Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C22orf29 Gene

Aliases for C22orf29 Gene

  • Chromosome 22 Open Reading Frame 29 2 3 5
  • BH3-Only Protein 2 3 4
  • BOP 3 4
  • Protein Bop 3

External Ids for C22orf29 Gene

Previous GeneCards Identifiers for C22orf29 Gene

  • GC22M018213
  • GC22M003453

Summaries for C22orf29 Gene

GeneCards Summary for C22orf29 Gene

C22orf29 (Chromosome 22 Open Reading Frame 29) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C22orf29 Gene

  • Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf29 Gene

Genomics for C22orf29 Gene

Regulatory Elements for C22orf29 Gene

Enhancers for C22orf29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F019852 0.7 ENCODE 12.8 -0.2 -153 4.8 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143 KLF13 ZNF263 TXNRD2 C22orf29 ABHD17AP4 GNB1L RPL8P5 GC22P019862
GH22F019429 0.5 ENCODE 11.8 +423.1 423123 4.7 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RPL7AP70 DGCR8 UFD1L LINC01311 ENSG00000273300 DGCR11 C22orf29 E2F6P1 CLTCL1 RPL8P5
GH22F019780 0.7 Ensembl ENCODE 10.3 +74.4 74384 1.2 HDGF ATF1 PKNOX1 ARNT CREB3L1 FOS REST KAT8 CREB3 SMARCA4 TBX1 C22orf29 RPL7AP70 RPL8P5
GH22F019775 0.4 Ensembl 7.7 +78.4 78359 1.3 HDGF HDAC1 ATF1 CBX3 TBL1XR1 CREB3L1 KDM4B CREM KLF13 SMARCA5 C22orf29 RPL8P5 RPL7AP70 TBX1
GH22F019884 1.5 FANTOM5 Ensembl ENCODE 6.4 -31.8 -31805 5.4 ATF1 PKNOX1 FEZF1 ZNF2 GLIS2 KLF7 TSHZ1 GLIS1 HMBOX1 WT1 TXNRD2 RPL8P5 GNB1L C22orf29 COMT TRMT2A GC22M019875
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C22orf29 on UCSC Golden Path with GeneCards custom track

Promoters for C22orf29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001041723 96 2401 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143 KLF13 ZNF263

Genomic Location for C22orf29 Gene

Chromosome:
22
Start:
19,846,138 bp from pter
End:
19,854,896 bp from pter
Size:
8,759 bases
Orientation:
Minus strand

Genomic View for C22orf29 Gene

Genes around C22orf29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf29 Gene

Proteins for C22orf29 Gene

  • Protein details for C22orf29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L3V2-BOP_HUMAN
    Recommended name:
    Protein Bop
    Protein Accession:
    Q7L3V2
    Secondary Accessions:
    • A8K5E7
    • D3DX21
    • Q6MZM8
    • Q6N000
    • Q9H7A0

    Protein attributes for C22orf29 Gene

    Size:
    364 amino acids
    Molecular mass:
    39299 Da
    Quaternary structure:
    • Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.
    • Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.
    SequenceCaution:
    • Sequence=BAB14998.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for C22orf29 Gene

Post-translational modifications for C22orf29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf29 Gene

No data available for DME Specific Peptides for C22orf29 Gene

Domains & Families for C22orf29 Gene

Gene Families for C22orf29 Gene

Protein Domains for C22orf29 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L3V2

UniProtKB/Swiss-Prot:

BOP_HUMAN :
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
Domain:
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
genes like me logo Genes that share domains with C22orf29: view

No data available for Suggested Antigen Peptide Sequences for C22orf29 Gene

Function for C22orf29 Gene

Molecular function for C22orf29 Gene

UniProtKB/Swiss-Prot Function:
Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

Gene Ontology (GO) - Molecular Function for C22orf29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23055042
genes like me logo Genes that share ontologies with C22orf29: view
genes like me logo Genes that share phenotypes with C22orf29: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C22orf29 Gene

Localization for C22orf29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C22orf29 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C22orf29 Gene COMPARTMENTS Subcellular localization image for C22orf29 gene
Compartment Confidence
mitochondrion 5
cytosol 3
endoplasmic reticulum 2
nucleus 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C22orf29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 23055042
genes like me logo Genes that share ontologies with C22orf29: view

Pathways & Interactions for C22orf29 Gene

SuperPathways for C22orf29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C22orf29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0051881 regulation of mitochondrial membrane potential IEA,IMP 23055042
GO:0097345 mitochondrial outer membrane permeabilization IEA,IMP 23055042
genes like me logo Genes that share ontologies with C22orf29: view

No data available for Pathways by source and SIGNOR curated interactions for C22orf29 Gene

Transcripts for C22orf29 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf29 Gene

No ASD Table

Relevant External Links for C22orf29 Gene

GeneLoc Exon Structure for
C22orf29
ECgene alternative splicing isoforms for
C22orf29

Expression for C22orf29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C22orf29 Gene

NURSA nuclear receptor signaling pathways regulating expression of C22orf29 Gene:

C22orf29

mRNA Expression by UniProt/SwissProt for C22orf29 Gene:

Q7L3V2-BOP_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with C22orf29: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for C22orf29 Gene

Orthologs for C22orf29 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22H22orf29 34
  • 98.63 (n)
C22H22ORF29 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C26H22orf29 34
  • 73.38 (n)
mouse
(Mus musculus)
Mammalia Gm16314 35
  • 33 (a)
OneToOne
Species where no ortholog for C22orf29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf29 Gene

ENSEMBL:
Gene Tree for C22orf29 (if available)
TreeFam:
Gene Tree for C22orf29 (if available)

Paralogs for C22orf29 Gene

(1) SIMAP similar genes for C22orf29 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C22orf29: view

No data available for Paralogs for C22orf29 Gene

Variants for C22orf29 Gene

Sequence variations from dbSNP and Humsavar for C22orf29 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10372 -- 19,849,775(-) AACAA(C/T)ACCTT intron-variant, utr-variant-3-prime
rs1052978 -- 19,846,503(-) GCTTC(C/T)GTGGT intron-variant, utr-variant-3-prime
rs1052988 -- 19,846,466(-) CCAGG(C/T)CCTGG intron-variant, utr-variant-3-prime
rs1053001 -- 19,846,258(-) AACTG(C/T)GGCAG intron-variant, utr-variant-3-prime
rs111394748 -- 19,852,204(+) ATAAT(A/T)GGCGG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for C22orf29 Gene

Variant ID Type Subtype PubMed ID
dgv7983n54 CNV gain 21841781
esv3568260 CNV loss 25503493
esv3575418 CNV gain 25503493
esv3647279 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv828949 CNV gain 20364138
nsv834129 CNV loss 17160897
nsv834130 CNV loss 17160897
nsv953024 CNV deletion 24416366

Variation tolerance for C22orf29 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf29 Gene

Disorders for C22orf29 Gene

Relevant External Links for C22orf29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf29

No disorders were found for C22orf29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf29 Gene

Publications for C22orf29 Gene

  1. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PMID: 23055042) Zhang X. … Tang H. (Protein Cell 2012) 2 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. BH3-only proteins: possible proapoptotic triggers for melanoma therapy. (PMID: 24673301) PlAPtz M. … Eberle J. (Exp. Dermatol. 2014) 3 64
  5. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3 64

Products for C22orf29 Gene

Sources for C22orf29 Gene

Content
Loading form....