C1orf63 Gene
protein-coding GIFtS : 43
GCID: GC01 M025568
chromosome 1 open reading frame 63
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Aliasesfor C1orf63 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 1 Open Reading Frame 63 1 2 DJ465N24.2.11 2 NPD0142 RP3-465N24.42 UPF0471 Protein C1orf632
Export aliases for C1orf63 gene to outside databases Previous GC identifers: GC01M025315 GC01M025441 GC01M023822
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Summariesfor C1orf63 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor C1orf63 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004610.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C1orf63 gene promoter: NF-1 NF-1/L AML1a Pax-6 MyoD STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for C1orf63 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C1orf63
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36.13-p35.1 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.13-p35.1 C1orf63 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M025568: view genomic region
(about GC identifiers )
Start:
25,568,728 bp from pter
End:
25,664,704 bp from pter
Size:
95,977 bases
Orientation:
minus strand
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Proteinsfor C1orf63 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
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ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CA063_HUMAN, Q9BUV0 (See
protein sequence )Recommended Name: UPF0471 protein C1orf63 Size : 290 amino acids; 33613 Da
Secondary accessions : A8K917 Q49AA4 Q5TH71 Q9GZP6Alternative splicing : 3 isoforms : Q9BUV0-1 Q9BUV0-2 Q9BUV0-3 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for C1orf63: NX_Q9BUV0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BUV0 C1orf63 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_064713.3 ENSEMBL proteins: ENSP00000243189 ENSP00000454463 ENSP00000455127 ENSP00000457195 ENSP00000457582 ENSP00000454590 ENSP00000456995 ENSP00000458042 ENSP00000411631 ENSP00000391510 Human Recombinant Protein Products: C1orf63 Antibody Products: Assay Products for C1orf63:
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Protein
Domains / Familiesfor C1orf63 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9BUV0
UniProtKB/Swiss-Prot: CA063_HUMAN, Q9BUV0 Similarity : Belongs to the UPF0471 family
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Functionfor C1orf63 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C1orf63 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C1orf63OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C1orf63 (NM_020317 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf63 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C1orf63
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf63
3 GenomeRNAi human phenotypes for C1orf63 :
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Pathways & Interactionsfor C1orf63 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf63 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for C1orf63 (Q9BUV0 2 , 3 ENSP00000243189 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor C1orf63 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C1orf63 Search CenterWatch for drugs/clinical trials and news about C1orf63 / CA063
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Transcriptsfor C1orf63 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for C1orf63 gene (2 alternative transcripts): NM_207035.1 NM_020317.3 Unigene Cluster for C1orf63:
Chromosome 1 open reading frame 63 Hs.259412 [show with all ESTs ] Unigene Representative Sequence: AK226012 18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23 ): ENST00000243189 (uc001bjw.3 ) ENST00000569495 ENST00000498238 (uc021oji.1 )ENST00000566395 ENST00000565733 ENST00000568254 ENST00000473314 (uc021ojj.1 )ENST00000570063 ENST00000564223 ENST00000475766 ENST00000491378 ENST00000568212 ENST00000568701 ENST00000561867 ENST00000568996 ENST00000450820 ENST00000568399 ENST00000562018 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C1orf63 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C1orf63OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C1orf63 (NM_020317 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf63 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C1orf63
Additional cDNA sequence: AF247168.1 AK027318.1 AK226012.1 AK296798.1 BC001892.1 BC065040.1
18 DOTS entries : DT.100036430 DT.92444561
DT.92444573 DT.97761901 DT.100670250 DT.121396632 DT.95163776 DT.95163773 DT.100796109 DT.100796110 DT.100796112 DT.121396671 DT.121396497 DT.100796115 DT.100009410 DT.100796111 DT.121396597 DT.95362469 24/414 AceView cDNA sequences (see all 414 ):
AI573203 BU752440 BM017679 AI521650 AI274256 AI094144 AI697644 CD723923 CB162740 BM978513 CR598998 AA452803 BG776566 BP360014 NM_020317 T35157 CA413250 AA405426 AI681349 AI744487 BF432966 AA227678 CN483760 BM127333 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf63 (see all 11 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 SP1 :         -   -   -   -   -   -   -   -   -   -   -             -           SP2 :                                         -   -   -       SP3 :                                                   SP4 :                             -   -   -                   SP5 :                                                  
ECgene alternative splicing isoforms for C1orf63
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Expression for C1orf63 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C1orf63 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAACTGCAC
About this image C1orf63 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Ovigerous Cord Ovarian Somatic Cells Ovary Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See C1orf63 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C1orf63 SOURCE GeneReport for Unigene cluster: Hs.259412 SABiosciences Custom PCR Arrays for C1orf63 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C1orf63Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C1orf63 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C1orf63 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C1orf63 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf63
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Orthologsfor C1orf63 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for C1orf63 gene from 5/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for C1orf63 (if available)TreeFam Gene Tree for C1orf63 (if available)
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Paralogsfor C1orf63 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for C1orf63 gene CLASRP 2 RSRC1 2 SON 2
C1orf63 for paralogs About GeneDecksing
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Genomic Variantsfor C1orf63 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C1orf63 (25568728 - 25664704 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for C1orf63 4 CNVs : 0381 34801 2047 0680
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C1orf63
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Disorders
/ Diseasesfor C1orf63 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor C1orf63 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C1orf63 gene integrated from 9 sources : (articles sorted by number of sources associating them with C1orf63) Utopia : connect your pdf to the dynamic world of online information
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Complement receptor 1 gene variants are associated wi th erythrocyte sedimentation rate. (PubMed id 21700265) 1 Kullo I.J....Chute C.G. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 1 Maruyama K. and Sugano S. (1994)
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External Searches for C1orf63 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C1orf63 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C1orf63 gene
(According to HUGE )
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Specialized Databases showing C1orf63 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C1orf63 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C1orf63 gene: Search GeneIP for patents involving C1orf63 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C1orf63 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C1orf63 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C1orf63 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C1orf63 OriGene Protein Over-expression Lysate for C1orf63 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C1orf63 OriGene 3'-UTR Clone for C1orf63 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C1orf63 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C1orf63 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C1orf63 OriGene Custom Protein Services for C1orf63 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf63 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C1orf63 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C1orf63 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C1orf63 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C1orf63 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C1orf63
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C1orf63 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf63
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C1orf63
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Aliases for C1orf63
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