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Aliases for C20orf27 Gene

Aliases for C20orf27 Gene

  • Chromosome 20 Open Reading Frame 27 2 3 5
  • Hypothetical Protein LOC54976 2

External Ids for C20orf27 Gene

Previous GeneCards Identifiers for C20orf27 Gene

  • GC20M003722
  • GC20M003729
  • GC20M003682

Summaries for C20orf27 Gene

GeneCards Summary for C20orf27 Gene

C20orf27 (Chromosome 20 Open Reading Frame 27) is a Protein Coding gene.

Gene Wiki entry for C20orf27 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C20orf27 Gene

Genomics for C20orf27 Gene

Regulatory Elements for C20orf27 Gene

Enhancers for C20orf27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F003763 1.1 ENCODE 23 +1.5 1500 6.3 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 C20orf27 CDC25B GC20M003756
GH20F003744 0.5 Ensembl ENCODE 12.1 +23.1 23114 1.7 ATF1 CBX3 KLF17 KLF7 CREM EGR2 SP3 ZBTB2 SP5 SP1 C20orf27 SPEF1 CDC25B CENPB AP5S1 ENSG00000229539 PANK2 PIR58376 HSPA12B
GH20F003738 1.5 FANTOM5 Ensembl ENCODE 11.6 +28.9 28888 1.4 SAP130 MAX CEBPG ZIC2 RARA ZFHX2 EGR2 THAP11 GATAD2A ZNF263 C20orf27 SIGLEC1 CDC25B CENPB SPEF1 ENSG00000229539 PANK2 HSPA12B PIR58376
GH20F003760 1.1 ENCODE 11.1 +6.6 6615 2.7 OSR2 ZNF341 C20orf27 CDC25B GC20M003756
GH20F003838 0.9 Ensembl ENCODE 11.1 -70.9 -70913 1.8 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ENSG00000229539 CDC25B HSPA12B CENPB PANK2 SPEF1 VPS16 C20orf27 MAVS AP5S1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C20orf27 on UCSC Golden Path with GeneCards custom track

Promoters for C20orf27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000396799 588 2001 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF263

Genomic Location for C20orf27 Gene

Chromosome:
20
Start:
3,753,499 bp from pter
End:
3,768,388 bp from pter
Size:
14,890 bases
Orientation:
Minus strand

Genomic View for C20orf27 Gene

Genes around C20orf27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C20orf27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C20orf27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C20orf27 Gene

Proteins for C20orf27 Gene

  • Protein details for C20orf27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN8-CT027_HUMAN
    Recommended name:
    UPF0687 protein C20orf27
    Protein Accession:
    Q9GZN8
    Secondary Accessions:
    • A8K4J0
    • D3DVX8
    • Q5JX81
    • Q9NWX3

    Protein attributes for C20orf27 Gene

    Size:
    174 amino acids
    Molecular mass:
    19291 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C20orf27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C20orf27 Gene

Post-translational modifications for C20orf27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C20orf27 Gene

No data available for DME Specific Peptides for C20orf27 Gene

Domains & Families for C20orf27 Gene

Protein Domains for C20orf27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C20orf27 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZN8

UniProtKB/Swiss-Prot:

CT027_HUMAN :
  • Belongs to the UPF0687 family.
Family:
  • Belongs to the UPF0687 family.
genes like me logo Genes that share domains with C20orf27: view

No data available for Gene Families for C20orf27 Gene

Function for C20orf27 Gene

Gene Ontology (GO) - Molecular Function for C20orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C20orf27: view
genes like me logo Genes that share phenotypes with C20orf27: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C20orf27 Gene

Localization for C20orf27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C20orf27 Gene COMPARTMENTS Subcellular localization image for C20orf27 gene
Compartment Confidence
mitochondrion 3
cytosol 2
extracellular 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for C20orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C20orf27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C20orf27 Gene

Pathways & Interactions for C20orf27 Gene

SuperPathways for C20orf27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C20orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C20orf27: view

No data available for Pathways by source and SIGNOR curated interactions for C20orf27 Gene

Transcripts for C20orf27 Gene

Unigene Clusters for C20orf27 Gene

Chromosome 20 open reading frame 27:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C20orf27 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: - - - - - - -
SP9: - -

Relevant External Links for C20orf27 Gene

GeneLoc Exon Structure for
C20orf27
ECgene alternative splicing isoforms for
C20orf27

Expression for C20orf27 Gene

mRNA expression in normal human tissues for C20orf27 Gene

mRNA differential expression in normal tissues according to GTEx for C20orf27 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Putamen (basal ganglia) (x4.3), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for C20orf27 Gene

This gene is overexpressed in Cardia (11.6) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C20orf27 Gene



Protein tissue co-expression partners for C20orf27 Gene

NURSA nuclear receptor signaling pathways regulating expression of C20orf27 Gene:

C20orf27

SOURCE GeneReport for Unigene cluster for C20orf27 Gene:

Hs.274422
genes like me logo Genes that share expression patterns with C20orf27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C20orf27 Gene

Orthologs for C20orf27 Gene

This gene was present in the common ancestor of animals.

Orthologs for C20orf27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C20H20orf27 34
  • 99.33 (n)
C20orf27 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C20orf27 35
  • 92 (a)
OneToOne
C13H20orf27 34
  • 87.98 (n)
dog
(Canis familiaris)
Mammalia C24H20orf27 34
  • 90.5 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311739 34
  • 87.02 (n)
mouse
(Mus musculus)
Mammalia 1700037H04Rik 34 16 35
  • 86.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C20orf27 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858801 34
  • 69.93 (n)
C20orf27 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c20orf27 34
  • 67.83 (n)
Str.268 34
zebrafish
(Danio rerio)
Actinopterygii LOC560941 34
  • 62.96 (n)
C20orf27 (1 of 2) 35
  • 56 (a)
OneToMany
C20orf27 (2 of 2) 35
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6983 35
  • 28 (a)
OneToOne
Species where no ortholog for C20orf27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C20orf27 Gene

ENSEMBL:
Gene Tree for C20orf27 (if available)
TreeFam:
Gene Tree for C20orf27 (if available)

Paralogs for C20orf27 Gene

Pseudogenes.org Pseudogenes for C20orf27 Gene

genes like me logo Genes that share paralogs with C20orf27: view

No data available for Paralogs for C20orf27 Gene

Variants for C20orf27 Gene

Sequence variations from dbSNP and Humsavar for C20orf27 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10529959 -- 3,757,048(+) AATAA(-/ATAAATAAATAAATAA/ATAAATAAATAAATAAATAA)CATTT intron-variant
rs111355817 -- 3,754,082(+) TCGCT(A/G)TGCTC nc-transcript-variant, reference, synonymous-codon
rs111383129 -- 3,768,128(+) CGGGA(A/G)GGCTG nc-transcript-variant, upstream-variant-2KB
rs111614529 -- 3,757,866(+) GCAGC(A/G)CAGCA intron-variant
rs112250119 -- 3,760,892(+) CTGAG(A/C)ATCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C20orf27 Gene

Variant ID Type Subtype PubMed ID
esv2722120 CNV deletion 23290073
esv3645048 CNV loss 21293372
nsv585284 CNV loss 21841781
nsv585285 CNV loss 21841781
nsv585286 CNV loss 21841781
nsv828673 CNV gain 20364138
nsv833899 CNV loss 17160897

Variation tolerance for C20orf27 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C20orf27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C20orf27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C20orf27 Gene

Disorders for C20orf27 Gene

Relevant External Links for C20orf27

Genetic Association Database (GAD)
C20orf27
Human Genome Epidemiology (HuGE) Navigator
C20orf27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C20orf27

No disorders were found for C20orf27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C20orf27 Gene

Publications for C20orf27 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C20orf27 Gene

Sources for C20orf27 Gene

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