Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1orf50 Gene

Aliases for C1orf50 Gene

  • Chromosome 1 Open Reading Frame 50 2 3 5

External Ids for C1orf50 Gene

Previous GeneCards Identifiers for C1orf50 Gene

  • GC01P042903
  • GC01P043005
  • GC01P043232
  • GC01P041352

Summaries for C1orf50 Gene

GeneCards Summary for C1orf50 Gene

C1orf50 (Chromosome 1 Open Reading Frame 50) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf50 Gene

Genomics for C1orf50 Gene

Regulatory Elements for C1orf50 Gene

Enhancers for C1orf50 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F042736 1 Ensembl ENCODE 11.5 -30.2 -30245 2.0 GATAD2A CTCF KLF1 SAP130 BHLHE40 CEBPB KLF4 RAD21 YY1 KLF16 P3H1 PPIH C1orf50 SVBP YBX1 ZMYND12 CLDN19 GC01P042719
GH01F042735 0.5 ENCODE 11.5 -31.7 -31661 0.2 GATAD2A SAP130 FOXA3 FOXA1 YY1 RARA ATF3 RCOR2 BCL6 IRF1 PPIH P3H1 C1orf50 YBX1 CLDN19 GC01P042719
GH01F043090 0.6 ENCODE 10.5 +324.1 324103 1.8 PKNOX1 KLF9 CEBPB FAM183A RNU6-880P C1orf50 P3H1 PPIH SZT2 ENSG00000277513 GC01P043068
GH01F042824 0.4 ENCODE 10.1 +58.1 58099 2.0 HDGF PKNOX1 ATF1 ARNT CREB3L1 SIN3A ELK1 GATA2 ZNF263 JUNB ZNF691 LOC105378682 KDM4A P3H1 C1orf50 SVBP SZT2
GH01F042688 0.9 Ensembl ENCODE 10 -75.6 -75612 6.1 ZNF121 CTCF ZNF664 POLR2A ZNF512 HLF FEZF1 ZBTB17 SVBP PPIH C1orf50 ZMYND12 CLDN19 YBX1 GC01P042719
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1orf50 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf50 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076739 -445 3601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for C1orf50 Gene

42,767,245 bp from pter
42,775,747 bp from pter
8,503 bases
Plus strand

Genomic View for C1orf50 Gene

Genes around C1orf50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf50 Gene

Proteins for C1orf50 Gene

  • Protein details for C1orf50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C1orf50
    Protein Accession:

    Protein attributes for C1orf50 Gene

    199 amino acids
    Molecular mass:
    21877 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf50 Gene

Post-translational modifications for C1orf50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf50 Gene

Domains & Families for C1orf50 Gene

Protein Domains for C1orf50 Gene


Suggested Antigen Peptide Sequences for C1orf50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf50: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf50 Gene

Function for C1orf50 Gene

Gene Ontology (GO) - Molecular Function for C1orf50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with C1orf50: view
genes like me logo Genes that share phenotypes with C1orf50: view

Animal Model Products

miRNA for C1orf50 Gene

miRTarBase miRNAs that target C1orf50

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf50 Gene

Localization for C1orf50 Gene

Subcellular locations from

Jensen Localization Image for C1orf50 Gene COMPARTMENTS Subcellular localization image for C1orf50 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf50 Gene

Pathways & Interactions for C1orf50 Gene

SuperPathways for C1orf50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf50 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf50 Gene

Transcripts for C1orf50 Gene

mRNA/cDNA for C1orf50 Gene

Unigene Clusters for C1orf50 Gene

Chromosome 1 open reading frame 50:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf50 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - - -
SP5: -
SP6: - - -

Relevant External Links for C1orf50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf50 Gene

Protein differential expression in normal tissues from HIPED for C1orf50 Gene

This gene is overexpressed in Fetal ovary (17.1) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C1orf50 Gene

Protein tissue co-expression partners for C1orf50 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf50 Gene:


SOURCE GeneReport for Unigene cluster for C1orf50 Gene:

genes like me logo Genes that share expression patterns with C1orf50: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1orf50 Gene

Orthologs for C1orf50 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1orf50 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf50 34
  • 99.66 (n)
C1H1ORF50 35
  • 99 (a)
(Canis familiaris)
Mammalia C15H1orf50 34
  • 91.57 (n)
C1orf50 35
  • 74 (a)
(Bos Taurus)
Mammalia C3H1orf50 34
  • 87.8 (n)
C3H1ORF50 35
  • 84 (a)
(Mus musculus)
Mammalia AU022252 34 16 35
  • 85.09 (n)
(Rattus norvegicus)
Mammalia RGD1564804 34
  • 84.25 (n)
(Monodelphis domestica)
Mammalia C1orf50 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf50 35
  • 71 (a)
(Gallus gallus)
Aves C1ORF50 34
  • 76.52 (n)
C1orf50 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf50 34
  • 68.41 (n)
Str.11019 34
(Danio rerio)
Actinopterygii zgc:112255 34
  • 68.8 (n)
C11H1orf50 35
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4067 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008853 34
  • 56.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31800 34 35
  • 54.9 (n)
(Caenorhabditis elegans)
Secernentea C08B11.9 34 35
  • 51.52 (n)
Species where no ortholog for C1orf50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C1orf50 Gene

Gene Tree for C1orf50 (if available)
Gene Tree for C1orf50 (if available)

Paralogs for C1orf50 Gene

(1) SIMAP similar genes for C1orf50 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with C1orf50: view

No data available for Paralogs for C1orf50 Gene

Variants for C1orf50 Gene

Sequence variations from dbSNP and Humsavar for C1orf50 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs72659347 Pathogenic 42,766,580(-) CCACT(A/C/G)GCTCA nc-transcript-variant, upstream-variant-2KB, reference, missense, stop-gained, utr-variant-5-prime
rs10715539 -- 42,772,781(+) GTCTG(-/A)AAAAA intron-variant
rs10715817 -- 42,771,975(+) GCCTC(-/A)AAAAA intron-variant
rs11210712 -- 42,767,127(+) AGCCC(G/T)GATCC upstream-variant-2KB
rs11210713 -- 42,768,572(+) TTTTT(A/T)AAATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf50 Gene

Variant ID Type Subtype PubMed ID
esv3577249 CNV gain 25503493
nsv829682 CNV loss 17160897

Variation tolerance for C1orf50 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf50 Gene

Disorders for C1orf50 Gene

Relevant External Links for C1orf50

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1orf50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf50 Gene

Publications for C1orf50 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for C1orf50 Gene

Sources for C1orf50 Gene

Loading form....