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Aliases for C22orf15 Gene

Aliases for C22orf15 Gene

  • Chromosome 22 Open Reading Frame 15 2 3 5
  • Protein N27C7-3 3 4
  • Uncharacterized Protein C22orf15 3
  • N27C7-3 3

External Ids for C22orf15 Gene

Previous GeneCards Identifiers for C22orf15 Gene

  • GC22P022430
  • GC22P022431
  • GC22P022435
  • GC22P024105
  • GC22P007093

Summaries for C22orf15 Gene

GeneCards Summary for C22orf15 Gene

C22orf15 (Chromosome 22 Open Reading Frame 15) is a Protein Coding gene.

Additional gene information for C22orf15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf15 Gene

Genomics for C22orf15 Gene

GeneHancer (GH) Regulatory Elements for C22orf15 Gene

Promoters and enhancers for C22orf15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I023762 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 550.8 +3.4 3436 1.7 RFX1 NR2F1 EBF1 MNT FEZF1 GABPA ETS1 POLR2A GABPB1 ZBTB33 C22orf15 VPREB3 SMARCB1 MMP11
GH22I023716 Promoter/Enhancer 1.6 Ensembl ENCODE 11.9 -42.9 -42861 1.5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ENSG00000272578 ENSG00000273000 GUSBP11 ZNF70 ENSG00000234353 SPECC1L VPREB3 C22orf15 RGL4 CHCHD10
GH22I023821 Enhancer 1 FANTOM5 ENCODE dbSUPER 11 +64.9 64915 6.1 OSR2 ZNF362 GLIS1 ZNF384 RCOR1 ZIC2 ZNF18 ZBTB17 SMARCB1 MMP11 CHCHD10 VPREB3 ZNF70 C22orf15 ENSG00000234353 DERL3 SLC2A11
GH22I023692 Enhancer 0.9 Ensembl ENCODE 11.3 -64.9 -64850 6.3 CTCF ZNF687 CBFB MIER2 EBF1 REST GABPA POLR2A GLIS1 IKZF1 ENSG00000234353 C22orf15 MMP11 CHCHD10 VPREB3 ZNF70 SMARCB1 ENSG00000251357 SLC2A11 RN7SL268P
GH22I023804 Enhancer 0.7 ENCODE dbSUPER 11.2 +45.6 45632 1.8 HDGF ZNF687 IKZF1 ZBTB33 MLLT1 IKZF2 RUNX3 MMP11 CHCHD10 SMARCB1 C22orf15 SLC2A11 ENSG00000251357 RN7SL268P MIF GUSBP11 MIF-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C22orf15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C22orf15 gene promoter:

Genomic Locations for C22orf15 Gene

Genomic Locations for C22orf15 Gene
chr22:23,760,033-23,765,863
(GRCh38/hg38)
Size:
5,831 bases
Orientation:
Plus strand
chr22:24,105,208-24,108,050
(GRCh37/hg19)

Genomic View for C22orf15 Gene

Genes around C22orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf15 Gene

Proteins for C22orf15 Gene

  • Protein details for C22orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYQ4-CV015_HUMAN
    Recommended name:
    Uncharacterized protein C22orf15
    Protein Accession:
    Q8WYQ4
    Secondary Accessions:
    • Q6ICJ7

    Protein attributes for C22orf15 Gene

    Size:
    148 amino acids
    Molecular mass:
    16487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C22orf15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C22orf15 Gene

Post-translational modifications for C22orf15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C22orf15 Gene

Domains & Families for C22orf15 Gene

Gene Families for C22orf15 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C22orf15 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C22orf15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf15: view

No data available for UniProtKB/Swiss-Prot for C22orf15 Gene

Function for C22orf15 Gene

genes like me logo Genes that share phenotypes with C22orf15: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf15 Gene

Localization for C22orf15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf15 gene
Compartment Confidence
extracellular 2
mitochondrion 2
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C22orf15 Gene

Pathways & Interactions for C22orf15 Gene

SuperPathways for C22orf15 Gene

No Data Available

Interacting Proteins for C22orf15 Gene

Gene Ontology (GO) - Biological Process for C22orf15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf15 Gene

Drugs & Compounds for C22orf15 Gene

No Compound Related Data Available

Transcripts for C22orf15 Gene

Unigene Clusters for C22orf15 Gene

Chromosome 22 open reading frame 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - - - -
SP3:

Relevant External Links for C22orf15 Gene

GeneLoc Exon Structure for
C22orf15
ECgene alternative splicing isoforms for
C22orf15

Expression for C22orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf15 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf15 Gene

This gene is overexpressed in Testis (x8.1), Fallopian Tube (x5.1), Lung (x4.6), and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for C22orf15 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C22orf15 Gene



Protein tissue co-expression partners for C22orf15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C22orf15 Gene:

C22orf15

SOURCE GeneReport for Unigene cluster for C22orf15 Gene:

Hs.116254
genes like me logo Genes that share expression patterns with C22orf15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf15 Gene

Orthologs for C22orf15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22H22orf15 33
  • 99.1 (n)
C22orf15 34
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C26H22orf15 33
  • 77.08 (n)
C22orf15 34
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C17H22orf15 33
  • 76.26 (n)
C22orf15 34
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm867 33 16 34
  • 69.27 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564162 33
  • 68.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C22orf15 34
  • 49 (a)
OneToOne
Species where no ortholog for C22orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf15 Gene

ENSEMBL:
Gene Tree for C22orf15 (if available)
TreeFam:
Gene Tree for C22orf15 (if available)

Paralogs for C22orf15 Gene

No data available for Paralogs for C22orf15 Gene

Variants for C22orf15 Gene

Sequence variations from dbSNP and Humsavar for C22orf15 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs111677724 benign, Frontotemporal dementia and/or amyotrophic lateral sclerosis 2, Myopathy, isolated mitochondrial, autosomal dominant, Spinal muscular atrophy, jokela type 23,766,251(+) G/T downstream_transcript_variant
rs138183274 benign, Frontotemporal dementia and/or amyotrophic lateral sclerosis 2, Myopathy, isolated mitochondrial, autosomal dominant, Spinal muscular atrophy, jokela type 23,766,207(+) C/T downstream_transcript_variant
rs199579266 likely-benign, Frontotemporal dementia and/or amyotrophic lateral sclerosis 2, Myopathy, isolated mitochondrial, autosomal dominant, Spinal muscular atrophy, jokela type 23,766,159(+) G/A downstream_transcript_variant
rs931085449 uncertain-significance, Frontotemporal dementia and/or amyotrophic lateral sclerosis 2, Myopathy, isolated mitochondrial, autosomal dominant, Spinal muscular atrophy, jokela type 23,766,188(+) T/A downstream_transcript_variant
rs9153 benign, not specified 23,766,225(+) G/A/C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C22orf15 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for C22orf15 Gene

Gene Damage Index Score: 2.47; 43.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C22orf15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf15 Gene

Disorders for C22orf15 Gene

Additional Disease Information for C22orf15

No disorders were found for C22orf15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf15 Gene

Publications for C22orf15 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C22orf15 Gene

Sources for C22orf15 Gene

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