C22orf32 Gene
protein-coding GIFtS: 39
GCID: GC22P042475
|
|
chromosome 22 open reading frame 32
| |
Aliases
for C22orf32 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 22 Open Reading Frame 321 2 | | DDDD1 2 | | DJ186O1.11 | | UPF0466 Protein C22orf32, Mitochondrial2 |
Export aliases for C22orf32 gene to outside databasesPrevious GC identifers: GC22P040805 GC22P025441 |
Summaries
for C22orf32 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C22orf32 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C22orf32 gene promoter:
GR Max1 AREB6 AML1a MyoD c-Myb GR-alpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for C22orf32
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C22orf32 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2C22orf32 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P042475: view genomic region
(about GC identifiers)
Start:
|
42,475,695 bp from pter |
End:
|
42,532,261 bp from pter |
Size:
|
56,567 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr22+,PATCHES 42,484,013-42,486,337 |
|
Proteins
for C22orf32 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CV032_HUMAN, Q9H4I9 (See
protein sequence)Recommended Name: UPF0466 protein C22orf32, mitochondrial precursor Size: 107 amino acids; 11441 Da
Subcellular location: Mitochondrion (Potential). Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B2R5D1 Q8TAB9Explore the universe of human proteins at neXtProt for C22orf32: NX_Q9H4I9
C22orf32 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_201575.3
ENSEMBL proteins: ENSP00000402623 ENSP00000327467
Human Recombinant Protein Products for C22orf32:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
C22orf32 for ontologies About GeneDecksing
C22orf32 Antibody Products:
Assay Products for C22orf32: |
Protein
Domains /
Families
for C22orf32 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C22orf32 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H4I9ProtoNet protein and cluster: Q9H4I9 UniProtKB/Swiss-Prot: CV032_HUMAN, Q9H4I9Similarity: Belongs to the UPF0466 family |
Function
for C22orf32 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for C22orf32:
1 MGI phenotypic allele  for 1500032L24Rik (no phenotypes)
C22orf32 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf32 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf32
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for C22orf32 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf32 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf32 |
|
Pathways & Interactions
for C22orf32 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C22orf32
|
Drugs & Compounds
for C22orf32 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C22orf32
Search CenterWatch for drugs/clinical trials and news about C22orf32 / CV032
|
Transcripts
for C22orf32 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C22orf32 gene: NM_033318.4 Unigene Cluster for C22orf32: Chromosome 22 open reading frame 32 Hs.306083 [show with all ESTs]Unigene Representative Sequence: NM_0333187 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000422252 ENST00000331479(uc003bca.3) ENST00000484235 ENST00000547929
ENST00000549112 ENST00000548016 ENST00000550923
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf32 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf32
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C22orf32 (NM_033318) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C22orf32 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf32 |
Additional cDNA sequence: AK312142.1 AL449243.1 BC024237.2 CR456453.1 9 DOTS entries: DT.415825 DT.95241308 DT.95375085 DT.100810411 DT.102836323 DT.120644859 DT.95253705 DT.91757809 DT.99961342 24/262 AceView cDNA sequences (see all 262): BU783799 BQ944898 AA988287 AJ713576 BM705258 AW043630 BQ185128 AK095636 BU786271 CR597807 CF528491 F02766 BF975361 T34012 BU734488 BQ217986 AI080188 BM767050 AI493681 BU736824 BU622667 AL449243 F05371 CR617408
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C22orf32 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b |
|---|
|
| SP1: | | | | | - | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C22orf32
|
Expression
for C22orf32 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C22orf32 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCGTATTCC
About this image
See C22orf32 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C22orf32
SOURCE GeneReport for Unigene cluster: Hs.306083
SABiosciences Custom PCR Arrays for C22orf32
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C22orf32
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C22orf32 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C22orf32 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C22orf32 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf32 |
Orthologs
for C22orf32 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C22orf32 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
1500032L24Rik1 , 5 |
RIKEN cDNA 1500032L24 gene1, 5 |
84.42(n)1
81.31(a)1 |
|
15 (38.56 cM)5
690291 NM_026914.11 NP_081190.11
823389595 |
chicken
(Gallus gallus) |
Aves |
C1H22orf321 |
chromosome 1 open reading frame, human C22orf32 |
67.75(n)
77.17(a) |
|
770755 XM_001233648.2 XP_001233649.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C22orf326 |
-- |
62(a) |
1 ↔ 1 |
5(27093313-27095283) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480375402 |
-- |
75.24(n) |
|
48037540 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.294722 |
Transcribed sequence with weak similarity to protein more |
79.9(n) |
|
CK395719.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG176806 |
-- |
45(a) |
1 ↔ 1 |
2R(14034802-14035499) |
ENSEMBL Gene Tree for C22orf32 (if available)
TreeFam Gene Tree for C22orf32 (if available) |
Paralogs
for C22orf32 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C22orf32 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C22orf32 (42475695 - 42532261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C22orf32: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C22orf32 |
|
Disorders
/ Diseases
for C22orf32 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C22orf32 for disorders About MalaCards
C22orf32 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C22orf32 (1 document)
Export disorders for C22orf32 gene to outside databases
|
Publications
for C22orf32 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C22orf32 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C22orf32) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)2 Collins J.E.... Dunham I. (2003)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
|
External Searches for C22orf32 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C22orf32 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C22orf32 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C22orf32 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C22orf32 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C22orf32 gene:
Search GeneIP for patents involving C22orf32
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C22orf32 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C22orf32 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C22orf32 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C22orf32 | | | OriGene Protein Over-expression Lysate for C22orf32 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C22orf32 | | OriGene 3'-UTR Clone for C22orf32 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf32 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf32 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C22orf32 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C22orf32 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C22orf32 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C22orf32 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C22orf32 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C22orf32 |
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 | | | C22orf32 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf32 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C22orf32 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf32 |
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