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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C20orf166 Gene

protein-coding   GIFtS: 35
GCID: GC20P061147

Chromosome 20 Open Reading Frame 166

  Search for C20orf166
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 20 Open Reading Frame 1661 2
dJ353C17.12
Uncharacterized Protein C20orf1662

External Ids:    HGNC: 161591   Entrez Gene: 1288262   Ensembl: ENSG000001744077   UniProtKB: Q9H1L03   

Export aliases for C20orf166 gene to outside databases

Previous GC identifers: GC20U990102 GC20M060924 GC20M061766 GC20M061814 GC20M061815 GC20P060558 GC20P057902


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C20orf166 Gene: 
C20orf166 (chromosome 20 open reading frame 166) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C20orf166 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   FOXO3b   Nkx3-1 v2   MEF-2A   FOXO3a   Nkx3-1 v3   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC20orf166 promoter sequence
   Search SABiosciences Chromatin IP Primers for C20orf166

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C20orf166


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

C20orf166 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C20orf166 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061147:  view genomic region     (about GC identifiers)

Start:
61,147,660 bp from pter      End:
61,167,971 bp from pter
Size:
20,312 bases      Orientation:
plus strand

1 alternative location:
Chr20+,NW_003571063 93,971-114,282     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CT166_HUMAN, Q9H1L0 (See protein sequence)
Recommended Name: Uncharacterized protein C20orf166  
Size: 117 amino acids; 12410 Da
Secondary accessions: Q2TB30

Explore the universe of human proteins at neXtProt for C20orf166: NX_Q9H1L0

Explore proteomics data for C20orf166 at MOPED 

C20orf166 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C20orf166 Protein Expression

REFSEQ proteins: NP_848558.1  
ENSEMBL proteins: 
 ENSP00000359558   ENSP00000359554   ENSP00000359555  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9H1L0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for C20orf166 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C20orf166

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C20orf166 (CT166)

Search CenterWatch for drugs/clinical trials and news about C20orf166 / CT166

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C20orf166 gene: 
NM_178463.3  

Unigene Cluster for C20orf166:

Chromosome 20 open reading frame 166
Hs.86507  [show with all ESTs]
Unigene Representative Sequence: NM_178463
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370527(uc011aaj.2) ENST00000370523 ENST00000370524
miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C20orf166

Additional mRNA sequence: 

AK056985.1 BC110595.2 

2 DOTS entries:

DT.40117703  DT.95262538 

5 AceView cDNA sequences:

F35285 AK056985 F37115 F28420 NM_178463 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C20orf166 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATACGGGGT
C20orf166 Expression
About this image


See C20orf166 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C20orf166

SOURCE GeneReport for Unigene cluster: Hs.86507
    SABiosciences Custom PCR Arrays for C20orf166
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C20orf166

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for C20orf166 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia C20orf1666
chromosome 20 open reading frame 166
97(a)
1 ↔ 1
20(59817516-59838956)


ENSEMBL Gene Tree for C20orf166 (if available)
TreeFam Gene Tree for C20orf166 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/463 SNPs in C20orf166 are shown (see all 463)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0196554
----see VAR_0196552 V A mis40--------
VAR_0368984
----see VAR_0368982 I V mis40--------
rs1435621661,2
--61145680(+) GTAAAC/TGGGGG 1 -- us2k10--------
rs455521311,2
C,F--61145681(+) TAAACG/AGGGGA 1 -- us2k16Minor allele frequency- A:0.24NA CSA WA EA 364
rs606407281,2
C,F--61145810(+) GGCTGC/ACGTGA 1 -- us2k16Minor allele frequency- A:0.23NA CSA WA EA 364
rs1806834491,2
--61145835(+) GGCCAC/TGTCTG 1 -- us2k10--------
rs60897541,2
C,F,A,H--61145839(-) GCAGCG/AGACGT 1 -- us2k117Minor allele frequency- A:0.03NS NA WA CSA EA 1054
rs785925301,2
C--61146138(+) GGTAGA/CAGCTT 1 -- us2k13Minor allele frequency- C:0.16CSA WA EA 240
rs1864568701,2
--61146244(+) ACTGGC/GCAGGT 1 -- us2k10--------
rs791607921,2
C,F--61146302(+) AGAGTG/AGGTGT 1 -- us2k12Minor allele frequency- A:0.07WA NA 238

HapMap Linkage Disequilibrium report for C20orf166 (61147660 - 61167971 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/12 variations for C20orf166 (see all 12):    About this table     
Variant IDTypeSubtypePubMed ID
esv2422398CNV Duplication17116639
nsv913073CNV Loss21882294
nsv913047CNV Loss21882294
nsv913103CNV Loss21882294
dgv4610n71CNV Loss21882294
nsv470556CNV Loss18288195
dgv4603n71CNV Loss21882294
nsv913101CNV Loss21882294
dgv4608n71CNV Loss21882294
nsv459065CNV Gain19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C20orf166 for disorders           About MalaCards

C20orf166 for disorders           About GeneDecksing

Genetic Association Database (GAD): C20orf166

Export disorders for C20orf166 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C20orf166 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C20orf166)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  4. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. (PubMed id 8681137)1 Lanfranchi G....Valle G. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 128826 HGNC: 16159 AceView: C20orf166 Ensembl:ENSG00000174407 euGenes: HUgn128826
ECgene: C20orf166 H-InvDB: C20orf166

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C20orf166 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C20orf166 gene:
Search GeneIP for patents involving C20orf166

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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