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C20orf96 Gene

protein-coding   GIFtS: 41
GCID: GC20M000246

Chromosome 20 Open Reading Frame 96

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 20 Open Reading Frame 961 2
dJ1103G7.22
Uncharacterized Protein C20orf962

External Ids:    HGNC: 162271   Entrez Gene: 1406802   Ensembl: ENSG000001964767   UniProtKB: Q9NUD73   

Export aliases for C20orf96 gene to outside databases

Previous GC identifers: GC20U990108 GC20M000199


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C20orf96 Gene:
C20orf96 (chromosome 20 open reading frame 96) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C20orf96 gene promoter:
         AML1a   GATA-3   C/EBPalpha   GATA-1   GATA-2   AREB6   Max   CHOP-10   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC20orf96 promoter sequence
   Search Chromatin IP Primers for C20orf96

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C20orf96


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

C20orf96 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C20orf96 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M000246:  view genomic region     (about GC identifiers)

Start:
251,504 bp from pter      End:
271,419 bp from pter
Size:
19,916 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CT096_HUMAN, Q9NUD7 (See protein sequence)
Recommended Name: Uncharacterized protein C20orf96  
Size: 363 amino acids; 42859 Da
Sequence caution: Sequence=BAC03772.1; Type=Frameshift; Positions=304;
Secondary accessions: A3KPE0 B2RPH9 Q8N840 Q8NAX5

Explore the universe of human proteins at neXtProt for C20orf96: NX_Q9NUD7

Explore proteomics data for C20orf96 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C20orf96 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_542138.1  NP_695001.2  

    ENSEMBL proteins: 
     ENSP00000371806   ENSP00000353470   ENSP00000383128  

    C20orf96 Human Recombinant Protein Products:

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    antibodies-online proteins for C20orf96 

     
    Search antibodies-online for peptides for C20orf96

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    antibodies-online antibodies for C20orf96 (13 products) 

    C20orf96 Assay Products:

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    Cloud-Clone Corp. ELISAs for C20orf96
    Cloud-Clone Corp. CLIAs for C20orf96
    Search eBioscience for ELISAs for C20orf96 
    antibodies-online kits for C20orf96 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9NUD7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C20orf96
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C20orf96

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C20orf96
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C20orf96

    miRNA
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    miRTarBase miRNAs that target C20orf96:
    hsa-mir-335-5p (MIRT018471), hsa-mir-1296-5p (MIRT036149)

    Block miRNA regulation of human, mouse, rat C20orf96 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate C20orf96:
    hsa-miR-1321 hsa-miR-1182
    SwitchGear 3'UTR luciferase reporter plasmidC20orf96 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C20orf96

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    GenScript: all cDNA clones in your preferred vector: C20orf96 (NM_153269)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C20orf96
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C20orf96

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C20orf96


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C20orf96
    Interactions:

        Search GeneGlobe Interaction Network for C20orf96

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C20orf96 (ENSP000003534704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C20orf96 (CT096)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C20orf96 gene (2 alternative transcripts): 
    NM_080571.1  NM_153269.2  

    Unigene Cluster for C20orf96:

    Chromosome 20 open reading frame 96
    Hs.348112  [show with all ESTs]
    Unigene Representative Sequence: NM_080571
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382369(uc010zpj.1) ENST00000360321(uc021vzl.1 uc002wde.2 uc010zpi.2)
    ENST00000400269(uc010zpk.2)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate C20orf96:
    hsa-miR-1321 hsa-miR-1182
    SwitchGear 3'UTR luciferase reporter plasmidC20orf96 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for C20orf96
    Predesigned siRNA for gene silencing in human, mouse, rat C20orf96
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    GenScript: all cDNA clones in your preferred vector: C20orf96 (NM_153269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C20orf96
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C20orf96
    Primer
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    OriGene qPCR primer pairs and template standards for C20orf96
    OriGene qSTAR qPCR primer pairs in human, mouse for C20orf96
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C20orf96
      QuantiTect SYBR Green Assays in human, mouse, rat C20orf96
      QuantiFast Probe-based Assays in human, mouse, rat C20orf96

    Additional mRNA sequence: 

    AK097394.1 AK302223.1 AK304526.1 BC134417.1 BC137450.1 BC144649.1 

    11 DOTS entries:

    DT.101978218  DT.95274744  DT.100777928  DT.307089  DT.307090  DT.97812242  DT.95262079  DT.97765173 
    DT.91797622  DT.91997301  DT.95237009 

    Selected AceView cDNA sequences (see all 108):

    BC051762 AI474251 CR614965 CR621146 BX104512 AA426503 BU517215 AA771721 
    CA431350 BF927848 BM696584 AI953644 CR597939 AI474578 AL542177 BF352831 
    BF930652 BX279767 BX332293 BQ024743 BG390647 AL522690 BI827922 AK097394 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C20orf96 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                                                  -     -           -     -                                             
    SP2:                                                  -     -           -     -                                             
    SP3:                                                  -     -     -     -     -                                             
    SP4:                    -     -     -                 -     -           -     -                                             
    SP5:                                            -     -     -           -     -                                             


    ECgene alternative splicing isoforms for C20orf96

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C20orf96 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCGCCCTC
    C20orf96 Expression
    About this image

    C20orf96 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C20orf96 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348112
        Custom PCR Arrays for C20orf96
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C20orf96

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C20orf96 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 6820408C15Rik1 , 5 RIKEN cDNA 6820408C15 gene1, 5 67.72(n)1
    52.16(a)1
      2 (74.99 cM)5
    2287781  NM_177656.31  NP_808324.11 
     1524155875 
    chicken
    (Gallus gallus)
    Aves C20ORF961 chromosome 20 open reading frame, human C20orf96 47.37(n)
    31.82(a)
      419273  XM_417446.4  XP_417446.3 
    lizard
    (Anolis carolinensis)
    Reptilia C20orf966
    chromosome 20 open reading frame 96
    30(a)
    1 ↔ 1
    GL343346.1(1187530-1215428)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-76p14.21 si:dkey-76p14.2 44.23(n)
    29.18(a)
      562567  XM_685947.4  XP_691039.2 


    ENSEMBL Gene Tree for C20orf96 (if available)
    TreeFam Gene Tree for C20orf96 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C20orf96 gene
    1 SIMAP similar gene for C20orf96 using alignment to 4 protein entries:     CT096_HUMAN (see all proteins):
    DKFZp686G24192

    Find genes that share paralogs with C20orf96           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C20orf96 (see all 707)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134954081,2
    C--251073(+) CAACTG/AAGGAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1432899781,2
    C--251096(+) CAGGAC/TTGGGC 2 -- int10--------
    rs1123309601,2
    C--251107(+) ACAGGG/CAGAAG 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs786010461,2
    C,F--251447(+) AGTCCG/ATTCCC 2 -- int11Minor allele frequency- A:0.03EA 120
    rs60459241,2
    C,F,A,H--251494(+) GACACT/GGGCAA 2 -- int129Minor allele frequency- G:0.26NS EA NA CSA WA 2973
    rs1178584201,2
    C,F--251604(+) GAAGAG/CAGGAA 2 -- ut311Minor allele frequency- C:0.03NA 120
    rs3682253571,2
    C--251685(+) GGAAG-/AGGG  
            
    GGGAG
    2 -- ut310--------
    rs1878119131,2
    --251714(+) AAAGAG/TGGAGG 2 -- ut310--------
    rs1119254871,2
    C,F--251770(+) GATCCG/AGTCCT 2 -- ut312Minor allele frequency- A:0.13CSA WA 120
    rs1439706361,2
    C--251830(+) AGGGCA/GGCCCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for C20orf96 (251504 - 271419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for C20orf96:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3248CNV Insertion18451855
    esv33186CNV Loss17666407
    nsv469544CNV Loss16826518
    dgv65n68CNV Loss17160897
    esv32859CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C20orf96
    DNA2.0 Custom Variant and Variant Library Synthesis for C20orf96

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C20orf96 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C20orf96)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140680 HGNC: 16227 AceView: C20orf96 Ensembl:ENSG00000196476 euGenes: HUgn140680
    ECgene: C20orf96 H-InvDB: C20orf96

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C20orf96 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C20orf96 gene:
    Search GeneIP for patents involving C20orf96

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat C20orf96 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C20orf96
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C20orf96 Predesigned siRNA for gene silencing in human, mouse, rat C20orf96
     QuantiFast Probe-based Assays in human, mouse, rat C20orf96 QuantiTect SYBR Green Assays in human, mouse, rat C20orf96
     Custom PCR Arrays for C20orf96 Search Chromatin IP Primers for C20orf96
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     GenScript Custom Purified and Recombinant Proteins Services for C20orf96 GenScript cDNA clones with any tag delivered in your preferred vector for C20orf96
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C20orf96
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     antibodies-online antibodies for C20orf96 (13 products)
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