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C22orf29 Gene

protein-coding   GIFtS: 33
GCID: GC22M019833

Chromosome 22 Open Reading Frame 29

  Search for C22orf29
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 22 Open Reading Frame 291 2
BH3-Only Protein2 3
BOP2
Protein Bop2

External Ids:    HGNC: 261121   Entrez Gene: 796802   Ensembl: ENSG000002150127   UniProtKB: Q7L3V23   
ORGUL members:         

Export aliases for C22orf29 gene to outside databases

Previous GC identifers: GC22M018213 GC22M003453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C22orf29 Gene:
C22orf29 (chromosome 22 open reading frame 29) is a protein-coding gene.

UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2
Function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family
members may play a key role in modulation BOP intrinsic apoptotic signaling activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the C22orf29 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   LCR-F1   C/EBPalpha   CHOP-10   E2F   E2F-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C22orf29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

C22orf29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C22orf29 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M019833:  view genomic region     (about GC identifiers)

Start:
19,833,661 bp from pter      End:
19,842,419 bp from pter
Size:
8,759 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2 (See protein sequence)
Recommended Name: Protein Bop  
Size: 364 amino acids; 39299 Da
Subunit: Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1
isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK
Sequence caution: Sequence=BAB14998.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5E7 D3DX21 Q6MZM8 Q6N000 Q9H7A0

Explore the universe of human proteins at neXtProt for C22orf29: NX_Q7L3V2

Explore proteomics data for C22orf29 at MOPED


See C22orf29 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_078903.3  
ENSEMBL proteins: 
 ENSP00000386111   ENSP00000330596   ENSP00000384924   ENSP00000392994  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q7L3V2

UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2
Domain: The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family
members (PubMed:23055042)


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: BOP_HUMAN, Q7L3V2
Function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family
members may play a key role in modulation BOP intrinsic apoptotic signaling activity

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
     
Find genes that share ontologies with C22orf29           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for C22orf29:
 Increased gamma-H2AX phosphory 

Animal Models:
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miRTarBase miRNAs that target C22orf29:
hsa-mir-193b-3p (MIRT041572), hsa-mir-92a-3p (MIRT049700), hsa-mir-26b-5p (MIRT028925)

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Selected qRT-PCR Assays for microRNAs that regulate C22orf29 (see all 26):
hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-509-5p hsa-miR-1224-3p hsa-miR-3614-3p hsa-miR-1260b hsa-miR-342-3p hsa-miR-515-5p
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
BOP_HUMAN, Q7L3V2: Mitochondrion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol3
nucleus3
plasma membrane3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA--

Find genes that share ontologies with C22orf29           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C22orf29
Interactions:

    Search GeneGlobe Interaction Network for C22orf29

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0051881regulation of mitochondrial membrane potential IMP--
GO:0097345mitochondrial outer membrane permeabilization IMP--

Find genes that share ontologies with C22orf29           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for C22orf29 (BOP)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C22orf29 gene: 
NM_024627.5  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000407472(uc002zqi.3) ENST00000328554 ENST00000484072 ENST00000405640(uc002zqg.3 uc002zqh.3)
ENST00000416337
miRNA
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hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-509-5p hsa-miR-1224-3p hsa-miR-3614-3p hsa-miR-1260b hsa-miR-342-3p hsa-miR-515-5p
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Selected AceView cDNA sequences (see all 237):

BM793702 BX640998 CR456496 BG830467 CR621951 CR604918 BM987976 CR590999 
AI469345 BU190247 BM709551 BI193304 AF238328 BM712469 BX417873 AW247156 
BU952429 BU620565 BC008696 CR623885 BQ015288 NM_053004 CD673533 AF301895 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C22orf29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
C22orf29 Expression
About this image

C22orf29 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C22orf29 Protein Expression

UniProtKB/Swiss-Prot: BOP_HUMAN, Q7L3V2
Tissue specificity: Ubiquitously expressed

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for C22orf29 (if available)
TreeFam Gene Tree for C22orf29 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for C22orf29 gene
1 SIMAP similar gene for C22orf29 using alignment to 2 protein entries:     C9J0V4_HUMAN (see all proteins):
BOP

Find genes that share paralogs with C22orf29           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) Selected variations for C22orf29 (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
nsv435744CNV Deletion17901297
dgv4846n71CNV Loss21882294
dgv4847n71CNV Loss21882294
nsv834130CNV Loss17160897
nsv914288CNV Loss21882294
nsv914279CNV Loss21882294
nsv834129CNV Loss17160897
dgv4844n71CNV Loss21882294
nsv914296CNV Loss21882294
nsv828939CNV Loss20364138

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C22orf29 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C22orf29)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  3. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PubMed id 23055042)2 Zhang X.... Tang H. (Protein Cell 2012)
  4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)
  10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79680 HGNC: 26112 AceView: FLJ21125 Ensembl:ENSG00000215012 euGenes: HUgn79680
ECgene: C22orf29 H-InvDB: C22orf29

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C22orf29 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C22orf29 gene:
Search GeneIP for patents involving C22orf29

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for C22orf29
 Browse SwitchGear Promoter luciferase reporter plasmids for C22orf29
 ThermoFisher Antibodies for C22orf29
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf29
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C22orf29
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C22orf29
 Search LSBio for Antibodies for C22orf29
Customized transgenic rodents for:
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 Tissue-specific gene expresssion
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 Browse compounds at ApexBio
 Search Addgene for plasmids for C22orf29
  Search eBioscience for proteins for C22orf29
  Search eBioscience for elisas for C22orf29
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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