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Aliases for C21orf58 Gene

Aliases for C21orf58 Gene

  • Chromosome 21 Open Reading Frame 58 2 3 5

External Ids for C21orf58 Gene

Previous GeneCards Identifiers for C21orf58 Gene

  • GC21M044226
  • GC21M046576
  • GC21M046577
  • GC21M046545
  • GC21M047720
  • GC21M033104

Summaries for C21orf58 Gene

GeneCards Summary for C21orf58 Gene

C21orf58 (Chromosome 21 Open Reading Frame 58) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C21orf58 Gene

Genomics for C21orf58 Gene

Regulatory Elements for C21orf58 Gene

Enhancers for C21orf58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G046252 0.9 ENCODE 12.1 +69.8 69831 2.2 HDAC1 HDGF TBP PKNOX1 CREB3L1 ARNT INSM2 ZNF76 BRCA1 RARA YBEY MCM3AP-AS1 LSS C21orf58 ENSG00000223901 PCNT FTCD DIP2A DIP2A-IT1 SPATC1L
GH21G046386 0.6 FANTOM5 dbSUPER 12.4 -62.9 -62931 0.4 POLR2A SPATC1L YBEY C21orf58 PCNT MCM3AP FTCD PIR36884 GC21M046476
GH21G046442 0.6 dbSUPER 11.1 -119.5 -119546 1.7 STAT1 MAFG ZFHX2 ZNF316 NFE2L1 NFE2 MAFK EMSY NFE2L2 EGR2 S100B DIP2A C21orf58 PCNT SPATC1L MCM3AP-AS1 GC21M046475 RPL18AP2
GH21G046380 0.5 dbSUPER 12 -57.2 -57223 1.6 ZNF316 MAFK ZNF18 YBEY MCM3AP-AS1 MCM3AP PCNT C21orf58 LSS ENSG00000223901 FTCD SPATC1L PIR36884
GH21G046396 0.4 dbSUPER 12.9 -73.8 -73794 2.0 CTCF MCM3AP YBEY C21orf58 PCNT ENSG00000228137 LSS MCM3AP-AS1 ENSG00000223901 SPATC1L PIR36884
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C21orf58 on UCSC Golden Path with GeneCards custom track

Promoters for C21orf58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143378 -201 3001 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for C21orf58 Gene

Chromosome:
21
Start:
46,300,181 bp from pter
End:
46,323,899 bp from pter
Size:
23,719 bases
Orientation:
Minus strand

Genomic View for C21orf58 Gene

Genes around C21orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C21orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C21orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C21orf58 Gene

Proteins for C21orf58 Gene

  • Protein details for C21orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58505-CU058_HUMAN
    Recommended name:
    Uncharacterized protein C21orf58
    Protein Accession:
    P58505
    Secondary Accessions:
    • B3KPI1
    • Q8N7N9

    Protein attributes for C21orf58 Gene

    Size:
    322 amino acids
    Molecular mass:
    35003 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK72408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK72409.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C21orf58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C21orf58 Gene

Post-translational modifications for C21orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C21orf58 Gene

Domains & Families for C21orf58 Gene

Protein Domains for C21orf58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C21orf58 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C21orf58: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C21orf58 Gene

Function for C21orf58 Gene

Phenotypes for C21orf58 Gene

GenomeRNAi human phenotypes for C21orf58:
genes like me logo Genes that share phenotypes with C21orf58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C21orf58 Gene

Localization for C21orf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C21orf58 gene
Compartment Confidence
nucleus 4
mitochondrion 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C21orf58 Gene

Pathways & Interactions for C21orf58 Gene

SuperPathways for C21orf58 Gene

No Data Available

Interacting Proteins for C21orf58 Gene

Selected Interacting proteins: P58505-CU058_HUMAN for C21orf58 Gene via IID

Gene Ontology (GO) - Biological Process for C21orf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C21orf58 Gene

Transcripts for C21orf58 Gene

Unigene Clusters for C21orf58 Gene

Chromosome 21 open reading frame 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C21orf58 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - -
SP8: - -
SP9:
SP10: - - -
SP11:

Relevant External Links for C21orf58 Gene

GeneLoc Exon Structure for
C21orf58
ECgene alternative splicing isoforms for
C21orf58

Expression for C21orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C21orf58 Gene

mRNA differential expression in normal tissues according to GTEx for C21orf58 Gene

This gene is overexpressed in Pituitary (x7.6).

Protein differential expression in normal tissues from HIPED for C21orf58 Gene

This gene is overexpressed in Lung (38.1) and Colon muscle (30.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C21orf58 Gene



Protein tissue co-expression partners for C21orf58 Gene

NURSA nuclear receptor signaling pathways regulating expression of C21orf58 Gene:

C21orf58

SOURCE GeneReport for Unigene cluster for C21orf58 Gene:

Hs.236572

mRNA Expression by UniProt/SwissProt for C21orf58 Gene:

P58505-CU058_HUMAN
Tissue specificity: Expressed in skin and fetal lung.
genes like me logo Genes that share expression patterns with C21orf58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C21orf58 Gene

Orthologs for C21orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C21orf58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf58 34
  • 99.38 (n)
C21orf58 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H21orf58 34
  • 71.48 (n)
C21orf58 35
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C31H21orf58 34
  • 66.32 (n)
C21orf58 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C21orf58 35
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610028H24Rik 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves C21orf58 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C21orf58 35
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C6H21orf58 35
  • 39 (a)
OneToOne
Species where no ortholog for C21orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C21orf58 Gene

ENSEMBL:
Gene Tree for C21orf58 (if available)
TreeFam:
Gene Tree for C21orf58 (if available)

Paralogs for C21orf58 Gene

No data available for Paralogs for C21orf58 Gene

Variants for C21orf58 Gene

Sequence variations from dbSNP and Humsavar for C21orf58 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs138595914 Likely benign 46,324,213(+) CCCGC(A/G/T)CGGAG upstream-variant-2KB, utr-variant-5-prime
rs80017051 Likely benign 46,324,288(+) GTAAA(C/T)ATTAG intron-variant, upstream-variant-2KB
rs202239640 Uncertain significance 46,324,204(+) GCCGG(C/G)CGGCC upstream-variant-2KB, utr-variant-5-prime
rs375279759 Uncertain significance 46,324,252(+) CAGCG(A/C/G)CGCAG upstream-variant-2KB, reference, synonymous-codon
rs747401688 Uncertain significance 46,324,154(+) GGGAG(A/G)GAGTG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C21orf58 Gene

Variant ID Type Subtype PubMed ID
nsv1060978 CNV gain 25217958
nsv1139038 CNV deletion 24896259
nsv3547 CNV insertion 18451855
nsv470910 CNV gain 18288195
nsv519904 CNV loss 19592680
nsv527355 CNV gain 19592680
nsv587975 CNV gain 21841781
nsv587980 CNV loss 21841781

Variation tolerance for C21orf58 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.77; 94.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C21orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C21orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C21orf58 Gene

Disorders for C21orf58 Gene

Relevant External Links for C21orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C21orf58

No disorders were found for C21orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C21orf58 Gene

Publications for C21orf58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4 64
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PMID: 18624398) Wang J. … He F. (J. Proteome Res. 2008) 3 64

Products for C21orf58 Gene

Sources for C21orf58 Gene

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