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Aliases for C22orf46 Gene

Aliases for C22orf46 Gene

  • Chromosome 22 Open Reading Frame 46 2 3 5
  • Putative Uncharacterized Protein C22orf46 3
  • CTA-216E10.6 3

External Ids for C22orf46 Gene

Previous GeneCards Identifiers for C22orf46 Gene

  • GC22P040418
  • GC22P042085
  • GC22P025051

Summaries for C22orf46 Gene

GeneCards Summary for C22orf46 Gene

C22orf46 (Chromosome 22 Open Reading Frame 46) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf46 Gene

Genomics for C22orf46 Gene

Regulatory Elements for C22orf46 Gene

Promoters for C22orf46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C22orf46 on UCSC Golden Path with GeneCards custom track

Genomic Location for C22orf46 Gene

Chromosome:
22
Start:
41,688,939 bp from pter
End:
41,698,136 bp from pter
Size:
9,198 bases
Orientation:
Plus strand

Genomic View for C22orf46 Gene

Genes around C22orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf46 Gene

Proteins for C22orf46 Gene

  • Protein details for C22orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9J442-CV046_HUMAN
    Recommended name:
    Uncharacterized protein C22orf46
    Protein Accession:
    C9J442

    Protein attributes for C22orf46 Gene

    Size:
    243 amino acids
    Molecular mass:
    27532 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW60455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C22orf46 Gene

Proteomics data for C22orf46 Gene at MOPED

Post-translational modifications for C22orf46 Gene

  • Glycosylation at Asn 30 and Asn 165
  • Modification sites at PhosphoSitePlus

Other Protein References for C22orf46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C22orf46 Gene

Domains & Families for C22orf46 Gene

Protein Domains for C22orf46 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf46: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf46 Gene

Function for C22orf46 Gene

Phenotypes for C22orf46 Gene

GenomeRNAi human phenotypes for C22orf46:
genes like me logo Genes that share phenotypes with C22orf46: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C22orf46 Gene

Localization for C22orf46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C22orf46 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C22orf46 Gene COMPARTMENTS Subcellular localization image for C22orf46 gene
Compartment Confidence
extracellular 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for C22orf46 Gene

Pathways & Interactions for C22orf46 Gene

SuperPathways for C22orf46 Gene

No Data Available

Interacting Proteins for C22orf46 Gene

Selected Interacting proteins: C9J442-CV046_HUMAN for C22orf46 Gene via I2D

Symbol External ID(s) Details
SMAD2

Gene Ontology (GO) - Biological Process for C22orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf46 Gene

Drugs & Compounds for C22orf46 Gene

No Compound Related Data Available

Transcripts for C22orf46 Gene

mRNA/cDNA for C22orf46 Gene

Unigene Clusters for C22orf46 Gene

Chromosome 22 open reading frame 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf46 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2:
SP3:

Relevant External Links for C22orf46 Gene

GeneLoc Exon Structure for
C22orf46
ECgene alternative splicing isoforms for
C22orf46

Expression for C22orf46 Gene

mRNA expression in normal human tissues for C22orf46 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf46 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.3).

SOURCE GeneReport for Unigene cluster for C22orf46 Gene Hs.517653

genes like me logo Genes that share expression patterns with C22orf46: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C22orf46 Gene

Orthologs for C22orf46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf46 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C22orf46 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C22orf46 36
  • 62 (a)
OneToOne
Species with no ortholog for C22orf46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf46 Gene

ENSEMBL:
Gene Tree for C22orf46 (if available)
TreeFam:
Gene Tree for C22orf46 (if available)

Paralogs for C22orf46 Gene

No data available for Paralogs for C22orf46 Gene

Variants for C22orf46 Gene

Sequence variations from dbSNP and Humsavar for C22orf46 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs739134 -- 41,693,619(+) AATCA(C/T)GGGCC reference, missense
rs2032494 -- 41,695,430(+) TACCA(A/C/G)AGGGG utr-variant-3-prime
rs5758420 -- 41,692,577(+) tggcc(A/G)atttt intron-variant
rs5996052 -- 41,694,098(+) CCAGG(C/T)TCCAA utr-variant-3-prime
rs6002440 -- 41,692,743(+) tttca(A/G)atgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf46 Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv834209 CNV Loss 17160897
nsv915155 CNV Loss 21882294

Variation tolerance for C22orf46 Gene

Gene Damage Index Score: 2.17; 39.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf46 Gene

HapMap Linkage Disequilibrium report
C22orf46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf46 Gene

Disorders for C22orf46 Gene

Relevant External Links for C22orf46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf46

No disorders were found for C22orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf46 Gene

Publications for C22orf46 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3

Products for C22orf46 Gene

Sources for C22orf46 Gene

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