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Aliases for C22orf31 Gene

Aliases for C22orf31 Gene

  • Chromosome 22 Open Reading Frame 31 2 3 5
  • Uncharacterized Protein C22orf31 3
  • BK747E2.1 3
  • HS747E2A 3

External Ids for C22orf31 Gene

Previous GeneCards Identifiers for C22orf31 Gene

  • GC22M027784
  • GC22M029454
  • GC22M012418

Summaries for C22orf31 Gene

GeneCards Summary for C22orf31 Gene

C22orf31 (Chromosome 22 Open Reading Frame 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf31 Gene

Genomics for C22orf31 Gene

Regulatory Elements for C22orf31 Gene

Enhancers for C22orf31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C22orf31 on UCSC Golden Path with GeneCards custom track

Promoters for C22orf31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C22orf31 Gene

29,058,672 bp from pter
29,073,966 bp from pter
15,295 bases
Minus strand

Genomic View for C22orf31 Gene

Genes around C22orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf31 Gene

Proteins for C22orf31 Gene

  • Protein details for C22orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C22orf31
    Protein Accession:
    Secondary Accessions:
    • A0AV97

    Protein attributes for C22orf31 Gene

    290 amino acids
    Molecular mass:
    32655 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C22orf31 Gene

Post-translational modifications for C22orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C22orf31 Gene

Domains & Families for C22orf31 Gene

Protein Domains for C22orf31 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf31: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf31 Gene

Function for C22orf31 Gene

genes like me logo Genes that share phenotypes with C22orf31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf31 Gene

Localization for C22orf31 Gene

Subcellular locations from

Jensen Localization Image for C22orf31 Gene COMPARTMENTS Subcellular localization image for C22orf31 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C22orf31 Gene

Pathways & Interactions for C22orf31 Gene

SuperPathways for C22orf31 Gene

No Data Available

Interacting Proteins for C22orf31 Gene

Selected Interacting proteins: O95567-CV031_HUMAN for C22orf31 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C22orf31 Gene


No data available for Pathways by source and SIGNOR curated interactions for C22orf31 Gene

Drugs & Compounds for C22orf31 Gene

No Compound Related Data Available

Transcripts for C22orf31 Gene

mRNA/cDNA for C22orf31 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C22orf31 Gene

Chromosome 22 open reading frame 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf31 Gene

No ASD Table

Relevant External Links for C22orf31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C22orf31 Gene

mRNA expression in normal human tissues for C22orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C22orf31 Gene

This gene is overexpressed in Testis (x18.3) and Brain - Putamen (basal ganglia) (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of C22orf31 Gene:


SOURCE GeneReport for Unigene cluster for C22orf31 Gene:

genes like me logo Genes that share expression patterns with C22orf31: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C22orf31 Gene

Orthologs for C22orf31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C17H22orf31 34
  • 83.8 (n)
  • 77.82 (a)
C17H22orf31 35
  • 75 (a)
(Canis familiaris)
Mammalia C26H22orf31 34
  • 84.2 (n)
  • 77.85 (a)
C22orf31 35
  • 64 (a)
(Pan troglodytes)
Mammalia C22H22orf31 34
  • 99.77 (n)
  • 99.66 (a)
C22orf31 35
  • 100 (a)
(Monodelphis domestica)
Mammalia C22orf31 35
  • 41 (a)
Species where no ortholog for C22orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf31 Gene

Gene Tree for C22orf31 (if available)
Gene Tree for C22orf31 (if available)

Paralogs for C22orf31 Gene

No data available for Paralogs for C22orf31 Gene

Variants for C22orf31 Gene

Sequence variations from dbSNP and Humsavar for C22orf31 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs9625679 - 29,060,711(+) TGCAC(A/C/G)TGTTC upstream-variant-2KB, reference, missense
rs714136 - 29,058,986(-) CCCCA(C/G)AGAGG reference, missense
rs760627 -- 29,063,646(+) ATTTC(A/T)CCTAT intron-variant, upstream-variant-2KB
rs760628 -- 29,063,744(+) CAACC(A/G)TCCTA intron-variant, upstream-variant-2KB
rs13058510 -- 29,067,656(+) ccagg(C/G)tggac intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C22orf31 Gene

Variant ID Type Subtype PubMed ID
esv3647524 CNV loss 21293372
nsv1064079 CNV gain 25217958

Variation tolerance for C22orf31 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf31 Gene

Disorders for C22orf31 Gene

Relevant External Links for C22orf31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C22orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf31 Gene

Publications for C22orf31 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4 65
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 65

Products for C22orf31 Gene

Sources for C22orf31 Gene

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