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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1orf61 Gene

protein-coding GIFtS: 41
GCID: GC01M156374

chromosome 1 open reading frame 61

Explore 2 diseases affiliated with
C1orf61 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 1 Open Reading Frame 61¹ ²		Protein CROC-4²
CROC4¹ ² ³		Transcriptional Activator Of The C Fos Promoter²
Contingent Replication Of CDNA 4² ³		Transcriptional Activator Of The C-Fos Promoter²
Contingent Replication Of CDNA-4²

External Ids:	HGNC: 30780¹	Entrez Gene: 10485²	Ensembl: ENSG00000125462⁷	UniProtKB: Q13536³

ORGUL members:
	NONCODE:n338286

Export aliases for C1orf61 gene to outside databases

Previous GC identifers: GC01M153188 GC01M154640 GC01M127734

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CROC4_HUMAN, Q13536

Function: May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes

transcription of the FOS promoter

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1orf61 gene promoter:
Max1 Olf-1 Arnt HNF-4alpha1 MZF-1 S8 c-Rel ARP-1 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C1orf61

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf61

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22

C1orf61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf61 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M156374: view genomic region (about GC identifiers)

Start:	156,374,044 bp from pter	End:	156,400,493 bp from pter
Size:	26,450 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CROC4_HUMAN, Q13536 (See protein sequence)

Recommended Name: Protein CROC-4

Size: 156 amino acids; 17231 Da

Subcellular location: Nucleus. Note=Associates within the nuclear transcriptional apparatus during proliferation and

differentiation

Sequence caution: Sequence=CAI12173.1; Type=Erroneous gene model prediction; Sequence=CAI12175.1; Type=Erroneous gene

model prediction;

Secondary accessions: B1ALL5 B1ALL8

Explore the universe of human proteins at neXtProt for C1orf61: NX_Q13536

C1orf61 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_006356.1

ENSEMBL proteins:

ENSP00000383776 ENSP00000357225 ENSP00000310651 ENSP00000357226 ENSP00000350661

Human Recombinant Protein Products for C1orf61:

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	Uscn Proteins for C1orf61

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

C1orf61 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q13536

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CROC4_HUMAN, Q13536

Function: May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes

transcription of the FOS promoter

Phenotypes:
1 GenomeRNAi human phenotype for C1orf61:

Increased cell number in G2M,

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for C1orf61

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C1orf61

1 Interacting protein for C1orf61 (Q13536³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK5	Q00535³	I2D: score=2

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C1orf61
Search CenterWatch for drugs/clinical trials and news about C1orf61 / CROC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for C1orf61 gene:

NM_006365.1

Unigene Cluster for C1orf61:

Chromosome 1 open reading frame 61

Hs.380027 [show with all ESTs]

Unigene Representative Sequence: AK124566

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000400991 ENST00000368242 ENST00000471156 ENST00000497824(uc001fov.1 uc001fow.1 uc001fox.1)

ENST00000465270 ENST00000488498 ENST00000462458 ENST00000486517 ENST00000465570

ENST00000310027 ENST00000368243(uc001fou.1) ENST00000498346 ENST00000497822

ENST00000492750 ENST00000357975 ENST00000464238 ENST00000482932 ENST00000489918

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate C1orf61:
		hsa-miR-924
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Additional cDNA sequence:

AK091014.1 AK094493.1 AK095626.1 AK124566.1 AK124870.1 BC010558.1 BC016405.1 BC016978.1

BC043285.1 BC050448.1 BC050741.1 BC054045.1 BC059943.1 BC065916.1 BC107686.1 BC128199.1

BC128200.1 BC141918.1 BC141919.1 U49857.1

24 DOTS entries:

DT.95126609 DT.40107395 DT.95126602 DT.99939234 DT.40284009 DT.95126586 DT.117971 DT.92070426

DT.95262004 DT.121327860 DT.100678872 DT.101965733 DT.91758170 DT.100791255 DT.91758187 DT.95126588

DT.121327840 DT.40107394 DT.86838378 DT.91758177 DT.95126585 DT.100665815 DT.92001708 DT.95126599

24/236 AceView cDNA sequences (see all 236):

AW205953 BF223615 AL535057 AI205510 AI635555 BU726413 AI351742 AV727950

T34365 AI825197 BU733179 BF531078 AA984636 U49857 BI824013 BF530642

AW157623 CR600735 H51362 BC059943 Z45150 T33017 BM931742 Z45079

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf61 (see all 22) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d	·	12e	^
SP1:																					-		-		-		-		-		-		-				-						-		-		-		-		-
SP2:																											-		-				-		-		-												-		-
SP3:																															-		-		-		-						-		-		-		-		-
SP4:			-				-
SP5:																					-		-		-		-		-		-		-		-		-						-		-		-		-		-

ExUns:	13	^	14a	·	14b	·	14c	^	15a	·	15b	^	16a	·	16b	·	16c	·	16d	·	16e	·	16f	·	16g	·	16h
SP1:	-						-
SP2:	-
SP3:	-						-
SP4:
SP5:	-						-		-		-

ECgene alternative splicing isoforms for C1orf61

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1orf61 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCCCATAT

About this image

C1orf61 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for C1orf61

SOURCE GeneReport for Unigene cluster: Hs.380027

UniProtKB/Swiss-Prot: CROC4_HUMAN, Q13536

Tissue specificity: Expressed throughout the brain in the thalamus, subthalamic nucleus, corpus callosum, hippocampus,

substantia nigra, caudate nucleus, and amygdala

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for C1orf61 (if available)
TreeFam Gene Tree for C1orf61 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114394953^1,2	F	--	156373560(+)	`TGAGGG/TTGGAC`	1	--	ds500¹		1		WA	118
rs112336144^1,2		--	156373565(+)	`GTGGAG/CAGAGA`	1	--	ds500¹		1		CSA	2
rs16837368^1,2	C,F,H	--	156373583(+)	`GGAATG/AGAAGA`	1	--	ds500¹		17		NA NS EA WA CSA	1466
rs146812400^1,2		--	156373810(+)	`CTGACA/CGGATC`	1	--	ds500¹		0	--	--	--	--
rs140681515^1,2		--	156373811(+)	`TGACCA/GGATCA`	1	--	ds500¹		0	--	--	--	--
rs115917110^1,2		--	156373817(+)	`GATCAC/TGGATG`	1	--	ds500¹		1		WA	118
rs114537022^1,2	F	--	156373880(+)	`TCACCG/ACCCCA`	1	--	ds500¹		1		WA	118
rs61165186^1,2	C	--	156373887(+)	`CCCACC/TCCCTA`	1	--	ds500¹		2		WA	120
rs55870931^1,2	C	--	156374016(+)	`TCCAAC/ACCTGT`	1	--	ds500¹		1		WA	2
rs3431^1,2	C,F,A,H	--	156374256(+)	`CCCCAC/TTTCAT`	1	--	ut3¹		25		MN NS EA NA WA CSA	2923

HapMap Linkage Disequilibrium report for C1orf61 (156374044 - 156400493 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf61: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C1orf61 for disorders About GeneDecksing

2 diseases for C1orf61: About MalaCards

corpus callosum neuronitis

Export disorders for C1orf61 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1orf61 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf61)

Utopia: connect your pdf to the dynamic
world of online information

CROC-4: a novel brain specific transcriptional activator of c-fos expressed from proliferation through to maturation of multiple neuronal cell types. (PubMed id 10995546)^{1, 2, 3} Jeffrey P.L.... Lin S.L. (2000)
Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. (PubMed id 19922823)^{1, 3} Reppe S....Gautvik K.M. (2010)
C1orf61 acts as a tumor activator in human hepatocellu lar carcinoma and is associated with tumorigenesis and metastasis. (PubMed id 23012322)¹ Hu H.M....Li W. (2013)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (2012)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10485	HGNC: 30780	AceView: CROC4	Ensembl:ENSG00000125462	euGenes: HUgn10485
ECgene: C1orf61	H-InvDB: C1orf61

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1orf61	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C1orf61 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C1orf61 gene:
Search GeneIP for patents involving C1orf61

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf61
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf61

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C1orf61 gene at Home site.

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C1orf61 Gene

chromosome 1 open reading frame 61

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C1orf61 Gene

chromosome 1 open reading frame 61

Aliasesfor C1orf61 gene

Summariesfor C1orf61 gene

Genomic Viewsfor C1orf61 gene

Proteinsfor C1orf61 gene

Protein Domains /Familiesfor C1orf61 gene

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for C1orf61 gene

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