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Aliases for C1orf56 Gene

Aliases for C1orf56 Gene

  • Chromosome 1 Open Reading Frame 56 2 3
  • Methylated In Normal Thymocytes Protein 3 4
  • MENT 3 4
  • Methylated In Normal Thymocytes 2
  • Protein MENT 3

External Ids for C1orf56 Gene

Summaries for C1orf56 Gene

GeneCards Summary for C1orf56 Gene

C1orf56 (Chromosome 1 Open Reading Frame 56) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C1orf56 Gene

  • Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf56 Gene

Genomics for C1orf56 Gene

Genomic Location for C1orf56 Gene

Start:
151,046,979 bp from pter
End:
151,051,986 bp from pter
Size:
5,008 bases
Orientation:
Plus strand

Genomic View for C1orf56 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1orf56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf56 Gene

Regulatory Elements for C1orf56 Gene

Proteins for C1orf56 Gene

  • Protein details for C1orf56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUN1-MENT_HUMAN
    Recommended name:
    Protein MENT
    Protein Accession:
    Q9BUN1
    Secondary Accessions:
    • B2RDU8
    • Q9NWZ4

    Protein attributes for C1orf56 Gene

    Size:
    341 amino acids
    Molecular mass:
    36769 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf56 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf56 Gene

Proteomics data for C1orf56 Gene at MOPED

Post-translational modifications for C1orf56 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf56 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf56 Gene

Domains for C1orf56 Gene

Protein Domains for C1orf56 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf56: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf56 Gene

Function for C1orf56 Gene

Molecular function for C1orf56 Gene

UniProtKB/Swiss-Prot Function: Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.

Phenotypes for C1orf56 Gene

genes like me logo Genes that share phenotypes with C1orf56: view

Animal Models for C1orf56 Gene

MGI Knock Outs for C1orf56:

miRNA for C1orf56 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for C1orf56 Gene

Localization for C1orf56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf56 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf56 Gene COMPARTMENTS Subcellular localization image for C1orf56 gene
Compartment Confidence
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C1orf56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with C1orf56: view

Pathways for C1orf56 Gene

SuperPathways for C1orf56 Gene

No Data Available

Interacting Proteins for C1orf56 Gene

Gene Ontology (GO) - Biological Process for C1orf56 Gene

None

No data available for Pathways by source for C1orf56 Gene

Transcripts for C1orf56 Gene

mRNA/cDNA for C1orf56 Gene

Unigene Clusters for C1orf56 Gene

Chromosome 1 open reading frame 56:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf56 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:
SP2:
SP3:

Relevant External Links for C1orf56 Gene

GeneLoc Exon Structure for
C1orf56
ECgene alternative splicing isoforms for
C1orf56

Expression for C1orf56 Gene

mRNA expression in normal human tissues for C1orf56 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf56 Gene

This gene is overexpressed in Testis (15.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C1orf56 Gene

SOURCE GeneReport for Unigene cluster for C1orf56 Gene Hs.549171

mRNA Expression by UniProt/SwissProt for C1orf56 Gene

Q9BUN1-MENT_HUMAN
Tissue specificity: Plasma. Overexpressed in lymphomas.
genes like me logo Genes that share expressions with C1orf56: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C1orf56 Gene

Orthologs for C1orf56 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf56 35
  • 99.8 (n)
  • 99.41 (a)
C1orf56 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf56 36
  • 61 (a)
OneToOne
C3H1orf56 35
  • 73.04 (n)
  • 63.14 (a)
dog
(Canis familiaris)
Mammalia C17H1orf56 35
  • 74.87 (n)
  • 66.07 (a)
C1orf56 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm128 35
  • 71.12 (n)
  • 65.88 (a)
Gm128 16
Gm128 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf56 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1359334 35
  • 76.02 (n)
  • 69.21 (a)
Species with no ortholog for C1orf56:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf56 Gene

ENSEMBL:
Gene Tree for C1orf56 (if available)
TreeFam:
Gene Tree for C1orf56 (if available)

Paralogs for C1orf56 Gene

No data available for Paralogs for C1orf56 Gene

Variants for C1orf56 Gene

Sequence variations from dbSNP and Humsavar for C1orf56 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1132889 -- 151,048,709(+) CTACC(C/G)CCTTC reference, missense
rs6664387 -- 151,049,033(+) TATTT(A/G)TTGAG intron-variant
rs9436019 -- 151,049,270(+) CACCA(C/T)GCCCG intron-variant
rs11546017 -- 151,048,805(+) GCCTG(G/T)AGGAT reference, stop-gained
rs34253426 -- 151,048,321(+) CCCCC(-/G)GGGAG reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf56 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680

Relevant External Links for C1orf56 Gene

HapMap Linkage Disequilibrium report
C1orf56

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf56 Gene

Disorders for C1orf56 Gene

No disorders were found for C1orf56 Gene.

No data available for UniProtKB/Swiss-Prot for C1orf56 Gene

Publications for C1orf56 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. (PMID: 22133874) Hlady R.A. … Opavsky R. (J. Clin. Invest. 2012) 2 3 4
  3. DNMT3B7 expression related to MENT expression and its promoter methylation in human lymphomas. (PMID: 24094886) Alkebsi L. … Murakami H. (Leuk. Res. 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for C1orf56 Gene

Sources for C1orf56 Gene

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