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Aliases for C1orf74 Gene

Aliases for C1orf74 Gene

  • Chromosome 1 Open Reading Frame 74 2 3 5
  • Up-Regulated In Lung Cancer 4 3
  • URLC4 3

External Ids for C1orf74 Gene

Previous GeneCards Identifiers for C1orf74 Gene

  • GC01M206345
  • GC01M208022
  • GC01M209955
  • GC01M180630

Summaries for C1orf74 Gene

GeneCards Summary for C1orf74 Gene

C1orf74 (Chromosome 1 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf74 Gene

Genomics for C1orf74 Gene

Regulatory Elements for C1orf74 Gene

Promoters for C1orf74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf74 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf74 Gene

209,779,208 bp from pter
209,784,559 bp from pter
5,352 bases
Minus strand

Genomic View for C1orf74 Gene

Genes around C1orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf74 Gene

Proteins for C1orf74 Gene

  • Protein details for C1orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0739 protein C1orf74
    Protein Accession:

    Protein attributes for C1orf74 Gene

    269 amino acids
    Molecular mass:
    29561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf74 Gene

Proteomics data for C1orf74 Gene at MOPED

Post-translational modifications for C1orf74 Gene

No Post-translational modifications

Other Protein References for C1orf74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf74 Gene

Domains & Families for C1orf74 Gene

Protein Domains for C1orf74 Gene


Suggested Antigen Peptide Sequences for C1orf74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0739 family.
  • Belongs to the UPF0739 family.
genes like me logo Genes that share domains with C1orf74: view

No data available for Gene Families for C1orf74 Gene

Function for C1orf74 Gene

genes like me logo Genes that share phenotypes with C1orf74: view

Animal Model Products

CRISPR Products

miRNA for C1orf74 Gene

miRTarBase miRNAs that target C1orf74

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf74 Gene

Localization for C1orf74 Gene

Subcellular locations from

Jensen Localization Image for C1orf74 Gene COMPARTMENTS Subcellular localization image for C1orf74 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf74 Gene

Pathways & Interactions for C1orf74 Gene

SuperPathways for C1orf74 Gene

No Data Available

Interacting Proteins for C1orf74 Gene

Gene Ontology (GO) - Biological Process for C1orf74 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf74 Gene

Drugs & Compounds for C1orf74 Gene

No Compound Related Data Available

Transcripts for C1orf74 Gene

mRNA/cDNA for C1orf74 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf74 Gene

Chromosome 1 open reading frame 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf74 Gene

No ASD Table

Relevant External Links for C1orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf74 Gene

mRNA expression in normal human tissues for C1orf74 Gene

SOURCE GeneReport for Unigene cluster for C1orf74 Gene Hs.497642

genes like me logo Genes that share expression patterns with C1orf74: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C1orf74 Gene

Orthologs for C1orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C16H1orf74 35
  • 85.8 (n)
  • 84.79 (a)
C1orf74 36
  • 85 (a)
(Canis familiaris)
Mammalia C7H1orf74 35
  • 87.73 (n)
  • 86.99 (a)
C1orf74 36
  • 87 (a)
(Mus musculus)
Mammalia A130010J15Rik 35
  • 82 (n)
  • 79.09 (a)
A130010J15Rik 16
A130010J15Rik 36
  • 79 (a)
(Pan troglodytes)
Mammalia C1H1orf74 35
  • 99.5 (n)
  • 99.26 (a)
C1orf74 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100125367 35
  • 81.5 (n)
  • 77.95 (a)
(Monodelphis domestica)
Mammalia C1orf74 36
  • 63 (a)
(Gallus gallus)
Aves C1ORF74 35
  • 56.24 (n)
  • 47.49 (a)
C1orf74 36
  • 46 (a)
(Anolis carolinensis)
Reptilia C1orf74 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf74 35
  • 49.81 (n)
  • 38.7 (a)
(Danio rerio)
Actinopterygii zgc:112163 35
  • 50.13 (n)
  • 38.28 (a)
C6H1orf74 36
  • 37 (a)
Species with no ortholog for C1orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf74 Gene

Gene Tree for C1orf74 (if available)
Gene Tree for C1orf74 (if available)

Paralogs for C1orf74 Gene

No data available for Paralogs for C1orf74 Gene

Variants for C1orf74 Gene

Sequence variations from dbSNP and Humsavar for C1orf74 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7550857 - 209,783,197(+) CCCTG(A/C/T)AAATG reference, missense
rs34785917 -- 209,785,006(+) TTTTT(-/T)AACTT upstream-variant-2KB
rs17015193 -- 209,784,427(+) TTTGC(G/T)GCTTC utr-variant-5-prime
rs59261422 -- 209,784,814(+) TGCTT(A/C)GCCGA upstream-variant-2KB
rs35501229 -- 209,784,744(+) GGGAA(-/A)GGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf74 Gene

Variant ID Type Subtype PubMed ID
nsv873139 CNV Gain 21882294
nsv4343 CNV Loss 18451855

Variation tolerance for C1orf74 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf74 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf74 Gene

Disorders for C1orf74 Gene

Relevant External Links for C1orf74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf74 Gene

Publications for C1orf74 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. (PMID: 25763542) Hang Q. … Li Y. (Anticancer Drugs 2015) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for C1orf74 Gene

Sources for C1orf74 Gene

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