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C2CD2 Gene

protein-coding   GIFtS: 47
GCID: GC21M043306

C2 Calcium-Dependent Domain Containing 2

(Previous name: chromosome 21 open reading frame 25)
(Previous symbol: C21orf25)
  Search for C2CD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C2 Calcium-Dependent Domain Containing 21 2     Chromosome 21 Open Reading Frame 251
C21orf251 2 3     TMEM24L2
C21orf2582 3     C2 Domain-Containing Protein 22
TMEM24-like1     TMEM24 Related Geme2

External Ids:    HGNC: 12661   Entrez Gene: 259662   Ensembl: ENSG000001576177   UniProtKB: Q9Y4263   

Export aliases for C2CD2 gene to outside databases

Previous GC identifers: GC21M042179 GC21M028723


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C2CD2 Gene:
C2CD2 (C2 calcium-dependent domain containing 2) is a protein-coding gene. An important paralog of this gene is C2CD2L.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C2CD2 gene promoter:
         GATA-3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   NF-E2 p45   GATA-1   GATA-2   AREB6   PPAR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC2CD2 promoter sequence
   Search Chromatin IP Primers for C2CD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C2CD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

C2CD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C2CD2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M043306:  view genomic region     (about GC identifiers)

Start:
43,305,219 bp from pter      End:
43,373,999 bp from pter
Size:
68,781 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CU025_HUMAN, Q9Y426 (See protein sequence)
Recommended Name: C2 domain-containing protein 2 precursor  
Size: 696 amino acids; 75533 Da
Sequence caution: Sequence=BAA95528.1; Type=Erroneous gene model prediction; Sequence=CAH10536.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q5R2V7 Q6AHX8 Q9NSE6
Alternative splicing: 3 isoforms:  Q9Y426-1   Q9Y426-2   Q9Y426-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C2CD2: NX_Q9Y426

Explore proteomics data for C2CD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C2CD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056315.1  NP_950251.1  

    ENSEMBL proteins: 
     ENSP00000388704   ENSP00000329302   ENSP00000369853  

    C2CD2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for C2CD2

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    C2CD2 Assay Products:

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    Cloud-Clone Corp. CLIAs for C2CD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y426

    ProtoNet protein and cluster: Q9Y426

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: CU025_HUMAN, Q9Y426
    Similarity: Contains 1 C2 domain


    C2CD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C2CD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for C2CD2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C2CD2
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    miRNA
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    miRTarBase miRNAs that target C2CD2:
    hsa-mir-193b-3p (MIRT041416), hsa-mir-10a-5p (MIRT047619)

    Block miRNA regulation of human, mouse, rat C2CD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C2CD2 (see all 66):
    hsa-miR-124* hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-3622b-3p hsa-miR-548a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C2CD2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: C2CD2 (NM_014807)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2CD2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CU025_HUMAN, Q9Y426: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    extracellular3
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA16780588
    GO:0005829cytosol IDA16780588

    C2CD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C2CD2
    Interactions:

        Search GeneGlobe Interaction Network for C2CD2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C2CD2 (ENSP000003698534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C2CD2 (CU025)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C2CD2 gene (2 alternative transcripts): 
    NM_015500.1  NM_199050.2  

    Unigene Cluster for C2CD2:

    C2 calcium-dependent domain containing 2
    Hs.473894  [show with all ESTs]
    Unigene Representative Sequence: NM_015500
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449165 ENST00000329623(uc002yzs.3 uc002yzt.3 uc002yzu.3 uc002yzv.3)
    ENST00000380486(uc002yzw.3) ENST00000482186 ENST00000482084 ENST00000467074(uc002yzx.1)
    ENST00000490479 ENST00000478372
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C2CD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C2CD2 (see all 66):
    hsa-miR-124* hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-3622b-3p hsa-miR-548a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for C2CD2
    Predesigned siRNA for gene silencing in human, mouse, rat C2CD2
    Clone
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    OriGene clones in human, mouse for C2CD2 (see all 11)
    OriGene ORF clones in mouse, rat for C2CD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C2CD2 (NM_014807)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C2CD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2CD2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for C2CD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C2CD2
      QuantiTect SYBR Green Assays in human, mouse, rat C2CD2
      QuantiFast Probe-based Assays in human, mouse, rat C2CD2

    Additional mRNA sequence: 

    AB047784.1 AB047785.1 AK125120.1 AK128550.1 AL050173.1 AL833323.1 BC020927.1 BC035070.1 
    BC062323.1 

    11 DOTS entries:

    DT.92425939  DT.314791  DT.91746031  DT.95115516  DT.40190688  DT.100782488  DT.101974274  DT.92425938 
    DT.92425940  DT.40299780  DT.86836116 

    Selected AceView cDNA sequences (see all 141):

    AL833323 NM_199050 CD655727 AI168265 Z43345 AI523354 BM051485 CA389473 
    BC062323 AA346439 CA418044 BM754719 BU728212 CD652977 BG287744 BF439399 
    AK128550 BQ652161 BM715218 CD512125 AA447837 CA448203 AA724852 AA564823 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C2CD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C2CD2 Expression
    About this image


    C2CD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
    C2CD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C2CD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473894
        Custom PCR Arrays for C2CD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2CD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C2CD2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C2cd21 , 5 C2 calcium-dependent domain containing 21, 5 76.6(n)1
    72.82(a)1
      16 (57.70 cM)5
    2077811  NM_174847.21  NP_777272.21 
     978552105 
    chicken
    (Gallus gallus)
    Aves C2CD21 C2 calcium-dependent domain containing 2 63.8(n)
    57.87(a)
      418532  XM_416741.4  XP_416741.3 
    lizard
    (Anolis carolinensis)
    Reptilia C2CD26
    C2 calcium-dependent domain containing 2
    51(a)
    1 ↔ 1
    3(138088462-138130904)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia c2cd21 C2 calcium-dependent domain containing 2 59.98(n)
    53.39(a)
      100494938  XM_002941289.2  XP_002941335.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018843861 C2 domain-containing protein 2-like 59.81(n)
    56.45(a)
      101884386  XM_005172745.1  XP_005172802.1 


    ENSEMBL Gene Tree for C2CD2 (if available)
    TreeFam Gene Tree for C2CD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C2CD2 gene
    C2CD2L2  
    1 SIMAP similar gene for C2CD2 using alignment to 3 protein entries:     CU025_HUMAN (see all proteins):
    C2CD2L

    C2CD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C2CD2 (see all 1892)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134610231,2
    C--33809858(+) TTTTTT/-GAGAC 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1917776841,2
    --43304755(+) AGCATC/TGGGCT 2 -- int10--------
    rs1460124871,2
    --43304779(+) TACACA/GGTGTC 2 -- int10--------
    rs1825138081,2
    --43304793(+) CGAGCA/GGGCGG 2 -- int10--------
    rs15399681,2
    C,F,A,H--43304884(+) CACGTG/TCTCTG 2 -- int120Minor allele frequency- T:0.09NS EA NA WA 2310
    rs739061291,2
    C,F--43304960(+) GGCACG/AATGCC 2 -- int12Minor allele frequency- A:0.08WA 120
    rs781107841,2
    C--43304989(+) CACGTC/ATGTGA 2 -- int14Minor allele frequency- A:0.10NA EA 244
    rs1876202881,2
    --43305031(+) CGTGAA/GCCCCA 2 -- int10--------
    rs739061301,2
    C,F--43305183(+) GGACTT/CCCAGG 2 -- int13Minor allele frequency- C:0.19WA CSA 122
    rs31681,2
    C,F,A,H--43305435(+) TGCCAT/CTTTCT 2 -- ut31 trp331Minor allele frequency- C:0.17EA NA MN NS WA CSA 3424

    HapMap Linkage Disequilibrium report for C2CD2 (43305219 - 43373999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for C2CD2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723511CNV Deletion23290073
    esv2677768CNV Deletion23128226
    esv2723509CNV Deletion23290073
    esv2345767CNV Deletion18987734
    esv2659365CNV Deletion23128226
    esv2723510CNV Deletion23290073
    esv2723513CNV Deletion23290073
    esv2723512CNV Deletion23290073
    nsv459271CNV Loss19166990
    nsv817931CNV Loss17921354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    C2CD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C2CD2

    Export disorders for C2CD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C2CD2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C2CD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of TMEM24 family genes in silico. (PubMed id 15289880)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    2. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    4. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PubMed id 20494980)1 Warnatz H.J....Yaspo M.L. (Nucleic Acids Res. 2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (BMC Genomics 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25966 HGNC: 1266 AceView: C21orf25 Ensembl:ENSG00000157617 euGenes: HUgn25966
    ECgene: C2CD2 H-InvDB: C2CD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C2CD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C2CD2 gene:
    Search GeneIP for patents involving C2CD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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