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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C22orf29 Gene

protein-coding   GIFtS: 30
GCID: GC22M019833

Chromosome 22 Open Reading Frame 29

  Search for C22orf29
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 22 Open Reading Frame 291 2
BH3-Only Protein2 3
BOP2
Protein Bop2

External Ids:    HGNC: 261121   Entrez Gene: 796802   Ensembl: ENSG000002150127   UniProtKB: Q7L3V23   

Export aliases for C22orf29 gene to outside databases

Previous GC identifers: GC22M018213 GC22M003453


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C22orf29 Gene: 
C22orf29 (chromosome 22 open reading frame 29) is a protein-coding gene. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2
Function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family
members may play a key role in modulation BOP intrinsic apoptotic signaling activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C22orf29 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   LCR-F1   C/EBPalpha   CHOP-10   E2F   E2F-1   Pax-4a   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C22orf29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

C22orf29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C22orf29 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M019833:  view genomic region     (about GC identifiers)

Start:
19,833,661 bp from pter      End:
19,842,419 bp from pter
Size:
8,759 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2 (See protein sequence)
Recommended Name: Protein Bop  
Size: 364 amino acids; 39299 Da
Subunit: Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1
isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK
Subcellular location: Mitochondrion
Sequence caution: Sequence=BAB14998.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5E7 D3DX21 Q6MZM8 Q6N000 Q9H7A0

Explore the universe of human proteins at neXtProt for C22orf29: NX_Q7L3V2

Explore proteomics data for C22orf29 at MOPED 

C22orf29 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C22orf29 Protein Expression

REFSEQ proteins: NP_078903.3  
ENSEMBL proteins: 
 ENSP00000386111   ENSP00000330596   ENSP00000384924   ENSP00000392994  

Human Recombinant Protein Products for C22orf29: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA--

C22orf29 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q7L3V2

UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2
Domain: The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family
members (PubMed:23055042)


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: BOP_HUMAN, Q7L3V2
Function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family
members may play a key role in modulation BOP intrinsic apoptotic signaling activity

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
     
C22orf29 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for C22orf29:
 Increased gamma-H2AX phosphory 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C22orf29

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0051881regulation of mitochondrial membrane potential IMP--
GO:0097345mitochondrial outer membrane permeabilization IMP--

C22orf29 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for C22orf29 (BOP)

Search CenterWatch for drugs/clinical trials and news about C22orf29 / BOP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C22orf29 gene: 
NM_024627.5  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000407472(uc002zqi.3) ENST00000328554 ENST00000484072 ENST00000405640(uc002zqg.3 uc002zqh.3)
ENST00000416337
miRNA
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24/237 AceView cDNA sequences (see all 237):

AY007378 BM709551 AW016382 BU688361 CR621951 BI193304 BC012060 AI469871 
AI469345 BC008696 AK024778 AI086495 AW247156 BU952429 NM_053004 BQ015288 
CR456496 CR623885 BX417873 CR607852 AF238328 CR612767 BM793702 BM713233 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C22orf29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
C22orf29 Expression
About this image


See C22orf29 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C22orf29

UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2
Tissue specificity: Ubiquitously expressed

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for C22orf29 (if available)
TreeFam Gene Tree for C22orf29 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for C22orf29 gene
1 SIMAP similar gene for C22orf29 using alignment to 2 protein entries:     C9J0V4_HUMAN (see all proteins):
BOP

C22orf29 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 10/13 variations for C22orf29 (see all 13):    About this table     
Variant IDTypeSubtypePubMed ID
nsv435744CNV Deletion17901297
dgv4846n71CNV Loss21882294
dgv4847n71CNV Loss21882294
nsv834130CNV Loss17160897
nsv914288CNV Loss21882294
nsv914279CNV Loss21882294
nsv834129CNV Loss17160897
dgv4844n71CNV Loss21882294
nsv914296CNV Loss21882294
nsv828939CNV Loss20364138

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C22orf29 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C22orf29)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  2. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PubMed id 23055042)2 Zhang X.... Tang H. (2012)
  3. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  8. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
  9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79680 HGNC: 26112 AceView: FLJ21125 Ensembl:ENSG00000215012 euGenes: HUgn79680
ECgene: C22orf29 H-InvDB: C22orf29

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C22orf29 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C22orf29 gene:
Search GeneIP for patents involving C22orf29

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 ThermoFisher Antibodies for C22orf29
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf29
 inGenious Targeting Laboratory - Custom generated mouse model solutions for C22orf29
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C22orf29
Customized:
 lentivirus for stable overexpression of C22orf29
 lentivirus expression plasmids for stable overexpression of C22orf29
 adenovirus for overexpression of C22orf29
 Search LSBio for Antibodies for C22orf29
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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