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Aliases for C22orf15 Gene

Aliases for C22orf15 Gene

  • Chromosome 22 Open Reading Frame 15 2 3 5
  • Protein N27C7-3 3 4
  • Uncharacterized Protein C22orf15 3
  • N27C7-3 3

External Ids for C22orf15 Gene

Previous GeneCards Identifiers for C22orf15 Gene

  • GC22P022430
  • GC22P022431
  • GC22P022435
  • GC22P024105
  • GC22P007093

Summaries for C22orf15 Gene

GeneCards Summary for C22orf15 Gene

C22orf15 (Chromosome 22 Open Reading Frame 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C22orf15 Gene

Genomics for C22orf15 Gene

Regulatory Elements for C22orf15 Gene

Enhancers for C22orf15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G023821 1.2 FANTOM5 ENCODE dbSUPER 11 +64.9 64915 6.1 ZNF263 RFX1 KLF1 ZNF362 ZNF394 ZNF384 ZIC2 OSR2 POLR2A SMARCA4 SMARCB1 MMP11 CHCHD10 VPREB3 ZNF70 C22orf15 ENSG00000234353 DERL3 SLC2A11
GH22G023716 1.1 ENCODE 11.9 -42.8 -42805 1.4 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000234353 ZNF70 VPREB3 C22orf15 RGL4 CHCHD10 MMP11 SMARCB1 ENSG00000272578 ASLP1
GH22G023815 1 dbSUPER 11.3 +55.1 55086 0.5 HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 KLF7 KLF13 SMARCB1 DERL3 MMP11 CHCHD10 C22orf15 SLC2A11 ENSG00000251357 RN7SL268P MIF MIF-AS1
GH22G023692 1 Ensembl ENCODE 11.3 -64.9 -64850 6.3 CTCF EBF1 ZNF121 POLR2A EED ETV6 IKZF2 CREM SCRT1 ZNF680 ENSG00000234353 C22orf15 MMP11 CHCHD10 ZNF70 VPREB3 SMARCB1 ENSG00000251357 SLC2A11 RN7SL268P
GH22G023804 1 ENCODE dbSUPER 11.2 +45.6 45633 1.8 CTCF HDGF ELF3 MXI1 ZNF76 ZNF324 ZFHX2 POLR2A EED PATZ1 MMP11 CHCHD10 SMARCB1 C22orf15 SLC2A11 ENSG00000251357 RN7SL268P MIF GUSBP11 MIF-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C22orf15 on UCSC Golden Path with GeneCards custom track

Genomic Location for C22orf15 Gene

Chromosome:
22
Start:
23,760,033 bp from pter
End:
23,765,863 bp from pter
Size:
5,831 bases
Orientation:
Plus strand

Genomic View for C22orf15 Gene

Genes around C22orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C22orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C22orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C22orf15 Gene

Proteins for C22orf15 Gene

  • Protein details for C22orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYQ4-CV015_HUMAN
    Recommended name:
    Uncharacterized protein C22orf15
    Protein Accession:
    Q8WYQ4
    Secondary Accessions:
    • Q6ICJ7

    Protein attributes for C22orf15 Gene

    Size:
    148 amino acids
    Molecular mass:
    16487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C22orf15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C22orf15 Gene

Post-translational modifications for C22orf15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C22orf15 Gene

Domains & Families for C22orf15 Gene

Protein Domains for C22orf15 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C22orf15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C22orf15: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C22orf15 Gene

Function for C22orf15 Gene

genes like me logo Genes that share phenotypes with C22orf15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C22orf15 Gene

Localization for C22orf15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C22orf15 gene
Compartment Confidence
extracellular 2
mitochondrion 2
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C22orf15 Gene

Pathways & Interactions for C22orf15 Gene

SuperPathways for C22orf15 Gene

No Data Available

Interacting Proteins for C22orf15 Gene

Gene Ontology (GO) - Biological Process for C22orf15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C22orf15 Gene

Drugs & Compounds for C22orf15 Gene

No Compound Related Data Available

Transcripts for C22orf15 Gene

Unigene Clusters for C22orf15 Gene

Chromosome 22 open reading frame 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C22orf15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - - - -
SP3:

Relevant External Links for C22orf15 Gene

GeneLoc Exon Structure for
C22orf15
ECgene alternative splicing isoforms for
C22orf15

Expression for C22orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C22orf15 Gene

mRNA differential expression in normal tissues according to GTEx for C22orf15 Gene

This gene is overexpressed in Testis (x8.1), Fallopian Tube (x5.1), Lung (x4.6), and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for C22orf15 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C22orf15 Gene



Protein tissue co-expression partners for C22orf15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C22orf15 Gene:

C22orf15

SOURCE GeneReport for Unigene cluster for C22orf15 Gene:

Hs.116254
genes like me logo Genes that share expression patterns with C22orf15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C22orf15 Gene

Orthologs for C22orf15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C22orf15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22H22orf15 34
  • 99.1 (n)
C22orf15 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C26H22orf15 34
  • 77.08 (n)
C22orf15 35
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C17H22orf15 34
  • 76.26 (n)
C22orf15 35
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm867 34 16 35
  • 69.27 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564162 34
  • 68.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C22orf15 35
  • 49 (a)
OneToOne
Species where no ortholog for C22orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C22orf15 Gene

ENSEMBL:
Gene Tree for C22orf15 (if available)
TreeFam:
Gene Tree for C22orf15 (if available)

Paralogs for C22orf15 Gene

No data available for Paralogs for C22orf15 Gene

Variants for C22orf15 Gene

Sequence variations from dbSNP and Humsavar for C22orf15 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000149115 -- 23,762,123(+) GAAAC(A/C)CCGTC upstream-variant-2KB
rs1000462749 -- 23,765,941(+) TGTTG(C/T)GGTCT intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000576672 -- 23,766,147(+) CACTG(-/C)TTCAG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, frameshift-variant
rs1001083401 -- 23,760,826(+) CATGC(A/G)CCTGT upstream-variant-2KB
rs1001152107 -- 23,761,071(+) AGAGC(A/G)AAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C22orf15 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for C22orf15 Gene

Gene Damage Index Score: 2.47; 43.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C22orf15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C22orf15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C22orf15 Gene

Disorders for C22orf15 Gene

Relevant External Links for C22orf15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C22orf15

No disorders were found for C22orf15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C22orf15 Gene

Publications for C22orf15 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C22orf15 Gene

Sources for C22orf15 Gene

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