C22orf23 Gene
protein-coding GIFtS: 39
GCID: GC22M038339
|
|
chromosome 22 open reading frame 23
| |
Aliases
for C22orf23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 22 Open Reading Frame 231 2 | | EVG11 2 | | FLJ327871 | | LOC846451 | | DJ1039K5.61 | | UPF0193 Protein EVG12 |
Export aliases for C22orf23 gene to outside databasesPrevious GC identifers: GC22M034954 GC22M036582 GC22M036664 GC22M021305 |
Summaries
for C22orf23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C22orf23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C22orf23 gene promoter:
SRF AML1a SRF (504 AA) HTF Hand1 NF-kappaB E47 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C22orf23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C22orf23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1C22orf23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M038339: view genomic region
(about GC identifiers)
Start:
|
38,339,528 bp from pter |
End:
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38,349,676 bp from pter |
Size:
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10,149 bases |
Orientation:
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minus strand |
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Proteins
for C22orf23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EVG1_HUMAN, Q9BZE7 (See
protein sequence)Recommended Name: UPF0193 protein EVG1 Size: 217 amino acids; 24956 Da
Secondary accessions: Q5JYU9 Q96M68Explore the universe of human proteins at neXtProt for C22orf23: NX_Q9BZE7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZE7
C22orf23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001193991.1 NP_115950.3
ENSEMBL proteins: ENSP00000384667 ENSP00000249079 ENSP00000384618 ENSP00000395077 ENSP00000407707
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
C22orf23 for ontologies About GeneDecksing
C22orf23 Antibody Products:
Assay Products for C22orf23: |
Protein
Domains /
Families
for C22orf23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C22orf23 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BZE7ProtoNet protein and cluster: Q9BZE7 1 Blocks protein family: IPB007914 Protein of unknown function UPF0193
UniProtKB/Swiss-Prot: EVG1_HUMAN, Q9BZE7Similarity: Belongs to the UPF0193 (EVG1) family |
Function
for C22orf23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf23 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C22orf23 (NM_032561) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C22orf23 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf23 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf23 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C22orf23 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for C22orf23:
|
Pathways & Interactions
for C22orf23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C22orf23
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C22orf23 for ontologies About GeneDecksing
|
Drugs & Compounds
for C22orf23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C22orf23
Search CenterWatch for drugs/clinical trials and news about C22orf23 / EVG1
|
Transcripts
for C22orf23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C22orf23 gene (2 alternative transcripts): NM_001207062.1 NM_032561.4 Unigene Cluster for C22orf23: Chromosome 22 open reading frame 23 Hs.517612 [show with all ESTs]Unigene Representative Sequence: NM_0325615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000403305(uc003auj.2 uc021wpl.1) ENST00000249079 ENST00000403026
ENST00000418863 ENST00000422191
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf23 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C22orf23 (NM_032561) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C22orf23 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf23 |
Additional cDNA sequence: AF324466.1 AK097339.1 BC031998.1 CR456440.1 6 DOTS entries: DT.95275035 DT.95275040 DT.95255604 DT.97819165 DT.91987893 DT.95275042 24/47 AceView cDNA sequences (see all 47): BX115695 AW665305 BI767835 AA781685 BP368834 CR456440 BP368870 AI016233 BC031998 BI601285 AK057349 BG675443 AF324466 NM_032561 BI827500 BG721011 BI463610 AI017323 AI765407 BM563210 BI827388 AI208003 AI991437 BP371305
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C22orf23 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | - | | | | | | | | - | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C22orf23
|
Expression
for C22orf23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C22orf23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C22orf23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C22orf23
SOURCE GeneReport for Unigene cluster: Hs.517612
SABiosciences Custom PCR Arrays for C22orf23
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C22orf23
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C22orf23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C22orf23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C22orf23 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf23 |
Orthologs
for C22orf23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C22orf23 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for C22orf23 (if available)
TreeFam Gene Tree for C22orf23 (if available) |
Paralogs
for C22orf23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C22orf23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C22orf23 (38339528 - 38349676 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C22orf23: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C22orf23 |
|
Disorders
/ Diseases
for C22orf23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C22orf23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C22orf23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C22orf23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Experimental annotation of the human genome using microarray technology. (PubMed id 11237012)1, 2, 3 Shoemaker D.D.... Boguski M.S. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
|
External Searches for C22orf23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C22orf23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C22orf23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C22orf23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C22orf23 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C22orf23 gene:
Search GeneIP for patents involving C22orf23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C22orf23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C22orf23 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C22orf23 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C22orf23 | | | OriGene Protein Over-expression Lysate for C22orf23 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C22orf23 | | OriGene 3'-UTR Clone for C22orf23 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf23 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C22orf23 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C22orf23 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C22orf23 | | OriGene Custom Protein Services for C22orf23 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C22orf23 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C22orf23 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C22orf23 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C22orf23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C22orf23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C22orf23 |
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 | | | C22orf23 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C22orf23 |
|  |  |  | | | | Search ThermoFisher Antibodies for C22orf23 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C22orf23 |
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