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Aliases for C20orf57 Gene

Aliases for C20orf57 Gene

  • Chromosome 20 Open Reading Frame 57 2 3
  • Vaccinia Virus VH1-Related Dual-Specific Protein Phosphatase Y 4
  • VH1-Related Member Y 4
  • EC 4
  • EC 4
  • BA243J16.5 3
  • DUSP15 4
  • VHY 4

External Ids for C20orf57 Gene

Previous GeneCards Identifiers for C20orf57 Gene

  • GC20U990068
  • GC20M029900
  • GC20M030435
  • GC20M030440

Summaries for C20orf57 Gene

GeneCards Summary for C20orf57 Gene

C20orf57 (Chromosome 20 Open Reading Frame 57) is a Protein Coding gene. Diseases associated with C20orf57 include vaccinia.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C20orf57 Gene

Genomics for C20orf57 Gene

Genomic Location for C20orf57 Gene

31,847,644 bp from pter
31,861,400 bp from pter
13,757 bases
Minus strand

Genomic View for C20orf57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C20orf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C20orf57 Gene

No data available for Regulatory Elements for C20orf57 Gene

Proteins for C20orf57 Gene

  • Protein details for C20orf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 15
    Protein Accession:
    Secondary Accessions:
    • A6NH79
    • A8MVC8
    • Q5QP62
    • Q5QP63
    • Q5QP65
    • Q6PGN7
    • Q8N826
    • Q9BX24

    Protein attributes for C20orf57 Gene

    295 amino acids
    Molecular mass:
    31882 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for C20orf57 Gene

    Alternative splice isoforms for C20orf57 Gene


neXtProt entry for C20orf57 Gene

Proteomics data for C20orf57 Gene at MOPED

Post-translational modifications for C20orf57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C20orf57 Gene

Domains for C20orf57 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H1R2
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with C20orf57: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C20orf57 Gene

Function for C20orf57 Gene

Molecular function for C20orf57 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

Enzyme Numbers (IUBMB) for C20orf57 Gene

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C20orf57 Gene

Localization for C20orf57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C20orf57 Gene

Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for C20orf57 Gene COMPARTMENTS Subcellular localization image for C20orf57 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for C20orf57 Gene

Pathways for C20orf57 Gene

SuperPathways for C20orf57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C20orf57 Gene


No data available for Pathways by source for C20orf57 Gene

Transcripts for C20orf57 Gene

mRNA/cDNA for C20orf57 Gene

(1) Additional mRNA sequences :

Unigene Clusters for C20orf57 Gene

Chromosome 20 open reading frame 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C20orf57 Gene

No ASD Table

Relevant External Links for C20orf57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C20orf57 Gene

mRNA expression in normal human tissues for C20orf57 Gene

Protein differential expression in normal tissues for C20orf57 Gene

This gene is overexpressed in Spinal cord (38.3) and Frontal cortex (30.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C20orf57 Gene

SOURCE GeneReport for Unigene cluster for C20orf57 Gene Hs.434108

mRNA Expression by UniProt/SwissProt for C20orf57 Gene

Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expressions with C20orf57: view

Expression partners for C20orf57 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for C20orf57 Gene

Orthologs for C20orf57 Gene

No data available for Orthologs and Evolution for C20orf57 Gene

Paralogs for C20orf57 Gene

No data available for Paralogs for C20orf57 Gene

Variants for C20orf57 Gene

Sequence variations from dbSNP and Humsavar for C20orf57 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3746599 -- 31,849,719(+) GGGCA(A/G)TGGGT intron-variant
rs4911533 -- 31,855,670(+) GCATA(C/G)GTCTT intron-variant
rs4911534 -- 31,858,769(+) GCACA(C/G)GGATT intron-variant
rs6058474 -- 31,849,487(+) GCGTC(C/T)TTATG intron-variant
rs6060994 -- 31,848,084(+) AACAG(C/T)AGGTT nc-transcript-variant

Relevant External Links for C20orf57 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C20orf57 Gene

Disorders for C20orf57 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for C20orf57 Gene in MalaCards »

(1) Diseases for C20orf57 Gene including...

genes like me logo Genes that share disorders with C20orf57: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C20orf57 Gene

Publications for C20orf57 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. (PMID: 15138252) Alonso A. … Mustelin T. (J. Biol. Chem. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Crystal structure of the catalytic domain of human VHY, a dual- specificity protein phosphatase. (PMID: 16170801) Yoon T.-S. … Kim S.J. (Proteins 2005) 3 4

Products for C20orf57 Gene

Sources for C20orf57 Gene

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