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C21orf33 Gene

protein-coding   GIFtS: 60
GCID: GC21P045553

Chromosome 21 Open Reading Frame 33

  See C21orf33-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Chromosome 21 Open Reading Frame 331 2     KNPH2
HES12 3 5     ES1 Protein Homolog, Mitochondrial2
Human HES1 Protein, Homolog To E.Coli And Zebrafish ES1 Protein2 11     Keio Novel Protein I2
KNPI2 3     Protein GT3353
ES12 5     Protein KNP-I3
GT3352 5     

External Ids:    HGNC: 12731   Entrez Gene: 82092   Ensembl: ENSG000001602217   OMIM: 6016595   UniProtKB: P300423   

Export aliases for C21orf33 gene to outside databases

Previous GC identifers: GC21P042063 GC21P044410 GC21P044409 GC21P044377 GC21P030923


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C21orf33 Gene:
This gene encodes a potential mitochondrial protein that is a member of the DJ-1/PfpI gene family. This protein is
overexpressed in fetal Down syndrome brain. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, May 2010)

GeneCards Summary for C21orf33 Gene:
C21orf33 (chromosome 21 open reading frame 33) is a protein-coding gene. Diseases associated with C21orf33 include anophthalmia/microphthalmia, and down syndrome. An important paralog of this gene is LOC102724023.

Gene Wiki entry for C21orf33 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C21orf33 gene promoter:
         AML1a   p53   HSF1 (long)   XBP-1   Nkx2-5   Max   HSF1short   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC21orf33 promoter sequence

   Search Chromatin IP Primers for C21orf33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C21orf33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
C21orf33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C21orf33 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P045553:   GeneLoc Nature:405,311-319
Start:
45,553,487 bp from pter       31,062,955 bp from centromere
End:
45,565,605 bp from pter 31,074,982 bp from centromere
Size:
12,119 bases 12,028 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: Y07572
genomic clones: KUD6B5 KUD11C9


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ES1_HUMAN, P30042 (See protein sequence)
Recommended Name: ES1 protein homolog, mitochondrial precursor  
Size: 268 amino acids; 28170 Da
Secondary accessions: A6NFJ6 A6NJY7 O00650 O00660 O15011 O15012 P55346 P78474 Q92505 Q92507
Alternative splicing: 2 isoforms:  P30042-1   P30042-2   

Explore the universe of human proteins at neXtProt for C21orf33: NX_P30042

Explore proteomics data for C21orf33 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys116, Lys141, Lys185
  • Modification sites at PhosphoSitePlus

  • See C21orf33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004640.3  NP_937798.3  

    ENSEMBL proteins: 
     ENSP00000291577   ENSP00000396655   ENSP00000344901   ENSP00000374340   ENSP00000400044  
     ENSP00000405713  

    C21orf33 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for C21orf33

     
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    Search eBioscience for ELISAs for C21orf33 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002818 ThiJ/PfpI

    Graphical View of Domain Structure for InterPro Entry P30042

    ProtoNet protein and cluster: P30042

    1 Blocks protein domain: IPB002818 Family of unknown function ThiJ/PfpI

    UniProtKB/Swiss-Prot: ES1_HUMAN, P30042
    Similarity: Belongs to the ES1 family


    Find genes that share domains with C21orf33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C21orf33
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C21orf33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C21orf33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C21orf33

    miRNA
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    miRTarBase miRNAs that target C21orf33:
    hsa-mir-331-3p (MIRT043510)

    Block miRNA regulation of human, mouse, rat C21orf33 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate C21orf33:
    hsa-miR-204 hsa-miR-378* hsa-miR-3647-3p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidC21orf33 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C21orf33

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    GenScript: all cDNA clones in your preferred vector (see all 2): C21orf33 (NM_198155)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ES1_HUMAN, P30042: Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IBA--

    Find genes that share ontologies with C21orf33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for C21orf33 About    
    See pathways by source

    SuperPathContained pathways About
    1Gastric cancer network 1
    Gastric cancer network 1


    1 BioSystems Pathway for C21orf33
        Gastric cancer network 1


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C21orf33
    Interactions:

        Search GeneGlobe Interaction Network for C21orf33

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for C21orf33 (P300422, 3 ENSP000002915774) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FRA10AC1Q70Z532, 3MINT-64737 I2D: score=3 
    CLN3Q132863I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    SLC2A4P146723I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C21orf33 (ES1)

    2 Novoseek inferred chemical compound relationships for C21orf33 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyridoxal 56.5 2 15082224 (2)
    retinoic acid 8.67 5 15467735 (3), 14510471 (1)



    Find genes that share compounds with C21orf33           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C21orf33 gene (2 alternative transcripts): 
    NM_004649.6  NM_198155.3  

    Unigene Cluster for C21orf33:

    Chromosome 21 open reading frame 33
    Hs.413482  [show with all ESTs]
    Unigene Representative Sequence: AK127364
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291577(uc002zec.4 uc002zed.4) ENST00000495007 ENST00000427803
    ENST00000493883 ENST00000480786 ENST00000348499 ENST00000389690 ENST00000449622
    ENST00000488392 ENST00000419699 ENST00000470545
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate C21orf33:
    hsa-miR-204 hsa-miR-378* hsa-miR-3647-3p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidC21orf33 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat C21orf33
      QuantiTect SYBR Green Assays in human, mouse, rat C21orf33
      QuantiFast Probe-based Assays in human, mouse, rat C21orf33

    Additional mRNA sequence: 

    AK127364.1 BC002370.2 BC003587.1 D86061.1 D86062.1 U53003.1 Y07572.1 

    20 DOTS entries:

    DT.117863  DT.100038151  DT.92446068  DT.87016401  DT.40132549  DT.95090383  DT.100038148  DT.100038147 
    DT.100760621  DT.95170744  DT.95170750  DT.95170756  DT.92058071  DT.91693543  DT.100880974  DT.91695382 
    DT.91794282  DT.100665947  DT.100679117  DT.100880967 

    Selected AceView cDNA sequences (see all 427):

    BU859123 CF122906 BQ440725 BM927466 CR597695 AA772592 CR609783 BF516090 
    BE297974 BQ062020 BQ065585 AA932064 AA748497 BQ647697 BQ677053 CR599538 
    CR621591 BU145757 AA918531 CR626372 BQ636016 BQ056321 CA748865 BQ011869 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C21orf33 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
    SP1:                                            -                 -     -           -     -     -     -                                       
    SP2:                                            -                 -     -     -     -     -     -     -                                       
    SP3:                                      -     -                 -     -           -     -     -     -                                       
    SP4:                                            -                 -     -           -                                                         
    SP5:                                            -                 -     -           -     -                                                   


    ECgene alternative splicing isoforms for C21orf33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C21orf33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGTTGGT
    C21orf33 Expression
    About this image


    C21orf33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    C21orf33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C21orf33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413482

    UniProtKB/Swiss-Prot: ES1_HUMAN, P30042
    Tissue specificity: Ubiquitous, but strongly expressed in heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C21orf33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C21orf33 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia D10Jhu81e1 , 5 DNA segment, Chr 10, Johns Hopkins University 81 expressed1, 5 83.08(n)1
    89.85(a)1
      10 (39.72 cM)5
    282951  NM_138601.21  NP_613067.11 
     781620675 
    chicken
    (Gallus gallus)
    Aves C1H21ORF331 chromosome 1 open reading frame, human C21orf33 73.86(n)
    82.57(a)
      418552  NM_001030798.1  NP_001025969.1 
    lizard
    (Anolis carolinensis)
    Reptilia C21orf336
    chromosome 21 open reading frame 33
    76(a)
    1 ↔ 1
    3(136323508-136338724)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ029030.12   -- 71.39(n)    BJ029030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.112372 Transcribed sequence with moderate similarity to protein more 75.86(n)    CK029891.1 


    ENSEMBL Gene Tree for C21orf33 (if available)
    TreeFam Gene Tree for C21orf33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C21orf33 gene
    LOC102724023  

    Find genes that share paralogs with C21orf33           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C21orf33 (see all 416)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs92845121,2
    C,F,H--36048766(+) CCCTCG/ACCAGC 2 -- us2k19Minor allele frequency- A:0.19NS EA NA WA 662
    rs1924878831,2
    --36048783(+) GCCCCC/TAAGAC 2 -- us2k10--------
    rs1824691291,2
    --36048807(+) TGGCTC/GCCTTG 2 -- us2k10--------
    rs1162598741,2
    F--36049113(+) AAACAA/GTTTCC 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1879974411,2
    --36049187(+) TAGTCA/GCCCCT 2 -- us2k10--------
    rs1914815361,2
    --36049199(+) GGACAA/GCTGGA 2 -- us2k10--------
    rs22272651,2
    C,F,H--36049255(+) CTCCCG/CCACAC 2 -- us2k110Minor allele frequency- C:0.13EA NS NA WA 1968
    rs775648021,2
    C,F--36049292(+) ACACCG/AACTGA 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1443288171,2
    --36049334(+) AGTGGC/TGCTTG 2 -- us2k10--------
    rs1175414231,2
    F--36049466(+) AGTCAA/GATGTG 2 -- us2k11Minor allele frequency- G:0.01EA 120

    HapMap Linkage Disequilibrium report for C21orf33 (45553487 - 45565605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for C21orf33:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913890CNV Loss21882294
    esv33817CNV Loss17666407
    dgv4765n71CNV Loss21882294
    nsv913887CNV Loss21882294
    nsv913898CNV Loss21882294
    dgv4766n71CNV Loss21882294
    dgv4764n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C21orf33
    DNA2.0 Custom Variant and Variant Library Synthesis for C21orf33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601659    OMIM disorders: --

    2 diseases for C21orf33:    
    About MalaCards
    anophthalmia/microphthalmia    down syndrome


    Find genes that share disorders with C21orf33           About GenesLikeMe

    4 Novoseek inferred disease relationships for C21orf33 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 36.6 1 15082224 (1)
    tumors 14.6 1 20213410 (1)
    cancer 10.4 1 19308264 (1)
    breast cancer 9 2 20197467 (1), 15467735 (1)

    GeneTests: C21orf33
    GeneReviews: C21orf33
    Genetic Association Database (GAD): C21orf33
    Human Genome Epidemiology (HuGE) Navigator: C21orf33 (1 document)

    Export disorders for C21orf33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C21orf33 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with C21orf33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a human gene (HES1) with homology to an Escherichia coli and a zebrafish protein that maps to chromosome 21q22.3. (PubMed id 9150728)1, 2, 3, 9 Scott H.S.... Antonarakis S.E. (Hum. Genet. 1997)
    2. Isolation and characterization of GT335, a novel human gene conserved in Escherichia coli and mapping to 21q22.3. (PubMed id 8975701)1, 2, 3 Lafreniere R.G.... Rouleau G.A. (Genomics 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    5. Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21. (PubMed id 9205129)1, 2 Nagamine K....Shimizu N. (Genomics 1997)
    6. Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3. (PubMed id 8753807)1, 2 Nagamine K....Shimizu N. (Biochem. Biophys. Res. Commun. 1996)
    7. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (Electrophoresis 1992)
    8. Expression of cystathionine beta-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain. (PubMed id 15082224)1, 9 Shin J.H....Lubec G. (Neurochem. Int. 2004)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8209 HGNC: 1273 AceView: C21orf33 Ensembl:ENSG00000160221 euGenes: HUgn8209
    ECgene: C21orf33 H-InvDB: C21orf33

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C21orf33 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for C21orf33 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/500936/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C21orf33 gene:
    Search GeneIP for patents involving C21orf33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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