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Aliases for C22orf31 Gene

Aliases for C22orf31 Gene

  • Chromosome 22 Open Reading Frame 31 2 3 5
  • Uncharacterized Protein C22orf31 3
  • BK747E2.1 3
  • HS747E2A 3

External Ids for C22orf31 Gene

Previous GeneCards Identifiers for C22orf31 Gene

  • GC22M027784
  • GC22M029454
  • GC22M012418

Summaries for C22orf31 Gene

GeneCards Summary for C22orf31 Gene

C22orf31 (Chromosome 22 Open Reading Frame 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf31 Gene

Genomics for C22orf31 Gene

Regulatory Elements for C22orf31 Gene

Enhancers for C22orf31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G029028 1.7 FANTOM5 ENCODE dbSUPER 54.1 +42.7 42736 4.8 FOXA2 MLX ARID4B SIN3A YY1 ZNF766 FOS ZNF263 SP3 SP5 C22orf31 CCDC117 KREMEN1 ZNRF3 ENSG00000226471 XBP1 ENSG00000226772 RNU6-810P ZNRF3-AS1 ASCC2
GH22G029151 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -79.3 -79302 3.1 HDGF PKNOX1 ARNT ARID4B ZNF766 ZNF143 KLF13 REST ZNF592 KAT8 C22orf31 KREMEN1 XBP1 PIR36521 PIR48997
GH22G029201 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -131.8 -131760 8.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 ZNF766 EMID1 KREMEN1 C22orf31 CHEK2 EWSR1 LOC101929638 GC22P029193
GH22G028807 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +257.7 257695 18.1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCDC117 C22orf31 ZNRF3 ENSG00000272858 XBP1 HSCB TTC28 CHEK2 EMID1 GC22M028836
GH22G028922 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +150.2 150167 2.5 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF121 SP5 NFYC ZNRF3 C22orf31 HSCB CHEK2 GC22P028904 ZNRF3-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C22orf31 on UCSC Golden Path with GeneCards custom track

Promoters for C22orf31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145004 566 1601 PKNOX1 SIN3A YY1 GLIS2 ZNF207 KLF7 ZNF263 SP3 SP5 REST

Genomic Location for C22orf31 Gene

Chromosome:
22
Start:
29,058,672 bp from pter
End:
29,073,966 bp from pter
Size:
15,295 bases
Orientation:
Minus strand

Genomic View for C22orf31 Gene

Genes around C22orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf31 Gene

Proteins for C22orf31 Gene

  • Protein details for C22orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95567-CV031_HUMAN
    Recommended name:
    Uncharacterized protein C22orf31
    Protein Accession:
    O95567
    Secondary Accessions:
    • A0AV97

    Protein attributes for C22orf31 Gene

    Size:
    290 amino acids
    Molecular mass:
    32655 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C22orf31 Gene

Post-translational modifications for C22orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf31 Gene

No data available for DME Specific Peptides for C22orf31 Gene

Domains & Families for C22orf31 Gene

Protein Domains for C22orf31 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf31: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C22orf31 Gene

Function for C22orf31 Gene

genes like me logo Genes that share phenotypes with C22orf31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf31 Gene

Localization for C22orf31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf31 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C22orf31 Gene

Pathways & Interactions for C22orf31 Gene

SuperPathways for C22orf31 Gene

No Data Available

Interacting Proteins for C22orf31 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000216071%0d%0a9606.ENSP00000257867%0d%0a9606.ENSP00000362649%0d%0a
Selected Interacting proteins: ENSP00000216071 O95567-CV031_HUMAN for C22orf31 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C22orf31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf31 Gene

Transcripts for C22orf31 Gene

mRNA/cDNA for C22orf31 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C22orf31 Gene

Chromosome 22 open reading frame 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf31 Gene

No ASD Table

Relevant External Links for C22orf31 Gene

GeneLoc Exon Structure for
C22orf31
ECgene alternative splicing isoforms for
C22orf31

Expression for C22orf31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C22orf31 Gene

This gene is overexpressed in Testis (x18.3) and Brain - Putamen (basal ganglia) (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of C22orf31 Gene:

C22orf31

SOURCE GeneReport for Unigene cluster for C22orf31 Gene:

Hs.50891
genes like me logo Genes that share expression patterns with C22orf31: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf31 Gene

Orthologs for C22orf31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22orf31 35
  • 100 (a)
OneToOne
C22H22orf31 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia C26H22orf31 34
  • 84.2 (n)
C22orf31 35
  • 64 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C17H22orf31 34 35
  • 83.8 (n)
oppossum
(Monodelphis domestica)
Mammalia C22orf31 35
  • 41 (a)
OneToOne
Species where no ortholog for C22orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf31 Gene

ENSEMBL:
Gene Tree for C22orf31 (if available)
TreeFam:
Gene Tree for C22orf31 (if available)

Paralogs for C22orf31 Gene

No data available for Paralogs for C22orf31 Gene

Variants for C22orf31 Gene

Sequence variations from dbSNP and Humsavar for C22orf31 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000069822 -- 29,064,907(+) GAAGT(A/G)CAATG intron-variant
rs1000934495 -- 29,064,930(+) CTCAC(C/T)GCAAC intron-variant
rs1000983241 -- 29,064,645(+) AGTAG(A/C)TGGGA intron-variant
rs1001102414 -- 29,063,296(+) AAGAC(A/G)CTGGG intron-variant, upstream-variant-2KB
rs1001239381 -- 29,072,819(+) AGAGG(C/G)CCCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C22orf31 Gene

Variant ID Type Subtype PubMed ID
esv3647524 CNV loss 21293372
nsv1064079 CNV gain 25217958

Variation tolerance for C22orf31 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf31 Gene

Disorders for C22orf31 Gene

Relevant External Links for C22orf31

Genetic Association Database (GAD)
C22orf31
Human Genome Epidemiology (HuGE) Navigator
C22orf31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf31

No disorders were found for C22orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf31 Gene

Publications for C22orf31 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64

Products for C22orf31 Gene

Sources for C22orf31 Gene

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