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Aliases for C2CD2L Gene

Aliases for C2CD2L Gene

  • C2CD2 Like 2 3 5
  • Transmembrane Protein 24 2 3 4
  • TMEM24 3 4
  • C2 Domain-Containing Protein 2-Like 3
  • KIAA0285 4
  • DLNB23 3

External Ids for C2CD2L Gene

Previous HGNC Symbols for C2CD2L Gene

  • TMEM24

Previous GeneCards Identifiers for C2CD2L Gene

  • GC11P118484
  • GC11P118978
  • GC11P114917

Summaries for C2CD2L Gene

GeneCards Summary for C2CD2L Gene

C2CD2L (C2CD2 Like) is a Protein Coding gene. GO annotations related to this gene include insulin binding. An important paralog of this gene is C2CD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2CD2L Gene

Genomics for C2CD2L Gene

Regulatory Elements for C2CD2L Gene

Enhancers for C2CD2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C2CD2L on UCSC Golden Path with GeneCards custom track

Promoters for C2CD2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C2CD2L on UCSC Golden Path with GeneCards custom track

Genomic Location for C2CD2L Gene

119,102,198 bp from pter
119,118,544 bp from pter
16,347 bases
Plus strand

Genomic View for C2CD2L Gene

Genes around C2CD2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2CD2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2CD2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD2L Gene

Proteins for C2CD2L Gene

  • Protein details for C2CD2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C2 domain-containing protein 2-like
    Protein Accession:
    Secondary Accessions:
    • Q86UT7
    • Q86V04
    • Q8N522
    • Q8TBN4
    • Q96G10

    Protein attributes for C2CD2L Gene

    706 amino acids
    Molecular mass:
    76181 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH10071.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH21254.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C2CD2L Gene


neXtProt entry for C2CD2L Gene

Post-translational modifications for C2CD2L Gene

  • Ubiquitination at Lys 271
  • Modification sites at PhosphoSitePlus

Other Protein References for C2CD2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2CD2L Gene

Domains & Families for C2CD2L Gene

Protein Domains for C2CD2L Gene


Suggested Antigen Peptide Sequences for C2CD2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2CD2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C2CD2L Gene

Function for C2CD2L Gene

Gene Ontology (GO) - Molecular Function for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0043559 insulin binding IEA --
genes like me logo Genes that share ontologies with C2CD2L: view
genes like me logo Genes that share phenotypes with C2CD2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2CD2L Gene

Localization for C2CD2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2CD2L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C2CD2L Gene COMPARTMENTS Subcellular localization image for C2CD2L gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C2CD2L: view

Pathways & Interactions for C2CD2L Gene

SuperPathways for C2CD2L Gene

No Data Available

Interacting Proteins for C2CD2L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338885 O14523-C2C2L_HUMAN for C2CD2L Gene via STRING IID

Gene Ontology (GO) - Biological Process for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
genes like me logo Genes that share ontologies with C2CD2L: view

No data available for Pathways by source and SIGNOR curated interactions for C2CD2L Gene

Drugs & Compounds for C2CD2L Gene

No Compound Related Data Available

Transcripts for C2CD2L Gene

Unigene Clusters for C2CD2L Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14

Relevant External Links for C2CD2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2CD2L Gene

mRNA expression in normal human tissues for C2CD2L Gene

Protein differential expression in normal tissues from HIPED for C2CD2L Gene

This gene is overexpressed in Nasal epithelium (24.3) and Lung (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C2CD2L Gene

Protein tissue co-expression partners for C2CD2L Gene

NURSA nuclear receptor signaling pathways regulating expression of C2CD2L Gene:


SOURCE GeneReport for Unigene cluster for C2CD2L Gene:

genes like me logo Genes that share expression patterns with C2CD2L: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2CD2L Gene

Orthologs for C2CD2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2CD2L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C2CD2L 34
  • 91.37 (n)
  • 92.93 (a)
C2CD2L 35
  • 93 (a)
(Canis familiaris)
Mammalia C2CD2L 34
  • 91.32 (n)
  • 93.07 (a)
C2CD2L 35
  • 93 (a)
(Mus musculus)
Mammalia C2cd2l 34
  • 88.24 (n)
  • 90.79 (a)
C2cd2l 16
C2cd2l 35
  • 91 (a)
(Pan troglodytes)
Mammalia C2CD2L 34
  • 99.72 (n)
  • 99.72 (a)
C2CD2L 35
  • 100 (a)
(Rattus norvegicus)
Mammalia C2cd2l 34
  • 87.91 (n)
  • 91.08 (a)
(Monodelphis domestica)
Mammalia C2CD2L 35
  • 80 (a)
(Gallus gallus)
Aves C2CD2L 34
  • 65.6 (n)
  • 64.49 (a)
C2CD2L 35
  • 62 (a)
(Anolis carolinensis)
Reptilia C2CD2L 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c2cd2l 34
  • 54.16 (n)
  • 46.3 (a)
Str.12072 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10517 34
(Danio rerio)
Actinopterygii c2cd2l 34
  • 59.48 (n)
  • 55.24 (a)
c2cd2l 35
  • 49 (a)
Species where no ortholog for C2CD2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2CD2L Gene

Gene Tree for C2CD2L (if available)
Gene Tree for C2CD2L (if available)

Paralogs for C2CD2L Gene

Paralogs for C2CD2L Gene

(1) SIMAP similar genes for C2CD2L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C2CD2L: view

Variants for C2CD2L Gene

Sequence variations from dbSNP and Humsavar for C2CD2L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2239896 - 119,112,724(-) GTTCC(A/G)GGGAG reference, missense
rs1046471 -- 119,116,950(+) GCCGG(C/G)AGCCT utr-variant-3-prime
rs1129013 -- 119,118,388(+) ATGGC(C/G)TCCAG downstream-variant-500B
rs1177549 -- 119,114,772(-) tagta(A/G)agatg intron-variant
rs1305527 -- 119,114,960(-) AAAAA(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2CD2L Gene

Variant ID Type Subtype PubMed ID
nsv468879 CNV loss 19166990
nsv514 CNV deletion 18451855
nsv556466 CNV loss 21841781

Variation tolerance for C2CD2L Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2CD2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2CD2L Gene

Disorders for C2CD2L Gene

Relevant External Links for C2CD2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C2CD2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2CD2L Gene

Publications for C2CD2L Gene

  1. Identification and characterization of TMEM24 family genes in silico. (PMID: 15289880) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 22 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 65
  4. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4 65
  5. Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release. (PMID: 24012759) Pottekat A. … Balch W.E. (Cell Rep 2013) 3 65

Products for C2CD2L Gene

Sources for C2CD2L Gene