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Aliases for C21orf62 Gene

Aliases for C21orf62 Gene

  • Chromosome 21 Open Reading Frame 62 2 3 5
  • C21orf120 3 4
  • B37 3 4
  • Chromosome 21 Open Reading Frame 120 2
  • PRED81 3

External Ids for C21orf62 Gene

Previous HGNC Symbols for C21orf62 Gene

  • C21orf120

Previous GeneCards Identifiers for C21orf62 Gene

  • GC21M030743
  • GC21M033086
  • GC21M033087
  • GC21M034163
  • GC21M019572

Summaries for C21orf62 Gene

GeneCards Summary for C21orf62 Gene

C21orf62 (Chromosome 21 Open Reading Frame 62) is a Protein Coding gene. Diseases associated with C21orf62 include spinocerebellar ataxia, autosomal recessive 10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C21orf62 Gene

Genomics for C21orf62 Gene

Regulatory Elements for C21orf62 Gene

Genomic Location for C21orf62 Gene

Chromosome:
21
Start:
32,790,673 bp from pter
End:
32,814,181 bp from pter
Size:
23,509 bases
Orientation:
Minus strand

Genomic View for C21orf62 Gene

Genes around C21orf62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C21orf62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C21orf62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C21orf62 Gene

Proteins for C21orf62 Gene

  • Protein details for C21orf62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYP8-CU062_HUMAN
    Recommended name:
    Uncharacterized protein C21orf62
    Protein Accession:
    Q9NYP8
    Secondary Accessions:
    • A8K4L8

    Protein attributes for C21orf62 Gene

    Size:
    219 amino acids
    Molecular mass:
    24886 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF72946.1; Type=Frameshift; Positions=181; Evidence={ECO:0000305};

neXtProt entry for C21orf62 Gene

Proteomics data for C21orf62 Gene at MOPED

Post-translational modifications for C21orf62 Gene

  • Glycosylation at Asn 29, Asn 95, and Asn 188
  • Modification sites at PhosphoSitePlus

Other Protein References for C21orf62 Gene

No data available for DME Specific Peptides for C21orf62 Gene

Domains & Families for C21orf62 Gene

Protein Domains for C21orf62 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C21orf62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C21orf62: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C21orf62 Gene

Function for C21orf62 Gene

genes like me logo Genes that share phenotypes with C21orf62: view

Animal Models for C21orf62 Gene

MGI Knock Outs for C21orf62:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C21orf62 Gene

Localization for C21orf62 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C21orf62 Gene COMPARTMENTS Subcellular localization image for C21orf62 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C21orf62 Gene

Pathways & Interactions for C21orf62 Gene

SuperPathways for C21orf62 Gene

No Data Available

Interacting Proteins for C21orf62 Gene

Gene Ontology (GO) - Biological Process for C21orf62 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C21orf62 Gene

Drugs & Compounds for C21orf62 Gene

No Compound Related Data Available

Transcripts for C21orf62 Gene

Unigene Clusters for C21orf62 Gene

Chromosome 21 open reading frame 62:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C21orf62 Gene

No ASD Table

Relevant External Links for C21orf62 Gene

GeneLoc Exon Structure for
C21orf62
ECgene alternative splicing isoforms for
C21orf62

Expression for C21orf62 Gene

mRNA expression in normal human tissues for C21orf62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C21orf62 Gene

This gene is overexpressed in Pituitary (x10.5), Ovary (x9.1), Kidney - Cortex (x4.4), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for C21orf62 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C21orf62 Gene



SOURCE GeneReport for Unigene cluster for C21orf62 Gene Hs.517235

genes like me logo Genes that share expression patterns with C21orf62: view

Protein tissue co-expression partners for C21orf62 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C21orf62 Gene

Orthologs for C21orf62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C21orf62 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1H21orf62 35
  • 84.86 (n)
  • 78.9 (a)
C21orf62 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C31H21orf62 35
  • 84.02 (n)
  • 79.91 (a)
C31H21orf62 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4932438H23Rik 35
  • 79.4 (n)
  • 70.28 (a)
4932438H23Rik 16
4932438H23Rik 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf62 35
  • 98.78 (n)
  • 97.72 (a)
C21orf62 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562726 35
  • 78.67 (n)
  • 71.09 (a)
oppossum
(Monodelphis domestica)
Mammalia C21orf62 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H21ORF62 35
  • 63.51 (n)
  • 57.82 (a)
C21orf62 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C21orf62 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c21orf62 35
  • 59.08 (n)
  • 51.98 (a)
Species with no ortholog for C21orf62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C21orf62 Gene

ENSEMBL:
Gene Tree for C21orf62 (if available)
TreeFam:
Gene Tree for C21orf62 (if available)

Paralogs for C21orf62 Gene

No data available for Paralogs for C21orf62 Gene

Variants for C21orf62 Gene

Sequence variations from dbSNP and Humsavar for C21orf62 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs963636 -- 32,803,255(+) TAAAC(C/T)GACAC intron-variant
rs1892578 -- 32,800,493(+) TTTAA(C/T)AATCA intron-variant
rs1892579 -- 32,800,614(+) AGTTC(C/G)AGACC intron-variant
rs1892580 -- 32,806,186(+) AAGGG(C/T)GACAT intron-variant
rs1892581 -- 32,806,486(+) TAGAC(A/G)TAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C21orf62 Gene

Variant ID Type Subtype PubMed ID
nsv834086 CNV Loss 17160897
nsv509793 CNV Insertion 20534489

Variation tolerance for C21orf62 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C21orf62 Gene

HapMap Linkage Disequilibrium report
C21orf62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C21orf62 Gene

Disorders for C21orf62 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C21orf62 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia, autosomal recessive 10
  • autosomal recessive spinocerebellar ataxia 10
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C21orf62

Genetic Association Database (GAD)
C21orf62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C21orf62
genes like me logo Genes that share disorders with C21orf62: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C21orf62 Gene

Publications for C21orf62 Gene

  1. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PMID: 10773462) Slavov D. … Gardiner K. (Gene 2000) 3 4 67
  2. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PMID: 20494980) Warnatz H.J. … Yaspo M.L. (Nucleic Acids Res. 2010) 3
  3. Genome-wide association of serum bilirubin levels in Korean population. (PMID: 20639394) Kang T.W. … Kim Y.S. (Hum. Mol. Genet. 2010) 3
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F. … Reymond A. (Genome Res. 2007) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for C21orf62 Gene

Sources for C21orf62 Gene

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