Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C21orf140 Gene

Aliases for C21orf140 Gene

  • Chromosome 21 Open Reading Frame 140 2 3 5

External Ids for C21orf140 Gene

Previous GeneCards Identifiers for C21orf140 Gene

  • GC21M035773

Summaries for C21orf140 Gene

GeneCards Summary for C21orf140 Gene

C21orf140 (Chromosome 21 Open Reading Frame 140) is a Protein Coding gene. An important paralog of this gene is LOC102723451.

Additional gene information for C21orf140 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C21orf140 Gene

Genomics for C21orf140 Gene

Regulatory Elements for C21orf140 Gene

Enhancers for C21orf140 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H034543 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20.6 -144.4 -144428 3 PKNOX1 FOXA2 ARNT ZNF766 ZNF143 ZNF207 ATF7 RUNX3 JUNB REST DONSON RCAN1 C21orf140 KCNE1 GC21M034521 GC21M034577
GH21H033539 1.4 ENCODE dbSUPER 31 +858.1 858065 6 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 GLIS1 SON PAXBP1 TMEM50B GART DONSON C21orf140 C21orf59 PAXBP1-AS1 DNAJC28 ENSG00000231355
GH21H033640 1.4 ENCODE dbSUPER 18.8 +757.9 757925 5 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 TMEM50B PAXBP1 DONSON C21orf140 GART CRYZL1 SON SMIM34A ITSN1
GH21H034806 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -412.3 -412349 14 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ATF7 FOS RUNX3 JUNB TSHZ1 C21orf140 KCNE1 GC21M034823 PIR43744
GH21H035040 1.8 FANTOM5 ENCODE dbSUPER 9.7 -645.6 -645553 11 HDGF PKNOX1 ARID4B FEZF1 ZNF2 ZNF766 CBX5 ZNF302 ZNF143 ZNF207 SMIM11A RPL23AP3 C21orf140 RUNX1 RUNX1-IT1 GC21M035098
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C21orf140 on UCSC Golden Path with GeneCards custom track

Genomic Location for C21orf140 Gene

Chromosome:
21
Start:
34,400,112 bp from pter
End:
34,401,072 bp from pter
Size:
961 bases
Orientation:
Minus strand

Genomic View for C21orf140 Gene

Genes around C21orf140 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C21orf140 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C21orf140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C21orf140 Gene

Proteins for C21orf140 Gene

  • Protein details for C21orf140 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B9A014-CU140_HUMAN
    Recommended name:
    Uncharacterized protein C21orf140
    Protein Accession:
    B9A014

    Protein attributes for C21orf140 Gene

    Size:
    251 amino acids
    Molecular mass:
    29214 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C21orf140 Gene

Post-translational modifications for C21orf140 Gene

No Post-translational modifications

Other Protein References for C21orf140 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C21orf140 Gene

Domains & Families for C21orf140 Gene

Gene Families for C21orf140 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C21orf140 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C21orf140: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C21orf140 Gene

Function for C21orf140 Gene

Phenotypes From GWAS Catalog for C21orf140 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C21orf140 Gene

Localization for C21orf140 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C21orf140 Gene

Pathways & Interactions for C21orf140 Gene

SuperPathways for C21orf140 Gene

No Data Available

Interacting Proteins for C21orf140 Gene

Gene Ontology (GO) - Biological Process for C21orf140 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C21orf140 Gene

Drugs & Compounds for C21orf140 Gene

No Compound Related Data Available

Transcripts for C21orf140 Gene

mRNA/cDNA for C21orf140 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for C21orf140 Gene

No ASD Table

Relevant External Links for C21orf140 Gene

GeneLoc Exon Structure for
C21orf140
ECgene alternative splicing isoforms for
C21orf140

Expression for C21orf140 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C21orf140 Gene

NURSA nuclear receptor signaling pathways regulating expression of C21orf140 Gene:

C21orf140
genes like me logo Genes that share expression patterns with C21orf140: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C21orf140 Gene

Orthologs for C21orf140 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C21orf140 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101057936 33
  • 99.6 (n)
C21orf140 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102155325 33
  • 85.55 (n)
C21orf140 34
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC134427 33
  • 84.2 (n)
C21orf140 34
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930563D23Rik 33 34
  • 78.35 (n)
rat
(Rattus norvegicus)
Mammalia LOC498063 33
  • 75.7 (n)
oppossum
(Monodelphis domestica)
Mammalia C21orf140 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C21orf140 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101748326 33
  • 62.28 (n)
C21orf140 34
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C21orf140 34
  • 55 (a)
OneToOne
Species where no ortholog for C21orf140 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C21orf140 Gene

ENSEMBL:
Gene Tree for C21orf140 (if available)
TreeFam:
Gene Tree for C21orf140 (if available)

Paralogs for C21orf140 Gene

Paralogs for C21orf140 Gene

genes like me logo Genes that share paralogs with C21orf140: view

Variants for C21orf140 Gene

Sequence variations from dbSNP and Humsavar for C21orf140 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000480507 -- 34,400,211(+) GAGGT(C/T)GCTGT intron-variant, utr-variant-3-prime
rs1002288383 -- 34,401,504(+) GTGTC(-/TG)TGTAT intron-variant, upstream-variant-2KB
rs1002727666 -- 34,401,114(+) TGCAT(C/T)TGGGG intron-variant, upstream-variant-2KB
rs1003184464 -- 34,399,854(+) ATCTG(A/G)ACAAT intron-variant, utr-variant-3-prime
rs1004251659 -- 34,400,832(+) TCCTT(A/G)ACTAC intron-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for C21orf140 Gene

Variant ID Type Subtype PubMed ID
dgv4426n100 CNV gain 25217958
dgv7824n54 CNV gain 21841781
esv2762109 CNV gain 21179565
esv3575386 CNV gain 25503493
nsv1055429 CNV gain 25217958
nsv521323 CNV gain 19592680

Variation tolerance for C21orf140 Gene

Gene Damage Index Score: 1.39; 27.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C21orf140 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C21orf140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C21orf140 Gene

Disorders for C21orf140 Gene

Relevant External Links for C21orf140

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C21orf140

No disorders were found for C21orf140 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C21orf140 Gene

Publications for C21orf140 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 60

Products for C21orf140 Gene

Sources for C21orf140 Gene

Content
Loading form....