C20orf57 Gene
uncategorized GIFtS: 22
GCID: GC20M030440
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chromosome 20 open reading frame 57
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Aliases
for C20orf57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Chromosome 20 Open Reading Frame 571 2 | | EC 3.1.3.483 | | BA243J16.51 | | VHY3 | | FLJ206451 | | Vaccinia Virus VH1-Related Dual-Specific Protein Phosphatase Y3 | | EC 3.1.3.163 | | VH1-Related Member Y3 |
Export aliases for C20orf57 gene to outside databasesPrevious GC identifers: GC20U990068 GC20M029900 GC20M030435 |
Summaries
for C20orf57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for C20orf57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for C20orf57
Other transcription factors
Search SABiosciences Chromatin IP Primers for C20orf57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 HGNC chromosome: 20C20orf57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M030440: view genomic region
(about GC identifiers)
Start:
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30,436,207 bp from pter |
End:
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30,446,117 bp from pter |
Size:
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9,911 bases |
Orientation:
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minus strand |
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Proteins
for C20orf57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2 (See
protein sequence)Recommended Name: Dual specificity protein phosphatase 15 Size: 295 amino acids; 31882 Da
Subcellular location: Cytoplasm (Probable)
Subcellular location: Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side
Caution: Although assigned as two separate genes (c20orf57 and DUSP15), it is probable that C20orf57 does not exist byitself and is a part of the DUSP15 gene
1 PDB 3D structure from  and Proteopedia  for C20orf57:1YZ4 (3D)
Secondary accessions: A6NH79 A8MVC8 Q5QP62 Q5QP63 Q5QP65 Q6PGN7 Q8N826 Q9BX24Alternative splicing: 4 isoforms: Q9H1R2-1 Q9H1R2-2 Q9H1R2-3 Q9H1R2-4 (Initiator Met-1 is removed. Myristoylated on Gly-2)Explore the universe of human proteins at neXtProt for C20orf57: NX_Q9H1R2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1R2
C20orf57 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
C20orf57 Antibody Products:
Assay Products for C20orf57: |
Protein
Domains /
Families
for C20orf57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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C20orf57 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9H1R2ProtoNet protein and cluster: Q9H1R2 1 Blocks protein family: IPB000340 Dual specificity protein phosphatase
UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for C20orf57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateEnzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481
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Pathways & Interactions
for C20orf57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C20orf57
5/9 Interacting proteins for C20orf57 (Q9H1R21, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
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Drugs & Compounds
for C20orf57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C20orf57
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Transcripts
for C20orf57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for C20orf57: Chromosome 20 open reading frame 57 Hs.434108 [show with all ESTs]Unigene Representative Sequence: AK000652
Additional cDNA sequence: AK000652.1
GeneLoc Exon Structure
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Expression
for C20orf57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C20orf57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAATAAAGT
About this image
Genevestigator expression for C20orf57
SOURCE GeneReport for Unigene cluster: Hs.434108
UniProtKB/Swiss-Prot: DUS15_HUMAN, Q9H1R2Tissue specificity: Highly expressed in testis
SABiosciences Custom PCR Arrays for C20orf57
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat C20orf57 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C20orf57 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C20orf57 |
Orthologs
for C20orf57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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Paralogs
for C20orf57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for C20orf57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for C20orf57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C20orf57 for disorders About GeneDecksing
1  disease for C20orf57: About MalaCardsvaccinia
Export disorders for C20orf57 gene to outside databases
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Publications
for C20orf57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C20orf57 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C20orf57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Crystal structure of the catalytic domain of human VHY, a dual- specificity protein phosphatase. (PubMed id 16170801)1, 2 Yoon T.-S.... Kim S.J. (2005)
- VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. (PubMed id 15138252)1, 2 Alonso A.... Mustelin T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for C20orf57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C20orf57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing C20orf57 gene
(According to HUGE)
About This Section
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Specialized Databases showing C20orf57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C20orf57 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for C20orf57 gene:
Search GeneIP for patents involving C20orf57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C20orf57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C20orf57 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C20orf57 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf57 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C20orf57 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C20orf57 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C20orf57 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for C20orf57 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C20orf57 |
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