C1orf85 Gene
protein-coding GIFtS: 40
GCID: GC01M156259
|
|
chromosome 1 open reading frame 85
| |
Aliases
for C1orf85 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 1 Open Reading Frame 851 2 | | NCU-G11 2 | | MGC319631 | | Kidney Predominant Protein NCU-G12 | | Lysosomal Protein NCU-G12 |
Export aliases for C1orf85 gene to outside databasesPrevious GC identifers: GC01M153076 GC01M154531 GC01M156250 GC01M127623 |
Summaries
for C1orf85 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1orf85 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1orf85 gene promoter:
SRF Max SRF (504 AA) HOXA5 Nkx2-5 c-Myc YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1orf85
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf85 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22C1orf85 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M156259: view genomic region
(about GC identifiers)
Start:
|
156,259,880 bp from pter |
End:
|
156,265,463 bp from pter |
Size:
|
5,584 bases |
Orientation:
|
minus strand |
|
Proteins
for C1orf85 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCUG1_HUMAN, Q8WWB7 (See
protein sequence)Recommended Name: Lysosomal protein NCU-G1 precursor Size: 406 amino acids; 43864 Da
Subcellular location: Lysosome membrane; Single-pass type I membrane protein
Caution: According to PubMed:18021396, it binds DNA and acts as a transcription factor. However, the localization inlysosomes which was confirmed by different groups and the presence of transmembrane region strongly suggests that itdoes not have coactivator activity
Sequence caution: Sequence=AAH11575.1; Type=Erroneous initiation; Sequence=CAI14165.1; Type=Erroneous gene modelprediction;
Secondary accessions: A6NH16 B4DJN4 Q5SZX4 Q6UX96 Q8IV07 Q96F65Alternative splicing: 2 isoforms: Q8WWB7-1 Q8WWB7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C1orf85: NX_Q8WWB7
Post-translational modifications:
Highly N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWB7
C1orf85 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001243533.1 NP_001243534.1 NP_001243537.1 NP_001243538.1 NP_653181.1
ENSEMBL proteins: ENSP00000354553 ENSP00000357247
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
C1orf85 for ontologies About GeneDecksing
C1orf85 Antibody Products:
Assay Products for C1orf85: |
Protein
Domains /
Families
for C1orf85 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8WWB7 |
Function
for C1orf85 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NCUG1_HUMAN, Q8WWB7Induction: Transcription is activated by TFEB
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf85 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf85
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C1orf85 (NM_144580) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf85 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf85 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf85 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000988 | protein binding transcription factor activity |
IDA | 18021396 | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IMP | 18021396 | | GO:0004879 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
IMP | 18021396 | | GO:0044212 | transcription regulatory region DNA binding |
IDA | 18021396 |
C1orf85 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C1orf85:
Animal Models:
Mouse knock-out 0610031J06Riktm1Lex for C1orf85
1 MGI phenotypic allele  for 0610031J06Rik (no phenotypes)
C1orf85 for phenotypes About GeneDecksing
|
Pathways & Interactions
for C1orf85 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf85
1 Interacting protein for C1orf85 (Q8WWB73) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030522 | intracellular receptor mediated signaling pathway |
IMP | 18021396 | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IMP | 18021396 | | GO:2001141 | regulation of RNA biosynthetic process |
-- | -- |
C1orf85 for ontologies About GeneDecksing
|
Drugs & Compounds
for C1orf85 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1orf85
Search CenterWatch for drugs/clinical trials and news about C1orf85 / NCUG1
|
Transcripts
for C1orf85 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1orf85 gene (5 alternative transcripts): NM_001256604.1 NM_001256605.1 NM_001256608.1 NM_001256609.1 NM_144580.2 Unigene Cluster for C1orf85: Chromosome 1 open reading frame 85 Hs.202522 [show with all ESTs]Unigene Representative Sequence: NM_00125660912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461597(uc001fof.4) ENST00000497831 ENST00000472870 ENST00000480968
ENST00000482579 ENST00000362007(uc001foh.3) ENST00000481050 ENST00000476177
ENST00000497955 ENST00000368264 ENST00000479084 ENST00000484214
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf85 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf85
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1orf85 (NM_144580) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf85 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf85 |
Additional cDNA sequence: AK075349.1 AK296157.1 AY358450.1 BC011575.1 BC018757.1 BC036340.1 14 DOTS entries: DT.411705 DT.121329939 DT.70100287 DT.100845588 DT.95342523 DT.100845576 DT.121329908 DT.100674311 DT.100845584 DT.100706748 DT.100845579 DT.121329955 DT.411707 DT.121329944 24/255 AceView cDNA sequences (see all 255): BX099160 AI681458 BM759865 CR618333 BX339563 BE644724 BE293585 BI905785 CD369021 CR600990 AL559430 CR604091 BI764484 BX336388 BM833126 BX337223 BI909270 AF086351 BX375096 CR613276 BM789734 CR591234 CR626023 CR592268
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf85 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for C1orf85
|
Expression
for C1orf85 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1orf85 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTAGGGG
About this image
See C1orf85 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf85
SOURCE GeneReport for Unigene cluster: Hs.202522
SABiosciences Custom PCR Arrays for C1orf85
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf85
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1orf85 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf85 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf85 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf85 |
Orthologs
for C1orf85 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C1orf85 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for C1orf85 (if available)
TreeFam Gene Tree for C1orf85 (if available) |
Paralogs
for C1orf85 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C1orf85 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1orf85 (156259880 - 156265463 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf85: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf85 |
|
Disorders
/ Diseases
for C1orf85 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C1orf85 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1orf85 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with C1orf85) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- A gene network regulating lysosomal biogenesis and function. (PubMed id 19556463)1, 2 Sardiello M.... Ballabio A. (2009)
- Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. (PubMed id 18021396)1, 2 Steffensen K.R.... Eskild W. (2007)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
- Integral and associated lysosomal membrane proteins. (PubMed id 17897319)2 Schroeder B.... Hasilik A. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
|
External Searches for C1orf85 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C1orf85 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1orf85 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1orf85 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1orf85 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1orf85 gene:
Search GeneIP for patents involving C1orf85
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1orf85 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C1orf85 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf85 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf85 | | | OriGene Protein Over-expression Lysate for C1orf85 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C1orf85 | | OriGene 3'-UTR Clone for C1orf85 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf85 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf85 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C1orf85 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C1orf85 | | OriGene Custom Protein Services for C1orf85 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf85 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf85 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf85 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf85 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf85 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf85 |
| |
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| | | | Search Tocris compounds for C1orf85 |
| |  |  |  |  | | | | |
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 | | | C1orf85 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf85 |
|  |  |  | | | | Search ThermoFisher Antibodies for C1orf85 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf85 |
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