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Aliases for C1orf86 Gene

Aliases for C1orf86 Gene

  • Chromosome 1 Open Reading Frame 86 2 3
  • FAAP20 3 4 6
  • Fanconi Anemia-Associated Protein Of 20 KDa 3
  • FP7162 3

External Ids for C1orf86 Gene

Summaries for C1orf86 Gene

GeneCards Summary for C1orf86 Gene

C1orf86 (Chromosome 1 Open Reading Frame 86) is a Protein Coding gene. GO annotations related to this gene include ubiquitin binding and K63-linked polyubiquitin binding.

UniProtKB/Swiss-Prot for C1orf86 Gene

  • Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds Lys-63-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf86 Gene

Genomics for C1orf86 Gene

Genomic Location for C1orf86 Gene

Start:
2,184,460 bp from pter
End:
2,212,720 bp from pter
Size:
28,261 bases
Orientation:
Minus strand

Genomic View for C1orf86 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1orf86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf86 Gene

Regulatory Elements for C1orf86 Gene

Proteins for C1orf86 Gene

  • Protein details for C1orf86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZ36-FAP20_HUMAN
    Recommended name:
    Fanconi anemia-associated protein of 20 kDa
    Protein Accession:
    Q6NZ36
    Secondary Accessions:
    • A6PW39
    • A6PW40
    • A6PW41
    • A8MQT6
    • F2Z2L4
    • Q6ZT64
    • Q71M24
    • Q96ND7

    Protein attributes for C1orf86 Gene

    Size:
    180 amino acids
    Molecular mass:
    19869 Da
    Quaternary structure:
    • Component of the Fanconi anemia (FA) complex. Interacts with FANCA; interaction is direct. Interacts with REV1. Reported to bind monoubiquitinated REV1; however it binds better to non-ubiquitinated REV1 (PubMed:22266823).
    SequenceCaution:
    • Sequence=AAH66360.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for C1orf86 Gene

    Alternative splice isoforms for C1orf86 Gene

neXtProt entry for C1orf86 Gene

Proteomics data for C1orf86 Gene at MOPED

Post-translational modifications for C1orf86 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C1orf86 Gene

Domains for C1orf86 Gene

Protein Domains for C1orf86 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6NZ36

UniProtKB/Swiss-Prot:

FAP20_HUMAN
Domain:
  • The UBZ-type zinc finger binds both Lys-48- and Lys-63-linked polyubiquitin with preference for Lys-63-linked polyubiquitin.:
    • Q6NZ36
Similarity:
  • Contains 1 UBZ-type zinc finger.:
    • Q6NZ36
genes like me logo Genes that share domains with C1orf86: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C1orf86 Gene

Function for C1orf86 Gene

Molecular function for C1orf86 Gene

UniProtKB/Swiss-Prot Function: Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds Lys-63-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

Gene Ontology (GO) - Molecular Function for C1orf86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22266823
GO:0031593 polyubiquitin binding IDA 22396592
GO:0043130 ubiquitin binding IDA 22266823
GO:0046872 metal ion binding IEA --
GO:0070530 K63-linked polyubiquitin binding IDA 22343915
genes like me logo Genes that share ontologies with C1orf86: view

miRNA for C1orf86 Gene

miRTarBase miRNAs that target C1orf86

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C1orf86 Gene

Localization for C1orf86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf86 Gene

Nucleus. Chromosome. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf86 Gene COMPARTMENTS Subcellular localization image for C1orf86 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C1orf86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IDA 22266823
GO:0030054 cell junction IDA --
GO:0043240 Fanconi anaemia nuclear complex IDA 22266823
genes like me logo Genes that share ontologies with C1orf86: view

Pathways for C1orf86 Gene

SuperPathways for C1orf86 Gene

No Data Available

Interacting Proteins for C1orf86 Gene

Gene Ontology (GO) - Biological Process for C1orf86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 22266823
GO:0019985 translesion synthesis IMP 22266823
GO:0036297 interstrand cross-link repair IMP 22266823
genes like me logo Genes that share ontologies with C1orf86: view

No data available for Pathways by source for C1orf86 Gene

Transcripts for C1orf86 Gene

Unigene Clusters for C1orf86 Gene

Chromosome 1 open reading frame 86:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf86 Gene

No ASD Table

Relevant External Links for C1orf86 Gene

GeneLoc Exon Structure for
C1orf86
ECgene alternative splicing isoforms for
C1orf86

Expression for C1orf86 Gene

mRNA expression in normal human tissues for C1orf86 Gene

SOURCE GeneReport for Unigene cluster for C1orf86 Gene Hs.107101

genes like me logo Genes that share expressions with C1orf86: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for C1orf86 Gene

Orthologs for C1orf86 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf86 35
  • 99.53 (n)
  • 98.58 (a)
C1orf86 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAAP20 36
  • 44 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf86 36
  • 29 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610002J02Rik 35
  • 63.01 (n)
  • 56.1 (a)
2610002J02Rik 16
2610002J02Rik 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1308923 35
  • 64.78 (n)
  • 57.23 (a)
Species with no ortholog for C1orf86:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf86 Gene

ENSEMBL:
Gene Tree for C1orf86 (if available)
TreeFam:
Gene Tree for C1orf86 (if available)

Paralogs for C1orf86 Gene

Selected SIMAP similar genes for C1orf86 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C1orf86: view

No data available for Paralogs for C1orf86 Gene

Variants for C1orf86 Gene

Sequence variations from dbSNP and Humsavar for C1orf86 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs171904 -- 2,211,729(+) caggc(A/G)tgagc intron-variant
rs262658 -- 2,201,608(+) tccca(A/G)ttatt intron-variant
rs262659 -- 2,196,630(+) AGGCC(A/G)GGAGT intron-variant, upstream-variant-2KB
rs262684 -- 2,186,920(-) TCTGA(C/T)GAGCA intron-variant, utr-variant-5-prime
rs262685 -- 2,186,900(-) TCACA(C/T)ATTGT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C1orf86 Gene

Variant ID Type Subtype PubMed ID
dgv56n71 CNV Loss 21882294
nsv871701 CNV Loss 21882294
nsv871399 CNV Loss 21882294
nsv834557 CNV Loss 17160897
nsv870615 CNV Gain 21882294
dgv59n71 CNV Loss 21882294
nsv461727 CNV Loss 19166990
dgv60n71 CNV Loss 21882294
dgv61n71 CNV Loss 21882294
dgv62n71 CNV Loss 21882294
dgv63n71 CNV Loss 21882294
nsv470682 CNV Loss 18288195

Relevant External Links for C1orf86 Gene

HapMap Linkage Disequilibrium report
C1orf86

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf86 Gene

Disorders for C1orf86 Gene

No disorders were found for C1orf86 Gene.

No data available for UniProtKB/Swiss-Prot for C1orf86 Gene

Publications for C1orf86 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Regulation of Rev1 by the Fanconi anemia core complex. (PMID: 22266823) Kim H. … D'Andrea A.D. (Nat. Struct. Mol. Biol. 2012) 3 4
  3. FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. (PMID: 22343915) Ali A.M. … Meetei A.R. (Blood 2012) 3 4
  4. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross- link repair. (PMID: 22396592) Leung J.W. … Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  5. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. (PMID: 22705371) Yan Z. … Wang W. (Mol. Cell 2012) 3 4

Products for C1orf86 Gene

  • antibodies-online peptides for C1orf86
  • antibodies-online antibodies for C1orf86
  • antibodies-online kits for C1orf86

Sources for C1orf86 Gene

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