C1orf53 Gene
protein-coding GIFtS: 36
GCID: GC01P197871
|
|
chromosome 1 open reading frame 53
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Aliases
for C1orf53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Chromosome 1 Open Reading Frame 531 2 | | Uncharacterized Protein C1orf532 |
| External Ids: | HGNC: 300031 | Entrez Gene: 3887222 | Ensembl: ENSG000002037247 | UniProtKB: Q5VUE53 | | ORGUL members: | |
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| NONCODE:n338441 | |
Export aliases for C1orf53 gene to outside databasesPrevious GC identifers: GC01P194602 GC01P196138 GC01P169027
|---|
Summaries
for C1orf53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1orf53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1orf53 gene promoter:
ER-alpha STAT5B USF1 Pax-6 MyoD Nkx2-5 AREB6 Nkx6-1 FOXJ2 (long isoform) USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1orf53
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf53 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q31.3 Ensembl cytogenetic band: 1q31.3 HGNC cytogenetic band: 1q31.3C1orf53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P197871: view genomic region
(about GC identifiers)
Start:
|
197,871,682 bp from pter |
End:
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197,876,497 bp from pter |
Size:
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4,816 bases |
Orientation:
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plus strand |
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Proteins
for C1orf53 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CA053_HUMAN, Q5VUE5 (See
protein sequence)Recommended Name: Uncharacterized protein C1orf53 Size: 145 amino acids; 15483 Da
Sequence caution: Sequence=CAH71759.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L4N2 Q5VUE4Explore the universe of human proteins at neXtProt for C1orf53: NX_Q5VUE5
C1orf53 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001019765.1
ENSEMBL proteins: ENSP00000356363 ENSP00000396800
Human Recombinant Protein Products:
C1orf53 Antibody Products:
Assay Products for C1orf53: |
Protein
Domains /
Families
for C1orf53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5VUE5 |
Function
for C1orf53 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf53 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf53
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C1orf53 (NM_001024594) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf53 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf53 |
|
Pathways & Interactions
for C1orf53 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf53
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for C1orf53 (ENSP000003563634) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for C1orf53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1orf53
Search CenterWatch for drugs/clinical trials and news about C1orf53 / CA053
|
Transcripts
for C1orf53 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1orf53 gene: NM_001024594.2 Unigene Cluster for C1orf53: Chromosome 1 open reading frame 53 Hs.61329 [show with all ESTs]Unigene Representative Sequence: NM_0010245943 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367393(uc001guh.3) ENST00000436652 ENST00000542800
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf53 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf53
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1orf53 (NM_001024594) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf53 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf53 |
Additional cDNA sequence: BC038214.1 BC130608.1 BC130634.1 2 DOTS entries: DT.106650 DT.100743017 13 AceView cDNA sequences: AA036748 BC038214 AA027229 BX092465 BG188021 CA414863 AI499050 BI870104 CD512232 BG219885 AA057320 AA026168 BI832220
GeneLoc Exon Structure
|
Expression
for C1orf53 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1orf53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGCCAGGC
About this image
See C1orf53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf53
SOURCE GeneReport for Unigene cluster: Hs.61329
UniProtKB/Swiss-Prot: CA053_HUMAN, Q5VUE5Tissue specificity: Expressed in retina and retinoblastoma
SABiosciences Custom PCR Arrays for C1orf53
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf53
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1orf53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf53 |
Orthologs
for C1orf53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C1orf53 gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
2310009B15Rik1 , 5 |
RIKEN cDNA 2310009B15 gene1, 5 |
76.96(n)1
69.85(a)1 |
|
1 (60.82 cM)5
695491 NM_001081226.11 NP_001074695.11
1388519795 |
chicken
(Gallus gallus) |
Aves |
C1orf536 |
Uncharacterized protein |
47(a) |
1 ↔ 1 |
8(2307510-2310552) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
AL775797.22 |
-- |
74.75(n) |
|
AL775797.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-121a9.36 |
si:dkey-121a9.3 |
41(a) |
1 ↔ 1 |
22(24991113-24994384) |
worm
(Caenorhabditis elegans) |
Secernentea |
mrpl-146 |
Protein MRPL-14, isoform b |
21(a) |
1 ↔ 1 |
II(7308663-7310107) |
ENSEMBL Gene Tree for C1orf53 (if available)
TreeFam Gene Tree for C1orf53 (if available) |
Paralogs
for C1orf53 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C1orf53 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1orf53 (197871682 - 197876497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf53: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf53 |
|
Disorders
/ Diseases
for C1orf53 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C1orf53 for disorders About GeneDecksing
1  disease for C1orf53: About MalaCardsretinoblastoma
Export disorders for C1orf53 gene to outside databases
|
Publications
for C1orf53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1orf53 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf53) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. (PubMed id 15897902)1, 2, 3 Corson T.W.... Gallie B.L. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C1orf53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C1orf53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1orf53 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1orf53 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1orf53 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1orf53 gene:
Search GeneIP for patents involving C1orf53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1orf53 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf53 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf53 | | | OriGene Protein Over-expression Lysate for C1orf53 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for C1orf53 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf53 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf53 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C1orf53 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C1orf53 | | OriGene Custom Protein Services for C1orf53 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf53 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf53 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf53 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf53 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C1orf53 |
| |  |  |  |  | | | | |
 |
 |
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 | | | C1orf53 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf53 |
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