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Aliases for C21orf62 Gene

Aliases for C21orf62 Gene

  • Chromosome 21 Open Reading Frame 62 2 3 5
  • C21orf120 3 4
  • B37 3 4
  • Chromosome 21 Open Reading Frame 120 2
  • Uncharacterized Protein C21orf62 3
  • PRED81 3

External Ids for C21orf62 Gene

Previous HGNC Symbols for C21orf62 Gene

  • C21orf120

Previous GeneCards Identifiers for C21orf62 Gene

  • GC21M030743
  • GC21M033086
  • GC21M033087
  • GC21M034163
  • GC21M019572

Summaries for C21orf62 Gene

GeneCards Summary for C21orf62 Gene

C21orf62 (Chromosome 21 Open Reading Frame 62) is a Protein Coding gene.

Additional gene information for C21orf62 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C21orf62 Gene

Genomics for C21orf62 Gene

Regulatory Elements for C21orf62 Gene

Enhancers for C21orf62 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H032769 1.2 ENCODE 6.8 +42.8 42828 3 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZC3H11A ZFP41 PAXBP1 TMEM50B SON DONSON C21orf59 EVA1C URB1 MIS18A-AS1 MIS18A GART
GH21H032940 0.7 ENCODE 10.7 -126.4 -126427 0 CTCF ZNF654 L3MBTL2 REST ZBTB8A RAD21 ZNF239 ZNF26 SMC3 ZNF143 PAXBP1 TMEM50B LINC01548 C21orf62 SON LINC01690 GC21P032918
GH21H032809 0.5 ENCODE 5.3 +5.6 5566 0 OSR2 ZFP69B PRDM6 KLF8 C21orf62-AS1 PAXBP1 C21orf62 ENSG00000279690
GH21H032810 0.5 FANTOM5 4.5 +4.5 4533 0 ZNF366 ZNF512 C21orf62-AS1 PAXBP1 C21orf62 OLIG1 ENSG00000279690
GH21H032450 0.5 FANTOM5 dbSUPER 1.9 +363.8 363788 0 EVA1C TCP10L ENSG00000252045 C21orf62 LOC101928078
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C21orf62 on UCSC Golden Path with GeneCards custom track

Genomic Location for C21orf62 Gene

Chromosome:
21
Start:
32,790,673 bp from pter
End:
32,814,181 bp from pter
Size:
23,509 bases
Orientation:
Minus strand

Genomic View for C21orf62 Gene

Genes around C21orf62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C21orf62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C21orf62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C21orf62 Gene

Proteins for C21orf62 Gene

  • Protein details for C21orf62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYP8-CU062_HUMAN
    Recommended name:
    Uncharacterized protein C21orf62
    Protein Accession:
    Q9NYP8
    Secondary Accessions:
    • A8K4L8

    Protein attributes for C21orf62 Gene

    Size:
    219 amino acids
    Molecular mass:
    24886 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF72946.1; Type=Frameshift; Positions=181; Evidence={ECO:0000305};

neXtProt entry for C21orf62 Gene

Post-translational modifications for C21orf62 Gene

  • Glycosylation at posLast=2929, posLast=9595, and posLast=188188
  • Modification sites at PhosphoSitePlus

Other Protein References for C21orf62 Gene

No data available for DME Specific Peptides for C21orf62 Gene

Domains & Families for C21orf62 Gene

Gene Families for C21orf62 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C21orf62 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C21orf62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C21orf62: view

No data available for UniProtKB/Swiss-Prot for C21orf62 Gene

Function for C21orf62 Gene

Gene Ontology (GO) - Molecular Function for C21orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C21orf62: view
genes like me logo Genes that share phenotypes with C21orf62: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C21orf62
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C21orf62 Gene

Localization for C21orf62 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C21orf62 gene
Compartment Confidence
extracellular 2
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C21orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C21orf62: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for C21orf62 Gene

Pathways & Interactions for C21orf62 Gene

SuperPathways for C21orf62 Gene

No Data Available

Interacting Proteins for C21orf62 Gene

Gene Ontology (GO) - Biological Process for C21orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C21orf62: view

No data available for Pathways by source and SIGNOR curated interactions for C21orf62 Gene

Drugs & Compounds for C21orf62 Gene

No Compound Related Data Available

Transcripts for C21orf62 Gene

Unigene Clusters for C21orf62 Gene

Chromosome 21 open reading frame 62:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C21orf62
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C21orf62 Gene

No ASD Table

Relevant External Links for C21orf62 Gene

GeneLoc Exon Structure for
C21orf62
ECgene alternative splicing isoforms for
C21orf62

Expression for C21orf62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C21orf62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C21orf62 Gene

This gene is overexpressed in Pituitary (x10.5), Ovary (x9.1), Kidney - Cortex (x4.4), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for C21orf62 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C21orf62 Gene



Protein tissue co-expression partners for C21orf62 Gene

NURSA nuclear receptor signaling pathways regulating expression of C21orf62 Gene:

C21orf62

SOURCE GeneReport for Unigene cluster for C21orf62 Gene:

Hs.517235
genes like me logo Genes that share expression patterns with C21orf62: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C21orf62 Gene

Orthologs for C21orf62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C21orf62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf62 33
  • 98.78 (n)
C21orf62 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H21orf62 33
  • 84.86 (n)
C21orf62 34
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C31H21orf62 33 34
  • 84.02 (n)
mouse
(Mus musculus)
Mammalia 4932438H23Rik 33 16 34
  • 79.4 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562726 33
  • 78.67 (n)
oppossum
(Monodelphis domestica)
Mammalia C21orf62 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H21ORF62 33
  • 63.51 (n)
C21orf62 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C21orf62 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c21orf62 33
  • 59.08 (n)
Species where no ortholog for C21orf62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C21orf62 Gene

ENSEMBL:
Gene Tree for C21orf62 (if available)
TreeFam:
Gene Tree for C21orf62 (if available)

Paralogs for C21orf62 Gene

No data available for Paralogs for C21orf62 Gene

Variants for C21orf62 Gene

Sequence variations from dbSNP and Humsavar for C21orf62 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000060357 -- 32,810,501(+) CGTGA(C/T)CCGCC intron-variant
rs1000102137 -- 32,795,026(+) TTTAG(A/T)TAATG intron-variant
rs1000155007 -- 32,809,835(+) GAATA(A/G)GTGAC intron-variant
rs1000252370 -- 32,809,324(+) TCTTT(A/C)TTTCT intron-variant
rs1000303408 -- 32,813,739(+) TCTTC(A/G)GAGGG reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C21orf62 Gene

Variant ID Type Subtype PubMed ID
esv3646895 CNV loss 21293372
nsv473538 CNV novel sequence insertion 20440878
nsv481301 CNV novel sequence insertion 20440878
nsv509793 CNV insertion 20534489
nsv834086 CNV loss 17160897

Variation tolerance for C21orf62 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C21orf62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C21orf62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C21orf62 Gene

Disorders for C21orf62 Gene

Relevant External Links for C21orf62

Genetic Association Database (GAD)
C21orf62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C21orf62

No disorders were found for C21orf62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C21orf62 Gene

Publications for C21orf62 Gene

  1. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PMID: 10773462) Slavov D … Gardiner K (Gene 2000) 3 4 60
  2. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PMID: 20494980) Warnatz HJ … Yaspo ML (Nucleic acids research 2010) 3 60
  3. Genome-wide association of serum bilirubin levels in Korean population. (PMID: 20639394) Kang TW … Kim YS (Human molecular genetics 2010) 3 60
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F … Reymond A (Genome research 2007) 3 60
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 45 60

Products for C21orf62 Gene

Sources for C21orf62 Gene

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