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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C21orf37 Gene

protein-coding   GIFtS: 29
GCID: GC21P018811

Chromosome 21 Open Reading Frame 37

  Search for C21orf37
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 21 Open Reading Frame 371 2
Spliced EST N4734811

External Ids:    HGNC: 12771   Entrez Gene: 1005059292   Ensembl: ENSG000002325607   UniProtKB: A6NIU23   
ORGUL members:         
NONCODE14:n346080 n410447 n383976      

Export aliases for C21orf37 gene to outside databases

Previous GC identifers: GC21U990066 GC21P017733 GC14M105741


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C21orf37 Gene: 
C21orf37 (chromosome 21 open reading frame 37) is a protein-coding gene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C21orf37
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C21orf37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q21.1
Nature(405: 311-319) cytogenetic band:   21q21.1
C21orf37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C21orf37 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P018811:   GeneLoc Nature:405,311-319
Start:
18,811,208 bp from pter       4,475,612 bp from centromere
End:
18,821,503 bp from pter 4,485,648 bp from centromere
Size:
10,296 bases 10,037 bases
Orientation:
plus strand plus strand

genomic clones: R651M22


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CU037_HUMAN, A6NIU2 (See protein sequence)
Recommended Name: Putative uncharacterized protein C21orf37  
Size: 74 amino acids; 8470 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for C21orf37: NX_A6NIU2

Explore proteomics data for C21orf37 at MOPED 

C21orf37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C21orf37 Protein Expression

ENSEMBL proteins: 
 ENSP00000388953  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A6NIU2


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C21orf37

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C21orf37 (CU037)

Search CenterWatch for drugs/clinical trials and news about C21orf37 / CU037

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C21orf37 gene: 
NM_001005521.1  

Unigene Cluster for C21orf37:

Chromosome 21 open reading frame 37
Hs.46707  [show with all ESTs]
Unigene Representative Sequence: NR_037585
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000440664(uc011abz.2 uc002ykg.2)
miRNA
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Additional mRNA sequence: 

BC130500.1 BC130504.1 BC144390.1 BC144391.1 NR_037585.1 NR_037586.1 

1 DOTS entry:

DT.303861 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


See C21orf37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C21orf37

SOURCE GeneReport for Unigene cluster: Hs.46707
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for C21orf37 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia C21orf376
chromosome 21 open reading frame 37
99(a)
1 ↔ 1
21(3906155-3913263)


ENSEMBL Gene Tree for C21orf37 (if available)
TreeFam Gene Tree for C21orf37 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for C21orf37 gene
18/49 SIMAP similar genes for C21orf37 using alignment to 1 protein entry:     CU037_HUMAN(see all similar genes):
SLC16A3    HINFP    ARIH1    IDNK    RPS13    UBXN4
VPS33A    DOCK8    LOC100996426    SLC35E3    TNNT1    NEK4
ADCK1    EIF3G    MUC20    TMEM78    ZNF28    AAR2

C21orf37 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/244 SNPs in C21orf37 are shown (see all 244)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1435056921,2
--18809216(+) GTGCTG/TATTCT 2 -- us2k10--------
rs1481358661,2
--18809376(+) TAGTGC/TTGTTT 2 -- us2k10--------
rs1419611191,2
--18809463(+) TGGGGC/TGATAA 2 -- us2k10--------
rs2088861,2
C,F,A,H--18809606(+) GGGAAA/TTCCCC 2 -- us2k110Minor allele frequency- T:0.48NA WA EA 374
rs733205761,2
C,F--18809640(+) TGCCTT/CTCAGC 2 -- us2k13Minor allele frequency- C:0.10WA 122
rs2088871,2
C,F,A,H--18809658(+) AACGCG/AATGAA 2 -- us2k115Minor allele frequency- A:0.50EA NS NA WA CSA 691
rs1829285561,2
--18809675(+) CATTAA/GTAATC 2 -- us2k10--------
rs1868967791,2
--18809696(+) CAGGCA/GCAGTG 2 -- us2k10--------
rs1901095351,2
C--18809834(+) GCGTGA/GTGGCG 2 -- us2k10--------
rs2088881,2
C,F,H--18809843(+) CGGGTG/AGCTGG 2 -- us2k19Minor allele frequency- A:0.15NA WA CSA 20

HapMap Linkage Disequilibrium report for C21orf37 (18811208 - 18821503 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for C21orf37:    About this table     
Variant IDTypeSubtypePubMed ID
esv2723192CNV Deletion23290073
nsv913430CNV Gain21882294
dgv4684n71CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C21orf37 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C21orf37)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  3. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100505929 HGNC: 1277 Ensembl:ENSG00000232560 euGenes: HUgn100505929 ECgene: C21orf37
H-InvDB: C21orf37

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C21orf37 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C21orf37 gene:
Search GeneIP for patents involving C21orf37

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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