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C21orf34 Gene

protein-coding   GIFtS: 35

GC21P016364
chromosome 21 open reading frame 34
(Previous name: chromosome 21 open reading frame 35 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C21orf35, FLJ38295)
Services    

Aliases &
Descriptions
for C21orf34

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section
Aliases
C21orf35 2, 3
FLJ38295 2
Descriptions
chromosome 21 open reading frame 34 2
chromosome 21 open reading frame 35 1
hypothetical protein LOC388815 2
spliced EST AA451643 9
External Ids
HGNC: 12741
Entrez Gene: 3888152
UniProtKB: A1L4M73
Ensembl: ENSG000002153867
Search outside databases for aliases for C21orf34 gene

Previous GC identifers: GC21U990069 GC21P016488

Summaries
for C21orf34

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for C21orf34

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q11-q21.1
Nature(405: 311-319) cytogenetic band:   21q11
C21orf34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P016364:   GeneLoc Nature:405,311-319
Start:
 16,364,713 bp from pter       3,107,948 bp from centromere
End:
 16,901,413 bp from pter 3,267,833 bp from centromere
Size:
 536,701 bases 159,886 bases
Orientation:
 plus strand plus strand

1 alternative location:
Chr21+ 16,488,614-16,901,413     
RefSeq DNA sequence:
NC_000021.7  NT_011512.10  

genomic clones: R746N6 to R649M24

Proteins
for C21orf34

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CU034_HUMAN, A1L4M7 (See protein sequence)
Recommended Name: Putative uncharacterized protein C21orf34  
Size: 104 amino acids; 12149 Da
Caution: Previously annotated as two separate genes based on spliced ESTs, C21orf34 and C21orf35
were shown by RT-PCR experiments to represent a single gene
Alternative splicing: 1 isoform:  A1L4M7-1   (C21orf34 is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs. Exons 3, 6, 7 and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible transcript is 1300 bp, with the only significant open reading frame located in exons 1 and 2. If this indeed represents a translated product, it implies C21orf34 has an unusual 3'-UTR composed of 9 exons)

REFSEQ proteins (3 alternative transcripts): 
NP_001005732.1  NP_001005733.1  NP_001005734.1  


ENSEMBL proteins: 
ENSP00000383038 ENSP00000383040 ENSP00000310334 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: C21orf34 


Antibodies for C21orf34: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C21orf34

Assays for C21orf34: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for C21orf34

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A1L4M7

Gene Function
for C21orf34

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C21orf34)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001005732

              Applied Biosystems Silencer® siRNAs for C21orf34

              Sigma-Aldrich siRNA for C21orf34  
                     Sigma-Aldrich shRNA for C21orf34  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for C21orf34
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001005732
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001005732
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001005732 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001005734

Pathways & Interactions
for C21orf34

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for C21orf34

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C21orf34

Transcripts
for C21orf34

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C21orf34)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001005732

              Sigma-Aldrich siRNA for C21orf34  
                     Sigma-Aldrich shRNA for C21orf34  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001005732  NM_001005733  NM_001005734  

REFSEQ mRNAs for C21orf34 gene (3 alternative transcripts): 

NM_001005732.1   NM_001005733.1   NM_001005734.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001005732  NM_001005733  NM_001005734  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001005732
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001005732
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001005732 

Additional cDNA sequence: 

AF486622.1 AK095614.1 BC130602.1 BC130606.1 

15 DOTS entries:

DT.75190109  DT.95151249  DT.206314  DT.97814097  DT.121129328  DT.95287438  DT.100741909  DT.100741910 
DT.121129362  DT.101979635  DT.121129353  DT.121129357  DT.40129624  DT.75150469  DT.40201236 

22 AceView cDNA sequences:

AA328997 C01866 CD103615 AI220090 N64579 AI925480 BF593437 AA193551 
BM903597 AK095614 AI220334 R67826 H04858 H41067 AI809641 BG698577 
BG204172 BF516134 N66393 AA332169 CF135136 AI376321 

highest scoring ESTs for C21orf34:

AA193551 C01866 H41067 AA328997 AA451643 AI220090 AI220334 AI809641 AI925480 BF516134 

Unigene Cluster for C21orf34:

Chromosome 21 open reading frame 34
Hs.719301  [show with all ESTs]
Unigene Representative Sequence: AK095614


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000400176  ENST00000400178  ENST00000308787  

Expression
for C21orf34

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C21orf34 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C21orf34

1 / 2 / 3

5 probe-sets matching C21orf34 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
60181_at2, 3 U95-C 1 0.75 1.00 1.00 1.00 AA093075 0.60 0.75 0.68 1

60691_at2, 3 U95-C 1 0.31 1.00 0.29 0.41 H41067 0.60 1.00 0.82 1

1559901_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1559412_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --

1555558_at*2 U133Plus2 4 1.00 0.25 -- -- -- -- -- -- --
GeneDecks  C21orf34 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719301

UniProtKB/Swiss-Prot: CU034_HUMAN, A1L4M7
Tissue specificity: Ubiquitous

Orthologs
for C21orf34

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for C21orf34 gene from 2 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 LOC7432631   -- hypothetical protein LOC743263 99.1(n)
97.3(a)		 743263  XM_001155849.1  XP_001155849.1 
mouse
(Mus musculus)		 2810055G20Rik5 16 RIKEN cDNA 2810055G20 gene   -- AK148800 
About this table        Species with no ortholog for C21orf34

ENSEMBL Gene Tree for C21orf34

Paralogs
for C21orf34

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for C21orf34

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/3422 NCBI SNPs in C21orf34 are shown (see all 3422 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1152)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 21 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs28236341,2
A,C,F,H,O16486581(+) TGTGCG/ATGTAG 3 -- int1 ng518Minor allele frequency- A:0.28NA EU EA WA 580
rs28236351,2
C,F,H,O16487516(+) GTGTTC/TTCAAG 3 -- ng51 int112Minor allele frequency- T:0.49NA EU EA WA 998
rs28235951,2
A,C,F,H16364258(+) TTTAAA/TTAATA 2 -- ng519Minor allele frequency- N:0.01NA EA EU WA 629
rs72825851,2
A,C,F,H16486985(+) TATCAG/ATGACT 3 -- int1 ng5111Minor allele frequency- A:0.15EU EA WA NA 978
rs172097571,2
C,F,H16363516(+) CAAGAA/GATATG 2 -- ng5111Minor allele frequency- G:0.02NA EU EA WA 940
rs169944271,2
C,F,H16487204(+) ATGTCA/TCTGTC 3 -- ng51 int111Minor allele frequency- T:0.03NA EU EA WA 968
rs169944251,2
C,F,H16486896(+) AAAACG/ATCCAT 3 -- int1 ng517Minor allele frequency- A:0.03NA EU EA WA 542
rs99840171,2
F,H16363636(+) ATGAAT/CGGCCA 2 -- ng514Minor allele frequency- C:0.07EU EA WA 398
rs1894521,2
A,H16488316(+) ATTGAG/AAAAGG 3 -- ng51 int15Minor allele frequency- A:0.00MN EU EA WA 598
rs169944291,2
F,H16487496(+) GTGGCG/AGCTAC 3 -- int1 ng517Minor allele frequency- A:0.02NA EU EA WA 544
About this table

HapMap Linkage Disequilibrium images for C21orf34 (up to first 250kb)

Disorders & Mutations
for C21orf34

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for C21orf34

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for C21orf34

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for C21orf34 gene:

Search for C21orf34

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing C21orf34

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 388815 HGNC: 1274 AceView: C21orf34 Ensembl:ENSG00000215386 euGenes: HUgn388815
ECgene: C21orf34 H-InvDB: C21orf34

Other Databases showing C21orf34

(According to HUGE)
About This Section

   --

Specialized Databases showing C21orf34

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for C21orf34

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for C21orf34

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C21orf34:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
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 Predesigned and custom siRNAs for C21orf34 Browse antibodies at Sigma-Aldrich
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 Lentivirus-delivered shRNAs for C21orf34 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for C21orf34

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