Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1orf56 Gene

Aliases for C1orf56 Gene

  • Chromosome 1 Open Reading Frame 56 2 3 5
  • Methylated In Normal Thymocytes Protein 3 4
  • MENT 3 4
  • Methylated In Normal Thymocytes 2
  • Protein MENT 3

External Ids for C1orf56 Gene

Previous GeneCards Identifiers for C1orf56 Gene

  • GC01P147836
  • GC01P147837
  • GC01P149287
  • GC01P149288
  • GC01P122397

Summaries for C1orf56 Gene

GeneCards Summary for C1orf56 Gene

C1orf56 (Chromosome 1 Open Reading Frame 56) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C1orf56 Gene

  • Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf56 Gene

Genomics for C1orf56 Gene

Regulatory Elements for C1orf56 Gene

Enhancers for C1orf56 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C1orf56 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf56 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C1orf56 Gene

151,047,740 bp from pter
151,051,986 bp from pter
4,247 bases
Plus strand

Genomic View for C1orf56 Gene

Genes around C1orf56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf56 Gene

Proteins for C1orf56 Gene

  • Protein details for C1orf56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MENT
    Protein Accession:
    Secondary Accessions:
    • B2RDU8
    • Q9NWZ4

    Protein attributes for C1orf56 Gene

    341 amino acids
    Molecular mass:
    36769 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf56 Gene


neXtProt entry for C1orf56 Gene

Post-translational modifications for C1orf56 Gene

  • Phosphorylation sites are present in the extracellular medium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf56 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf56 Gene

Domains & Families for C1orf56 Gene

Protein Domains for C1orf56 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf56: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf56 Gene

Function for C1orf56 Gene

Molecular function for C1orf56 Gene

UniProtKB/Swiss-Prot Function:
Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.
genes like me logo Genes that share phenotypes with C1orf56: view

Animal Models for C1orf56 Gene

MGI Knock Outs for C1orf56:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1orf56

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf56 Gene

Localization for C1orf56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf56 Gene


Subcellular locations from

Jensen Localization Image for C1orf56 Gene COMPARTMENTS Subcellular localization image for C1orf56 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for C1orf56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with C1orf56: view

Pathways & Interactions for C1orf56 Gene

SuperPathways for C1orf56 Gene

No Data Available

Interacting Proteins for C1orf56 Gene

Gene Ontology (GO) - Biological Process for C1orf56 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf56 Gene

Drugs & Compounds for C1orf56 Gene

No Compound Related Data Available

Transcripts for C1orf56 Gene

mRNA/cDNA for C1orf56 Gene

Unigene Clusters for C1orf56 Gene

Chromosome 1 open reading frame 56:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf56 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b

Relevant External Links for C1orf56 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf56 Gene

mRNA expression in normal human tissues for C1orf56 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf56 Gene

This gene is overexpressed in Testis (x15.7).

Protein differential expression in normal tissues from HIPED for C1orf56 Gene

This gene is overexpressed in Serum (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf56 Gene

Protein tissue co-expression partners for C1orf56 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf56 Gene:


SOURCE GeneReport for Unigene cluster for C1orf56 Gene:


mRNA Expression by UniProt/SwissProt for C1orf56 Gene:

Tissue specificity: Plasma. Overexpressed in lymphomas.
genes like me logo Genes that share expression patterns with C1orf56: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C1orf56 Gene

Orthologs for C1orf56 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf56 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C3H1orf56 34
  • 73.04 (n)
  • 63.14 (a)
C1orf56 35
  • 61 (a)
(Canis familiaris)
Mammalia C17H1orf56 34
  • 74.87 (n)
  • 66.07 (a)
C1orf56 35
  • 63 (a)
(Mus musculus)
Mammalia Gm128 34
  • 71.12 (n)
  • 65.88 (a)
Gm128 16
Gm128 35
  • 63 (a)
(Pan troglodytes)
Mammalia C1H1orf56 34
  • 99.8 (n)
  • 99.41 (a)
C1orf56 35
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1359334 34
  • 76.02 (n)
  • 69.21 (a)
(Monodelphis domestica)
Mammalia C1orf56 35
  • 32 (a)
Species where no ortholog for C1orf56 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf56 Gene

Gene Tree for C1orf56 (if available)
Gene Tree for C1orf56 (if available)

Paralogs for C1orf56 Gene

No data available for Paralogs for C1orf56 Gene

Variants for C1orf56 Gene

Sequence variations from dbSNP and Humsavar for C1orf56 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1132889 -- 151,048,709(+) CTACC(C/G)CCTTC reference, missense
rs6664387 -- 151,049,033(+) TATTT(A/G)TTGAG intron-variant
rs9436019 -- 151,049,270(+) CACCA(C/T)GCCCG intron-variant
rs34253426 -- 151,048,321(+) CCCCC(-/G)GGGAG reference, frameshift-variant
rs35720154 -- 151,048,109(+) GGCCG(-/C)CCACG reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf56 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV gain 19592680

Variation tolerance for C1orf56 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf56 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf56 Gene

Disorders for C1orf56 Gene

Relevant External Links for C1orf56

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1orf56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf56 Gene

Publications for C1orf56 Gene

  1. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. (PMID: 22133874) Hlady R.A. … Opavsky R. (J. Clin. Invest. 2012) 2 3 4 65
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 65
  3. DNMT3B7 expression related to MENT expression and its promoter methylation in human lymphomas. (PMID: 24094886) Alkebsi L. … Murakami H. (Leuk. Res. 2013) 3 65
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65

Products for C1orf56 Gene

Sources for C1orf56 Gene

Loading form....