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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf65 Gene

protein-coding   GIFtS: 41
GCID: GC01P223566

Chromosome 1 Open Reading Frame 65

  Search for C1orf65
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 651 2
RP11-76K24.12
Uncharacterized Protein C1orf652

External Ids:    HGNC: 266541   Entrez Gene: 1641272   Ensembl: ENSG000001783957   UniProtKB: Q8N7153   

Export aliases for C1orf65 gene to outside databases

Previous GC identifers: GC01P219939 GC01P221633 GC01P194241


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C1orf65 Gene: 
C1orf65 (chromosome 1 open reading frame 65) is a protein-coding gene. An important paralog of this gene is ENSG00000267909.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf65 gene promoter:
         AML1a   NRSF form 1   CUTL1   NRSF form 2   Evi-1   HEN1   CREB   deltaCREB   SEF-1 (1)   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C1orf65

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf65


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q42.11

C1orf65 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf65 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P223566:  view genomic region     (about GC identifiers)

Start:
223,566,715 bp from pter      End:
223,568,812 bp from pter
Size:
2,098 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CA065_HUMAN, Q8N715 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf65  
Size: 623 amino acids; 72349 Da
Secondary accessions: Q8N746 Q8NA93

Explore the universe of human proteins at neXtProt for C1orf65: NX_Q8N715

Explore proteomics data for C1orf65 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N715

  • C1orf65 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C1orf65 Protein Expression
    REFSEQ proteins: NP_689823.2  
    ENSEMBL proteins: 
     ENSP00000355840  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N715


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf65

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for C1orf65 (Q8N7152, 3 ENSP000003558404) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66907 I2D: score=4 STRING: ENSP00000311695
    KRT15P190122, 3, ENSP000002540434MINT-66812 I2D: score=4 STRING: ENSP00000254043
    PDLIM7Q9NR122, 3, ENSP000003480994MINT-67764 I2D: score=4 STRING: ENSP00000348099
    CALCOCO2Q131372, 3, ENSP000002589474MINT-66108 I2D: score=4 STRING: ENSP00000258947
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66937 I2D: score=4 STRING: ENSP00000377582
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1orf65 (CA065)

    Search CenterWatch for drugs/clinical trials and news about C1orf65 / CA065

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1orf65 gene: 
    NM_152610.2  

    Unigene Cluster for C1orf65:

    Chromosome 1 open reading frame 65
    Hs.192090  [show with all ESTs]
    Unigene Representative Sequence: NM_152610
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366875(uc001hoa.2)
    miRNA
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    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: C1orf65 (NM_152610)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1orf65
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf65
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                         Customized lentivirus expression plasmids for stable overexpression of C1orf65 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf65
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf65

    Additional mRNA sequence: 

    AK093047.1 BC030026.1 BC031066.1 

    1 DOTS entry:

    DT.100010230 

    11 AceView cDNA sequences:

    AX747883 AA922243 NM_152610 BC031066 AK093047 BC030026 BI460921 AW182555 
    BG719211 AW102721 AA432007 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf65 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATAGCT
    C1orf65 Expression
    About this image


    See C1orf65 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf65

    SOURCE GeneReport for Unigene cluster: Hs.192090
        SABiosciences Custom PCR Arrays for C1orf65
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf65

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C1orf65 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4922505E12Rik1 , 5 RIKEN cDNA 4922505E12 gene1, 5 71.19(n)1
    56.79(a)1
      1 (85.92 cM)5
    4333861  NM_001033547.21  NP_001028719.11 
     1827471265 
    lizard
    (Anolis carolinensis)
    Reptilia C1ORF656
    Uncharacterized protein
    33(a)
    1 ↔ 1
    1(182203073-182204176)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-102c2.86
    C13H1orf656
    (see all 3)
    chromosome 1 open reading frame 65
    (see all 3)
    4(a)
    19(a)
    (see all 3)
    possible ortholog
    1 ↔ 1
    (see all 3)
    5(28409790-28428403)
    13(47229746-47231404)
    fruit fly
    (Drosophila melanogaster)
    Insecta Crtp6
    CG67936
    --
    5(a)
    5(a)
    many ↔ many
    many ↔ many
    2R(20382041-20384550)
    3L(12035487-12037317)


    ENSEMBL Gene Tree for C1orf65 (if available)
    TreeFam Gene Tree for C1orf65 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C1orf65 gene
    ENSG000002679092  

    C1orf65 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/160 SNPs in C1orf65 are shown (see all 160)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115799951,2
    C,F,H--223564720(+) CTGGGG/AAAATC 1 -- us2k19Minor allele frequency- A:0.09NS EA NA WA 780
    rs1441716091,2
    --223564893(+) GAATGC/TTATCC 1 -- us2k10--------
    rs1449890631,2
    --223564905(+) GAACTC/GTTTCC 1 -- us2k10--------
    rs1145651621,2
    C,F--223564917(+) CATTGC/AAACCC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1900043181,2
    --223565104(+) CCTCGC/TGTGAC 1 -- us2k10--------
    rs755477901,2
    C,F--223565191(+) CCTAAT/CCACCT 1 -- us2k11Minor allele frequency- C:0.10EA 120
    rs1167416151,2
    F--223565323(+) GGACAC/TGACAG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1490911951,2
    C--223565422(+) TCTGCA/GGAAAT 1 -- us2k10--------
    rs781806841,2
    --223565623(+) ATTTTA/TAAAAT 1 -- us2k10--------
    rs67014531,2
    C,F,H--223565676(+) ctaagT/Gcctgg 1 -- us2k19Minor allele frequency- G:0.07NS EA NA CSA WA 768

    HapMap Linkage Disequilibrium report for C1orf65 (223566715 - 223568812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C1orf65:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4687CNV Loss18451855
    nsv517708CNV Loss19592680
    nsv832670CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C1orf65 for disorders           About MalaCards

    C1orf65 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C1orf65

    Export disorders for C1orf65 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf65 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1orf65)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 164127 HGNC: 26654 AceView: FLJ35728 Ensembl:ENSG00000178395 euGenes: HUgn164127
    ECgene: C1orf65 H-InvDB: C1orf65

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf65 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1orf65 gene:
    Search GeneIP for patents involving C1orf65

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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