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Aliases for C22orf23 Gene

Aliases for C22orf23 Gene

  • Chromosome 22 Open Reading Frame 23 2 3 5
  • DJ1039K5.6 3
  • EVG1 3

External Ids for C22orf23 Gene

Previous GeneCards Identifiers for C22orf23 Gene

  • GC22M034954
  • GC22M036582
  • GC22M036664
  • GC22M038339
  • GC22M021305
  • GC22M038391
  • GC22M038513

Summaries for C22orf23 Gene

GeneCards Summary for C22orf23 Gene

C22orf23 (Chromosome 22 Open Reading Frame 23) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf23 Gene

Genomics for C22orf23 Gene

Regulatory Elements for C22orf23 Gene

Genomic Location for C22orf23 Gene

37,943,050 bp from pter
37,953,669 bp from pter
10,620 bases
Minus strand

Genomic View for C22orf23 Gene

Genes around C22orf23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf23 Gene

Proteins for C22orf23 Gene

  • Protein details for C22orf23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0193 protein EVG1
    Protein Accession:
    Secondary Accessions:
    • Q5JYU9
    • Q96M68

    Protein attributes for C22orf23 Gene

    217 amino acids
    Molecular mass:
    24956 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C22orf23 Gene

Proteomics data for C22orf23 Gene at MOPED

Post-translational modifications for C22orf23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf23 Gene

No data available for DME Specific Peptides for C22orf23 Gene

Domains & Families for C22orf23 Gene

Protein Domains for C22orf23 Gene


Suggested Antigen Peptide Sequences for C22orf23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0193 (EVG1) family.
  • Belongs to the UPF0193 (EVG1) family.
genes like me logo Genes that share domains with C22orf23: view

No data available for Gene Families for C22orf23 Gene

Function for C22orf23 Gene

genes like me logo Genes that share phenotypes with C22orf23: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf23 Gene

Localization for C22orf23 Gene

Subcellular locations from

Jensen Localization Image for C22orf23 Gene COMPARTMENTS Subcellular localization image for C22orf23 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C22orf23 Gene

Pathways & Interactions for C22orf23 Gene

SuperPathways for C22orf23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C22orf23 Gene


No data available for Pathways by source and SIGNOR curated interactions for C22orf23 Gene

Drugs & Compounds for C22orf23 Gene

No Compound Related Data Available

Transcripts for C22orf23 Gene

Unigene Clusters for C22orf23 Gene

Chromosome 22 open reading frame 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf23 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP7: -

Relevant External Links for C22orf23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C22orf23 Gene

mRNA expression in normal human tissues for C22orf23 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf23 Gene

This gene is overexpressed in Testis (x11.7).

SOURCE GeneReport for Unigene cluster for C22orf23 Gene Hs.517612

genes like me logo Genes that share expression patterns with C22orf23: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C22orf23 Gene

Orthologs for C22orf23 Gene

This gene was present in the common ancestor of animals.

Orthologs for C22orf23 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C5H22orf23 35
  • 87.56 (n)
  • 84.33 (a)
C22orf23 36
  • 84 (a)
(Canis familiaris)
Mammalia C10H22orf23 35
  • 88.46 (n)
  • 86.06 (a)
C22orf23 36
  • 84 (a)
(Mus musculus)
Mammalia 1700088E04Rik 35
  • 81.17 (n)
  • 81.02 (a)
1700088E04Rik 16
1700088E04Rik 36
  • 81 (a)
(Pan troglodytes)
Mammalia C22H22orf23 35
  • 99.08 (n)
  • 99.08 (a)
C22orf23 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1359634 35
  • 83.33 (n)
  • 80.09 (a)
(Monodelphis domestica)
Mammalia C22orf23 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
-- 36
  • 55 (a)
(Gallus gallus)
Aves C1H22ORF23 35
  • 62.37 (n)
  • 55.91 (a)
C22orf23 36
  • 53 (a)
(Anolis carolinensis)
Reptilia C22orf23 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485066 35
  • 56.76 (n)
  • 52.36 (a)
(Danio rerio)
Actinopterygii si:dkey-43k4.3 35
  • 53.93 (n)
  • 43.82 (a)
C6H22orf23 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5280 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for C22orf23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C22orf23 Gene

Gene Tree for C22orf23 (if available)
Gene Tree for C22orf23 (if available)

Paralogs for C22orf23 Gene

No data available for Paralogs for C22orf23 Gene

Variants for C22orf23 Gene

Sequence variations from dbSNP and Humsavar for C22orf23 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs35562630 - 37,945,117(+) CTCCA(G/T)GTCCT reference, missense
rs139859 -- 37,945,127(+) TTCCC(A/C/T)GTGGC reference, synonymous-codon
rs139860 -- 37,947,136(+) CAACA(C/T)GTGCT intron-variant
rs139861 -- 37,951,087(+) ggcac(-/C)tatag intron-variant
rs1053719 -- 37,943,885(+) CACTT(A/C/G/T)TGACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C22orf23 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294
dgv830e199 CNV Deletion 23128226
nsv915053 CNV Loss 21882294

Variation tolerance for C22orf23 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf23 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf23 Gene

Disorders for C22orf23 Gene

Relevant External Links for C22orf23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C22orf23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf23 Gene

Publications for C22orf23 Gene

  1. Experimental annotation of the human genome using microarray technology. (PMID: 11237012) Shoemaker D.D. … Boguski M.S. (Nature 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for C22orf23 Gene

Sources for C22orf23 Gene

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