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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C20orf24 Gene

protein-coding   GIFtS: 43
GCID: GC20P035234

Chromosome 20 Open Reading Frame 24

  Search for C20orf24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 20 Open Reading Frame 241 2
Rab5-Interacting Protein2 3
RIP52 3
Uncharacterized Protein C20orf242

External Ids:    HGNC: 158701   Entrez Gene: 559692   Ensembl: ENSG000001010847   UniProtKB: Q9BUV83   
ORGUL members:         
NONCODE14:n407149      

Export aliases for C20orf24 gene to outside databases

Previous GC identifers: GC20P034962 GC20P035872 GC20P035919 GC20P034667 GC20P031970


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C20orf24 Gene: 
C20orf24 (chromosome 20 open reading frame 24) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include molecular_function. An important paralog of this gene is TGIF2-C20orf24.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C20orf24 gene promoter:
         ER-alpha   Tal-1   LCR-F1   C/EBPalpha   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC20orf24 promoter sequence
   Search SABiosciences Chromatin IP Primers for C20orf24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

C20orf24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C20orf24 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P035234:  view genomic region     (about GC identifiers)

Start:
35,234,137 bp from pter      End:
35,240,960 bp from pter
Size:
6,824 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CT024_HUMAN, Q9BUV8 (See protein sequence)
Recommended Name: Uncharacterized protein C20orf24  
Size: 137 amino acids; 15487 Da
Secondary accessions: E1P5U0 O00605 Q5QPG6 Q5QPG7 Q9BT03 Q9BZU7 Q9UI05
Alternative splicing: 5 isoforms:  Q9BUV8-1   Q9BUV8-2   Q9BUV8-3   Q9BUV8-4   Q9BUV8-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for C20orf24: NX_Q9BUV8

Explore proteomics data for C20orf24 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BUV8

  • C20orf24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C20orf24 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186463.1  NP_061328.1  NP_955777.1  

    ENSEMBL proteins: 
     ENSP00000340164   ENSP00000435871   ENSP00000432510   ENSP00000362958   ENSP00000341213  

    Human Recombinant Protein Products for C20orf24: 
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    OriGene Protein Over-expression Lysate for C20orf24
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    Novus Biologicals C20orf24 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for C20orf24 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    C20orf24 for ontologies           About GeneDecksing



    C20orf24 Antibody Products: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for C20orf24 
    Cloud-Clone Corp. CLIAs for C20orf24


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR010742 Rab5ip

    Graphical View of Domain Structure for InterPro Entry Q9BUV8

    ProtoNet protein and cluster: Q9BUV8


    C20orf24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    C20orf24 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for C20orf24:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C20orf24 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C20orf24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C20orf24 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C20orf24 

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate C20orf24 (see all 12):
    hsa-miR-203 hsa-miR-548am hsa-miR-3688-3p hsa-miR-4272 hsa-miR-7 hsa-miR-1297 hsa-miR-570 hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidC20orf24 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C20orf24


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C20orf24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for C20orf24 (Q9BUV83 ENSP000003412134) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIFM1O958313, ENSP000002872954I2D: score=2 STRING: ENSP00000287295
    FAR1Q8WVX93, ENSP000003468744I2D: score=2 STRING: ENSP00000346874
    PSMD3O432423, ENSP000002646394I2D: score=2 STRING: ENSP00000264639
    RFXANKO145933, ENSP000003050714I2D: score=2 STRING: ENSP00000305071
    SPTLC1O152693, ENSP000002625544I2D: score=2 STRING: ENSP00000262554
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    C20orf24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C20orf24 (CT024)

    Search CenterWatch for drugs/clinical trials and news about C20orf24 / CT024

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C20orf24 gene (5 alternative transcripts): 
    NM_199484.1  NM_199485.1  NM_001199534.1  NM_018840.4  NM_199483.2  

    Unigene Cluster for C20orf24:

    Chromosome 20 open reading frame 24
    Hs.584985  [show with all ESTs]
    Unigene Representative Sequence: BM912350
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344795(uc002xfs.3 uc002xfq.3 uc002xfr.3) ENST00000492721
    ENST00000483815(uc002xft.3) ENST00000491113 ENST00000373852 ENST00000342422
    ENST00000494506
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C20orf24
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate C20orf24 (see all 12):
    hsa-miR-203 hsa-miR-548am hsa-miR-3688-3p hsa-miR-4272 hsa-miR-7 hsa-miR-1297 hsa-miR-570 hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidC20orf24 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C20orf24
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    Additional mRNA sequence: 

    AF112213.1 AF274936.1 AF274948.1 BC001871.1 NR_026562.3 S83364.1 

    20 DOTS entries:

    DT.100820463  DT.454954  DT.100820460  DT.100820465  DT.100820467  DT.100820468  DT.95156298  DT.102832981 
    DT.100820469  DT.92447903  DT.100038420  DT.95156290  DT.100844526  DT.120831794  DT.121641440  DT.92447900 
    DT.92447906  DT.95156293  DT.97809146  DT.120831686 

    24/554 AceView cDNA sequences (see all 554):

    AA922999 BM793776 AI193425 AA806662 AA737921 BG105079 BQ438290 AI760384 
    BQ880519 BE263177 CA314550 AA349299 CR609489 AI340141 CD370524 BM845390 
    BM686634 BI467205 AW193751 AA426444 BM980705 AI346938 AI061327 BQ437371 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for C20orf24    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                          -     -           -                           
    SP2:                                                                        
    SP3:                          -     -                                       
    SP4:                          -     -     -     -                           
    SP5:                                            -                           


    ECgene alternative splicing isoforms for C20orf24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C20orf24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCATCTAA
    C20orf24 Expression
    About this image


    See C20orf24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C20orf24

    SOURCE GeneReport for Unigene cluster: Hs.584985
        SABiosciences Custom PCR Arrays for C20orf24
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C20orf24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for C20orf24 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1110008F13Rik1 , 5 RIKEN cDNA 1110008F13 gene1, 5 92.76(n)1
    98.45(a)1
      2 (77.89 cM)5
    673881  NM_026124.31  NP_080400.11 
     1568631285 
    chicken
    (Gallus gallus)
    Aves C20H20orf241 chromosome 20 open reading frame, human C20orf24 77.78(n)
    82.95(a)
      768550  NM_001079737.1  NP_001073205.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    4(138567511-138573783)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.72732 Xenopus laevis transcribed sequence with moderate similarity more 75.59(n)    48019709 
    zebrafish
    (Danio rerio)
    Actinopterygii c20orf242 c20orf24 homolog (human) 79.39(n)   334006  BC042320.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121071 CG12107 65.26(n)
    64.21(a)
      35712  NM_136470.3  NP_610314.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F44E7.91 Protein F44E7.9 52.86(n)
    43.43(a)
      185741  NM_072118.2  NP_504519.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G594101 Rab5-interacting family protein 47.15(n)
    38.74(a)
      836060  NM_125332.3  NP_200749.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01106001 hypothetical protein 52.19(n)
    38.52(a)
      4337590  NM_001060976.1  NP_001054441.1 


    ENSEMBL Gene Tree for C20orf24 (if available)
    TreeFam Gene Tree for C20orf24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C20orf24 gene
    TGIF2-C20orf242  

    C20orf24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C20orf24:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833967CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C20orf24
    DNA2.0 Custom Variant and Variant Library Synthesis for C20orf24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C20orf24 for disorders           About MalaCards

    C20orf24 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: C20orf24 (1 document)

    Export disorders for C20orf24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C20orf24 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with C20orf24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. RIP5 is a RIP-homologous inducer of cell death. (PubMed id 15178406)1, 3 Zha J.... Shu H.B. (2004)
    3. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic. (PubMed id 8824393)1, 2 Vitale G.... Zerial M. (1995)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55969 HGNC: 15870 AceView: C20orf24andTGIF2 Ensembl:ENSG00000101084 euGenes: HUgn55969
    ECgene: C20orf24 H-InvDB: C20orf24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C20orf24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C20orf24 gene:
    Search GeneIP for patents involving C20orf24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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