Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C2CD2 Gene

protein-coding GIFtS: 44
GCID: GC21M043306

C2 calcium-dependent domain containing 2

(Previous name: chromosome 21 open reading frame 25 )
(Previous symbol: C21orf25)

Search for C2CD2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
C2 Calcium-Dependent Domain Containing 2¹ ²		DKFZP586F0422¹
C21orf25¹ ² ³		Chromosome 21 Open Reading Frame 25¹
C21orf258¹ ² ³		C2 Domain-Containing Protein 2²
TMEM24L¹ ²		TMEM24 Related Geme²

External Ids:	HGNC: 1266¹	Entrez Gene: 25966²	Ensembl: ENSG00000157617⁷	UniProtKB: Q9Y426³

Export aliases for C2CD2 gene to outside databases

Previous GC identifers: GC21M042179 GC21M028723

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011515.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C2CD2 gene promoter:
GATA-3 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 NF-E2 p45 GATA-1 GATA-2 AREB6 PPAR-alpha NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C2CD2 promoter sequence

Search SABiosciences Chromatin IP Primers for C2CD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2CD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3

C2CD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C2CD2 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21M043306: view genomic region (about GC identifiers)

Start:	43,305,219 bp from pter	End:	43,373,999 bp from pter
Size:	68,781 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CU025_HUMAN, Q9Y426 (See protein sequence)

Recommended Name: C2 domain-containing protein 2 precursor

Size: 696 amino acids; 75533 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=BAA95528.1; Type=Erroneous gene model prediction; Sequence=CAH10536.1; Type=Miscellaneous

discrepancy; Note=Intron retention;

Secondary accessions: Q5R2V7 Q6AHX8 Q9NSE6

Alternative splicing: 3 isoforms: Q9Y426-1 Q9Y426-2 Q9Y426-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C2CD2: NX_Q9Y426

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y426

C2CD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_056315.1 NP_950251.1

ENSEMBL proteins:

ENSP00000388704 ENSP00000329302 ENSP00000369853

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: C2CD2 OriGene Custom Protein Services for C2CD2
	GenScript Custom Purified and Recombinant Proteins Services for C2CD2
	Novus Biologicals C2CD2 Protein Novus Biologicals C2CD2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for C2CD2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005634	nucleus	IDA	16780588
GO:0005829	cytosol	IDA	16780588

C2CD2 for ontologies About GeneDecksing

C2CD2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for C2CD2
	GenScript Custom Superior Antibodies Services for C2CD2
	Novus Biologicals C2CD2 Antibodies
	Search for Antibodies for C2CD2 at Abcam
	Uscn Antibodies for C2CD2
	Search ThermoFisher Antibodies for C2CD2

Assay Products for C2CD2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for C2CD2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for C2CD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C2CD2 for domains About GeneDecksing

2 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR000008 C2_Ca-dep

Graphical View of Domain Structure for InterPro Entry Q9Y426

ProtoNet protein and cluster: Q9Y426

1 Blocks protein family: IPB000008 C2 domain

UniProtKB/Swiss-Prot: CU025_HUMAN, Q9Y426

Similarity: Contains 1 C2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone (see all 2): C2CD2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C2CD2
		8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate C2CD2 (see all 66):
		hsa-miR-124* hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-3622b-3p hsa-miR-548a-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2CD2 (see all 4) OriGene shRNA RFP: C2CD2 OriGene siRNA: C2CD2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2CD2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for C2CD2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: C2CD2 (NM_014807)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for C2CD2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2CD2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for C2CD2
		Search LifeMap BioReagents cell lines for C2CD2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD2

1 GenomeRNAi human phenotype for C2CD2:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C2CD2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for C2CD2 (ENSP00000369853⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C2CD2
Search CenterWatch for drugs/clinical trials and news about C2CD2 / CU025

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C2CD2 gene (2 alternative transcripts):

NM_015500.1 NM_199050.2

Unigene Clusters for C2CD2:

C2 calcium-dependent domain containing 2

Hs.473894 [show with all ESTs], Hs.675058 [show with all ESTs]

Unigene Representative Sequences: NM_015500, AK129520

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000449165 ENST00000329623(uc002yzs.3 uc002yzt.3 uc002yzu.3 uc002yzv.3)

ENST00000380486(uc002yzw.3) ENST00000482186 ENST00000482084 ENST00000467074(uc002yzx.1)

ENST00000490479 ENST00000478372

miRNA Products:		OriGene 3'-UTR Clone (see all 2): C2CD2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C2CD2
		8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate C2CD2 (see all 66):
		hsa-miR-124* hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-3622b-3p hsa-miR-548a-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2CD2 (see all 4) OriGene shRNA RFP: C2CD2 OriGene siRNA: C2CD2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2CD2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: C2CD2 (NM_014807)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for C2CD2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2CD2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat C2CD2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2CD2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2CD2

Additional cDNA sequence: AK129520.1

11 DOTS entries:

DT.92425939 DT.314791 DT.91746031 DT.95115516 DT.40190688 DT.100782488 DT.101974274 DT.92425938

DT.92425940 DT.40299780 DT.86836116

24/141 AceView cDNA sequences (see all 141):

BC062323 AL833323 CA389473 AI523354 CA418044 AI168265 NM_199050 BM754719

BM051485 CD655727 AA346439 Z43345 BU728212 CD652977 AW150801 BF439399

BG741299 CF454915 AA724852 AL050173 AI801057 BM739460 AA373841 AA610864

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C2CD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C2CD2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C2CD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2CD2

SOURCE GeneReport for Unigene clusters: Hs.473894 Hs.675058

SABiosciences Custom PCR Arrays for C2CD2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat C2CD2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2CD2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2CD2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C2CD2 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	C2cd2^{1 , 5}	C2 calcium-dependent domain containing 2^{1, 5}	77.37(n)¹ 73.4(a)¹		16 (57.70 cM)⁵ 207781¹ NM_174847.2¹ NP_777272.2¹ 97855210⁵
chicken (Gallus gallus)	Aves	C2CD2¹	C2 calcium-dependent domain containing 2	63.85(n) 57.5(a)		418532 XM_416741.3 XP_416741.3
lizard (Anolis carolinensis)	Reptilia	C2CD2⁶	--	51(a)	1 ↔ 1	3(138089335-138130904)
zebrafish (Danio rerio)	Actinopterygii	BX088525.1⁶	--	42(a)	1 ↔ 1	10(34257606-34370562)

ENSEMBL Gene Tree for C2CD2 (if available)
TreeFam Gene Tree for C2CD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for C2CD2 gene

C2CD2L²

1 SIMAP similar gene for C2CD2 using alignment to 3 protein entries: CU025_HUMAN (see all proteins):

C2CD2L

C2CD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191777684^1,2		--	43304755(+)	`AGCATC/TGGGCT`	2	--	int¹		0	--	--	--	--
rs146012487^1,2		--	43304779(+)	`TACACA/GGTGTC`	2	--	int¹		0	--	--	--	--
rs182513808^1,2		--	43304793(+)	`CGAGCA/GGGCGG`	2	--	int¹		0	--	--	--	--
rs1539968^1,2	C,F,A,H,	--	43304884(+)	`CACGTG/TCTCTG`	2	--	int¹		20		NS EA NA WA	2310
rs73906129^1,2	C,	--	43304960(+)	`GGCACG/AATGCC`	2	--	int¹		2		WA	120
rs78110784^1,2	C,	--	43304989(+)	`CACGTC/ATGTGA`	2	--	int¹		4		NA EA	244
rs187620288^1,2		--	43305031(+)	`CGTGAA/GCCCCA`	2	--	int¹		0	--	--	--	--
rs73906130^1,2	C,F,	--	43305183(+)	`GGACTT/CCCAGG`	2	--	int¹		3		WA CSA	122
rs3168^1,2	C,F,A,H,	--	43305435(+)	`TGCCAT/CTTTCT`	2	--	ut3¹ trp³		31		EA NA MN NS WA CSA	3424
rs3169^1,2	C,F,A,H,	--	43305463(+)	`GTTTCA/GACATA`	2	--	ut3¹ ese³		34		MN NA NS EA WA	3720

HapMap Linkage Disequilibrium report for C2CD2 (43305219 - 43373999 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C2CD2
2 CNVs: 67794 10602

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2CD2

DNA2.0 Custom Variant and Variant Library Synthesis for C2CD2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C2CD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2CD2)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of TMEM24 family genes in silico. (PubMed id 15289880)^{1, 3, 9} Katoh M. and Katoh M. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Functional analysis and identification of cis-regulat ory elements of human chromosome 21 gene promoters. (PubMed id 20494980)¹ Warnatz H.J....Yaspo M.L. (2010)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)¹ Hu Y.H....Janitz M. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25966	HGNC: 1266	AceView: C21orf25	Ensembl:ENSG00000157617	euGenes: HUgn25966
ECgene: C2CD2	H-InvDB: C2CD2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C2CD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C2CD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C2CD2 gene:
Search GeneIP for patents involving C2CD2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for C2CD2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2CD2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2CD2
	OriGene Protein Over-expression Lysate for C2CD2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for C2CD2		OriGene 3'-UTR Clone for C2CD2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2CD2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for C2CD2		OriGene Custom Protein Services for C2CD2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C2CD2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2CD2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2CD2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2CD2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2CD2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2CD2

	GenScript Custom Purified and Recombinant Proteins Services for C2CD2		GenScript cDNA clones with any tag delivered in your preferred vector for C2CD2
	GenScript Custom Assay Services for C2CD2		GenScript Custom Superior Antibodies Services for C2CD2
	GenScript Custom overexpressing Cell Line Services for C2CD2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in C2CD2 promoter
	Search Chromatin IP Primers for C2CD2
	RT² qPCR Primer Assay in human, mouse, rat C2CD2
	Search GNC Networks for C2CD2
	SABiosciences Custom PCR Arrays for C2CD2

Search Tocris compounds for C2CD2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	C2CD2 antibodies
	C2CD2 proteins
	C2CD2 lysates

	Search for Antibodies for C2CD2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for C2CD2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

C2CD2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for C2CD2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for C2CD2
	SwitchGear Promoter luciferase reporter plasmids for C2CD2

Search ThermoFisher Antibodies for C2CD2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2CD2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C2CD2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

C2CD2 Gene

C2 calcium-dependent domain containing 2

Aliases
for C2CD2 gene

Summaries
for C2CD2 gene

Genomic Views
for C2CD2 gene

Proteins
for C2CD2 gene

Protein Domains /
Families
for C2CD2 gene

Function
for C2CD2 gene

Pathways & Interactions
for C2CD2 gene

Drugs & Compounds
for C2CD2 gene

Transcripts
for C2CD2 gene

Expression
for C2CD2 gene

Orthologs
for C2CD2 gene

Paralogs
for C2CD2 gene

Genomic Variants
for C2CD2 gene

Disorders / Diseases
for C2CD2 gene

Publications
for C2CD2 gene

External Searches for C2CD2 gene

Genome Databases showing C2CD2 gene

Other Databases showing C2CD2 gene

Specialized Databases showing C2CD2 gene

Intellectual Property
for C2CD2 gene

Products
for C2CD2 gene

View Random Gene

Advanced Search

Export list of displayed genes

C2CD2 Gene

C2 calcium-dependent domain containing 2

Aliasesfor C2CD2 gene

Summariesfor C2CD2 gene

Genomic Viewsfor C2CD2 gene

Proteinsfor C2CD2 gene

Protein Domains /Familiesfor C2CD2 gene

Functionfor C2CD2 gene

Pathways & Interactionsfor C2CD2 gene

Drugs & Compoundsfor C2CD2 gene

Transcriptsfor C2CD2 gene

Expression for C2CD2 gene

Orthologsfor C2CD2 gene

Paralogsfor C2CD2 gene

Genomic Variantsfor C2CD2 gene

Disorders / Diseasesfor C2CD2 gene

Publicationsfor C2CD2 gene

External Searches for C2CD2 gene

Genome Databases showing C2CD2 gene

Other Databases showing C2CD2 gene

Specialized Databases showing C2CD2 gene

Intellectual Propertyfor C2CD2 gene

Productsfor C2CD2 gene

View Random Gene

Aliases
for C2CD2 gene

Summaries
for C2CD2 gene

Genomic Views
for C2CD2 gene

Proteins
for C2CD2 gene

Protein Domains /
Families
for C2CD2 gene

Function
for C2CD2 gene

Pathways & Interactions
for C2CD2 gene

Drugs & Compounds
for C2CD2 gene

Transcripts
for C2CD2 gene

Expression
for C2CD2 gene

Orthologs
for C2CD2 gene

Paralogs
for C2CD2 gene

Genomic Variants
for C2CD2 gene

Disorders / Diseases
for C2CD2 gene

Publications
for C2CD2 gene

Intellectual Property
for C2CD2 gene

Products
for C2CD2 gene