT.91831681 DT.455486 DT.100785092 DT.95370586 24/128 AceView cDNA sequences (see all 128): CR615888 BE260059 BC040131 CD242553 BC021254 AB094094 BU727518 BM545436 BC010071 CD242710 CK903758 AI399936 AA872837 D31407 BC022219 D31478 BE312719 AI871543 BQ051620 BM721292 BU623225 BM672166 BC052246 BC003598
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C2CD2L About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C2CD2L
|
Expression
for C2CD2L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2CD2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C2CD2L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2CD2L
SOURCE GeneReport for Unigene cluster: Hs.26899
SABiosciences Custom PCR Arrays for C2CD2L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD2L
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD2L |
Orthologs
for C2CD2L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C2CD2L gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
C2CD2L1 |
C2CD2-like |
65.86(n)
64.89(a) |
|
428233 XM_425792.3 XP_425792.3 |
lizard
(Anolis carolinensis) |
Reptilia |
C2CD2L6 |
-- |
51(a) |
1 ↔ 1 |
GL344481.1(26807-30844) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.105172 |
Xenopus laevis transcribed sequences |
72.53(n) |
|
BJ622404.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
c2cd2l1 |
c2cd2-like |
59.25(n)
54.63(a) |
|
566488 NM_001077383.1 NP_001070851.1 |
ENSEMBL Gene Tree for C2CD2L (if available)
TreeFam Gene Tree for C2CD2L (if available) |
Paralogs
for C2CD2L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C2CD2L gene
- C2CD22
1 SIMAP similar gene for C2CD2L using alignment to 4 protein entries: C2C2L_HUMAN (see all proteins):C2CD2
C2CD2L for paralogs About GeneDecksing
|
Genomic Variants
for C2CD2L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C2CD2L (118972908 - 118989252 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C2CD2L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2CD2L |
|
Disorders
/ Diseases
for C2CD2L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C2CD2L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2CD2L gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C2CD2L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of TMEM24 family genes in silico. (PubMed id 15289880)1, 3, 9 Katoh M. and Katoh M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (1997)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. (PubMed id 16368544)1 Calinisan V....Gascard P. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C2CD2L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C2CD2L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2CD2L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing C2CD2L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2CD2L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C2CD2L gene:
Search GeneIP for patents involving C2CD2L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2CD2L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2CD2L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2CD2L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD2L | | | OriGene Protein Over-expression Lysate for C2CD2L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C2CD2L | | OriGene 3'-UTR Clone for C2CD2L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C2CD2L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C2CD2L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2CD2L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2CD2L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2CD2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2CD2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2CD2L |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD2L |
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