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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C21orf59 Gene

protein-coding   GIFtS: 45
GCID: GC21M033951

chromosome 21 open reading frame 59

(Previous name: chromosome 21 open reading frame 48 )
(Previous symbol: C21orf48)
 Explore 3 diseases affiliated with
C21orf59 via our new
 Human Malady Compendium 
Biological research products
for C21orf59
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chromosome 21 Open Reading Frame 591 2
C21orf481 2 3
FLJ204671
Chromosome 21 Open Reading Frame 481
Prostate Cancer Upregulated Protein 12
Uncharacterized Protein C21orf592

External Ids:    HGNC: 13011   Entrez Gene: 566832   Ensembl: ENSG000001590797   UniProtKB: P570763   

Export aliases for C21orf59 gene to outside databases

Previous GC identifers: GC21M030551 GC21M030634 GC21M032894 GC21M032895 GC21M019383


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for C21orf59


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C21orf59 gene promoter:
         SRF   TBP   ISGF-3   AML1a   SRF (504 AA)   HTF   E4BP4   Evi-1   TFIID   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC21orf59 promoter sequence
   Search SABiosciences Chromatin IP Primers for C21orf59

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C21orf59


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.1   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

C21orf59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C21orf59 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M033951:  view genomic region     (about GC identifiers)

Start:
33,964,389 bp from pter      End:
33,985,176 bp from pter
Size:
20,788 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CU059_HUMAN, P57076 (See protein sequence)
Recommended Name: Uncharacterized protein C21orf59  
Size: 290 amino acids; 33224 Da

Explore the universe of human proteins at neXtProt for C21orf59: NX_P57076

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2 (C21orf59)
  • View neXtProt modification sites for NX_P57076

  • C21orf59 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067077.1  
    ENSEMBL proteins: 
     ENSP00000411306   ENSP00000411467   ENSP00000371989   ENSP00000290155   ENSP00000407362  
     ENSP00000300260   ENSP00000393104   ENSP00000440339  

    Human Recombinant Protein Products: 
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    Novus Biologicals C21orf59 Protein
    Novus Biologicals C21orf59 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for C21orf59

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16780588
    GO:0005829cytosol IDA16780588


    C21orf59 for ontologies           About GeneDecksing



    C21orf59 Antibody Products: 
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    Uscn ELISAs and CLIAs for C21orf59


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    C21orf59 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR021298 DUF2870

    Graphical View of Domain Structure for InterPro Entry P57076

    ProtoNet protein and cluster: P57076

    UniProtKB/Swiss-Prot: CU059_HUMAN, P57076
    Similarity: To D.melanogaster CG18675


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: C21orf59
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    Inhib. RNA
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    OriGene shRNA RFP: C21orf59
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C21orf59 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf59


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C21orf59

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for C21orf59 (P570762, 3 ENSP000002901554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8260801 I2D: score=2 
    PPP1R21Q6ZMI03I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C21orf59
    Search CenterWatch for drugs/clinical trials and news about C21orf59 / CU059 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C21orf59 gene (2 alternative transcripts): 
    NM_017835.1  NM_021254.2  

    Unigene Cluster for C21orf59:

    Chromosome 21 open reading frame 59
    Hs.5811  [show with all ESTs]
    Unigene Representative Sequence: AK225697
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431599 ENST00000440966 ENST00000382549(uc002yqb.4 uc011adr.2)
    ENST00000290155(uc002ypy.2 uc002ypz.2 uc002yqc.3 uc010glx.3)
    ENST00000425336 ENST00000300260 ENST00000483315(uc002yqa.3) ENST00000458138
    ENST00000540881

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: C21orf59
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C21orf59
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate C21orf59
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C21orf59 (see all 4)
    OriGene shRNA RFP: C21orf59
    OriGene siRNA: C21orf59
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C21orf59
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C21orf59 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: C21orf59 (NM_021254)
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    Additional cDNA sequence: 

    AF282851.1 AK055328.1 AK094456.1 AK097566.1 AK098577.1 AK223318.1 AK225697.1 AK300970.1 
    AL355729.1 BC000709.2 DQ655906.2 DQ655907.2 DQ655908.2 DQ655909.2 DQ655910.2 DQ656039.2 
    FJ649644.1 NR_036552.1 

    21 DOTS entries:

    DT.448753  DT.100772146  DT.100029358  DT.100029357  DT.100029361  DT.100795170  DT.100680948  DT.121131074 
    DT.100795166  DT.121131048  DT.100017796  DT.100795172  DT.100795175  DT.115351  DT.40132918  DT.100682479 
    DT.100772147  DT.121131046  DT.121131050  DT.100705344  DT.91754960 

    24/282 AceView cDNA sequences (see all 282):

    BM782234 NM_017835 BE895295 CA432004 BQ686490 BU170248 AL526969 CR616421 
    BQ446946 BI521382 AI752839 CK429723 BM474907 BM553977 BU165399 CR591409 
    AA383297 BM790052 CA313045 BE859074 BU178909 AA046948 BQ889210 BM559458 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C21orf59 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                                            -                             -                     
    SP2:                                      -     -                             -                     
    SP3:                                            -                                                   
    SP4:                          -                 -                                                   
    SP5:                                                                          -     -               


    ECgene alternative splicing isoforms for C21orf59

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C21orf59 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTGAAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    C21orf59 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    BrainChoroid PlexusBrain
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C21orf59 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C21orf59

    SOURCE GeneReport for Unigene cluster: Hs.5811
        SABiosciences Custom PCR Arrays for C21orf59
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf59

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for C21orf59 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1110004E09Rik1 , 5 RIKEN cDNA 1110004E09 gene1, 5 84.37(n)1
    92.41(a)1
      16 (52.17 cM)5
    680011  NM_026502.21  NP_080778.21 
     909258095 
    chicken
    (Gallus gallus)
    Aves C1H21orf591 chromosome 1 open reading frame, human C21orf59 74.94(n)
    77.93(a)
      418497  NM_001006258.1  NP_001006258.1 
    lizard
    (Anolis carolinensis)
    Reptilia C21orf596
    --
    78(a)
    1 → many
    3(145199899-145206116)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.44682 Xenopus laevis transcribed sequence with moderate similarity more 76.5(n)    CA790668.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb6152 sbcb615 77.97(n)   368366  BC053230.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG186751 CG18675 55.29(n)
    49.66(a)
      50169  NM_144077.2  NP_652334.2 
    rice
    (Oryza sativa)
    Liliopsida --
    expressed protein
    27(a)
    1 → many
    5(1103381-1105213)


    ENSEMBL Gene Tree for C21orf59 (if available)
    TreeFam Gene Tree for C21orf59 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C21orf59 gene
    ENSG000002655902  

    C21orf59 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for C21orf59
    PGOHUM00000238686 PGOHUM00000243457


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 NCBI SNPs in C21orf59 are shown (see all 294    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770978301,2
    C,F,--33973496(+) CTGGCG/AGCATC 2 -- ds50011Minor allele frequency- A:0.18EA 120
    rs1856224621,2
    --33973579(+) AATCAG/TGAAGA 2 -- ds50010--------
    rs1429286861,2
    --33973639(+) TTTCGC/TTCTGT 2 -- ds50010--------
    rs1112384931,2
    --33973798(+) GAGACA/GGGGTT 2 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1136444791,2
    --33973828(+) GGTCTC/TGATCT 2 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1477106591,2
    --33973902(+) GCGCCC/TGGCCA 2 -- ds50010--------
    rs10433301,2
    C,--33974108(-) AATTTT/AAAAAA 2 -- nc-transcript-variantut311Minor allele frequency- A:0.50WA 2
    rs1420901481,2
    --33974131(+) GAGAAA/GGGTGA 2 -- ut31 nc-transcript-variant0--------
    rs1997571311,2
    --33974137(+) GGTGAA/GCTAAT 2 -- ut31 nc-transcript-variant0--------
    rs1458972631,2
    C,--33974229(+) AGCAGA/TGTTAT 3 T S nc-transcript-variantmis10--------

    HapMap Linkage Disequilibrium report for C21orf59 (33964389 - 33985176 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C21orf59: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C21orf59
    DNA2.0 Custom Variant and Variant Library Synthesis for C21orf59

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C21orf59 for disorders           About GeneDecksing

    3 diseases for C21orf59:    About MalaCards
    prostate cancer    prostatitis    malaria


    Export disorders for C21orf59 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C21orf59 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with C21orf59)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56683 HGNC: 1301 AceView: C21orf59 Ensembl:ENSG00000159079 euGenes: HUgn56683
    ECgene: C21orf59 H-InvDB: C21orf59

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C21orf59 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C21orf59 gene:
    Search GeneIP for patents involving C21orf59

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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