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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C20orf57 Gene

protein-coding   GIFtS: 22
GCID: GC20U990068

Chromosome 20 Open Reading Frame 57

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 20 Open Reading Frame 571 2     VHY3
bA243J16.52     Vaccinia Virus VH1-Related Dual-Specific Protein Phosphatase Y3
EC 3.1.3.163     VH1-Related Member Y3
EC 3.1.3.483     

External Ids:    HGNC: 161901   Entrez Gene: 837472   UniProtKB: Q9H1R23   

Export aliases for C20orf57 gene to outside databases

Previous GC identifers: GC20M029900 GC20M030435 GC20M030440


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C20orf57 Gene: 
C20orf57 (chromosome 20 open reading frame 57) is a protein-coding gene. Diseases associated with C20orf57 include vaccinia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C20orf57
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C20orf57

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf57


Genomic Location:
Chromosome:20   

Entrez Gene cytogenetic band: 20q11.21   HGNC chromosome: 20

GeneLoc information about chromosome 20        


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 15  
Size: 295 amino acids; 31882 Da
Subcellular location: Cytoplasm (Probable)
Subcellular location: Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side
Caution: Although assigned as two separate genes (c20orf57 and DUSP15), it is probable that C20orf57 does not
exist by itself and is a part of the DUSP15 gene
1 PDB 3D structure from and Proteopedia for C20orf57:
1YZ4 (3D)    
Secondary accessions: A6NH79 A8MVC8 Q5QP62 Q5QP63 Q5QP65 Q6PGN7 Q8N826 Q9BX24
Alternative splicing: 4 isoforms:  Q9H1R2-1   Q9H1R2-2   Q9H1R2-3   Q9H1R2-4   (Initiator Met-1 is removed. Myristoylated on Gly-2)

Explore the universe of human proteins at neXtProt for C20orf57: NX_Q9H1R2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1R2

  • C20orf57 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR000387 Tyr/Dual-sp_Pase
     IPR008984 SMAD_FHA_domain
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR017855 SMAD_dom-like
     IPR016130 Tyr_Pase_AS

    Graphical View of Domain Structure for InterPro Entry Q9H1R2

    ProtoNet protein and cluster: Q9H1R2

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    C20orf57 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS15_HUMAN, Q9H1R2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C20orf57

    5/9 Interacting proteins for C20orf57 (Q9H1R21, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 2, 3EBI-1752795,EBI-79387 MINT-8112495 I2D: score=3 
    ABL1P005192, 3MINT-8110287 I2D: score=3 
    PIK3R1P279862, 3MINT-8111907 I2D: score=3 
    SRCP129312, 3MINT-8113071 I2D: score=3 
    NCK1P163331, 3EBI-1752795,EBI-389883 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about C20orf57 / DUS15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    Unigene Cluster for C20orf57:

    Chromosome 20 open reading frame 57
    Hs.434108  [show with all ESTs]
    Unigene Representative Sequence: AK000652
    miRNA
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    Additional mRNA sequence: AK000652.1 


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C20orf57 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATAAAGT
    C20orf57 Expression
    About this image


    Genevestigator expression for C20orf57

    SOURCE GeneReport for Unigene cluster: Hs.434108

    UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2
    Tissue specificity: Highly expressed in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for C20orf57:    About MalaCards
    vaccinia    


    C20orf57 for disorders           About GeneDecksing


    Export disorders for C20orf57 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C20orf57 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C20orf57)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the catalytic domain of human VHY, a dual- specificity protein phosphatase. (PubMed id 16170801)1, 2 Yoon T.-S.... Kim S.J. (2005)
    2. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. (PubMed id 15138252)1, 2 Alonso A.... Mustelin T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83747 HGNC: 16190 euGenes: HUgn83747 ECgene: C20orf57 H-InvDB: C20orf57

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C20orf57 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C20orf57 gene:
    Search GeneIP for patents involving C20orf57

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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