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Aliases for C1orf53 Gene

Aliases for C1orf53 Gene

  • Chromosome 1 Open Reading Frame 53 2 3 5

External Ids for C1orf53 Gene

Previous GeneCards Identifiers for C1orf53 Gene

  • GC01P194602
  • GC01P196138
  • GC01P169027

Summaries for C1orf53 Gene

GeneCards Summary for C1orf53 Gene

C1orf53 (Chromosome 1 Open Reading Frame 53) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf53 Gene

Genomics for C1orf53 Gene

Regulatory Elements for C1orf53 Gene

Promoters for C1orf53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf53 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf53 Gene

Chromosome:
1
Start:
197,902,552 bp from pter
End:
197,907,367 bp from pter
Size:
4,816 bases
Orientation:
Plus strand

Genomic View for C1orf53 Gene

Genes around C1orf53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf53 Gene

Proteins for C1orf53 Gene

  • Protein details for C1orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUE5-CA053_HUMAN
    Recommended name:
    Uncharacterized protein C1orf53
    Protein Accession:
    Q5VUE5
    Secondary Accessions:
    • A1L4N2
    • Q5VUE4

    Protein attributes for C1orf53 Gene

    Size:
    145 amino acids
    Molecular mass:
    15483 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH71759.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C1orf53 Gene

Proteomics data for C1orf53 Gene at MOPED

Post-translational modifications for C1orf53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf53 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf53 Gene

Domains & Families for C1orf53 Gene

Protein Domains for C1orf53 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf53: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf53 Gene

Function for C1orf53 Gene

Phenotypes for C1orf53 Gene

genes like me logo Genes that share phenotypes with C1orf53: view

Animal Model Products

CRISPR Products

miRNA for C1orf53 Gene

miRTarBase miRNAs that target C1orf53

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf53 Gene

Localization for C1orf53 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf53 Gene COMPARTMENTS Subcellular localization image for C1orf53 gene
Compartment Confidence
mitochondrion 3
cytosol 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf53 Gene

Pathways & Interactions for C1orf53 Gene

SuperPathways for C1orf53 Gene

No Data Available

Interacting Proteins for C1orf53 Gene

Gene Ontology (GO) - Biological Process for C1orf53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf53 Gene

Drugs & Compounds for C1orf53 Gene

No Compound Related Data Available

Transcripts for C1orf53 Gene

mRNA/cDNA for C1orf53 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf53 Gene

Chromosome 1 open reading frame 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf53 Gene

No ASD Table

Relevant External Links for C1orf53 Gene

GeneLoc Exon Structure for
C1orf53
ECgene alternative splicing isoforms for
C1orf53

Expression for C1orf53 Gene

mRNA expression in normal human tissues for C1orf53 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf53 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for C1orf53 Gene

This gene is overexpressed in Gallbladder (36.5) and Adrenal (32.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf53 Gene



SOURCE GeneReport for Unigene cluster for C1orf53 Gene Hs.61329

mRNA Expression by UniProt/SwissProt for C1orf53 Gene

Q5VUE5-CA053_HUMAN
Tissue specificity: Expressed in retina and retinoblastoma.
genes like me logo Genes that share expression patterns with C1orf53: view

Protein tissue co-expression partners for C1orf53 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C1orf53 Gene

Orthologs for C1orf53 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1orf53 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC781739 35
  • 79.06 (n)
  • 72.57 (a)
dog
(Canis familiaris)
Mammalia C7H1orf53 35
  • 77.44 (n)
  • 73.85 (a)
C1orf53 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310009B15Rik 35
  • 76.96 (n)
  • 69.85 (a)
2310009B15Rik 16
2310009B15Rik 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf53 35
  • 99.31 (n)
  • 100 (a)
C1orf53 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566099 35
  • 81.42 (n)
  • 76.99 (a)
oppossum
(Monodelphis domestica)
Mammalia C1orf53 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf53 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C22H1orf53 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-14 36
  • 21 (a)
OneToOne
Species with no ortholog for C1orf53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for C1orf53 Gene

ENSEMBL:
Gene Tree for C1orf53 (if available)
TreeFam:
Gene Tree for C1orf53 (if available)

Paralogs for C1orf53 Gene

No data available for Paralogs for C1orf53 Gene

Variants for C1orf53 Gene

Sequence variations from dbSNP and Humsavar for C1orf53 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1039286 -- 197,901,180(+) CATCT(C/T)CACCA upstream-variant-2KB
rs1546244 -- 197,907,403(-) ATAAC(G/T)ATCAA downstream-variant-500B
rs2270762 -- 197,905,752(+) TATGA(C/T)GAATA intron-variant
rs2270763 -- 197,905,819(+) GTGGA(C/T)CCAGC reference, synonymous-codon
rs4539165 -- 197,902,889(+) ATCGC(G/T)GAGCT reference, synonymous-codon

Variation tolerance for C1orf53 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf53 Gene

HapMap Linkage Disequilibrium report
C1orf53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C1orf53 Gene

Disorders for C1orf53 Gene

Relevant External Links for C1orf53

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf53

No disorders were found for C1orf53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf53 Gene

Publications for C1orf53 Gene

  1. KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. (PMID: 15897902) Corson T.W. … Gallie B.L. (Oncogene 2005) 2 3 4 67
  2. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C1orf53 Gene

Sources for C1orf53 Gene

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