C1orf74 Gene
protein-coding GIFtS: 36
GCID: GC01M209955 (predicted)
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chromosome 1 open reading frame 74
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Aliases
for C1orf74 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Chromosome 1 Open Reading Frame 741 2 | | FLJ250781 | | UPF0739 Protein C1orf742 |
Export aliases for C1orf74 gene to outside databasesPrevious GC identifers: GC01M206345 GC01M208022 GC01M180630 |
Summaries
for C1orf74 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1orf74 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1orf74 gene promoter:
AhR SRF p53 SRF (504 AA) MIF-1 Arnt CREB POU2F1 POU2F1a ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1orf74
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf74 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.2 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32.2C1orf74 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M209955: view genomic region
(about GC identifiers)
Start:
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209,955,661 bp from pter |
End:
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209,957,904 bp from pter |
Size:
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2,244 bases |
Orientation:
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minus strand |
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Proteins
for C1orf74 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CA074_HUMAN, Q96LT6 (See
protein sequence)Recommended Name: UPF0739 protein C1orf74 Size: 269 amino acids; 29561 Da
Caution: It is uncertain whether Met-1 or Met-7 is the initiatorExplore the universe of human proteins at neXtProt for C1orf74: NX_Q96LT6
C1orf74 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689698.1
ENSEMBL proteins: ENSP00000294811
Human Recombinant Protein Products:
C1orf74 Antibody Products:
Assay Products for C1orf74: |
Protein
Domains /
Families
for C1orf74 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96LT6 UniProtKB/Swiss-Prot: CA074_HUMAN, Q96LT6Similarity: Belongs to the UPF0739 family |
Function
for C1orf74 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf74 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf74 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C1orf74 (NM_152485) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf74 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf74 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf74 |
|
Pathways & Interactions
for C1orf74 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf74
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C1orf74 (ENSP000002948114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for C1orf74 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1orf74
Search CenterWatch for drugs/clinical trials and news about C1orf74 / CA074
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Transcripts
for C1orf74 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1orf74 gene: NM_152485.2 Unigene Cluster for C1orf74: Chromosome 1 open reading frame 74 Hs.497642 [show with all ESTs]Unigene Representative Sequence: NM_1524851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000294811(uc001hhp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf74 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf74 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1orf74 (NM_152485) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf74 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf74 |
Additional cDNA sequence: AK057807.1 BC039719.1 2 DOTS entries: DT.40273725 DT.91651981 24/40 AceView cDNA sequences (see all 40): BM928183 AK057807 CK905015 AA305114 AA923305 AA978280 CR598637 BQ050973 NM_152485 CR599983 BC039719 BX118371 AW591616 AW295407 BM924230 AW591522 BX416671 BQ081919 BX325253 AI809608 BX325252 BM977388 BQ441295 AI818014
GeneLoc Exon Structure
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Expression
for C1orf74 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1orf74 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATATGCC
About this image
See C1orf74 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf74
SOURCE GeneReport for Unigene cluster: Hs.497642
SABiosciences Custom PCR Arrays for C1orf74
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf74
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1orf74 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf74 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf74 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf74 |
Orthologs
for C1orf74 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for C1orf74 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for C1orf74 (if available)
TreeFam Gene Tree for C1orf74 (if available) |
Paralogs
for C1orf74 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C1orf74 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for C1orf74 (209955661 - 209957904 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf74: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for C1orf74 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C1orf74 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1orf74 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf74) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
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External Searches for C1orf74 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C1orf74 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing C1orf74 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1orf74 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1orf74 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C1orf74 gene:
Search GeneIP for patents involving C1orf74
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1orf74 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C1orf74 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf74 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf74 | | | OriGene Protein Over-expression Lysate for C1orf74 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C1orf74 | | OriGene 3'-UTR Clone for C1orf74 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf74 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf74 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C1orf74 | | OriGene Custom Protein Services for C1orf74 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf74 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf74 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf74 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf74 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf74 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf74 |
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| | | | Search Tocris compounds for C1orf74 |
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 | | | C1orf74 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf74 |
|  |  |  | | | | ThermoFisher Antibodies for C1orf74 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf74 |
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