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Aliases for C1orf61 Gene

Aliases for C1orf61 Gene

  • Chromosome 1 Open Reading Frame 61 2 3 5
  • Transcriptional Activator Of The C Fos Promoter 2 3
  • Contingent Replication Of CDNA-4 2 3
  • Contingent Replication Of CDNA 4 3 4
  • CROC4 3 4
  • Transcriptional Activator Of The C-Fos Promoter 3

External Ids for C1orf61 Gene

Previous GeneCards Identifiers for C1orf61 Gene

  • GC01M153188
  • GC01M154640
  • GC01M156374
  • GC01M127734

Summaries for C1orf61 Gene

GeneCards Summary for C1orf61 Gene

C1orf61 (Chromosome 1 Open Reading Frame 61) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C1orf61 Gene

  • May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf61 Gene

Genomics for C1orf61 Gene

Regulatory Elements for C1orf61 Gene

Enhancers for C1orf61 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C1orf61 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf61 Gene

Chromosome:
1
Start:
156,404,250 bp from pter
End:
156,434,325 bp from pter
Size:
30,076 bases
Orientation:
Minus strand

Genomic View for C1orf61 Gene

Genes around C1orf61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf61 Gene

Proteins for C1orf61 Gene

  • Protein details for C1orf61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13536-CROC4_HUMAN
    Recommended name:
    Protein CROC-4
    Protein Accession:
    Q13536
    Secondary Accessions:
    • B1ALL5
    • B1ALL8

    Protein attributes for C1orf61 Gene

    Size:
    156 amino acids
    Molecular mass:
    17231 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C1orf61 Gene

Proteomics data for C1orf61 Gene at MOPED

Post-translational modifications for C1orf61 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C1orf61 Gene

Domains & Families for C1orf61 Gene

Protein Domains for C1orf61 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf61: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf61 Gene

Function for C1orf61 Gene

Molecular function for C1orf61 Gene

UniProtKB/Swiss-Prot Function:
May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.
genes like me logo Genes that share phenotypes with C1orf61: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf61 Gene

Localization for C1orf61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf61 Gene

Nucleus. Note=Associates within the nuclear transcriptional apparatus during proliferation and differentiation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf61 Gene COMPARTMENTS Subcellular localization image for C1orf61 gene
Compartment Confidence
nucleus 4
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for C1orf61 Gene

Pathways & Interactions for C1orf61 Gene

SuperPathways for C1orf61 Gene

No Data Available

Interacting Proteins for C1orf61 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357226%0d%0a9606.ENSP00000419782%0d%0a
Selected Interacting proteins: ENSP00000357226 Q13536-CROC4_HUMAN for C1orf61 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C1orf61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf61 Gene

Drugs & Compounds for C1orf61 Gene

No Compound Related Data Available

Transcripts for C1orf61 Gene

Unigene Clusters for C1orf61 Gene

Chromosome 1 open reading frame 61:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf61 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - -
SP17: -
SP18: - - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - -
SP21: - - - - -
SP22: - - - - - - - - - - - - - - - - -

ExUns: 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g · 16h
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - -
SP8:
SP9: - - - - - -
SP10:
SP11: - - - - - -
SP12: -
SP13: - - - - - -
SP14: - - - - - -
SP15:
SP16: -
SP17:
SP18: - - - - - -
SP19: - - - - - -
SP20: - - - - - -
SP21: - - - - - -
SP22: - - - - - -

Relevant External Links for C1orf61 Gene

GeneLoc Exon Structure for
C1orf61
ECgene alternative splicing isoforms for
C1orf61

Expression for C1orf61 Gene

mRNA expression in normal human tissues for C1orf61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf61 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x5.8), Brain - Amygdala (x5.8), Brain - Putamen (basal ganglia) (x5.8), Brain - Substantia nigra (x4.6), and Brain - Hippocampus (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf61 Gene



SOURCE GeneReport for Unigene cluster for C1orf61 Gene Hs.380027

mRNA Expression by UniProt/SwissProt for C1orf61 Gene

Q13536-CROC4_HUMAN
Tissue specificity: Expressed throughout the brain in the thalamus, subthalamic nucleus, corpus callosum, hippocampus, substantia nigra, caudate nucleus, and amygdala.
genes like me logo Genes that share expression patterns with C1orf61: view

Protein tissue co-expression partners for C1orf61 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for C1orf61 Gene

Orthologs for C1orf61 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C1orf61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf61 35
  • 89.38 (n)
  • 87.91 (a)
C1orf61 36
  • 99 (a)
OneToOne
Species with no ortholog for C1orf61:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf61 Gene

ENSEMBL:
Gene Tree for C1orf61 (if available)
TreeFam:
Gene Tree for C1orf61 (if available)

Paralogs for C1orf61 Gene

No data available for Paralogs for C1orf61 Gene

Variants for C1orf61 Gene

Sequence variations from dbSNP and Humsavar for C1orf61 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3431 -- 156,404,464(+) CCCCA(C/T)TTCAT utr-variant-3-prime
rs2296373 -- 156,416,995(-) TGTGC(A/G)GAAAA intron-variant
rs2025579 -- 156,435,245(-) CAGCA(C/T)ACATA upstream-variant-2KB
rs3032849 -- 156,435,353(+) gtgtg(-/TGTG)atatt upstream-variant-2KB
rs4661168 -- 156,404,926(+) CGTCC(A/G)GCCAA intron-variant

Variation tolerance for C1orf61 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf61 Gene

HapMap Linkage Disequilibrium report
C1orf61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C1orf61 Gene

Disorders for C1orf61 Gene

Relevant External Links for C1orf61

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf61

No disorders were found for C1orf61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf61 Gene

Publications for C1orf61 Gene

  1. CROC-4: a novel brain specific transcriptional activator of c-fos expressed from proliferation through to maturation of multiple neuronal cell types. (PMID: 10995546) Jeffrey P.L. … Lin S.L. (Mol. Cell. Neurosci. 2000) 2 3 4 67
  2. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. (PMID: 23012322) Hu H.M. … Li W. (FASEB J. 2013) 2 3
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  4. Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. (PMID: 19922823) Reppe S. … Gautvik K.M. (Bone 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for C1orf61 Gene

Sources for C1orf61 Gene

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