C21orf58 Gene
protein-coding GIFtS: 40
GCID: GC21M047720
|
|
chromosome 21 open reading frame 58
| |
Aliases
for C21orf58 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
|
| Aliases |
|---|
| Chromosome 21 Open Reading Frame 581 2 | | Spliced ESTs Z25278,AA82526611 | | Uncharacterized Protein C21orf582 |
Export aliases for C21orf58 gene to outside databasesPrevious GC identifers: GC21M044226 GC21M046576 GC21M046577 GC21M046545 GC21M033104 |
Summaries
for C21orf58 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C21orf58 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
|
| GC21M047720: |
GeneLoc |
Nature:405,311-319 |
Start:
|
47,720,095 bp from pter |
33,227,047 bp from centromere |
End:
|
47,743,789 bp from pter |
33,244,524 bp from centromere |
Size:
|
23,695 bases |
17,478 bases |
Orientation:
|
minus strand |
minus strand |
Proteins
for C21orf58 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CU058_HUMAN, P58505 (See
protein sequence)Recommended Name: Uncharacterized protein C21orf58 Size: 322 amino acids; 35003 Da
Sequence caution: Sequence=AAK72408.1; Type=Erroneous initiation; Sequence=AAK72409.1; Type=Erroneous initiation;
Secondary accessions: B3KPI1Alternative splicing: 2 isoforms: P58505-1 P58505-2 Explore the universe of human proteins at neXtProt for C21orf58: NX_P58505
C21orf58 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_478060.2
ENSEMBL proteins: ENSP00000431312 ENSP00000380799 ENSP00000402356 ENSP00000380798 ENSP00000291691 ENSP00000380796 ENSP00000380797 ENSP00000390432 ENSP00000380801
Human Recombinant Protein Products:
C21orf58 Antibody Products:
Assay Products for C21orf58: |
Protein
Domains /
Families
for C21orf58 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P58505 |
Function
for C21orf58 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C21orf58 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C21orf58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C21orf58 (NM_058180) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C21orf58 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C21orf58 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf58 |
1 GenomeRNAi human phenotype for C21orf58:
|
Pathways & Interactions
for C21orf58 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C21orf58
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C21orf58 (P585053 ENSP000002916914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C21orf58 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C21orf58
Search CenterWatch for drugs/clinical trials and news about C21orf58 / CU058
|
Transcripts
for C21orf58 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C21orf58 gene (2 alternative transcripts): NM_199071.2 NM_058180.3 Unigene Cluster for C21orf58: Chromosome 21 open reading frame 58 Hs.236572 [show with all ESTs]Unigene Representative Sequence: NM_05818011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491666 ENST00000397683(uc002ziz.3 uc002zja.3) ENST00000417060
ENST00000397682(uc010gqj.2) ENST00000291691(uc002zjf.3) ENST00000397679(uc002zjc.3)
ENST00000397680(uc011afx.2) ENST00000472607 ENST00000445935 ENST00000475776
ENST00000397685(uc002zjg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C21orf58 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C21orf58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C21orf58 (NM_058180) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C21orf58 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C21orf58 |
Additional cDNA sequence: AK056387.1 AK096641.1 AK098098.1 AY039243.1 AY039244.1 BC026042.1 BC028934.1 BC031638.1 BC044223.1 BC067876.1 BC121007.1 BC121008.1 11 DOTS entries: DT.100780908 DT.92033544 DT.40225837 DT.95369017 DT.40271356 DT.40261613 DT.430998 DT.99933439 DT.121142349 DT.92415775 DT.91689356 24/48 AceView cDNA sequences (see all 48): CB856841 AK096641 AY039244 AI859860 BU789102 AK098098 BC026042 NM_199071 AY039243 AI979100 BC044223 BX283720 BG388644 CA868521 AK056387 BM802252 CB305953 BE019649 BX405373 CA446226 BI223146 BI756723 CB151279 BM469866
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C21orf58 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | - | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | - | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C21orf58
|
Expression
for C21orf58 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C21orf58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCAACCTCG
About this image
See C21orf58 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C21orf58
SOURCE GeneReport for Unigene cluster: Hs.236572
UniProtKB/Swiss-Prot: CU058_HUMAN, P58505Tissue specificity: Expressed in skin and fetal lung
SABiosciences Custom PCR Arrays for C21orf58
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C21orf58
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C21orf58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C21orf58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C21orf58 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf58 |
Orthologs
for C21orf58 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C21orf58 gene from 5/8 species (see all 8) About this table
ENSEMBL Gene Tree for C21orf58 (if available)
TreeFam Gene Tree for C21orf58 (if available) |
Paralogs
for C21orf58 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C21orf58 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C21orf58 (47720095 - 47743789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C21orf58
1 Indel: 40488 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C21orf58 |
|
Disorders
/ Diseases
for C21orf58 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C21orf58 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C21orf58 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C21orf58) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (2001)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- [IMAGE: molecular integration of the analysis of the human genome and its expression] (PubMed id 7757816)1 Auffray C....Lamy B. (1995)
|
External Searches for C21orf58 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C21orf58 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C21orf58 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C21orf58 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C21orf58 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C21orf58 gene:
Search GeneIP for patents involving C21orf58
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C21orf58 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C21orf58 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C21orf58 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C21orf58 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C21orf58 | | OriGene 3'-UTR Clone for C21orf58 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C21orf58 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C21orf58 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C21orf58 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C21orf58 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C21orf58 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C21orf58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C21orf58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C21orf58 |
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 | | | C21orf58 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf58 |
|  |  |  | | | | Search ThermoFisher Antibodies for C21orf58 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C21orf58 |
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