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Aliases for C2CD2L Gene

Aliases for C2CD2L Gene

  • C2CD2 Like 2 3
  • Transmembrane Protein 24 2 3 4
  • C2CD2-Like 3 5
  • TMEM24 3 4
  • KIAA0285 4
  • DLNB23 3

External Ids for C2CD2L Gene

Previous HGNC Symbols for C2CD2L Gene

  • TMEM24

Previous GeneCards Identifiers for C2CD2L Gene

  • GC11P118484
  • GC11P118978
  • GC11P114917

Summaries for C2CD2L Gene

GeneCards Summary for C2CD2L Gene

C2CD2L (C2CD2 Like) is a Protein Coding gene. GO annotations related to this gene include insulin binding. An important paralog of this gene is C2CD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2CD2L Gene

Genomics for C2CD2L Gene

Regulatory Elements for C2CD2L Gene

Enhancers for C2CD2L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C2CD2L on UCSC Golden Path with GeneCards custom track

Promoters for C2CD2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C2CD2L on UCSC Golden Path with GeneCards custom track

Genomic Location for C2CD2L Gene

119,102,198 bp from pter
119,118,544 bp from pter
16,347 bases
Plus strand

Genomic View for C2CD2L Gene

Genes around C2CD2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2CD2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2CD2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD2L Gene

Proteins for C2CD2L Gene

  • Protein details for C2CD2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C2 domain-containing protein 2-like
    Protein Accession:
    Secondary Accessions:
    • Q86UT7
    • Q86V04
    • Q8N522
    • Q8TBN4
    • Q96G10

    Protein attributes for C2CD2L Gene

    706 amino acids
    Molecular mass:
    76181 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH10071.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH21254.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C2CD2L Gene


neXtProt entry for C2CD2L Gene

Proteomics data for C2CD2L Gene at MOPED

Post-translational modifications for C2CD2L Gene

  • Ubiquitination at Lys 271
  • Modification sites at PhosphoSitePlus

Other Protein References for C2CD2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2CD2L Gene

Domains & Families for C2CD2L Gene

Protein Domains for C2CD2L Gene


Suggested Antigen Peptide Sequences for C2CD2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2CD2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C2CD2L Gene

Function for C2CD2L Gene

Gene Ontology (GO) - Molecular Function for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C2CD2L: view
genes like me logo Genes that share phenotypes with C2CD2L: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2CD2L Gene

Localization for C2CD2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2CD2L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C2CD2L Gene COMPARTMENTS Subcellular localization image for C2CD2L gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for C2CD2L Gene

Pathways & Interactions for C2CD2L Gene

SuperPathways for C2CD2L Gene

No Data Available

Interacting Proteins for C2CD2L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338885 O14523-C2C2L_HUMAN for C2CD2L Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C2CD2L: view

No data available for Pathways by source and SIGNOR curated interactions for C2CD2L Gene

Drugs & Compounds for C2CD2L Gene

No Compound Related Data Available

Transcripts for C2CD2L Gene

Unigene Clusters for C2CD2L Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14

Relevant External Links for C2CD2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2CD2L Gene

mRNA expression in normal human tissues for C2CD2L Gene

Protein differential expression in normal tissues from HIPED for C2CD2L Gene

This gene is overexpressed in Nasal epithelium (24.3) and Lung (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C2CD2L Gene

SOURCE GeneReport for Unigene cluster for C2CD2L Gene Hs.26899

genes like me logo Genes that share expression patterns with C2CD2L: view

Protein tissue co-expression partners for C2CD2L Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2CD2L Gene

Orthologs for C2CD2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2CD2L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C2CD2L 35
  • 91.37 (n)
  • 92.93 (a)
C2CD2L 36
  • 93 (a)
(Canis familiaris)
Mammalia C2CD2L 35
  • 91.32 (n)
  • 93.07 (a)
C2CD2L 36
  • 93 (a)
(Mus musculus)
Mammalia C2cd2l 35
  • 88.24 (n)
  • 90.79 (a)
C2cd2l 16
C2cd2l 36
  • 91 (a)
(Pan troglodytes)
Mammalia C2CD2L 35
  • 99.72 (n)
  • 99.72 (a)
C2CD2L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia C2cd2l 35
  • 87.91 (n)
  • 91.08 (a)
(Monodelphis domestica)
Mammalia C2CD2L 36
  • 80 (a)
(Gallus gallus)
Aves C2CD2L 35
  • 65.6 (n)
  • 64.49 (a)
C2CD2L 36
  • 62 (a)
(Anolis carolinensis)
Reptilia C2CD2L 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c2cd2l 35
  • 54.16 (n)
  • 46.3 (a)
Str.12072 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10517 35
(Danio rerio)
Actinopterygii c2cd2l 35
  • 59.48 (n)
  • 55.24 (a)
c2cd2l 36
  • 49 (a)
Species with no ortholog for C2CD2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2CD2L Gene

Gene Tree for C2CD2L (if available)
Gene Tree for C2CD2L (if available)

Paralogs for C2CD2L Gene

Paralogs for C2CD2L Gene

(1) SIMAP similar genes for C2CD2L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C2CD2L: view

Variants for C2CD2L Gene

Sequence variations from dbSNP and Humsavar for C2CD2L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2239896 - 119,112,724(-) GTTCC(A/G)GGGAG reference, missense
rs554589 -- 119,111,960(-) CCTCC(A/G)TGAAG intron-variant
rs571445 -- 119,117,261(+) GCAGG(A/G)AAGAA downstream-variant-500B, utr-variant-3-prime
rs574266 -- 119,113,580(-) GCTGG(C/G)AGGTG intron-variant
rs588539 -- 119,111,961(+) TTCAT(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2CD2L Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294
nsv468879 CNV Loss 19166990
nsv514 CNV Loss 18451855

Variation tolerance for C2CD2L Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C2CD2L Gene

Disorders for C2CD2L Gene

Relevant External Links for C2CD2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C2CD2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2CD2L Gene

Publications for C2CD2L Gene

  1. Identification and characterization of TMEM24 family genes in silico. (PMID: 15289880) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23 67
  2. Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release. (PMID: 24012759) Pottekat A. … Balch W.E. (Cell Rep 2013) 3
  3. New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. (PMID: 16368544) Calinisan V. … Gascard P. (Front. Biosci. 2006) 3
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  5. Positioning of proteins in membranes: a computational approach. (PMID: 16731967) Lomize A.L. … Mosberg H.I. (Protein Sci. 2006) 23

Products for C2CD2L Gene

Sources for C2CD2L Gene