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Aliases for C1orf87 Gene

Aliases for C1orf87 Gene

  • Chromosome 1 Open Reading Frame 87 2 3 5
  • Carcinoma-Related EF-Hand Protein 2 3
  • Uncharacterized Protein C1orf87 3
  • CREF 3

External Ids for C1orf87 Gene

Previous GeneCards Identifiers for C1orf87 Gene

  • GC01M060169
  • GC01M060228
  • GC01M060452
  • GC01M058567

Summaries for C1orf87 Gene

GeneCards Summary for C1orf87 Gene

C1orf87 (Chromosome 1 Open Reading Frame 87) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf87 Gene

Genomics for C1orf87 Gene

Regulatory Elements for C1orf87 Gene

Enhancers for C1orf87 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G060132 1.2 FANTOM5 Ensembl ENCODE 11.1 -59.7 -59710 1.6 SIN3A MAX CEBPG JUND ZNF512 TCF7 ZNF652 PRDM1 TCF7L2 C1orf87 ENSG00000238242 LOC105378760
GH01G059966 1.1 Ensembl ENCODE 10.2 +106.5 106458 1.1 TBP CBX3 ARNT CHAMP1 TCF12 GATA2 GTF2B NCOA1 ZEB2 CREB3 C1orf87 CYP2J2 HOOK1 RN7SL475P GC01M059975
GH01G059993 0.6 Ensembl ENCODE 18.1 +78.7 78702 2.3 GLIS1 C1orf87 RN7SL475P GC01M059975
GH01G060265 0.8 ENCODE 10.1 -192.5 -192536 1.1 FOXA2 MAX CEBPG RARA YY1 NCOR1 SOX5 GATAD2A FOXA3 NR2F1 C1orf87 LOC105378761 LOC105378760
GH01G060035 0.5 ENCODE 11 +37.9 37908 1.4 CTCF PKNOX1 MNT RAD21 C1orf87 GC01M059975 RN7SL475P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf87 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf87 Gene

Chromosome:
1
Start:
59,987,269 bp from pter
End:
60,073,770 bp from pter
Size:
86,502 bases
Orientation:
Minus strand

Genomic View for C1orf87 Gene

Genes around C1orf87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf87 Gene

Proteins for C1orf87 Gene

  • Protein details for C1orf87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0U7-CA087_HUMAN
    Recommended name:
    Uncharacterized protein C1orf87
    Protein Accession:
    Q8N0U7
    Secondary Accessions:
    • Q6ZU07
    • Q8IVS0

    Protein attributes for C1orf87 Gene

    Size:
    546 amino acids
    Molecular mass:
    62035 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf87 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf87 Gene

Post-translational modifications for C1orf87 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf87 Gene

No data available for DME Specific Peptides for C1orf87 Gene

Domains & Families for C1orf87 Gene

Protein Domains for C1orf87 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf87: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf87 Gene

Function for C1orf87 Gene

genes like me logo Genes that share phenotypes with C1orf87: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf87 Gene

Localization for C1orf87 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf87 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf87 Gene

Pathways & Interactions for C1orf87 Gene

SuperPathways for C1orf87 Gene

No Data Available

Interacting Proteins for C1orf87 Gene

Selected Interacting proteins: Q8N0U7-CA087_HUMAN for C1orf87 Gene via IID

Gene Ontology (GO) - Biological Process for C1orf87 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf87 Gene

Drugs & Compounds for C1orf87 Gene

No Compound Related Data Available

Transcripts for C1orf87 Gene

Unigene Clusters for C1orf87 Gene

Chromosome 1 open reading frame 87:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf87 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
SP1: - - - -
SP2:
SP3: - - -
SP4: - - - -
SP5: -

Relevant External Links for C1orf87 Gene

GeneLoc Exon Structure for
C1orf87
ECgene alternative splicing isoforms for
C1orf87

Expression for C1orf87 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf87 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf87 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x9.0), Testis (x7.7), Brain - Hypothalamus (x6.3), Fallopian Tube (x5.2), and Brain - Nucleus accumbens (basal ganglia) (x5.0).

Protein differential expression in normal tissues from HIPED for C1orf87 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf87 Gene



Protein tissue co-expression partners for C1orf87 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf87 Gene:

C1orf87

SOURCE GeneReport for Unigene cluster for C1orf87 Gene:

Hs.47385

Evidence on tissue expression from TISSUES for C1orf87 Gene

  • Lung(2.2)
genes like me logo Genes that share expression patterns with C1orf87: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf87 Gene

Orthologs for C1orf87 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf87 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf87 34
  • 99.63 (n)
C1orf87 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf87 34
  • 82.91 (n)
C1orf87 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H1orf87 34
  • 81.8 (n)
C1ORF87 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560146 34
  • 76 (n)
mouse
(Mus musculus)
Mammalia Gm12695 34 16 35
  • 75.87 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf87 35
  • 51 (a)
OneToOne
Species where no ortholog for C1orf87 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf87 Gene

ENSEMBL:
Gene Tree for C1orf87 (if available)
TreeFam:
Gene Tree for C1orf87 (if available)

Paralogs for C1orf87 Gene

No data available for Paralogs for C1orf87 Gene

Variants for C1orf87 Gene

Sequence variations from dbSNP and Humsavar for C1orf87 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035493 A breast cancer sample
rs1000046124 -- 60,008,490(+) GTAGG(A/G)CCTTT intron-variant
rs1000093610 -- 60,062,741(+) ACATA(G/T)GTTGT intron-variant
rs1000148257 -- 60,020,802(+) GAAGG(C/T)ATGAT intron-variant
rs1000157856 -- 60,059,083(+) TATTT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf87 Gene

Variant ID Type Subtype PubMed ID
dgv98e59 CNV tandem duplication 20981092
esv1587281 CNV insertion 17803354
esv2675852 CNV deletion 23128226
esv3306878 CNV mobile element insertion 20981092
esv3372359 CNV insertion 20981092
esv3438840 CNV duplication 20981092
esv3586198 CNV loss 21293372
nsv1013226 CNV gain 25217958
nsv1111001 CNV tandem duplication 24896259
nsv478542 CNV novel sequence insertion 20440878

Variation tolerance for C1orf87 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.90; 79.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf87 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf87

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf87 Gene

Disorders for C1orf87 Gene

Relevant External Links for C1orf87

Genetic Association Database (GAD)
C1orf87
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf87

No disorders were found for C1orf87 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf87 Gene

Publications for C1orf87 Gene

  1. Open reading frames associated with cancer in the dark matter of the human genome. (PMID: 25048349) Delgado A.P. … Narayanan R. (Cancer Genomics Proteomics 2014) 2 3 64
  2. Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance. (PMID: 28282151) Blackburn K. … Ostrowski L.E. (J. Proteome Res. 2017) 3 64
  3. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. (PMID: 25169055) Lindskog C. … Micke P. (FASEB J. 2014) 3 64
  4. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3 64
  5. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J. … Platt A. (Pharmacogenomics J. 2013) 46 64

Products for C1orf87 Gene

Sources for C1orf87 Gene

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