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Aliases for C21orf58 Gene

Aliases for C21orf58 Gene

  • Chromosome 21 Open Reading Frame 58 2 3

External Ids for C21orf58 Gene

Previous GeneCards Identifiers for C21orf58 Gene

  • GC21M044226
  • GC21M046576
  • GC21M046577
  • GC21M046545
  • GC21M047720
  • GC21M033104

Summaries for C21orf58 Gene

GeneCards Summary for C21orf58 Gene

C21orf58 (Chromosome 21 Open Reading Frame 58) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C21orf58 Gene

Genomics for C21orf58 Gene

Regulatory Elements for C21orf58 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C21orf58 Gene

Start:
46,300,181 bp from pter
End:
46,323,899 bp from pter
Size:
23,719 bases
Orientation:
Minus strand

Genomic View for C21orf58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C21orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C21orf58 Gene

Proteins for C21orf58 Gene

  • Protein details for C21orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58505-CU058_HUMAN
    Recommended name:
    Uncharacterized protein C21orf58
    Protein Accession:
    P58505
    Secondary Accessions:
    • B3KPI1

    Protein attributes for C21orf58 Gene

    Size:
    322 amino acids
    Molecular mass:
    35003 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK72408.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK72409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C21orf58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C21orf58 Gene

Proteomics data for C21orf58 Gene at MOPED

Post-translational modifications for C21orf58 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C21orf58 Gene

Domains for C21orf58 Gene

Protein Domains for C21orf58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C21orf58 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C21orf58: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C21orf58 Gene

Function for C21orf58 Gene

Phenotypes for C21orf58 Gene

GenomeRNAi human phenotypes for C21orf58:
genes like me logo Genes that share phenotypes with C21orf58: view

Animal Model Products

CRISPR Products

miRNA for C21orf58 Gene

miRTarBase miRNAs that target C21orf58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for C21orf58 Gene

Localization for C21orf58 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C21orf58 Gene COMPARTMENTS Subcellular localization image for C21orf58 gene
Compartment Confidence
mitochondrion 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C21orf58 Gene

Pathways for C21orf58 Gene

SuperPathways for C21orf58 Gene

No Data Available

Interacting Proteins for C21orf58 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000291691%0d%0a9606.ENSP00000392057%0d%0a9606.ENSP00000339007%0d%0a9606.ENSP00000318914%0d%0a
Selected Interacting proteins: ENSP00000291691 P58505-CU058_HUMAN for C21orf58 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C21orf58 Gene

None

No data available for Pathways by source for C21orf58 Gene

Transcripts for C21orf58 Gene

Unigene Clusters for C21orf58 Gene

Chromosome 21 open reading frame 58:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C21orf58

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C21orf58

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C21orf58 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - -
SP8: - -
SP9:
SP10: - - -
SP11:

Relevant External Links for C21orf58 Gene

GeneLoc Exon Structure for
C21orf58
ECgene alternative splicing isoforms for
C21orf58

Expression for C21orf58 Gene

mRNA expression in normal human tissues for C21orf58 Gene

mRNA differential expression in normal tissues according to GTEx for C21orf58 Gene

This gene is overexpressed in Pituitary (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C21orf58 Gene

SOURCE GeneReport for Unigene cluster for C21orf58 Gene Hs.236572

mRNA Expression by UniProt/SwissProt for C21orf58 Gene

P58505-CU058_HUMAN
Tissue specificity: Expressed in skin and fetal lung
genes like me logo Genes that share expressions with C21orf58: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C21orf58 Gene

Orthologs for C21orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C21orf58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf58 35
  • 99.38 (n)
  • 98.76 (a)
C21orf58 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H21orf58 35
  • 71.48 (n)
  • 58.59 (a)
C21orf58 36
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C21orf58 36
  • 51 (a)
OneToOne
C31H21orf58 35
  • 66.32 (n)
  • 51.58 (a)
mouse
(Mus musculus)
Mammalia 2610028H24Rik 16
2610028H24Rik 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C21orf58 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves C21orf58 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C21orf58 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C6H21orf58 36
  • 39 (a)
OneToOne
Species with no ortholog for C21orf58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C21orf58 Gene

ENSEMBL:
Gene Tree for C21orf58 (if available)
TreeFam:
Gene Tree for C21orf58 (if available)

Paralogs for C21orf58 Gene

No data available for Paralogs for C21orf58 Gene

Variants for C21orf58 Gene

Sequence variations from dbSNP and Humsavar for C21orf58 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs747439 -- 46,320,991(+) ctaGT(A/T)GTATA upstream-variant-2KB, intron-variant
rs2015083 -- 46,321,178(+) TATAt(A/T)ttttt upstream-variant-2KB, intron-variant
rs2839210 -- 46,315,821(+) TGAAA(A/T)GACGC intron-variant
rs2839211 -- 46,320,096(+) aagga(C/G)tccat intron-variant, upstream-variant-2KB
rs4819236 -- 46,319,232(+) CACCT(C/T)ACTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C21orf58 Gene

Variant ID Type Subtype PubMed ID
nsv470910 CNV Gain 18288195
nsv519904 CNV Loss 19592680
nsv527355 CNV Gain 19592680
nsv914135 CNV Loss 21882294
dgv4817n71 CNV Loss 21882294
nsv3547 CNV Insertion 18451855
nsv914139 CNV Gain 21882294
nsv914141 CNV Loss 21882294

Relevant External Links for C21orf58 Gene

HapMap Linkage Disequilibrium report
C21orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C21orf58 Gene

Disorders for C21orf58 Gene

No disorders were found for C21orf58 Gene.

No data available for UniProtKB/Swiss-Prot for C21orf58 Gene

Publications for C21orf58 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PMID: 18624398) Wang J. … He F. (J. Proteome Res. 2008) 3

Products for C21orf58 Gene

Sources for C21orf58 Gene

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