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Aliases for C1orf68 Gene

Aliases for C1orf68 Gene

  • Chromosome 1 Open Reading Frame 68 2 3 5
  • XP32 3 4
  • Skin-Specific Protein (Xp32) 3
  • Skin-Specific Protein 32 2
  • LEP7 3

External Ids for C1orf68 Gene

Previous GeneCards Identifiers for C1orf68 Gene

  • GC01U901169
  • GC01P150958
  • GC01P124065

Summaries for C1orf68 Gene

GeneCards Summary for C1orf68 Gene

C1orf68 (Chromosome 1 Open Reading Frame 68) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf68 Gene

Genomics for C1orf68 Gene

Regulatory Elements for C1orf68 Gene

Genomic Location for C1orf68 Gene

Chromosome:
1
Start:
152,719,522 bp from pter
End:
152,720,470 bp from pter
Size:
949 bases
Orientation:
Plus strand

Genomic View for C1orf68 Gene

Genes around C1orf68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf68 Gene

Proteins for C1orf68 Gene

  • Protein details for C1orf68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T750-XP32_HUMAN
    Recommended name:
    Skin-specific protein 32
    Protein Accession:
    Q5T750
    Secondary Accessions:
    • O14634

    Protein attributes for C1orf68 Gene

    Size:
    250 amino acids
    Molecular mass:
    26238 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB83961.1; Type=Frameshift; Positions=241; Evidence={ECO:0000305};

neXtProt entry for C1orf68 Gene

Proteomics data for C1orf68 Gene at MOPED

Post-translational modifications for C1orf68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf68 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf68 Gene

Domains & Families for C1orf68 Gene

Protein Domains for C1orf68 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf68: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf68 Gene

Function for C1orf68 Gene

Gene Ontology (GO) - Molecular Function for C1orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C1orf68: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf68 Gene

Localization for C1orf68 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf68 Gene COMPARTMENTS Subcellular localization image for C1orf68 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C1orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with C1orf68: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf68 Gene

Pathways & Interactions for C1orf68 Gene

SuperPathways for C1orf68 Gene

No Data Available

Interacting Proteins for C1orf68 Gene

Gene Ontology (GO) - Biological Process for C1orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 9344646
GO:0018149 peptide cross-linking IBA --
genes like me logo Genes that share ontologies with C1orf68: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf68 Gene

Drugs & Compounds for C1orf68 Gene

No Compound Related Data Available

Transcripts for C1orf68 Gene

mRNA/cDNA for C1orf68 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf68 Gene

Chromosome 1 open reading frame 68:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf68 Gene

No ASD Table

Relevant External Links for C1orf68 Gene

GeneLoc Exon Structure for
C1orf68
ECgene alternative splicing isoforms for
C1orf68

Expression for C1orf68 Gene

mRNA expression in normal human tissues for C1orf68 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf68 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x32.4) and Skin - Not Sun Exposed (Suprapubic) (x20.2).

Protein differential expression in normal tissues from HIPED for C1orf68 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (16.4), Bone (11.0), Breast (10.3), and Urinary Bladder (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf68 Gene



SOURCE GeneReport for Unigene cluster for C1orf68 Gene Hs.601077

mRNA Expression by UniProt/SwissProt for C1orf68 Gene

Q5T750-XP32_HUMAN
Tissue specificity: Expressed at high levels in normal and psoriatic skin, but not in normal keratinocytes, A-431 cells, or any of the other cell lines or tissues tested.
genes like me logo Genes that share expression patterns with C1orf68: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for C1orf68 Gene

Orthologs for C1orf68 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf68 35
  • 99.2 (n)
  • 98 (a)
C1orf68 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf68 36
  • 73 (a)
OneToOne
LOC100139483 35
  • 77.68 (n)
  • 72.38 (a)
dog
(Canis familiaris)
Mammalia C17H1orf68 35
  • 82.19 (n)
  • 75.21 (a)
C1orf68 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310050C09Rik 36
  • 69 (a)
OneToOne
2310050C09Rik 16
2310050C09Rik 35
  • 78.06 (n)
  • 75 (a)
rat
(Rattus norvegicus)
Mammalia LOC686143 35
  • 77.22 (n)
  • 75.42 (a)
Species with no ortholog for C1orf68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf68 Gene

ENSEMBL:
Gene Tree for C1orf68 (if available)
TreeFam:
Gene Tree for C1orf68 (if available)

Paralogs for C1orf68 Gene

No data available for Paralogs for C1orf68 Gene

Variants for C1orf68 Gene

Sequence variations from dbSNP and Humsavar for C1orf68 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs873775 -- 152,719,996(-) GTCAG(G/T)GACAC reference, missense
rs1332498 -- 152,717,972(+) TAGAA(C/T)AACCT upstream-variant-2KB
rs1332500 -- 152,719,598(+) GGGTA(C/G)CAATG reference, missense
rs3814352 -- 152,720,472(+) ATGCA(A/T)TTCGT downstream-variant-500B
rs4845468 -- 152,718,602(+) CACTG(A/G)CTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf68 Gene

Variant ID Type Subtype PubMed ID
dgv131e1 CNV Complex 17122850
esv33483 CNV Gain+Loss 17666407
nsv469873 CNV Complex 16826518
nsv509480 CNV Insertion 20534489
esv34854 CNV Gain 17911159
nsv818478 CNV Gain 17921354
essv16576 CNV CNV 17122850

Variation tolerance for C1orf68 Gene

Gene Damage Index Score: 9.01; 87.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf68 Gene

HapMap Linkage Disequilibrium report
C1orf68
Human Gene Mutation Database (HGMD)
C1orf68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf68 Gene

Disorders for C1orf68 Gene

Relevant External Links for C1orf68

Human Genome Epidemiology (HuGE) Navigator
C1orf68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf68

No disorders were found for C1orf68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf68 Gene

Publications for C1orf68 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D. … Byrne C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3
  4. Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. (PMID: 25197941) Kumar V. … Netea M.G. (Nat Commun 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for C1orf68 Gene

Sources for C1orf68 Gene

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