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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf63 Gene

protein-coding   GIFtS: 43
GCID: GC01M025568

chromosome 1 open reading frame 63

  Search for C1orf63
in our new
 Human Malady Compendium 
Biological research products
for C1orf63
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 631 2
DJ465N24.2.11 2
NPD0142
RP3-465N24.42
UPF0471 Protein C1orf632

External Ids:    HGNC: 252341   Entrez Gene: 570352   Ensembl: ENSG000001176167   UniProtKB: Q9BUV03   

Export aliases for C1orf63 gene to outside databases

Previous GC identifers: GC01M025315 GC01M025441 GC01M023822


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf63 gene promoter:
         NF-1   NF-1/L   AML1a   Pax-6   MyoD   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC1orf63 promoter sequence
   Search SABiosciences Chromatin IP Primers for C1orf63

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13-p35.1   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.13-p35.1

C1orf63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf63 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M025568:  view genomic region     (about GC identifiers)

Start:
25,568,728 bp from pter      End:
25,664,704 bp from pter
Size:
95,977 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CA063_HUMAN, Q9BUV0 (See protein sequence)
Recommended Name: UPF0471 protein C1orf63  
Size: 290 amino acids; 33613 Da
Secondary accessions: A8K917 Q49AA4 Q5TH71 Q9GZP6
Alternative splicing: 3 isoforms:  Q9BUV0-1   Q9BUV0-2   Q9BUV0-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for C1orf63: NX_Q9BUV0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUV0

  • C1orf63 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064713.3  
    ENSEMBL proteins: 
     ENSP00000243189   ENSP00000454463   ENSP00000455127   ENSP00000457195   ENSP00000457582  
     ENSP00000454590   ENSP00000456995   ENSP00000458042   ENSP00000411631   ENSP00000391510  

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    Uscn Proteins for C1orf63


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    Uscn Antibodies for C1orf63
    Search ThermoFisher Antibodies for C1orf63

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    Uscn ELISAs and CLIAs for C1orf63


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9BUV0

    UniProtKB/Swiss-Prot: CA063_HUMAN, Q9BUV0
    Similarity: Belongs to the UPF0471 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: C1orf63
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C1orf63
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate C1orf63 (see all 17):
    hsa-miR-300 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidC1orf63 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf63 (see all 4)
    OriGene shRNA RFP: C1orf63
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf63 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf63

    3 GenomeRNAi human phenotypes for C1orf63:
     Decreased homologous recombina  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf63

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for C1orf63 (Q9BUV02, 3 ENSP000002431894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLK3P497612, 3MINT-66690 I2D: score=5 
    --ENSP000003915184STRING: ENSP00000391518
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1orf63
    Search CenterWatch for drugs/clinical trials and news about C1orf63 / CA063 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1orf63 gene (2 alternative transcripts): 
    NM_207035.1  NM_020317.3  

    Unigene Cluster for C1orf63:

    Chromosome 1 open reading frame 63
    Hs.259412  [show with all ESTs]
    Unigene Representative Sequence: AK226012
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000243189(uc001bjw.3) ENST00000569495 ENST00000498238(uc021oji.1)
    ENST00000566395 ENST00000565733 ENST00000568254 ENST00000473314(uc021ojj.1)
    ENST00000570063 ENST00000564223 ENST00000475766 ENST00000491378 ENST00000568212
    ENST00000568701 ENST00000561867 ENST00000568996 ENST00000450820 ENST00000568399
    ENST00000562018

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C1orf63
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate C1orf63 (see all 17):
    hsa-miR-300 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidC1orf63 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf63 (see all 4)
    OriGene shRNA RFP: C1orf63
    OriGene siRNA: C1orf63
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf63
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf63 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf63
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: C1orf63 (NM_020317)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf63
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    Additional cDNA sequence: 

    AF247168.1 AK027318.1 AK226012.1 AK296798.1 BC001892.1 BC065040.1 

    18 DOTS entries:

    DT.100036430  DT.92444561  DT.92444573  DT.97761901  DT.100670250  DT.121396632  DT.95163776  DT.95163773 
    DT.100796109  DT.100796110  DT.100796112  DT.121396671  DT.121396497  DT.100796115  DT.100009410  DT.100796111 
    DT.121396597  DT.95362469 

    24/414 AceView cDNA sequences (see all 414):

    AI573203 BU752440 BM017679 AI521650 AI274256 AI094144 AI697644 CD723923 
    CB162740 BM978513 CR598998 AA452803 BG776566 BP360014 NM_020317 T35157 
    CA413250 AA405426 AI681349 AI744487 BF432966 AA227678 CN483760 BM127333 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf63 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                          -     -     -     -     -     -     -     -     -     -     -                                   -                           
    SP2:                                                                                                                          -     -     -               
    SP3:                                                                                                                                                      
    SP4:                                                                                      -     -     -                                                   
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for C1orf63

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf63 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACTGCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    C1orf63 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordOvarian Somatic CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C1orf63 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf63

    SOURCE GeneReport for Unigene cluster: Hs.259412
        SABiosciences Custom PCR Arrays for C1orf63
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf63

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for C1orf63 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008587851 uncharacterized LOC100858785 61.44(n)
    64.22(a)
      100858785  XM_003643659.1  XP_003643707.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1364741 zgc:136474 43.76(n)
    41.7(a)
      724003  NM_001045308.1  NP_001038773.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C04G2.86
    T27A3.46
    (see all 3)
    --
    9(a)
    8(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    IV(10110326-10111556)
    I(6098979-6099728)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G369806
    splicing factor, arginine/serine-rich 16
    3(a)
    1 → many
    4(17433601-17437069)
    rice
    (Oryza sativa)
    Liliopsida --
    splicing factor, arginine/serine-rich 16, putative...
    2(a)
    1 → many
    3(15985072-15991482)


    ENSEMBL Gene Tree for C1orf63 (if available)
    TreeFam Gene Tree for C1orf63 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C1orf63 gene
    CLASRP2  RSRC12  SON2  

    C1orf63 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/150 NCBI SNPs in C1orf63 are shown (see all 150    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117098671,2
    C,--25568348(+) AGATCA/GCACCA 1 -- int12Minor allele frequency- G:0.25WA CSA 4
    rs743896231,2
    C,--25568360(+) TGCACT/GCCATC 1 -- int12Minor allele frequency- G:0.02NA 122
    rs1410820851,2
    --25568361(+) GCACTC/GCATCT 1 -- int10--------
    rs728850501,2
    C,F,--25568386(+) ACTTAG/CAATGC 1 -- int15Minor allele frequency- C:0.22WA CSA 125
    rs1469418961,2
    --25568461(+) CCTCCC/TCTTTC 1 -- int10--------
    rs1921924031,2
    --25568889(+) CATCTA/GTGCTA 1 -- ut310--------
    rs1831202291,2
    --25568894(+) GTGCTA/CTCTCT 1 -- ut310--------
    rs1878886531,2
    --25568966(+) TGTTGA/GTTTTT 1 -- ut310--------
    rs1926394701,2
    --25569025(+) AAACAA/CTAACT 1 -- ut310--------
    rs2015893141,2
    --25569042(+) AAAGTA/GCAGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C1orf63 (25568728 - 25664704 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for C1orf63
         4 CNVs: 0381 34801 2047 0680

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf63
    DNA2.0 Custom Variant and Variant Library Synthesis for C1orf63

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf63 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1orf63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Complement receptor 1 gene variants are associated wi th erythrocyte sedimentation rate. (PubMed id 21700265)1 Kullo I.J....Chute C.G. (2011)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57035 HGNC: 25234 AceView: NPD014 Ensembl:ENSG00000117616 euGenes: HUgn57035
    ECgene: C1orf63 H-InvDB: C1orf63

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf63 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1orf63 gene:
    Search GeneIP for patents involving C1orf63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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