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Aliases for C21orf91 Gene

Aliases for C21orf91 Gene

  • Chromosome 21 Open Reading Frame 91 2 3
  • Early Undifferentiated Retina And Lens 2 3
  • Cold Sore Susceptibility Gene 1 2 3
  • C21orf14 3 4
  • C21orf38 3 4
  • EURL 3 4
  • YG81 3 4
  • Chromosome 21 Open Reading Frame 38 2
  • Protein EURL Homolog 3
  • C21orf7 4
  • CSSG1 3

External Ids for C21orf91 Gene

Previous Symbols for C21orf91 Gene

  • C21orf38
  • C21orf14

Summaries for C21orf91 Gene

GeneCards Summary for C21orf91 Gene

C21orf91 (Chromosome 21 Open Reading Frame 91) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C21orf91 Gene

Genomics for C21orf91 Gene

Genomic Location for C21orf91 Gene

Start:
17,788,967 bp from pter
End:
17,819,386 bp from pter
Size:
30,420 bases
Orientation:
Minus strand

Genomic View for C21orf91 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C21orf91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C21orf91 Gene

Regulatory Elements for C21orf91 Gene

Proteins for C21orf91 Gene

  • Protein details for C21orf91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYK6-EURL_HUMAN
    Recommended name:
    Protein EURL homolog
    Protein Accession:
    Q9NYK6
    Secondary Accessions:
    • B2RB30
    • Q96BK9
    • Q9H8C6

    Protein attributes for C21orf91 Gene

    Size:
    297 amino acids
    Molecular mass:
    33948 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14691.1; Type=Erroneous termination; Positions=164; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for C21orf91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C21orf91 Gene

Proteomics data for C21orf91 Gene at MOPED

Post-translational modifications for C21orf91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C21orf91 Gene

No data available for DME Specific Peptides for C21orf91 Gene

Domains for C21orf91 Gene

Protein Domains for C21orf91 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

EURL_HUMAN
Family:
  • Belongs to the EURL family.:
    • Q9NYK6
genes like me logo Genes that share domains with C21orf91: view

No data available for Gene Families for C21orf91 Gene

Function for C21orf91 Gene

miRNA for C21orf91 Gene

miRTarBase miRNAs that target C21orf91

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C21orf91 Gene

Localization for C21orf91 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C21orf91 Gene COMPARTMENTS Subcellular localization image for C21orf91 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for C21orf91 Gene

Pathways for C21orf91 Gene

SuperPathways for C21orf91 Gene

No Data Available

Interacting Proteins for C21orf91 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284881%0d%0a9606.ENSP00000311695%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: Q9NYK6-EURL_HUMAN ENSP00000284881 for C21orf91 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for C21orf91 Gene

None

No data available for Pathways by source for C21orf91 Gene

Transcripts for C21orf91 Gene

Unigene Clusters for C21orf91 Gene

Chromosome 21 open reading frame 91:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C21orf91 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for C21orf91 Gene

GeneLoc Exon Structure for
C21orf91
ECgene alternative splicing isoforms for
C21orf91

Expression for C21orf91 Gene

mRNA expression in normal human tissues for C21orf91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C21orf91 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C21orf91 Gene

SOURCE GeneReport for Unigene cluster for C21orf91 Gene Hs.293811

genes like me logo Genes that share expressions with C21orf91: view

Orthologs for C21orf91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C21orf91 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf91 36
  • 99.78 (n)
  • 99.66 (a)
C21orf91 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H21orf91 36
  • 91.69 (n)
  • 89.56 (a)
C1H21ORF91 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C21orf91 37
  • 91 (a)
OneToOne
C31H21orf91 36
  • 92.48 (n)
  • 91.25 (a)
mouse
(Mus musculus)
Mammalia D16Ertd472e 36
  • 83.97 (n)
  • 82.7 (a)
D16Ertd472e 16
D16Ertd472e 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C21orf91 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C21orf91 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563888 36
  • 83.68 (n)
  • 84.83 (a)
chicken
(Gallus gallus)
Aves C1H21ORF91 36
  • 74 (n)
  • 74.91 (a)
C1H21ORF91 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C21orf91 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5392 36
tropical clawed frog
(Silurana tropicalis)
Amphibia c21orf91 36
  • 66.89 (n)
  • 66.21 (a)
zebrafish
(Danio rerio)
Actinopterygii C10H21orf91 37
  • 53 (a)
OneToOne
zgc:110006 36
  • 56.58 (n)
  • 54.98 (a)
Species with no ortholog for C21orf91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C21orf91 Gene

ENSEMBL:
Gene Tree for C21orf91 (if available)
TreeFam:
Gene Tree for C21orf91 (if available)

Paralogs for C21orf91 Gene

Selected SIMAP similar genes for C21orf91 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C21orf91: view

No data available for Paralogs for C21orf91 Gene

Variants for C21orf91 Gene

Sequence variations from dbSNP and Humsavar for C21orf91 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs173390 -- 17,798,249(-) TTTGG(A/C)GTTCA intron-variant
rs243553 -- 17,799,138(-) AAAAT(A/T)TAACA intron-variant
rs243554 -- 17,807,143(-) gggaa(A/C)acaaa intron-variant
rs243555 -- 17,813,921(-) GACCT(C/T)GAGCA intron-variant
rs243556 -- 17,818,110(-) AAAAT(A/G)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C21orf91 Gene

Variant ID Type Subtype PubMed ID
nsv834055 CNV Gain 17160897

Relevant External Links for C21orf91 Gene

HapMap Linkage Disequilibrium report
C21orf91
Human Gene Mutation Database (HGMD)
C21orf91

Disorders for C21orf91 Gene

No disorders were found for C21orf91 Gene.

No data available for UniProtKB/Swiss-Prot for C21orf91 Gene

Publications for C21orf91 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility gene. (PMID: 22039568) Kriesel J.D. … Hobbs M.R. (J. Infect. Dis. 2011) 2 3
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for C21orf91 Gene

Sources for C21orf91 Gene

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