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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C20orf26 Gene

protein-coding GIFtS: 43
GCID: GC20P020033

chromosome 20 open reading frame 26

Search for C20orf26
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 20 Open Reading Frame 26¹ ²
DJ1002M8.3¹
DKFZP434K156¹
DJ1178H5.4¹
Uncharacterized Protein C20orf26²

External Ids:	HGNC: 15872¹	Entrez Gene: 26074²	Ensembl: ENSG00000089101⁷	UniProtKB: Q8NHU2³

Export aliases for C20orf26 gene to outside databases

Previous GC identifers: GC20P020021 GC20P020028 GC20P019981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C20orf26 gene promoter:
C/EBPbeta STAT1 STAT1beta Nkx2-5 C/EBPalpha STAT1alpha AREB6 POU2F1 POU2F1a ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C20orf26 promoter sequence

Search SABiosciences Chromatin IP Primers for C20orf26

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf26

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23 Ensembl cytogenetic band: 20p11.23 HGNC cytogenetic band: 20p11.23

C20orf26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C20orf26 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P020033: view genomic region (about GC identifiers)

Start:	20,033,158 bp from pter	End:	20,341,346 bp from pter
Size:	308,189 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CT026_HUMAN, Q8NHU2 (See protein sequence)

Recommended Name: Uncharacterized protein C20orf26

Size: 1237 amino acids; 141349 Da

Sequence caution: Sequence=CAI42114.1; Type=Erroneous gene model prediction;

Secondary accessions: A6NHA1 Q5JXV4 Q5TE18 Q8N5R9 Q96M59 Q9BQL2 Q9H127 Q9H128 Q9NQH4 Q9UFV8 Q9Y4V7

Alternative splicing: 5 isoforms: Q8NHU2-1 Q8NHU2-3 Q8NHU2-4 Q8NHU2-5 Q8NHU2-6 (Ref.1 (BAB71452) sequence is in conflict in position: 123:L->P)

Explore the universe of human proteins at neXtProt for C20orf26: NX_Q8NHU2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NHU2

C20orf26 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001161288.1 NP_056400.3

ENSEMBL proteins:

ENSP00000345553 ENSP00000245957 ENSP00000366521 ENSP00000366518 ENSP00000420438

ENSP00000417086 ENSP00000420498 ENSP00000397311 ENSP00000388074 ENSP00000366508

ENSP00000366523 ENSP00000414537 ENSP00000366524 ENSP00000374307

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C20orf26 for domains About GeneDecksing

1 InterPro domain/family:

IPR016181 Acyl_CoA_acyltransferase

Graphical View of Domain Structure for InterPro Entry Q8NHU2

ProtoNet protein and cluster: Q8NHU2

1 Blocks protein family: IPB000515 Binding-protein-dependent transport systems inner membrane component

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: C20orf26 Browse MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate C20orf26:
		hsa-miR-137
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C20orf26

1 Interacting protein for C20orf26 (Q8NHU2²) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	P31016²	MINT-8108462

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C20orf26
Search CenterWatch for drugs/clinical trials and news about C20orf26 / CT026

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C20orf26 gene (2 alternative transcripts):

NM_001167816.1 NM_015585.3

Unigene Cluster for C20orf26:

Chromosome 20 open reading frame 26

Hs.729168 [show with all ESTs]

Unigene Representative Sequence: NM_015585

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000340348(uc010gcw.2) ENST00000245957(uc002wru.3) ENST00000377306

ENST00000377303 ENST00000494029 ENST00000475466 ENST00000472660 ENST00000442372

ENST00000431753 ENST00000471716 ENST00000468719 ENST00000476414 ENST00000493330

ENST00000497372 ENST00000377293(uc002wrv.3) ENST00000377308(uc002wrw.3)

ENST00000486624 ENST00000488640

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		hsa-miR-137
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Additional cDNA sequence:

AK056971.1 AK057364.1 AK304174.1 AK307817.1 AL117439.1 BC015959.2 BC028708.2 BC031674.1

15 DOTS entries:

DT.100035867 DT.40112578 DT.95280290 DT.40247435 DT.92414261 DT.95244616 DT.97837586 DT.100035869

DT.100035870 DT.40112420 DT.440449 DT.97764933 DT.97779906 DT.99959534 DT.97800907

24/63 AceView cDNA sequences (see all 63):

N41529 CA391989 CA391988 BX102421 BC015959 AL844425 AA383822 AI332439

AI382780 BI826012 AW072227 AW665817 AA195214 AA195217 AL731963 N27455

AA369924 AL117439 BG722454 BC028708 N33550 AW629158 AI694326 AL844472

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for C20orf26 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^
SP1:																																			-		-		-		-		-		-		-		-
SP2:																																																	-
SP3:
SP4:																																									-		-
SP5:																																							-

ExUns:	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33a	·	33b
SP1:
SP2:									-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for C20orf26

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C20orf26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTGTGCA

About this image

C20orf26 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See C20orf26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C20orf26

SOURCE GeneReport for Unigene cluster: Hs.729168

SABiosciences Custom PCR Arrays for C20orf26

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for C20orf26 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4930529M08Rik⁵	RIKEN cDNA 4930529M08 gene	--		2 (71.28 cM) 145934784
chicken (Gallus gallus)	Aves	C3H20orf26¹	chromosome 3 open reading frame, human C20orf26	66.9(n) 60.42(a)		421242 XM_419314.3 XP_419314.3
lizard (Anolis carolinensis)	Reptilia	C20orf26⁶	--	62(a)	1 ↔ 1	4(80545203-80669258)
zebrafish (Danio rerio)	Actinopterygii	LOC100002842¹	uncharacterized protein C20orf26-like	55.8(n) 46.89(a)		100002842 XM_001342490.4 XP_001342526.4
fruit fly (Drosophila melanogaster)	Insecta	CG30268¹	CG30268	41.51(n) 24.91(a)		37610 NM_137868.2 NP_611712.2

ENSEMBL Gene Tree for C20orf26 (if available)
TreeFam Gene Tree for C20orf26 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5840866^1,2	C,	--	20021734(+)	`TGCTA-/TTTTTT`	1	--	int¹ trp³		1		CSA	2
rs151136145^1,2	C,	--	20031283(+)	`GAAGAC/TATTTC`	2	--	us2k¹ int¹		0	--	--	--	--
rs6035531^1,2	H,	--	20031334(+)	`AACATA/GCATTT`	2	--	int¹ us2k¹ tfbs³		4		NS EA	420
rs145182406^1,2		--	20031410(+)	`TCCATC/GAGACT`	2	--	int¹ us2k¹		0	--	--	--	--
rs62200275^1,2	C,F,	--	20031435(+)	`AATACC/TGTTTT`	2	--	us2k¹ int¹		6		NA CSA WA EA	364
rs139010279^1,2		--	20031436(+)	`ATACCA/GTTTTC`	2	--	us2k¹ int¹		0	--	--	--	--
rs140689546^1,2		--	20031519(+)	`CAAGTC/TTTCCC`	2	--	int¹ us2k¹		0	--	--	--	--
rs145748159^1,2		--	20031621(+)	`TAACAA/GCATTA`	2	--	us2k¹ int¹		0	--	--	--	--
rs16981480^1,2	C,F,H,	--	20031632(+)	`CAACCT/CGCATT`	2	--	int¹ us2k¹		31		NA EA NS CSA WA	3402
rs16981483^1,2	C,F,H,	--	20031667(+)	`TGCCCC/TGGTGT`	2	--	us2k¹ int¹		21		NA NS EA CSA WA	2482

HapMap Linkage Disequilibrium report for C20orf26 (20033158 - 20283158 bp, first 250kb of C20orf26)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for C20orf26
4 CNVs: 90498 50631 90499 73478
3 Indels: 50630 40444 46074

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C20orf26 for disorders About MalaCards

C20orf26 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: C20orf26 (2 documents)

Export disorders for C20orf26 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C20orf26 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C20orf26)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2, 3} Deloukas P....Rogers J. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26074	HGNC: 15872	AceView: C20orf26	Ensembl:ENSG00000089101	euGenes: HUgn26074
ECgene: C20orf26	H-InvDB: C20orf26

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C20orf26	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C20orf26 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C20orf26 gene:
Search GeneIP for patents involving C20orf26

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for C20orf26
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C20orf26		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C20orf26
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	OriGene siRNA for C20orf26		OriGene 3'-UTR Clone for C20orf26
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C20orf26		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C20orf26
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C20orf26
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C20orf26
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf26
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C20orf26
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C20orf26
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	GenScript Custom Purified and Recombinant Proteins Services for C20orf26		GenScript cDNA clones with any tag delivered in your preferred vector for C20orf26
	GenScript Custom Assay Services for C20orf26		GenScript Custom Superior Antibodies Services for C20orf26
	GenScript Custom overexpressing Cell Line Services for C20orf26		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C20orf26

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C20orf26 gene at Home site.

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C20orf26 Gene

chromosome 20 open reading frame 26

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C20orf26 Gene

chromosome 20 open reading frame 26

Aliasesfor C20orf26 gene

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Genomic Viewsfor C20orf26 gene

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