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Aliases for C22orf29 Gene

Aliases for C22orf29 Gene

  • Chromosome 22 Open Reading Frame 29 2 3
  • BH3-Only Protein 3 4
  • BOP 3 4
  • Protein Bop 3

External Ids for C22orf29 Gene

Previous GeneCards Identifiers for C22orf29 Gene

  • GC22M018213
  • GC22M003453

Summaries for C22orf29 Gene

GeneCards Summary for C22orf29 Gene

C22orf29 (Chromosome 22 Open Reading Frame 29) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C22orf29 Gene

  • Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf29 Gene

Genomics for C22orf29 Gene

Regulatory Elements for C22orf29 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C22orf29 Gene

19,846,138 bp from pter
19,854,896 bp from pter
8,759 bases
Minus strand

Genomic View for C22orf29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C22orf29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf29 Gene

Proteins for C22orf29 Gene

  • Protein details for C22orf29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Bop
    Protein Accession:
    Secondary Accessions:
    • A8K5E7
    • D3DX21
    • Q6MZM8
    • Q6N000
    • Q9H7A0

    Protein attributes for C22orf29 Gene

    364 amino acids
    Molecular mass:
    39299 Da
    Quaternary structure:
    • Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.
    • Sequence=BAB14998.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for C22orf29 Gene

Proteomics data for C22orf29 Gene at MOPED

Post-translational modifications for C22orf29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf29 Gene

No data available for DME Specific Peptides for C22orf29 Gene

Domains for C22orf29 Gene

Protein Domains for C22orf29 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q7L3V2
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
genes like me logo Genes that share domains with C22orf29: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C22orf29 Gene

Function for C22orf29 Gene

Molecular function for C22orf29 Gene

UniProtKB/Swiss-Prot Function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

Gene Ontology (GO) - Molecular Function for C22orf29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23055042
genes like me logo Genes that share ontologies with C22orf29: view

Phenotypes for C22orf29 Gene

GenomeRNAi human phenotypes for C22orf29:
genes like me logo Genes that share phenotypes with C22orf29: view

Animal Model Products

CRISPR Products

miRNA for C22orf29 Gene

miRTarBase miRNAs that target C22orf29

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C22orf29 Gene

Localization for C22orf29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C22orf29 Gene


Subcellular locations from

Jensen Localization Image for C22orf29 Gene COMPARTMENTS Subcellular localization image for C22orf29 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for C22orf29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 23055042
genes like me logo Genes that share ontologies with C22orf29: view

Pathways for C22orf29 Gene

SuperPathways for C22orf29 Gene

No Data Available

Interacting Proteins for C22orf29 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000330596 for C22orf29 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C22orf29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051881 regulation of mitochondrial membrane potential IMP 23055042
GO:0097345 mitochondrial outer membrane permeabilization IMP 23055042
genes like me logo Genes that share ontologies with C22orf29: view

No data available for Pathways by source for C22orf29 Gene

Transcripts for C22orf29 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C22orf29

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf29 Gene

No ASD Table

Relevant External Links for C22orf29 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C22orf29 Gene

mRNA expression in normal human tissues for C22orf29 Gene

mRNA Expression by UniProt/SwissProt for C22orf29 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with C22orf29: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for C22orf29 Gene

Orthologs for C22orf29 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf29 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C22H22orf29 35
  • 98.63 (n)
  • 97.53 (a)
C22H22ORF29 36
  • 98 (a)
(Canis familiaris)
Mammalia C26H22orf29 35
  • 73.38 (n)
  • 55.94 (a)
(Mus musculus)
Mammalia Gm16314 36
  • 33 (a)
Species with no ortholog for C22orf29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf29 Gene

Gene Tree for C22orf29 (if available)
Gene Tree for C22orf29 (if available)

Paralogs for C22orf29 Gene

Selected SIMAP similar genes for C22orf29 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C22orf29: view

No data available for Paralogs for C22orf29 Gene

Variants for C22orf29 Gene

Structural Variations from Database of Genomic Variants (DGV) for C22orf29 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv914263 CNV Gain 21882294
nsv914279 CNV Loss 21882294
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv834129 CNV Loss 17160897
nsv914288 CNV Loss 21882294
dgv4844n71 CNV Loss 21882294
nsv914296 CNV Loss 21882294
dgv4846n71 CNV Loss 21882294
nsv834130 CNV Loss 17160897
nsv828949 CNV Gain 20364138
dgv4847n71 CNV Loss 21882294

Relevant External Links for C22orf29 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C22orf29 Gene

Disorders for C22orf29 Gene

No disorders were found for C22orf29 Gene.

No data available for UniProtKB/Swiss-Prot for C22orf29 Gene

Publications for C22orf29 Gene

  1. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PMID: 23055042) Zhang X. … Tang H. (Protein Cell 2012) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for C22orf29 Gene

Sources for C22orf29 Gene

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