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Aliases for C22orf39 Gene

Aliases for C22orf39 Gene

  • Chromosome 22 Open Reading Frame 39 2 3 5

External Ids for C22orf39 Gene

Previous GeneCards Identifiers for C22orf39 Gene

  • GC22M017808
  • GC22M003049

Summaries for C22orf39 Gene

GeneCards Summary for C22orf39 Gene

C22orf39 (Chromosome 22 Open Reading Frame 39) is a Protein Coding gene.

Additional gene information for C22orf39 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf39 Gene

Genomics for C22orf39 Gene

Regulatory Elements for C22orf39 Gene

Enhancers for C22orf39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H019396 1.3 ENCODE dbSUPER 12.2 +50.5 50548 2 HDGF PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 CBX5 GATA2 ELK1 UFD1 DGCR8 TRMT2A E2F6P1 HIRA LOC105372860 C22orf39 LINC01311 TBX1 RPL8P5
GH22H019213 0.6 ENCODE 12.1 +234.1 234140 0 ATF1 MAX USF2 MNT PYGO2 ZIC2 POLR2A GATA2 CLTCL1 C22orf39 HIRA LOC105372860 PIR49429 RPL34P35
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C22orf39 on UCSC Golden Path with GeneCards custom track

Promoters for C22orf39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143746 732 1401 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for C22orf39 Gene

Chromosome:
22
Start:
19,351,368 bp from pter
End:
19,448,232 bp from pter
Size:
96,865 bases
Orientation:
Minus strand

Genomic View for C22orf39 Gene

Genes around C22orf39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf39 Gene

Proteins for C22orf39 Gene

  • Protein details for C22orf39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5X5-CV039_HUMAN
    Recommended name:
    UPF0545 protein C22orf39
    Protein Accession:
    Q6P5X5
    Secondary Accessions:
    • A8MTW6
    • D3DX18
    • F5H3A8
    • J3KNP9

    Protein attributes for C22orf39 Gene

    Size:
    142 amino acids
    Molecular mass:
    16805 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH62599.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF82762.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAG30225.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX03040.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C22orf39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C22orf39 Gene

Post-translational modifications for C22orf39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf39 Gene

No data available for DME Specific Peptides for C22orf39 Gene

Domains & Families for C22orf39 Gene

Gene Families for C22orf39 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C22orf39 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C22orf39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5X5

UniProtKB/Swiss-Prot:

CV039_HUMAN :
  • Belongs to the UPF0545 family.
Family:
  • Belongs to the UPF0545 family.
genes like me logo Genes that share domains with C22orf39: view

Function for C22orf39 Gene

Gene Ontology (GO) - Molecular Function for C22orf39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C22orf39: view

Phenotypes for C22orf39 Gene

GenomeRNAi human phenotypes for C22orf39:
genes like me logo Genes that share phenotypes with C22orf39: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C22orf39
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C22orf39 Gene

Localization for C22orf39 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C22orf39 Gene

Pathways & Interactions for C22orf39 Gene

SuperPathways for C22orf39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C22orf39 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf39 Gene

Drugs & Compounds for C22orf39 Gene

No Compound Related Data Available

Transcripts for C22orf39 Gene

Unigene Clusters for C22orf39 Gene

Chromosome 22 open reading frame 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C22orf39
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf39 Gene

No ASD Table

Relevant External Links for C22orf39 Gene

GeneLoc Exon Structure for
C22orf39
ECgene alternative splicing isoforms for
C22orf39

Expression for C22orf39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf39 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf39 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for C22orf39 Gene

This gene is overexpressed in Pancreas (56.6) and Fetal ovary (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C22orf39 Gene



Protein tissue co-expression partners for C22orf39 Gene

NURSA nuclear receptor signaling pathways regulating expression of C22orf39 Gene:

C22orf39

SOURCE GeneReport for Unigene cluster for C22orf39 Gene:

Hs.659565

Evidence on tissue expression from TISSUES for C22orf39 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with C22orf39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf39 Gene

Orthologs for C22orf39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C22orf39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22H22orf39 33
  • 98.3 (n)
C22orf39 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C22orf39 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2510002D24Rik 34
  • 72 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C22orf39 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C22orf39 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C22orf39 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C22orf39 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C8H22orf39 34
  • 44 (a)
OneToOne
Species where no ortholog for C22orf39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C22orf39 Gene

ENSEMBL:
Gene Tree for C22orf39 (if available)
TreeFam:
Gene Tree for C22orf39 (if available)

Paralogs for C22orf39 Gene

(1) SIMAP similar genes for C22orf39 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C22orf39: view

No data available for Paralogs for C22orf39 Gene

Variants for C22orf39 Gene

Sequence variations from dbSNP and Humsavar for C22orf39 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000975672 -- 19,447,109(+) GCCAG(C/G)TGATG intron-variant, upstream-variant-2KB
rs1001204812 -- 19,446,707(+) CTCTC(-/TT)TTTTT intron-variant, upstream-variant-2KB
rs1001476759 -- 19,447,266(+) GAGGA(C/T)AGGGA intron-variant, upstream-variant-2KB
rs1001502549 -- 19,440,796(+) TGTCC(A/G)GCACA downstream-variant-500B
rs1001843126 -- 19,448,726(+) GCACA(A/G)GAGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C22orf39 Gene

Variant ID Type Subtype PubMed ID
esv2751940 CNV gain 17911159
esv3575418 CNV gain 25503493
nsv588216 CNV gain 21841781
nsv834124 CNV loss 17160897
nsv834127 CNV loss 17160897

Variation tolerance for C22orf39 Gene

Gene Damage Index Score: 1.63; 31.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf39 Gene

Disorders for C22orf39 Gene

Relevant External Links for C22orf39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf39

No disorders were found for C22orf39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf39 Gene

Publications for C22orf39 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 60

Products for C22orf39 Gene

Sources for C22orf39 Gene

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