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Aliases for C1orf74 Gene

Aliases for C1orf74 Gene

  • Chromosome 1 Open Reading Frame 74 2 3
  • Up-Regulated In Lung Cancer 4 3
  • UPF0739 Protein C1orf74 3
  • URLC4 3

External Ids for C1orf74 Gene

Previous GeneCards Identifiers for C1orf74 Gene

  • GC01M206345
  • GC01M208022
  • GC01M209955
  • GC01M180630

Summaries for C1orf74 Gene

GeneCards Summary for C1orf74 Gene

C1orf74 (Chromosome 1 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf74 Gene

Genomics for C1orf74 Gene

Regulatory Elements for C1orf74 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C1orf74 Gene

209,779,208 bp from pter
209,784,559 bp from pter
5,352 bases
Minus strand

Genomic View for C1orf74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf74 Gene

Proteins for C1orf74 Gene

  • Protein details for C1orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0739 protein C1orf74
    Protein Accession:
    Secondary Accessions:

    Protein attributes for C1orf74 Gene

    269 amino acids
    Molecular mass:
    29561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf74 Gene

Proteomics data for C1orf74 Gene at MOPED

Post-translational modifications for C1orf74 Gene

No Post-translational modifications

Other Protein References for C1orf74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf74 Gene

Domains for C1orf74 Gene

Protein Domains for C1orf74 Gene


Suggested Antigen Peptide Sequences for C1orf74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0739 family.
  • Belongs to the UPF0739 family.
genes like me logo Genes that share domains with C1orf74: view

No data available for Gene Families for C1orf74 Gene

Function for C1orf74 Gene

Animal Model Products

CRISPR Products

miRNA for C1orf74 Gene

miRTarBase miRNAs that target C1orf74

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1orf74

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf74 Gene

Localization for C1orf74 Gene

Subcellular locations from

Jensen Localization Image for C1orf74 Gene COMPARTMENTS Subcellular localization image for C1orf74 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf74 Gene

Pathways for C1orf74 Gene

SuperPathways for C1orf74 Gene

No Data Available

Interacting Proteins for C1orf74 Gene

Gene Ontology (GO) - Biological Process for C1orf74 Gene


No data available for Pathways by source for C1orf74 Gene

Transcripts for C1orf74 Gene

mRNA/cDNA for C1orf74 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf74 Gene

Chromosome 1 open reading frame 74:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1orf74

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf74 Gene

No ASD Table

Relevant External Links for C1orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf74 Gene

mRNA expression in normal human tissues for C1orf74 Gene

SOURCE GeneReport for Unigene cluster for C1orf74 Gene Hs.497642

genes like me logo Genes that share expressions with C1orf74: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for C1orf74 Gene

Orthologs for C1orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C16H1orf74 35
  • 85.8 (n)
  • 84.79 (a)
C1orf74 36
  • 85 (a)
(Canis familiaris)
Mammalia C7H1orf74 35
  • 87.73 (n)
  • 86.99 (a)
C1orf74 36
  • 87 (a)
(Mus musculus)
Mammalia A130010J15Rik 35
  • 82 (n)
  • 79.09 (a)
A130010J15Rik 16
A130010J15Rik 36
  • 79 (a)
(Pan troglodytes)
Mammalia C1H1orf74 35
  • 99.5 (n)
  • 99.26 (a)
C1orf74 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100125367 35
  • 81.5 (n)
  • 77.95 (a)
(Monodelphis domestica)
Mammalia C1orf74 36
  • 63 (a)
(Gallus gallus)
Aves C1ORF74 35
  • 56.24 (n)
  • 47.49 (a)
C1orf74 36
  • 46 (a)
(Anolis carolinensis)
Reptilia C1orf74 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf74 35
  • 49.81 (n)
  • 38.7 (a)
(Danio rerio)
Actinopterygii zgc:112163 35
  • 50.13 (n)
  • 38.28 (a)
C6H1orf74 36
  • 37 (a)
Species with no ortholog for C1orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf74 Gene

Gene Tree for C1orf74 (if available)
Gene Tree for C1orf74 (if available)

Paralogs for C1orf74 Gene

No data available for Paralogs for C1orf74 Gene

Variants for C1orf74 Gene

Sequence variations from dbSNP and Humsavar for C1orf74 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7550857 - 209,783,197(+) CCCTG(A/C)AAATG reference, missense
rs17015193 -- 209,784,427(+) TTTGC(G/T)GCTTC utr-variant-5-prime
rs34785917 -- 209,785,006(+) TTTTT(-/T)AACTT upstream-variant-2KB
rs35501229 -- 209,784,744(+) GGGAA(-/A)GGGCG upstream-variant-2KB
rs41303289 -- 209,784,565(+) GCGCA(C/T)CCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf74 Gene

Variant ID Type Subtype PubMed ID
nsv873139 CNV Gain 21882294
nsv4343 CNV Loss 18451855

Relevant External Links for C1orf74 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf74 Gene

Disorders for C1orf74 Gene

No disorders were found for C1orf74 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C1orf74 Gene

Publications for C1orf74 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. (PMID: 25763542) Hang Q. … Li Y. (Anticancer Drugs 2015) 3

Products for C1orf74 Gene

Sources for C1orf74 Gene

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