C1orf43 Gene
protein-coding GIFtS: 41
GCID: GC01M154179
|
|
chromosome 1 open reading frame 43
| |
Aliases
for C1orf43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 1 Open Reading Frame 431 2 | | S863-32 3 | | NICE-31 2 | | HCV NS5A-Transactivated Protein 42 3 | | Hepatitis C Virus NS5A-Transactivated Protein 42 3 | | DKFZp586G17221 | | Protein NICE-32 3 | | Uncharacterized Protein C1orf432 | | NS5ATP42 3 | | NICE33 |
Export aliases for C1orf43 gene to outside databasesPrevious GC identifers: GC01M150992 GC01M152445 GC01M125542 |
Summaries
for C1orf43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1orf43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1orf43 gene promoter:
COUP-TF1 Max1 COUP HNF-4alpha1 E47 AREB6 COUP-TF Hand1 Pax-4a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1orf43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.2C1orf43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M154179: view genomic region
(about GC identifiers)
Start:
|
154,179,183 bp from pter |
End:
|
154,193,273 bp from pter |
Size:
|
14,091 bases |
Orientation:
|
minus strand |
|
Proteins
for C1orf43 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CA043_HUMAN, Q9BWL3 (See
protein sequence)Recommended Name: Uncharacterized protein C1orf43 Size: 253 amino acids; 28779 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=CAH71276.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K3G8 D3DV72 D3DV74 Q5M801 Q5VU73 Q5VU83 Q96HP7 Q9UFU2 Q9UGL7 Q9UGL8 Q9Y2R6Alternative splicing: 5 isoforms: Q9BWL3-1 Q9BWL3-2 Q9BWL3-3 Q9BWL3-4 Q9BWL3-5 Explore the universe of human proteins at neXtProt for C1orf43: NX_Q9BWL3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWL3
C1orf43 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001092086.1 NP_056264.1 NP_620077.1
ENSEMBL proteins: ENSP00000271925 ENSP00000357507 ENSP00000354496 ENSP00000357505 ENSP00000357504 ENSP00000357502
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
C1orf43 for ontologies About GeneDecksing
C1orf43 Antibody Products:
Assay Products for C1orf43: |
Protein
Domains /
Families
for C1orf43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C1orf43 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BWL3ProtoNet protein and cluster: Q9BWL3 |
Function
for C1orf43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf43 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf43 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): C1orf43 (NM_138740) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf43 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf43 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf43 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
IEA | -- | | GO:0050662 | coenzyme binding |
IEA | -- |
C1orf43 for ontologies About GeneDecksing
|
Pathways & Interactions
for C1orf43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf43
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for C1orf43 (ENSP000003575074) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for C1orf43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1orf43
Search CenterWatch for drugs/clinical trials and news about C1orf43 / CA043
|
Transcripts
for C1orf43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1orf43 gene (3 alternative transcripts): NM_001098616.1 NM_015449.2 NM_138740.2 Unigene Cluster for C1orf43: Chromosome 1 open reading frame 43 Hs.287471 [show with all ESTs]Unigene Representative Sequence: NM_0010986169 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000350592(uc001feg.2 uc001feh.2) ENST00000368521(uc001fei.2 uc009wos.1)
ENST00000362076 ENST00000368519 ENST00000483282 ENST00000493814 ENST00000368518(uc001fek.3)
ENST00000368516 ENST00000470180
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf43 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf43 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): C1orf43 (NM_138740) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf43 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf43 |
Additional cDNA sequence: AF077036.1 AF109185.1 AF529365.1 AJ243663.1 AJ243664.1 AJ243665.1 AK093707.1 AK290583.1 AL117463.1 BC000152.2 BC001377.2 BC006514.1 BC008306.1 BC014391.1 BC088353.1 CR457131.1 DQ908899.1 24/26 DOTS entries (see all 26): DT.97862716 DT.100045235 DT.95261089 DT.95336983 DT.100880647 DT.100880672 DT.121356007 DT.91774407 DT.100880648 DT.100880667 DT.100880683 DT.100880689 DT.100880650 DT.100880688 DT.100880654 DT.40113419 DT.95261145 DT.100045232 DT.121356163 DT.91774410 DT.101962639 DT.100880659 DT.121356087 DT.95261053 24/966 AceView cDNA sequences (see all 966): BE547786 BQ029066 CR609329 CR606555 AA825286 BQ439319 BU169566 BE218032 AA377626 BQ920434 BU164647 BM751863 BQ430752 BQ230063 BM919362 AI274326 AL117463 CR605126 CR626375 BU170735 AW469074 BQ900746 CD674083 BQ950236
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf43 (see all 15) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | · | 1i | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 7f | · | 7g | · | 7h | · | 7i |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for C1orf43
|
Expression
for C1orf43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1orf43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGGATCTA
About this image
See C1orf43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf43
SOURCE GeneReport for Unigene cluster: Hs.287471
SABiosciences Custom PCR Arrays for C1orf43
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1orf43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf43 |
Orthologs
for C1orf43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C1orf43 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for C1orf43 (if available)
TreeFam Gene Tree for C1orf43 (if available) |
Paralogs
for C1orf43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C1orf43 gene
1 SIMAP similar gene for C1orf43 using alignment to 1 protein entry: CA043_HUMAN:NS5ATP4A
C1orf43 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C1orf43
PGOHUM00000235961
|
Genomic Variants
for C1orf43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1orf43 (154179183 - 154193273 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf43: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf43 |
|
Disorders
/ Diseases
for C1orf43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C1orf43 for disorders About GeneDecksing
2  diseases for C1orf43: About MalaCardshepatitis c hepatitis
Export disorders for C1orf43 gene to outside databases
|
Publications
for C1orf43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1orf43 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C1orf43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)1, 2, 3 Marenholz I....Mischke D. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1 Tao W.A.... Aebersold R. (2005)
|
External Searches for C1orf43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C1orf43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1orf43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1orf43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1orf43 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1orf43 gene:
Search GeneIP for patents involving C1orf43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1orf43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf43 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf43 |
| |
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| | | | Search Tocris compounds for C1orf43 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | C1orf43 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf43 |
|  |  |  | | | | Search ThermoFisher Antibodies for C1orf43 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf43 |
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