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Aliases for C1orf64 Gene

Aliases for C1orf64 Gene

  • Chromosome 1 Open Reading Frame 64 2 3 5
  • ER-Related Factor 2 3
  • Uncharacterized Protein C1orf64 3
  • ERRF 3

External Ids for C1orf64 Gene

Previous GeneCards Identifiers for C1orf64 Gene

  • GC01P016077
  • GC01P016203
  • GC01P016330
  • GC01P014849

Summaries for C1orf64 Gene

GeneCards Summary for C1orf64 Gene

C1orf64 (Chromosome 1 Open Reading Frame 64) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf64 Gene

Genomics for C1orf64 Gene

Regulatory Elements for C1orf64 Gene

Enhancers for C1orf64 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G015947 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.5 -53.1 -53058 7.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF766 FOS DEK ZNF263 HSPB7 CLCNKA PLEKHM2 ZBTB17 LINC01772 ENSG00000233078 SPEN FBLIM1 C1orf64 CLCNKB
GH01G015882 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.4 -118.9 -118924 5.4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SPEN EIF1AXP1 RPL22P3 HSPB7 FLJ37453 ENSG00000237938 LINC01772 SPATA21 FBXO42 CLCNKA
GH01G015829 2 FANTOM5 Ensembl ENCODE dbSUPER 7.3 -170.2 -170236 9.6 CREB3L1 MLX DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 CLCNKA FLJ37453 SPEN ZBTB17 HSPB7 EFHD2 LINC01772 C1orf64 CLCNKB CASP9
GH01G015777 1.2 ENCODE dbSUPER 12.1 -224.4 -224352 4.7 PKNOX1 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF121 ZNF766 REST PPARG FBLIM1 ENSG00000237938 SLC25A34 C1orf64 ARHGEF19 CLCNKB CASP9 RPL12P14
GH01G015974 1.4 ENCODE dbSUPER 9.6 -28.6 -28596 2.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 HSPB7 C1orf64 TBC1D3P6 ENSG00000234607
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf64 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf64 Gene

Chromosome:
1
Start:
16,004,236 bp from pter
End:
16,008,807 bp from pter
Size:
4,572 bases
Orientation:
Plus strand

Genomic View for C1orf64 Gene

Genes around C1orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf64 Gene

Proteins for C1orf64 Gene

  • Protein details for C1orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEQ6-CA064_HUMAN
    Recommended name:
    Uncharacterized protein C1orf64
    Protein Accession:
    Q8NEQ6
    Secondary Accessions:
    • B3KXI9

    Protein attributes for C1orf64 Gene

    Size:
    169 amino acids
    Molecular mass:
    17657 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf64 Gene

Post-translational modifications for C1orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf64 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf64 Gene

Domains & Families for C1orf64 Gene

Protein Domains for C1orf64 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf64: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf64 Gene

Function for C1orf64 Gene

genes like me logo Genes that share phenotypes with C1orf64: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf64 Gene

Localization for C1orf64 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf64 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf64 Gene

Pathways & Interactions for C1orf64 Gene

SuperPathways for C1orf64 Gene

No Data Available

Interacting Proteins for C1orf64 Gene

Selected Interacting proteins: Q8NEQ6-CA064_HUMAN for C1orf64 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for C1orf64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf64 Gene

Drugs & Compounds for C1orf64 Gene

No Compound Related Data Available

Transcripts for C1orf64 Gene

mRNA/cDNA for C1orf64 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf64 Gene

Chromosome 1 open reading frame 64:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf64 Gene

No ASD Table

Relevant External Links for C1orf64 Gene

GeneLoc Exon Structure for
C1orf64
ECgene alternative splicing isoforms for
C1orf64

Expression for C1orf64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf64 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf64 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.2), Brain - Substantia nigra (x4.9), Brain - Spinal cord (cervical c-1) (x4.7), Brain - Caudate (basal ganglia) (x4.7), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for C1orf64 Gene

This gene is overexpressed in Blymphocyte (48.1) and Monocytes (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf64 Gene



Protein tissue co-expression partners for C1orf64 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf64 Gene:

C1orf64

SOURCE GeneReport for Unigene cluster for C1orf64 Gene:

Hs.29190
genes like me logo Genes that share expression patterns with C1orf64: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf64 Gene

Orthologs for C1orf64 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf64 35
  • 99 (a)
OneToOne
C1H1orf64 34
  • 98.62 (n)
cow
(Bos Taurus)
Mammalia C2H1orf64 34 35
  • 71.78 (n)
dog
(Canis familiaris)
Mammalia C1orf64 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm694 34 16 35
  • 64.4 (n)
rat
(Rattus norvegicus)
Mammalia RGD1566083 34
  • 64.36 (n)
Species where no ortholog for C1orf64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf64 Gene

ENSEMBL:
Gene Tree for C1orf64 (if available)
TreeFam:
Gene Tree for C1orf64 (if available)

Paralogs for C1orf64 Gene

No data available for Paralogs for C1orf64 Gene

Variants for C1orf64 Gene

Sequence variations from dbSNP and Humsavar for C1orf64 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035491 A breast cancer sample
VAR_035492 A breast cancer sample
rs1000173300 -- 16,005,062(+) AGCGG(G/T)GGGAT intron-variant
rs1000775103 -- 16,004,049(+) ATAGT(A/G)TCTGT upstream-variant-2KB
rs1001083012 -- 16,003,790(+) CACCC(A/G)TCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf64 Gene

Variant ID Type Subtype PubMed ID
nsv508936 CNV insertion 20534489
nsv517651 CNV gain+loss 19592680
nsv520148 CNV loss 19592680
nsv524045 CNV loss 19592680
nsv545627 CNV loss 21841781
nsv833758 CNV gain+loss 17160897
nsv997887 CNV gain 25217958

Variation tolerance for C1orf64 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf64 Gene

Disorders for C1orf64 Gene

Relevant External Links for C1orf64

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf64

No disorders were found for C1orf64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf64 Gene

Publications for C1orf64 Gene

  1. ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells. (PMID: 27125460) Luo A. … Zhang X. (Biochem. Biophys. Res. Commun. 2016) 2 3 64
  2. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. (PMID: 22341523) Su D. … Dong J.T. (Am. J. Pathol. 2012) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for C1orf64 Gene

Sources for C1orf64 Gene

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