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Aliases for C22orf23 Gene

Aliases for C22orf23 Gene

  • Chromosome 22 Open Reading Frame 23 2 3 5
  • UPF0193 Protein EVG1 3
  • DJ1039K5.6 3
  • EVG1 3

External Ids for C22orf23 Gene

Previous GeneCards Identifiers for C22orf23 Gene

  • GC22M034954
  • GC22M036582
  • GC22M036664
  • GC22M038339
  • GC22M021305
  • GC22M038391
  • GC22M038513
  • GC22M038825

Summaries for C22orf23 Gene

GeneCards Summary for C22orf23 Gene

C22orf23 (Chromosome 22 Open Reading Frame 23) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf23 Gene

Genomics for C22orf23 Gene

Regulatory Elements for C22orf23 Gene

Enhancers for C22orf23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C22orf23 on UCSC Golden Path with GeneCards custom track

Promoters for C22orf23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C22orf23 on UCSC Golden Path with GeneCards custom track

Genomic Location for C22orf23 Gene

Chromosome:
22
Start:
37,943,050 bp from pter
End:
37,953,669 bp from pter
Size:
10,620 bases
Orientation:
Minus strand

Genomic View for C22orf23 Gene

Genes around C22orf23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf23 Gene

Proteins for C22orf23 Gene

  • Protein details for C22orf23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE7-EVG1_HUMAN
    Recommended name:
    UPF0193 protein EVG1
    Protein Accession:
    Q9BZE7
    Secondary Accessions:
    • Q5JYU9
    • Q96M68

    Protein attributes for C22orf23 Gene

    Size:
    217 amino acids
    Molecular mass:
    24956 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C22orf23 Gene

Post-translational modifications for C22orf23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C22orf23 Gene

No data available for DME Specific Peptides for C22orf23 Gene

Domains & Families for C22orf23 Gene

Protein Domains for C22orf23 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for C22orf23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZE7

UniProtKB/Swiss-Prot:

EVG1_HUMAN :
  • Belongs to the UPF0193 (EVG1) family.
Family:
  • Belongs to the UPF0193 (EVG1) family.
genes like me logo Genes that share domains with C22orf23: view

No data available for Gene Families for C22orf23 Gene

Function for C22orf23 Gene

Gene Ontology (GO) - Molecular Function for C22orf23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C22orf23: view
genes like me logo Genes that share phenotypes with C22orf23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf23 Gene

Localization for C22orf23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C22orf23 Gene COMPARTMENTS Subcellular localization image for C22orf23 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for C22orf23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C22orf23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C22orf23 Gene

Pathways & Interactions for C22orf23 Gene

SuperPathways for C22orf23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C22orf23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C22orf23: view

No data available for Pathways by source and SIGNOR curated interactions for C22orf23 Gene

Drugs & Compounds for C22orf23 Gene

No Compound Related Data Available

Transcripts for C22orf23 Gene

Unigene Clusters for C22orf23 Gene

Chromosome 22 open reading frame 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf23 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6:
SP7: -

Relevant External Links for C22orf23 Gene

GeneLoc Exon Structure for
C22orf23
ECgene alternative splicing isoforms for
C22orf23

Expression for C22orf23 Gene

mRNA expression in normal human tissues for C22orf23 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf23 Gene

This gene is overexpressed in Testis (x11.7).

NURSA nuclear receptor signaling pathways regulating expression of C22orf23 Gene:

C22orf23

SOURCE GeneReport for Unigene cluster for C22orf23 Gene:

Hs.517612
genes like me logo Genes that share expression patterns with C22orf23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C22orf23 Gene

Orthologs for C22orf23 Gene

This gene was present in the common ancestor of animals.

Orthologs for C22orf23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C5H22orf23 34
  • 87.56 (n)
  • 84.33 (a)
C22orf23 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10H22orf23 34
  • 88.46 (n)
  • 86.06 (a)
C22orf23 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700088E04Rik 34
  • 81.17 (n)
  • 81.02 (a)
1700088E04Rik 16
1700088E04Rik 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C22H22orf23 34
  • 99.08 (n)
  • 99.08 (a)
C22orf23 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1359634 34
  • 83.33 (n)
  • 80.09 (a)
oppossum
(Monodelphis domestica)
Mammalia C22orf23 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves C1H22ORF23 34
  • 62.37 (n)
  • 55.91 (a)
C22orf23 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C22orf23 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485066 34
  • 56.76 (n)
  • 52.36 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-43k4.3 34
  • 53.93 (n)
  • 43.82 (a)
C6H22orf23 35
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5280 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for C22orf23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C22orf23 Gene

ENSEMBL:
Gene Tree for C22orf23 (if available)
TreeFam:
Gene Tree for C22orf23 (if available)

Paralogs for C22orf23 Gene

No data available for Paralogs for C22orf23 Gene

Variants for C22orf23 Gene

Sequence variations from dbSNP and Humsavar for C22orf23 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs35562630 - 37,945,117(+) CTCCA(G/T)GTCCT reference, missense
rs5995522 -- 37,951,621(+) CCATT(C/T)TGCAC intron-variant
rs13058517 -- 37,945,279(+) ATGCA(A/G)ACAGG intron-variant
rs6000946 -- 37,944,534(+) AGAGG(A/G)CTGTC intron-variant
rs6000947 -- 37,944,714(+) accaa(C/T)atggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf23 Gene

Variant ID Type Subtype PubMed ID
dgv830e199 CNV deletion 23128226
esv3575479 CNV gain 25503493
esv3647722 CNV loss 21293372

Variation tolerance for C22orf23 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf23 Gene

Disorders for C22orf23 Gene

Relevant External Links for C22orf23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf23

No disorders were found for C22orf23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf23 Gene

Publications for C22orf23 Gene

  1. Experimental annotation of the human genome using microarray technology. (PMID: 11237012) Shoemaker D.D. … Boguski M.S. (Nature 2001) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for C22orf23 Gene

Sources for C22orf23 Gene

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