C21orf59 Gene
protein-coding GIFtS : 45
GCID: GC21 M033951
chromosome 21 open reading frame 59 (Previous name: chromosome 21 open reading frame 48 ) (Previous symbol: C21orf48 )
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Aliasesfor C21orf59 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 21 Open Reading Frame 59 1 2 C21orf481 2 3 FLJ204671 Chromosome 21 Open Reading Frame 481 Prostate Cancer Upregulated Protein 12 Uncharacterized Protein C21orf592
Export aliases for C21orf59 gene to outside databases Previous GC identifers: GC21M030551 GC21M030634 GC21M032894 GC21M032895 GC21M019383
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Summariesfor C21orf59 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for C21orf59
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Genomic Viewsfor C21orf59 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000021.8 NC_018932.1 NT_011512.11 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C21orf59 gene promoter: SRF TBP ISGF-3 AML1a SRF (504 AA) HTF E4BP4 Evi-1 TFIID c-Myb Other transcription factors Search SABiosciences Chromatin IP Primers for C21orf59 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C21orf59
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 21q22.1 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.11 C21orf59 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 21 GeneLoc Exon Structure
GeneLoc location for GC21M033951: view genomic region
(about GC identifiers )
Start:
33,964,389 bp from pter
End:
33,985,176 bp from pter
Size:
20,788 bases
Orientation:
minus strand
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Proteinsfor C21orf59 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CU059_HUMAN, P57076 (See
protein sequence )Recommended Name: Uncharacterized protein C21orf59 Size : 290 amino acids; 33224 DaExplore the universe of human proteins at neXtProt for C21orf59: NX_P57076 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 (C21orf59) View neXtProt modification sites for NX_P57076 C21orf59 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_067077.1 ENSEMBL proteins: ENSP00000411306 ENSP00000411467 ENSP00000371989 ENSP00000290155 ENSP00000407362 ENSP00000300260 ENSP00000393104 ENSP00000440339 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
C21orf59 for ontologies About GeneDecksing C21orf59 Antibody Products: Assay Products for C21orf59:
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Protein
Domains / Familiesfor C21orf59 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
C21orf59 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry P57076 ProtoNet protein and cluster: P57076
UniProtKB/Swiss-Prot: CU059_HUMAN, P57076 Similarity : To D.melanogaster CG18675
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Functionfor C21orf59 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C21orf59 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C21orf59OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C21orf59 (NM_021254 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C21orf59 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C21orf59
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf59
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Pathways & Interactionsfor C21orf59 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C21orf59 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)4 Interacting proteins for C21orf59 (P57076 2 , 3 ENSP00000290155 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor C21orf59 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C21orf59 Search CenterWatch for drugs/clinical trials and news about C21orf59 / CU059
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Transcriptsfor C21orf59 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for C21orf59 gene (2 alternative transcripts): NM_017835.1 NM_021254.2 Unigene Cluster for C21orf59:
Chromosome 21 open reading frame 59 Hs.5811 [show with all ESTs ] Unigene Representative Sequence: AK225697 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000431599 ENST00000440966 ENST00000382549 (uc002yqb.4 uc011adr.2 )ENST00000290155 (uc002ypy.2 uc002ypz.2 uc002yqc.3 uc010glx.3 )ENST00000425336 ENST00000300260 ENST00000483315 (uc002yqa.3 ) ENST00000458138 ENST00000540881 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C21orf59 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C21orf59OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C21orf59 (NM_021254 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C21orf59 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C21orf59
Additional cDNA sequence: AF282851.1 AK055328.1 AK094456.1 AK097566.1 AK098577.1 AK223318.1 AK225697.1 AK300970.1 AL355729.1 BC000709.2 DQ655906.2 DQ655907.2 DQ655908.2 DQ655909.2 DQ655910.2 DQ656039.2 FJ649644.1 NR_036552.1
21 DOTS entries : DT.448753 DT.100772146
DT.100029358 DT.100029357 DT.100029361 DT.100795170 DT.100680948 DT.121131074 DT.100795166 DT.121131048 DT.100017796 DT.100795172 DT.100795175 DT.115351 DT.40132918 DT.100682479 DT.100772147 DT.121131046 DT.121131050 DT.100705344 DT.91754960 24/282 AceView cDNA sequences (see all 282 ):
BM782234 NM_017835 BE895295 CA432004 BQ686490 BU170248 AL526969 CR616421 BQ446946 BI521382 AI752839 CK429723 BM474907 BM553977 BU165399 CR591409 AA383297 BM790052 CA313045 BE859074 BU178909 AA046948 BQ889210 BM559458 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C21orf59 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b SP1 :               -           -         SP2 :             -   -           -         SP3 :               -                   SP4 :         -       -                   SP5 :                         -   -      
ECgene alternative splicing isoforms for C21orf59
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Expression for C21orf59 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C21orf59 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAGTGAAAGA
About this image C21orf59 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See C21orf59 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C21orf59 SOURCE GeneReport for Unigene cluster: Hs.5811 SABiosciences Custom PCR Arrays for C21orf59 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C21orf59Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C21orf59 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C21orf59 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C21orf59 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf59
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Orthologsfor C21orf59 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for C21orf59 gene from 7/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for C21orf59 (if available)TreeFam Gene Tree for C21orf59 (if available)
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Paralogsfor C21orf59 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for C21orf59 gene ENSG00000265590 2
C21orf59 for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for C21orf59 PGOHUM00000238686 PGOHUM00000243457
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Genomic Variantsfor C21orf59 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 21 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C21orf59 (33964389 - 33985176 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for C21orf59: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C21orf59
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Disorders
/ Diseasesfor C21orf59 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
C21orf59 for disorders About GeneDecksing 3 diseases for C21orf59 : About MalaCards prostate cancer prostatitis malaria Export disorders for C21orf59 gene to outside databases
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Publicationsfor C21orf59 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C21orf59 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with C21orf59) Utopia : connect your pdf to the dynamic world of online information
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265) 1 , 2 Denis N.J.... Figeys D. (2007) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 1 , 2 Rush J.... Comb M.J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206) 1 Vinayagam A....Wanker E.E. (2011) System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022) 1 Golebiowski F....Hay R.T. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994) 1 Denoeud F....Reymond A. (2007)
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External Searches for C21orf59 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C21orf59 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C21orf59 gene
(According to HUGE )
About This Section --
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Specialized Databases showing C21orf59 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C21orf59 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C21orf59 gene: Search GeneIP for patents involving C21orf59 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C21orf59 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for C21orf59 OriGene shRNA RFP for C21orf59 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C21orf59 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C21orf59 OriGene Protein Over-expression Lysate for C21orf59 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C21orf59 OriGene 3'-UTR Clone for C21orf59 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C21orf59 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C21orf59 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for C21orf59 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C21orf59 OriGene Custom Protein Services for C21orf59 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C21orf59 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C21orf59 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C21orf59 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C21orf59 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C21orf59 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C21orf59
C21orf59 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf59
Search ThermoFisher Antibodies for C21orf59
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C21orf59
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Aliases for C21orf59
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Disorders / Diseases for C21orf59
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