Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C2CD2 Gene

Aliases for C2CD2 Gene

  • C2 Calcium-Dependent Domain Containing 2 2 3
  • C21orf258 3 4
  • C21orf25 3 4
  • Chromosome 21 Open Reading Frame 25 2
  • C2 Domain-Containing Protein 2 3
  • TMEM24 Related Geme 3
  • TMEM24-Like 2
  • TMEM24L 3

External Ids for C2CD2 Gene

Previous HGNC Symbols for C2CD2 Gene

  • C21orf25

Previous GeneCards Identifiers for C2CD2 Gene

  • GC21M042179
  • GC21M043306
  • GC21M028723

Summaries for C2CD2 Gene

GeneCards Summary for C2CD2 Gene

C2CD2 (C2 Calcium-Dependent Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is C2CD2L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2CD2 Gene

Genomics for C2CD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C2CD2 Gene

41,885,110 bp from pter
41,953,890 bp from pter
68,781 bases
Minus strand

Genomic View for C2CD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2CD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD2 Gene

Proteins for C2CD2 Gene

  • Protein details for C2CD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C2 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5R2V7
    • Q6AHX8
    • Q9NSE6

    Protein attributes for C2CD2 Gene

    696 amino acids
    Molecular mass:
    75533 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA95528.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH10536.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for C2CD2 Gene


neXtProt entry for C2CD2 Gene

Proteomics data for C2CD2 Gene at MOPED

Post-translational modifications for C2CD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2CD2 Gene

No data available for DME Specific Peptides for C2CD2 Gene

Domains for C2CD2 Gene

Gene Families for C2CD2 Gene

Protein Domains for C2CD2 Gene


Suggested Antigen Peptide Sequences for C2CD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with C2CD2: view

Function for C2CD2 Gene

Gene Ontology (GO) - Molecular Function for C2CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with C2CD2: view

Phenotypes for C2CD2 Gene

GenomeRNAi human phenotypes for C2CD2:
genes like me logo Genes that share phenotypes with C2CD2: view

Animal Model Products

CRISPR Products

miRNA for C2CD2 Gene

miRTarBase miRNAs that target C2CD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2CD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C2CD2 Gene

Localization for C2CD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2CD2 Gene


Subcellular locations from

Jensen Localization Image for C2CD2 Gene COMPARTMENTS Subcellular localization image for C2CD2 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C2CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 16780588
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with C2CD2: view

Pathways for C2CD2 Gene

SuperPathways for C2CD2 Gene

No Data Available

Interacting Proteins for C2CD2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000369853 for C2CD2 Gene via STRING

Gene Ontology (GO) - Biological Process for C2CD2 Gene


No data available for Pathways by source for C2CD2 Gene

Transcripts for C2CD2 Gene

Unigene Clusters for C2CD2 Gene

C2 calcium-dependent domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2CD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD2 Gene

No ASD Table

Relevant External Links for C2CD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2CD2 Gene

mRNA expression in normal human tissues for C2CD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C2CD2 Gene

This gene is overexpressed in Adrenal Gland (8.2).

Protein differential expression in normal tissues for C2CD2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (14.5), Lung (14.2), Retina (10.9), and Adrenal (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2CD2 Gene

SOURCE GeneReport for Unigene cluster for C2CD2 Gene Hs.473894

genes like me logo Genes that share expressions with C2CD2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for C2CD2 Gene

Orthologs for C2CD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2CD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C2CD2 35
  • 79.02 (n)
  • 75.4 (a)
C2CD2 36
  • 74 (a)
(Canis familiaris)
Mammalia C2CD2 35
  • 81.48 (n)
  • 77.13 (a)
C2CD2 36
  • 73 (a)
(Mus musculus)
Mammalia C2cd2 35
  • 76.6 (n)
  • 72.82 (a)
C2cd2 16
C2cd2 36
  • 70 (a)
(Pan troglodytes)
Mammalia C2CD2 35
  • 98.85 (n)
  • 98.13 (a)
C2CD2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia C2cd2 35
  • 76.21 (n)
  • 72.97 (a)
(Monodelphis domestica)
Mammalia C2CD2 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia C2CD2 36
  • 62 (a)
(Gallus gallus)
Aves C2CD2 35
  • 63.8 (n)
  • 57.87 (a)
C2CD2 36
  • 53 (a)
(Anolis carolinensis)
Reptilia C2CD2 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c2cd2 35
  • 59.98 (n)
  • 53.39 (a)
(Danio rerio)
Actinopterygii LOC101884386 35
  • 59.81 (n)
  • 56.45 (a)
C2CD2 36
  • 42 (a)
Species with no ortholog for C2CD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2CD2 Gene

Gene Tree for C2CD2 (if available)
Gene Tree for C2CD2 (if available)

Paralogs for C2CD2 Gene

Paralogs for C2CD2 Gene

(1) SIMAP similar genes for C2CD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C2CD2: view

Variants for C2CD2 Gene

Sequence variations from dbSNP and Humsavar for C2CD2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs3168 -- 41,885,326(+) TGCCA(C/T)TTTCT utr-variant-3-prime
rs3169 -- 41,885,354(+) GTTTC(A/G)ACATA utr-variant-3-prime
rs10368 -- 41,885,510(-) CCCGC(A/G)GAATC utr-variant-3-prime
rs170134 -- 41,894,397(+) GGCTG(G/T)CTGGG intron-variant
rs170135 -- 41,894,495(+) GGACA(A/G)CGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2CD2 Gene

Variant ID Type Subtype PubMed ID
nsv913770 CNV Loss 21882294
dgv4744n71 CNV Loss 21882294
dgv4745n71 CNV Loss 21882294
nsv828881 CNV Gain 20364138
nsv459271 CNV Loss 19166990
esv2723509 CNV Deletion 23290073
esv2345767 CNV Deletion 18987734
esv2723510 CNV Deletion 23290073
nsv817931 CNV Loss 17921354
nsv3530 CNV Loss 18451855
esv2677768 CNV Deletion 23128226
esv2723511 CNV Deletion 23290073
esv26328 CNV Loss 19812545
esv2659365 CNV Deletion 23128226
esv2723512 CNV Deletion 23290073
esv2723513 CNV Deletion 23290073

Relevant External Links for C2CD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2CD2 Gene

Disorders for C2CD2 Gene

Relevant External Links for C2CD2

Genetic Association Database (GAD)

No disorders were found for C2CD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for C2CD2 Gene

Publications for C2CD2 Gene

  1. Identification and characterization of TMEM24 family genes in silico. (PMID: 15289880) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PMID: 16780588) Hu Y.H. … Janitz M. (BMC Genomics 2006) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for C2CD2 Gene

Sources for C2CD2 Gene

Back to Top