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Aliases for C2CD2L Gene

Aliases for C2CD2L Gene

  • C2CD2-Like 2 3
  • Transmembrane Protein 24 2 3 4
  • TMEM24 3 4
  • C2 Domain-Containing Protein 2-Like 3
  • KIAA0285 4
  • DLNB23 3

External Ids for C2CD2L Gene

Previous HGNC Symbols for C2CD2L Gene

  • TMEM24

Previous GeneCards Identifiers for C2CD2L Gene

  • GC11P118484
  • GC11P118978
  • GC11P114917

Summaries for C2CD2L Gene

GeneCards Summary for C2CD2L Gene

C2CD2L (C2CD2-Like) is a Protein Coding gene. An important paralog of this gene is C2CD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2CD2L Gene

Genomics for C2CD2L Gene

Regulatory Elements for C2CD2L Gene

Genomic Location for C2CD2L Gene

Start:
119,102,198 bp from pter
End:
119,118,544 bp from pter
Size:
16,347 bases
Orientation:
Plus strand

Genomic View for C2CD2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2CD2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD2L Gene

Proteins for C2CD2L Gene

  • Protein details for C2CD2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14523-C2C2L_HUMAN
    Recommended name:
    C2 domain-containing protein 2-like
    Protein Accession:
    O14523
    Secondary Accessions:
    • Q86UT7
    • Q86V04
    • Q8N522
    • Q8TBN4
    • Q96G10

    Protein attributes for C2CD2L Gene

    Size:
    706 amino acids
    Molecular mass:
    76181 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10071.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH21254.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C2CD2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C2CD2L Gene

Proteomics data for C2CD2L Gene at MOPED

Post-translational modifications for C2CD2L Gene

  • Ubiquitination at Lys271
  • Modification sites at PhosphoSitePlus

Other Protein References for C2CD2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2CD2L Gene

Domains for C2CD2L Gene

Protein Domains for C2CD2L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2CD2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2CD2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C2CD2L Gene

Function for C2CD2L Gene

Gene Ontology (GO) - Molecular Function for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0043559 insulin binding IEA --
genes like me logo Genes that share ontologies with C2CD2L: view

Phenotypes for C2CD2L Gene

GenomeRNAi human phenotypes for C2CD2L:
genes like me logo Genes that share phenotypes with C2CD2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2CD2L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C2CD2L Gene

Localization for C2CD2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2CD2L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2CD2L Gene COMPARTMENTS Subcellular localization image for C2CD2L gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C2CD2L: view

Pathways for C2CD2L Gene

SuperPathways for C2CD2L Gene

No Data Available

Interacting Proteins for C2CD2L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338885%0d%0a9606.ENSP00000345259%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000338885 O14523-C2C2L_HUMAN for C2CD2L Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C2CD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
genes like me logo Genes that share ontologies with C2CD2L: view

No data available for Pathways by source for C2CD2L Gene

Transcripts for C2CD2L Gene

Unigene Clusters for C2CD2L Gene

C2CD2-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2CD2L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C2CD2L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for C2CD2L Gene

GeneLoc Exon Structure for
C2CD2L
ECgene alternative splicing isoforms for
C2CD2L

Expression for C2CD2L Gene

mRNA expression in normal human tissues for C2CD2L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2CD2L Gene

SOURCE GeneReport for Unigene cluster for C2CD2L Gene Hs.26899

genes like me logo Genes that share expressions with C2CD2L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2CD2L Gene

Orthologs for C2CD2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2CD2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2CD2L 35
  • 99.72 (n)
  • 99.72 (a)
C2CD2L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C2CD2L 35
  • 91.37 (n)
  • 92.93 (a)
C2CD2L 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C2CD2L 35
  • 91.32 (n)
  • 93.07 (a)
C2CD2L 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C2cd2l 35
  • 88.24 (n)
  • 90.79 (a)
C2cd2l 16
C2cd2l 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C2CD2L 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C2cd2l 35
  • 87.91 (n)
  • 91.08 (a)
chicken
(Gallus gallus)
Aves C2CD2L 35
  • 65.6 (n)
  • 64.49 (a)
C2CD2L 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2CD2L 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10517 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c2cd2l 35
  • 54.16 (n)
  • 46.3 (a)
Str.12072 35
zebrafish
(Danio rerio)
Actinopterygii c2cd2l 35
  • 59.48 (n)
  • 55.24 (a)
c2cd2l 36
  • 49 (a)
OneToOne
Species with no ortholog for C2CD2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2CD2L Gene

ENSEMBL:
Gene Tree for C2CD2L (if available)
TreeFam:
Gene Tree for C2CD2L (if available)

Paralogs for C2CD2L Gene

Paralogs for C2CD2L Gene

Selected SIMAP similar genes for C2CD2L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C2CD2L: view

Variants for C2CD2L Gene

Sequence variations from dbSNP and Humsavar for C2CD2L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs510435 -- 119,109,329(-) AGTGC(A/G)GACAC intron-variant
rs554589 -- 119,111,960(-) CCTCC(A/G)TGAAG intron-variant
rs571445 -- 119,117,261(+) GCAGG(A/G)AAGAA intron-variant, downstream-variant-500B
rs574266 -- 119,113,580(-) GCTGG(C/G)AGGTG intron-variant
rs588539 -- 119,111,961(+) TTCAT(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2CD2L Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294
nsv468879 CNV Loss 19166990
nsv514 CNV Loss 18451855

Relevant External Links for C2CD2L Gene

HapMap Linkage Disequilibrium report
C2CD2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2CD2L Gene

Disorders for C2CD2L Gene

No disorders were found for C2CD2L Gene.

No data available for UniProtKB/Swiss-Prot for C2CD2L Gene

Publications for C2CD2L Gene

  1. Identification and characterization of TMEM24 family genes in silico. (PMID: 15289880) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23
  2. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. (PMID: 16368544) Calinisan V. … Gascard P. (Front. Biosci. 2006) 3

Products for C2CD2L Gene

Sources for C2CD2L Gene

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