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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C20orf195 Gene

protein-coding   GIFtS: 42
GCID: GC20P062184          (predicted)

Chromosome 20 Open Reading Frame 195

  Search for C20orf195
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 20 Open Reading Frame 1951 2
Uncharacterized Protein C20orf1952

External Ids:    HGNC: 287641   Entrez Gene: 790252   Ensembl: ENSG000001255317   UniProtKB: Q9BVV23   

Export aliases for C20orf195 gene to outside databases

Previous GC identifers: GC20P061655 GC20P058914


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C20orf195 Gene: 
C20orf195 (chromosome 20 open reading frame 195) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011333.6  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C20orf195 gene promoter:
         AREB6   S8   AP-1   ATF-2   Pax-2   ARP-1   Pax-2a   c-Jun   NF-kappaB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C20orf195

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf195


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

C20orf195 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C20orf195 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062184:  view genomic region     (about GC identifiers)

Start:
62,184,373 bp from pter      End:
62,188,061 bp from pter
Size:
3,689 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CT195_HUMAN, Q9BVV2 (See protein sequence)
Recommended Name: Uncharacterized protein C20orf195  
Size: 318 amino acids; 36526 Da

Explore the universe of human proteins at neXtProt for C20orf195: NX_Q9BVV2

Explore proteomics data for C20orf195 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BVV2

  • C20orf195 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C20orf195 Protein Expression
    REFSEQ proteins: NP_076964.1  
    ENSEMBL proteins: 
     ENSP00000359116   ENSP00000359115  

    Human Recombinant Protein Products for C20orf195: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9BVV2

    ProtoNet protein and cluster: Q9BVV2


    C20orf195 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C20orf195 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for C20orf195:
     Wnt reporter downregulated 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C20orf195

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for C20orf195 (Q9BVV22, 3 ENSP000003591154) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-68212 I2D: score=5 STRING: ENSP00000311695
    SSSCA1O602322, 3, ENSP000003123184MINT-66589 I2D: score=5 STRING: ENSP00000312318
    PDLIM7Q9NR122, 3, ENSP000003480994MINT-68104 I2D: score=5 STRING: ENSP00000348099
    CALCOCO2Q131372, 3, ENSP000002589474MINT-67765 I2D: score=5 STRING: ENSP00000258947
    KRT15P190123I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C20orf195 (CT195)

    Search CenterWatch for drugs/clinical trials and news about C20orf195 / CT195

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C20orf195 gene: 
    NM_024059.2  

    Unigene Cluster for C20orf195:

    Chromosome 20 open reading frame 195
    Hs.197755  [show with all ESTs]
    Unigene Representative Sequence: AK125168
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370098(uc002yfj.3) ENST00000370097
    miRNA
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    hsa-miR-3681
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C20orf195
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    Additional mRNA sequence: 

    AK125168.1 BC000912.2 

    4 DOTS entries:

    DT.424060  DT.95364136  DT.99968096  DT.97838619 

    24/29 AceView cDNA sequences (see all 29):

    BI754742 BC000912 BI828873 NM_024059 AA383482 BE301728 BE018248 AI655792 
    CR597897 BI562640 BM554007 BG717733 AK125168 AW590437 BQ109512 BX100339 
    AL731958 BG719056 BG772889 BQ920325 BX380560 AL731939 AW173177 AL731959 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C20orf195 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGCACCA
    C20orf195 Expression
    About this image


    See C20orf195 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C20orf195

    SOURCE GeneReport for Unigene cluster: Hs.197755
        SABiosciences Custom PCR Arrays for C20orf195
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C20orf195

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C20orf195 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0516281 , 5 cDNA sequence BC0516281, 5 83.07(n)1
    82.43(a)1
      2 (103.63 cM)5
    3327131  NM_199312.31  NP_955016.11 
     1812200135 
    chicken
    (Gallus gallus)
    Aves C20H20orf1951 chromosome 20 open reading frame, human C20orf195 59.83(n)
    51.65(a)
      419266  XM_417439.2  XP_417439.1 
    lizard
    (Anolis carolinensis)
    Reptilia C20ORF1956
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343401.1(565843-577473)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.24932 Oncorhynchus mykiss transcribed sequence with weak more 79.75(n)    BX087104.1 


    ENSEMBL Gene Tree for C20orf195 (if available)
    TreeFam Gene Tree for C20orf195 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 SNPs in C20orf195 are shown (see all 198)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400480621,2
    --62182396(+) CCCAAC/GACTGG 1 -- us2k10--------
    rs749698291,2
    F--62182546(+) CCCCTG/TGTGCC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1825612541,2
    --62182748(+) TGTCAA/GGGTCC 1 -- us2k10--------
    rs3106111,2
    C,F,A,H--62182755(-) ccccaC/Tgggac 1 -- us2k110Minor allele frequency- T:0.41NA WA CSA EA 369
    rs3106101,2
    C,F,A,H--62182802(-) aatcaC/Tgccag 1 -- us2k19Minor allele frequency- T:0.23NA WA CSA EA 369
    rs1858968511,2
    --62182972(+) TCTTAC/TTGCAC 1 -- us2k10--------
    rs61224751,2
    C,F,H--62182981(+) acccaG/Tgctgg 1 -- us2k14Minor allele frequency- T:0.00NS NA 402
    rs1899631211,2
    --62183005(+) AATCTC/TGGCTC 1 -- us2k10--------
    rs762002171,2
    C--62183157(+) AGTGCA/GGTGGC 1 -- us2k10--------
    rs1825454381,2
    --62183183(+) TGCAAA/GCTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C20orf195 (62184373 - 62188061 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for C20orf195 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722935CNV Deletion23290073
    nsv517702CNV Loss19592680
    dgv4644n71CNV Loss21882294
    dgv521n27CNV Loss19166990
    nsv913213CNV Loss21882294
    dgv4618n71CNV Loss21882294
    dgv35n64CNV Loss17921354
    dgv4643n71CNV Loss21882294
    nsv913207CNV Loss21882294
    nsv521734CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C20orf195 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C20orf195)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79025 HGNC: 28764 AceView: MGC5356 Ensembl:ENSG00000125531 euGenes: HUgn79025
    ECgene: C20orf195 H-InvDB: C20orf195

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C20orf195 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C20orf195 gene:
    Search GeneIP for patents involving C20orf195

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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