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Aliases for C1orf64 Gene

Aliases for C1orf64 Gene

  • Chromosome 1 Open Reading Frame 64 2 3 5
  • ER-Related Factor 2 3
  • ERRF 3

External Ids for C1orf64 Gene

Previous GeneCards Identifiers for C1orf64 Gene

  • GC01P016077
  • GC01P016203
  • GC01P016330
  • GC01P014849

Summaries for C1orf64 Gene

GeneCards Summary for C1orf64 Gene

C1orf64 (Chromosome 1 Open Reading Frame 64) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf64 Gene

Genomics for C1orf64 Gene

Regulatory Elements for C1orf64 Gene

Enhancers for C1orf64 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C1orf64 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf64 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf64 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf64 Gene

Chromosome:
1
Start:
16,004,236 bp from pter
End:
16,008,807 bp from pter
Size:
4,572 bases
Orientation:
Plus strand

Genomic View for C1orf64 Gene

Genes around C1orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf64 Gene

Proteins for C1orf64 Gene

  • Protein details for C1orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEQ6-CA064_HUMAN
    Recommended name:
    Uncharacterized protein C1orf64
    Protein Accession:
    Q8NEQ6
    Secondary Accessions:
    • B3KXI9

    Protein attributes for C1orf64 Gene

    Size:
    169 amino acids
    Molecular mass:
    17657 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf64 Gene

Proteomics data for C1orf64 Gene at MOPED

Post-translational modifications for C1orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf64 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C1orf64 Gene

Domains & Families for C1orf64 Gene

Protein Domains for C1orf64 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf64: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf64 Gene

Function for C1orf64 Gene

genes like me logo Genes that share phenotypes with C1orf64: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf64 Gene

Localization for C1orf64 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf64 Gene COMPARTMENTS Subcellular localization image for C1orf64 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf64 Gene

Pathways & Interactions for C1orf64 Gene

SuperPathways for C1orf64 Gene

No Data Available

Interacting Proteins for C1orf64 Gene

Gene Ontology (GO) - Biological Process for C1orf64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf64 Gene

Drugs & Compounds for C1orf64 Gene

No Compound Related Data Available

Transcripts for C1orf64 Gene

mRNA/cDNA for C1orf64 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf64 Gene

Chromosome 1 open reading frame 64:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf64 Gene

No ASD Table

Relevant External Links for C1orf64 Gene

GeneLoc Exon Structure for
C1orf64
ECgene alternative splicing isoforms for
C1orf64

Expression for C1orf64 Gene

mRNA expression in normal human tissues for C1orf64 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf64 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.2), Brain - Substantia nigra (x4.9), Brain - Spinal cord (cervical c-1) (x4.7), Brain - Caudate (basal ganglia) (x4.7), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for C1orf64 Gene

This gene is overexpressed in Blymphocyte (48.1) and Monocytes (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf64 Gene



SOURCE GeneReport for Unigene cluster for C1orf64 Gene Hs.29190

genes like me logo Genes that share expression patterns with C1orf64: view

Protein tissue co-expression partners for C1orf64 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C1orf64 Gene

Orthologs for C1orf64 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf64 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C2H1orf64 35
  • 71.78 (n)
  • 60.74 (a)
C2H1orf64 36
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm694 35
  • 64.4 (n)
  • 45.68 (a)
Gm694 16
Gm694 36
  • 45 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf64 35
  • 98.62 (n)
  • 98.82 (a)
C1orf64 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566083 35
  • 64.36 (n)
  • 47.69 (a)
dog
(Canis familiaris)
Mammalia C1orf64 36
  • 68 (a)
OneToOne
Species with no ortholog for C1orf64:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf64 Gene

ENSEMBL:
Gene Tree for C1orf64 (if available)
TreeFam:
Gene Tree for C1orf64 (if available)

Paralogs for C1orf64 Gene

No data available for Paralogs for C1orf64 Gene

Variants for C1orf64 Gene

Sequence variations from dbSNP and Humsavar for C1orf64 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34950166 - 16,006,170(+) TGCCG(C/T)TCTGC reference, missense
VAR_035491 A breast cancer sample
VAR_035492 A breast cancer sample
rs1739831 -- 16,003,062(+) ttaca(A/C)aggag upstream-variant-2KB
rs1739832 -- 16,003,745(+) TCACC(A/G)TGTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf64 Gene

Variant ID Type Subtype PubMed ID
nsv871162 CNV Gain 21882294
nsv508936 CNV Insertion 20534489
dgv174n71 CNV Loss 21882294
nsv833758 CNV Gain+Loss 17160897
nsv871695 CNV Loss 21882294
nsv517651 CNV Gain+Loss 19592680
dgv175n71 CNV Gain 21882294
dgv176n71 CNV Loss 21882294
nsv520148 CNV Loss 19592680
nsv871485 CNV Loss 21882294
nsv524045 CNV Loss 19592680

Variation tolerance for C1orf64 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf64 Gene

HapMap Linkage Disequilibrium report
C1orf64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf64 Gene

Disorders for C1orf64 Gene

Relevant External Links for C1orf64

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf64

No disorders were found for C1orf64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf64 Gene

Publications for C1orf64 Gene

  1. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. (PMID: 22341523) Su D. … Dong J.T. (Am. J. Pathol. 2012) 2 3 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C1orf64 Gene

Sources for C1orf64 Gene

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