C22orf29 Gene
protein-coding GIFtS: 31
GCID: GC22M019833
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chromosome 22 open reading frame 29
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Aliases
for C22orf29 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 22 Open Reading Frame 291 2 | | FLJ211251 | | Uncharacterized Protein C22orf292 | | BH3-Only Protein3 |
Export aliases for C22orf29 gene to outside databasesPrevious GC identifers: GC22M018213 GC22M003453 |
Summaries
for C22orf29 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2Function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 familymembers may play a key role in modulation BOP intrinsic apoptotic signaling activity
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Genomic Views
for C22orf29 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C22orf29 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 LCR-F1 C/EBPalpha CHOP-10 E2F E2F-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C22orf29
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C22orf29 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21C22orf29 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M019833: view genomic region
(about GC identifiers)
Start:
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19,833,661 bp from pter |
End:
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19,842,419 bp from pter |
Size:
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8,759 bases |
Orientation:
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minus strand |
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Proteins
for C22orf29 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2 (See
protein sequence)Recommended Name: Protein Bop Size: 364 amino acids; 39299 Da
Subunit: Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoformBcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK
Subcellular location: Mitochondrion
Sequence caution: Sequence=BAB14998.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5E7 D3DX21 Q6MZM8 Q6N000 Q9H7A0Explore the universe of human proteins at neXtProt for C22orf29: NX_Q7L3V2
C22orf29 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078903.3
ENSEMBL proteins: ENSP00000386111 ENSP00000330596 ENSP00000384924 ENSP00000392994
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- |
C22orf29 for ontologies About GeneDecksing
C22orf29 Antibody Products:
Assay Products for C22orf29: |
Protein
Domains /
Families
for C22orf29 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q7L3V2 UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2Domain: The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members(PubMed:23055042) |
Function
for C22orf29 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2Function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 familymembers may play a key role in modulation BOP intrinsic apoptotic signaling activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf29
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf29
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf29 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
C22orf29 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C22orf29:
|
Pathways & Interactions
for C22orf29 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C22orf29
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
IEA | -- | | GO:0006917 | induction of apoptosis |
IMP | -- | | GO:0051881 | regulation of mitochondrial membrane potential |
IMP | -- |
C22orf29 for ontologies About GeneDecksing
|
Drugs & Compounds
for C22orf29 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C22orf29
Search CenterWatch for drugs/clinical trials and news about C22orf29 / BOP
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Transcripts
for C22orf29 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C22orf29 gene: NM_024627.5 5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000407472(uc002zqi.3) ENST00000328554 ENST00000484072 ENST00000405640(uc002zqg.3 uc002zqh.3)
ENST00000416337
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf29
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf29
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C22orf29 (NM_024627) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C22orf29 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf29 |
24/237 AceView cDNA sequences (see all 237): AW016382 BM712469 AF301895 BI193304 CR590999 CR607852 BU159157 AY007378 CB149709 BC011679 AA029703 AI251887 CR604918 BU149870 BQ015288 CA446436 NM_024627 CR626303 AW247156 BM987976 BU952429 CR456496 BX640969 AI086495
GeneLoc Exon Structure
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Expression
for C22orf29 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C22orf29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C22orf29 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C22orf29
UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for C22orf29
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C22orf29
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat C22orf29 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C22orf29 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C22orf29 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf29 |
Orthologs
for C22orf29 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for C22orf29 (if available)
TreeFam Gene Tree for C22orf29 (if available) |
Paralogs
for C22orf29 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C22orf29 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C22orf29
1 CNV: 31071 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C22orf29 |
|
Disorders
/ Diseases
for C22orf29 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C22orf29 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C22orf29 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C22orf29) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PubMed id 23055042)2 Zhang X.... Tang H. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for C22orf29 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C22orf29 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C22orf29 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C22orf29 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C22orf29 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C22orf29 gene:
Search GeneIP for patents involving C22orf29
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C22orf29 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C22orf29 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C22orf29 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C22orf29 | | | OriGene Protein Over-expression Lysate for C22orf29 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for C22orf29 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf29 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf29 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C22orf29 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C22orf29 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C22orf29 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C22orf29 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C22orf29 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C22orf29 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C22orf29 |
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 | | | C22orf29 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf29 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf29 |
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