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Aliases for C22orf34 Gene

Aliases for C22orf34 Gene

  • Chromosome 22 Open Reading Frame 34 2 3 5

External Ids for C22orf34 Gene

Previous GeneCards Identifiers for C22orf34 Gene

  • GC22M048399
  • GC22M049808
  • GC22M032959

Summaries for C22orf34 Gene

GeneCards Summary for C22orf34 Gene

C22orf34 (Chromosome 22 Open Reading Frame 34) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf34 Gene

Genomics for C22orf34 Gene

Regulatory Elements for C22orf34 Gene

Promoters for C22orf34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C22orf34 on UCSC Golden Path with GeneCards custom track

Genomic Location for C22orf34 Gene

Chromosome:
22
Start:
49,414,524 bp from pter
End:
49,657,542 bp from pter
Size:
243,019 bases
Orientation:
Minus strand

Genomic View for C22orf34 Gene

Genes around C22orf34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf34 Gene

Proteins for C22orf34 Gene

  • Protein details for C22orf34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZV56-CV034_HUMAN
    Recommended name:
    Uncharacterized protein C22orf34
    Protein Accession:
    Q6ZV56
    Secondary Accessions:
    • Q147Y0
    • Q5R3D1
    • Q6ZTN8

    Protein attributes for C22orf34 Gene

    Size:
    151 amino acids
    Molecular mass:
    16313 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86548.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C22orf34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C22orf34 Gene

Proteomics data for C22orf34 Gene at MOPED

Post-translational modifications for C22orf34 Gene

No Post-translational modifications

Other Protein References for C22orf34 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C22orf34 Gene

Domains & Families for C22orf34 Gene

Protein Domains for C22orf34 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf34: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf34 Gene

Function for C22orf34 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf34 Gene

Localization for C22orf34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C22orf34 Gene COMPARTMENTS Subcellular localization image for C22orf34 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C22orf34 Gene

Pathways & Interactions for C22orf34 Gene

SuperPathways for C22orf34 Gene

No Data Available

Interacting Proteins for C22orf34 Gene

Gene Ontology (GO) - Biological Process for C22orf34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf34 Gene

Drugs & Compounds for C22orf34 Gene

No Compound Related Data Available

Transcripts for C22orf34 Gene

Unigene Clusters for C22orf34 Gene

Chromosome 22 open reading frame 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf34 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for C22orf34 Gene

GeneLoc Exon Structure for
C22orf34
ECgene alternative splicing isoforms for
C22orf34

Expression for C22orf34 Gene

mRNA expression in normal human tissues for C22orf34 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf34 Gene

This gene is overexpressed in Spleen (x5.1) and Whole Blood (x4.9).

SOURCE GeneReport for Unigene cluster for C22orf34 Gene Hs.133159

genes like me logo Genes that share expression patterns with C22orf34: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C22orf34 Gene

Orthologs for C22orf34 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C22orf34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22orf34 36
  • 94 (a)
OneToOne
Species with no ortholog for C22orf34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf34 Gene

ENSEMBL:
Gene Tree for C22orf34 (if available)
TreeFam:
Gene Tree for C22orf34 (if available)

Paralogs for C22orf34 Gene

No data available for Paralogs for C22orf34 Gene

Variants for C22orf34 Gene

Sequence variations from dbSNP and Humsavar for C22orf34 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs136774 -- 49,425,286(+) TATTC(C/T)ACTGT intron-variant
rs136775 -- 49,426,168(+) CTTAG(-/A)AAAAA intron-variant
rs136776 -- 49,426,445(+) ACGAA(-/G)TTTGC intron-variant
rs136777 -- 49,428,134(+) CTGGC(A/T)CAGGG intron-variant
rs136778 -- 49,428,320(+) ATGAT(C/G)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf34 Gene

Variant ID Type Subtype PubMed ID
nsv915485 CNV Loss 21882294
dgv5045n71 CNV Loss 21882294
nsv915488 CNV Loss 21882294
dgv5046n71 CNV Loss 21882294
nsv915491 CNV Loss 21882294
dgv5047n71 CNV Loss 21882294
nsv915495 CNV Loss 21882294
dgv5048n71 CNV Loss 21882294
esv2724691 CNV Deletion 23290073
esv2426256 CNV Deletion 19546169
esv2724692 CNV Deletion 23290073
esv2658037 CNV Deletion 23128226

Variation tolerance for C22orf34 Gene

Gene Damage Index Score: 1.88; 35.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf34 Gene

HapMap Linkage Disequilibrium report
C22orf34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf34 Gene

Disorders for C22orf34 Gene

Relevant External Links for C22orf34

Genetic Association Database (GAD)
C22orf34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf34

No disorders were found for C22orf34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf34 Gene

Publications for C22orf34 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  5. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3

Products for C22orf34 Gene

Sources for C22orf34 Gene

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