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Aliases for C22orf46 Gene

Aliases for C22orf46 Gene

  • Chromosome 22 Open Reading Frame 46 2 3 5
  • Putative Uncharacterized Protein C22orf46 3
  • Uncharacterized Protein C22orf46 3
  • CTA-216E10.6 3

External Ids for C22orf46 Gene

Previous GeneCards Identifiers for C22orf46 Gene

  • GC22P040418
  • GC22P042085
  • GC22P025051

Summaries for C22orf46 Gene

GeneCards Summary for C22orf46 Gene

C22orf46 (Chromosome 22 Open Reading Frame 46) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf46 Gene

Genomics for C22orf46 Gene

Regulatory Elements for C22orf46 Gene

Enhancers for C22orf46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F041660 0.2 ENCODE 12.5 -28.3 -28308 0.2 KLF1 INSM2 HIC1 ZFHX2 GLIS2 ZNF366 PATZ1 SCRT2 PRDM10 KLF8 C22orf46 SNU13 XRCC6 DESI1 CENPM MEI1 CSDC2 RNU6ATAC22P PIR49915 PIR47284
GH22F041897 0.5 ENCODE 10.6 +210.1 210060 2.4 ARID4B SIN3A ZNF48 SLC30A9 GLIS2 ZNF766 ZNF263 SP5 NFYC MXD4 NDUFA6 TNFRSF13C MIR378I CYP2D6 CENPM SNU13 C22orf46 SMDT1 RNU6ATAC22P WBP2NL
GH22F041750 0.7 FANTOM5 1.7 +61.2 61225 0.3 RNU6ATAC22P MEI1 SEPT3 C22orf46 ENSG00000206813 GC22P041758
GH22F041687 1 ENCODE 0.8 -0.5 -544 2.6 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF263 SP3 SP5 EP300 XRCC6 EP300-AS1 LOC100313968 ENSG00000232754 PHF5A RN7SKP80 ENSG00000273366 ENSG00000233903 CCDC134
GH22F041681 0.2 ENCODE 0.4 -6.5 -6543 2.4 PKNOX1 MLX CREB3L1 SIN3A ARID4B DMAP1 YY1 ZNF766 SP3 SP5 MEI1 RN7SKP80 RRP7BP EP300 PHF5A CCDC134 RNU6-476P C22orf46
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C22orf46 on UCSC Golden Path with GeneCards custom track

Promoters for C22orf46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001532938 -439 2601 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF263 SP3 SP5 NFYC

Genomic Location for C22orf46 Gene

Chromosome:
22
Start:
41,688,939 bp from pter
End:
41,698,136 bp from pter
Size:
9,198 bases
Orientation:
Plus strand

Genomic View for C22orf46 Gene

Genes around C22orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf46 Gene

Proteins for C22orf46 Gene

  • Protein details for C22orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9J442-CV046_HUMAN
    Recommended name:
    Uncharacterized protein C22orf46
    Protein Accession:
    C9J442

    Protein attributes for C22orf46 Gene

    Size:
    243 amino acids
    Molecular mass:
    27532 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW60455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C22orf46 Gene

Post-translational modifications for C22orf46 Gene

  • Glycosylation at Asn 30 and Asn 165
  • Modification sites at PhosphoSitePlus

Other Protein References for C22orf46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C22orf46 Gene

Domains & Families for C22orf46 Gene

Protein Domains for C22orf46 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf46: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf46 Gene

Function for C22orf46 Gene

Phenotypes for C22orf46 Gene

GenomeRNAi human phenotypes for C22orf46:
genes like me logo Genes that share phenotypes with C22orf46: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C22orf46 Gene

Localization for C22orf46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C22orf46 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C22orf46 Gene COMPARTMENTS Subcellular localization image for C22orf46 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for C22orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C22orf46: view

Pathways & Interactions for C22orf46 Gene

SuperPathways for C22orf46 Gene

No Data Available

Interacting Proteins for C22orf46 Gene

Selected Interacting proteins: C9J442-CV046_HUMAN for C22orf46 Gene via IID

Gene Ontology (GO) - Biological Process for C22orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf46 Gene

Transcripts for C22orf46 Gene

mRNA/cDNA for C22orf46 Gene

Unigene Clusters for C22orf46 Gene

Chromosome 22 open reading frame 46:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf46 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2:
SP3:

Relevant External Links for C22orf46 Gene

GeneLoc Exon Structure for
C22orf46
ECgene alternative splicing isoforms for
C22orf46

Expression for C22orf46 Gene

mRNA expression in normal human tissues for C22orf46 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf46 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of C22orf46 Gene:

C22orf46

SOURCE GeneReport for Unigene cluster for C22orf46 Gene:

Hs.517653
genes like me logo Genes that share expression patterns with C22orf46: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C22orf46 Gene

Orthologs for C22orf46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf46 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C22orf46 35
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C22orf46 35
  • 62 (a)
OneToOne
Species where no ortholog for C22orf46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf46 Gene

ENSEMBL:
Gene Tree for C22orf46 (if available)
TreeFam:
Gene Tree for C22orf46 (if available)

Paralogs for C22orf46 Gene

No data available for Paralogs for C22orf46 Gene

Variants for C22orf46 Gene

Sequence variations from dbSNP and Humsavar for C22orf46 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1045804 -- 41,697,608(+) GGAAT(C/T)TACAG upstream-variant-2KB, utr-variant-3-prime
rs10775759 -- 41,692,154(+) agtgg(C/T)gcgat intron-variant, upstream-variant-2KB
rs111247261 -- 41,687,041(+) ACCCC(C/T)GCCTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs111532345 -- 41,692,395(+) GGTCG(A/T)CTCTG intron-variant, upstream-variant-2KB
rs112062358 -- 41,692,656(+) GACCT(G/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf46 Gene

Variant ID Type Subtype PubMed ID
nsv1062939 CNV gain 25217958
nsv524585 CNV loss 19592680
nsv834209 CNV loss 17160897

Variation tolerance for C22orf46 Gene

Gene Damage Index Score: 2.17; 39.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf46 Gene

Disorders for C22orf46 Gene

Relevant External Links for C22orf46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf46

No disorders were found for C22orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf46 Gene

Publications for C22orf46 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3 64

Products for C22orf46 Gene

Sources for C22orf46 Gene

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