C21orf88 Gene
protein-coding GIFtS: 32
GCID: GC21M040969
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chromosome 21 open reading frame 88
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Aliases
for C21orf88 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Chromosome 21 Open Reading Frame 881 2 |
| External Ids: | HGNC: 164241 | Entrez Gene: 1140412 | Ensembl: ENSG000001848097 | UniProtKB: P590523 | | ORGUL members: | |
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| NONCODE:n384016 n386299 n344732 | |
Export aliases for C21orf88 gene to outside databasesPrevious GC identifers: GC00U991076 GC21M039890 GC21M039897 GC21M039891 GC21U900195 GC21M026438
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Summaries
for C21orf88 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C21orf88 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C21orf88 gene promoter:
TBP FOXD3 YY1 MEF-2A POU2F1 POU2F1a Chx10 Cart-1 c-Myb aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C21orf88
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C21orf88 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.2 Ensembl cytogenetic band: 21q22.2 HGNC cytogenetic band: 21q22.2C21orf88 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M040969: view genomic region
(about GC identifiers)
Start:
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40,969,074 bp from pter |
End:
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40,984,749 bp from pter |
Size:
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15,676 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
40969030 40977012 40984994 chr21
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Proteins
for C21orf88 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CU088_HUMAN, P59052 (See
protein sequence)Recommended Name: Putative uncharacterized protein C21orf88 Size: 145 amino acids; 15706 Da
Caution: Product of a dubious CDS prediction
Secondary accessions: Q0VDC1 Q547X5Alternative splicing: 2 isoforms: P59052-1 P59052-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C21orf88: NX_P59052
C21orf88 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000369986 ENSP00000369978 ENSP00000331922
Human Recombinant Protein Products:
C21orf88 Antibody Products:
Assay Products for C21orf88: |
Protein
Domains /
Families
for C21orf88 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P59052 |
Function
for C21orf88 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf88 |
|
Pathways & Interactions
for C21orf88 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C21orf88
|
Drugs & Compounds
for C21orf88 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C21orf88
Search CenterWatch for drugs/clinical trials and news about C21orf88 / CU088 
|
Transcripts
for C21orf88 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C21orf88 gene: NM_153754.1 Unigene Cluster for C21orf88: Chromosome 21 open reading frame 88 Hs.375120 [show with all ESTs]Unigene Representative Sequence: NR_0265424 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000489821 ENST00000380612(uc010gok.3) ENST00000380604 ENST00000329618(uc002yyd.4)
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C21orf88
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C21orf88 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C21orf88 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C21orf88 |
Additional cDNA sequence: AF426266.1 AF426267.1 AK129590.1 BC062296.1 BC080530.1 BC119737.2 BC119738.2 NR_026542.1 NR_026543.1 4 DOTS entries: DT.95156033 DT.40198600 DT.100018339 DT.101959199
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C21orf88 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C21orf88
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Expression
for C21orf88 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C21orf88 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACTGCCCT
About this image
See C21orf88 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C21orf88
SOURCE GeneReport for Unigene cluster: Hs.375120
UniProtKB/Swiss-Prot: CU088_HUMAN, P59052Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for C21orf88
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C21orf88
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C21orf88 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C21orf88 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C21orf88 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf88 |
Orthologs
for C21orf88 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for C21orf88 (if available)
TreeFam Gene Tree for C21orf88 (if available) |
Paralogs
for C21orf88 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C21orf88 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for C21orf88 (40969074 - 40984749 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C21orf88
2 CNVs: 67790 8896 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for C21orf88 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C21orf88 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C21orf88 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C21orf88) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nineteen additional unpredicted transcripts from human chromosome 21. (PubMed id 12036297)1, 2, 3 Reymond A....Antonarakis S.E. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional analysis and identification of cis-regulat ory elements of human chromosome 21 gene promoters. (PubMed id 20494980)1 Warnatz H.J....Yaspo M.L. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)2 Hattori M....Yaspo M.L. (2000)
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External Searches for C21orf88 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C21orf88 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C21orf88 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C21orf88 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C21orf88 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C21orf88 gene:
Search GeneIP for patents involving C21orf88
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C21orf88 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C21orf88 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C21orf88 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C21orf88 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C21orf88 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C21orf88 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C21orf88 |
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 | | | C21orf88 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf88 |
|  |  |  | | | | Search ThermoFisher Antibodies for C21orf88 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C21orf88 |
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