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Aliases for C22orf42 Gene

Aliases for C22orf42 Gene

  • Chromosome 22 Open Reading Frame 42 2 3 5
  • Uncharacterized Protein C22orf42 3
  • DJ90G24.6 3

External Ids for C22orf42 Gene

Previous GeneCards Identifiers for C22orf42 Gene

  • GC22M030875
  • GC22M032544
  • GC22M015501

Summaries for C22orf42 Gene

GeneCards Summary for C22orf42 Gene

C22orf42 (Chromosome 22 Open Reading Frame 42) is a Protein Coding gene.

Additional gene information for C22orf42 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf42 Gene

Genomics for C22orf42 Gene

Regulatory Elements for C22orf42 Gene

Enhancers for C22orf42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H032473 1.7 FANTOM5 ENCODE dbSUPER 2.6 -315.3 -315288 4.7 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3 FBXO7 BPIFC EIF4ENIF1 SLC5A4 RFPL3 C22orf42 RFPL2 PIR46477
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C22orf42 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C22orf42 Gene

Genomic Locations for C22orf42 Gene
11,427 bases
Minus strand

Genomic View for C22orf42 Gene

Genes around C22orf42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf42 Gene

Proteins for C22orf42 Gene

  • Protein details for C22orf42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C22orf42
    Protein Accession:
    Secondary Accessions:
    • A4QPH5

    Protein attributes for C22orf42 Gene

    251 amino acids
    Molecular mass:
    27691 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C22orf42 Gene

Post-translational modifications for C22orf42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf42 Gene

No data available for DME Specific Peptides for C22orf42 Gene

Domains & Families for C22orf42 Gene

Gene Families for C22orf42 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C22orf42 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf42: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf42 Gene

Function for C22orf42 Gene

Phenotypes From GWAS Catalog for C22orf42 Gene

Phenotypes for C22orf42 Gene

GenomeRNAi human phenotypes for C22orf42:
genes like me logo Genes that share phenotypes with C22orf42: view

Animal Model Products

CRISPR Products

miRNA for C22orf42 Gene

miRTarBase miRNAs that target C22orf42

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C22orf42 Gene

Localization for C22orf42 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf42 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C22orf42 Gene

Pathways & Interactions for C22orf42 Gene

SuperPathways for C22orf42 Gene

No Data Available

Interacting Proteins for C22orf42 Gene

Gene Ontology (GO) - Biological Process for C22orf42 Gene


No data available for Pathways by source and SIGNOR curated interactions for C22orf42 Gene

Drugs & Compounds for C22orf42 Gene

No Compound Related Data Available

Transcripts for C22orf42 Gene

mRNA/cDNA for C22orf42 Gene

Unigene Clusters for C22orf42 Gene

Chromosome 22 open reading frame 42:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf42 Gene

No ASD Table

Relevant External Links for C22orf42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C22orf42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C22orf42 Gene

This gene is overexpressed in Testis (x24.8) and Brain - Hypothalamus (x18.0).

NURSA nuclear receptor signaling pathways regulating expression of C22orf42 Gene:


SOURCE GeneReport for Unigene cluster for C22orf42 Gene:

genes like me logo Genes that share expression patterns with C22orf42: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf42 Gene

Orthologs for C22orf42 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C22orf42 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C22H22orf42 33
  • 98.07 (n)
C22orf42 34
  • 95 (a)
Species where no ortholog for C22orf42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf42 Gene

Gene Tree for C22orf42 (if available)
Gene Tree for C22orf42 (if available)

Paralogs for C22orf42 Gene Pseudogenes for C22orf42 Gene

genes like me logo Genes that share paralogs with C22orf42: view

No data available for Paralogs for C22orf42 Gene

Variants for C22orf42 Gene

Sequence variations from dbSNP and Humsavar for C22orf42 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000445492 -- 32,151,168(+) AGGAT(G/T)CTTGT intron-variant, downstream-variant-500B
rs1000790654 -- 32,157,330(+) TTAAC(A/C)GTAAT intron-variant
rs1000962915 -- 32,149,921(+) ATAGA(C/T)GATGT intron-variant, downstream-variant-500B
rs1001353674 -- 32,158,592(+) ACATA(C/T)TTGAG intron-variant
rs1001381628 -- 32,149,540(+) GAACA(C/T)TAAAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for C22orf42 Gene

Variant ID Type Subtype PubMed ID
nsv962789 CNV duplication 23825009
nsv834178 CNV loss 17160897
nsv834177 CNV gain 17160897
nsv1110864 OTHER inversion 24896259
esv3893474 CNV gain 25118596
esv3647597 CNV gain 21293372
esv3575476 CNV gain 25503493
esv2422247 CNV duplication 17116639

Variation tolerance for C22orf42 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf42 Gene

Disorders for C22orf42 Gene

Relevant External Links for C22orf42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C22orf42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf42 Gene

Publications for C22orf42 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 60

Products for C22orf42 Gene

Sources for C22orf42 Gene

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