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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf87 Gene

protein-coding   GIFtS: 42
GCID: GC01M060452

Chromosome 1 Open Reading Frame 87

  Search for C1orf87
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 871 2
Uncharacterized Protein C1orf872

External Ids:    HGNC: 285471   Entrez Gene: 1277952   Ensembl: ENSG000001625987   UniProtKB: Q8N0U73   

Export aliases for C1orf87 gene to outside databases

Previous GC identifers: GC01M060169 GC01M060228 GC01M058567


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C1orf87 Gene: 
C1orf87 (chromosome 1 open reading frame 87) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf87 gene promoter:
         GR   NF-1   C/EBPbeta   AML1a   ATF-2   Brachyury   LCR-F1   HFH-1   GR-alpha   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C1orf87

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf87


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.1   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32.1

C1orf87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf87 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M060452:  view genomic region     (about GC identifiers)

Start:
60,452,941 bp from pter      End:
60,539,442 bp from pter
Size:
86,502 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CA087_HUMAN, Q8N0U7 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf87  
Size: 546 amino acids; 62035 Da
Secondary accessions: Q6ZU07 Q8IVS0
Alternative splicing: 3 isoforms:  Q8N0U7-1   Q8N0U7-2   Q8N0U7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf87: NX_Q8N0U7

Explore proteomics data for C1orf87 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N0U7

  • C1orf87 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C1orf87 Protein Expression
    REFSEQ proteins: NP_689590.1  
    ENSEMBL proteins: 
     ENSP00000389432   ENSP00000360244   ENSP00000378921  

    Human Recombinant Protein Products for C1orf87: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR011992 EF-hand-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N0U7

    ProtoNet protein and cluster: Q8N0U7


    C1orf87 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    C1orf87 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for C1orf87:
     Decreased homologous recombina 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf87

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1orf87 (CA087)

    Search CenterWatch for drugs/clinical trials and news about C1orf87 / CA087

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1orf87 gene: 
    NM_152377.2  

    Unigene Cluster for C1orf87:

    Chromosome 1 open reading frame 87
    Hs.47385  [show with all ESTs]
    Unigene Representative Sequence: AK126061
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486478(uc001czr.1) ENST00000450089 ENST00000371201(uc001czs.2)
    ENST00000488027 ENST00000491817 ENST00000395552
    miRNA
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    hsa-miR-338-5p hsa-miR-103b hsa-miR-26b* hsa-miR-3175 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidC1orf87 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf87
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf87

    Additional mRNA sequence: 

    AK124828.1 AK126061.1 BC027878.1 BC042203.1 

    3 DOTS entries:

    DT.100018888  DT.95099476  DT.101959590 

    24 AceView cDNA sequences:

    NM_152377 AI858998 BU608239 AK124828 BC027878 BU570377 BC042203 BM543642 
    AA906694 BI831261 BI523716 N51972 AI015082 AA889253 AA889241 AA446167 
    AK126061 AA719014 BI768799 BU567483 CD703175 CD707889 BG220691 N53805 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf87    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
    SP1:                                                        -           -     -     -                                                   
    SP2:                                                                                                                                    
    SP3:                                                                    -     -     -                                                   
    SP4:                          -     -     -     -                                                                                       
    SP5:                                                                                -                                                   


    ECgene alternative splicing isoforms for C1orf87

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf87 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTCCCCA
    C1orf87 Expression
    About this image


    See C1orf87 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf87

    SOURCE GeneReport for Unigene cluster: Hs.47385
        SABiosciences Custom PCR Arrays for C1orf87
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf87

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for C1orf87 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm126951 , 5 predicted gene 126951, 5 75.87(n)1
    64.64(a)1
      4 (44.79 cM)5
    6207791  NM_001081284.11  NP_001074753.11 
     967236475 


    ENSEMBL Gene Tree for C1orf87 (if available)
    TreeFam Gene Tree for C1orf87 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1694 SNPs in C1orf87 are shown (see all 1694)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354934
    A breast cancer sample4--see VAR_0354932 Q E mis40--------
    rs1865857531,2
    C--60455608(+) AAGAAA/CTATGG 1 -- int10--------
    rs1908454701,2
    --60455666(+) GGATGC/TTACCT 1 -- int10--------
    rs1161601231,2
    F--60455682(+) CAAAAC/AGCTTT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs175005161,2
    C,F--60455683(+) AAAACG/ACTTTG 1 -- int16Minor allele frequency- A:0.06NA EA 384
    rs789151981,2
    C,F--60455705(+) CCTTCC/TTCAAA 1 -- int11Minor allele frequency- T:0.05EA 120
    rs1823320991,2
    --60455784(+) AAAATA/GTTGGA 1 -- int10--------
    rs1866431331,2
    --60455789(+) ATTGGA/CCTTGT 1 -- int10--------
    rs104932751,2
    C,F,H--60455797(+) TGTTCA/GGAAAA 1 -- int1101Minor allele frequency- G:0.14NS EA NA PA EU CA WA CSA 6300
    rs1447999891,2
    --60455858(+) TAATAC/TTTTTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for C1orf87 (60452941 - 60539442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for C1orf87:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675852CNV Deletion23128226
    esv1587281CNV Insertion17803354
    esv271154CNV Insertion20981092
    esv259709OTHER Complex20981092
    esv259663OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C1orf87 for disorders           About MalaCards

    C1orf87 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C1orf87

    Export disorders for C1orf87 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf87 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with C1orf87)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)4 Wang J....Platt A. (2012)
    3. Genetic loci associated with plasma phospholipid n-3 f atty acids: a meta-analysis of genome-wide association studies from the CHARGE C onsortium. (PubMed id 21829377)4 Lemaitre R.N....Steffen L.M. (2011)
    4. Propensity score-based nonparametric test revealing ge netic variants underlying bipolar disorder. (PubMed id 21254220)4 Jiang Y. and Zhang H. (2011)
    5. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PubMed id 21738484)4 Smith E.N....Kelsoe J.R. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PubMed id 19416921)4 Scott L.J....Boehnke M. (2009)
    8. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 127795 HGNC: 28547 AceView: MGC34837 Ensembl:ENSG00000162598 euGenes: HUgn127795
    ECgene: C1orf87 H-InvDB: C1orf87

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf87 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1orf87 gene:
    Search GeneIP for patents involving C1orf87

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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