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Aliases for C1orf43 Gene

Aliases for C1orf43 Gene

  • Chromosome 1 Open Reading Frame 43 2 3 5
  • Hepatitis C Virus NS5A-Transactivated Protein 4 3 4
  • HCV NS5A-Transactivated Protein 4 3 4
  • NS5ATP4 3 4
  • S863-3 3 4
  • Uncharacterized Protein C1orf43 3
  • Protein NICE-3 4
  • HSPC012 3
  • NICE-3 3
  • NICE3 4

External Ids for C1orf43 Gene

Previous GeneCards Identifiers for C1orf43 Gene

  • GC01M150992
  • GC01M152445
  • GC01M154179
  • GC01M125542

Summaries for C1orf43 Gene

GeneCards Summary for C1orf43 Gene

C1orf43 (Chromosome 1 Open Reading Frame 43) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and coenzyme binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf43 Gene

Genomics for C1orf43 Gene

Regulatory Elements for C1orf43 Gene

Enhancers for C1orf43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C1orf43 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf43 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf43 Gene

Chromosome:
1
Start:
154,206,701 bp from pter
End:
154,220,797 bp from pter
Size:
14,097 bases
Orientation:
Minus strand

Genomic View for C1orf43 Gene

Genes around C1orf43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf43 Gene

Proteins for C1orf43 Gene

  • Protein details for C1orf43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWL3-CA043_HUMAN
    Recommended name:
    Uncharacterized protein C1orf43
    Protein Accession:
    Q9BWL3
    Secondary Accessions:
    • A8K3G8
    • D3DV72
    • D3DV74
    • Q5M801
    • Q5VU73
    • Q5VU83
    • Q96HP7
    • Q9UFU2
    • Q9UGL7
    • Q9UGL8
    • Q9Y2R6

    Protein attributes for C1orf43 Gene

    Size:
    253 amino acids
    Molecular mass:
    28779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH71276.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C1orf43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf43 Gene

Post-translational modifications for C1orf43 Gene

  • Ubiquitination at Lys 73, Lys 151, and Lys 191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C1orf43 Gene

Domains & Families for C1orf43 Gene

Protein Domains for C1orf43 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf43: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf43 Gene

Function for C1orf43 Gene

Gene Ontology (GO) - Molecular Function for C1orf43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with C1orf43: view
genes like me logo Genes that share phenotypes with C1orf43: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf43 Gene

Localization for C1orf43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf43 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf43 Gene COMPARTMENTS Subcellular localization image for C1orf43 gene
Compartment Confidence
nucleus 3
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C1orf43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf43: view

Pathways & Interactions for C1orf43 Gene

SuperPathways for C1orf43 Gene

No Data Available

Interacting Proteins for C1orf43 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357507%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000357507 Q9BWL3-CA043_HUMAN for C1orf43 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C1orf43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with C1orf43: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf43 Gene

Drugs & Compounds for C1orf43 Gene

No Compound Related Data Available

Transcripts for C1orf43 Gene

Unigene Clusters for C1orf43 Gene

Chromosome 1 open reading frame 43:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf43 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - -
SP12: - - - - - - -
SP13: - - - - - - - -
SP14: - - -
SP15:

ExUns: 7f · 7g · 7h · 7i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for C1orf43 Gene

GeneLoc Exon Structure for
C1orf43
ECgene alternative splicing isoforms for
C1orf43

Expression for C1orf43 Gene

mRNA expression in normal human tissues for C1orf43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf43 Gene

This gene is overexpressed in Pancreas (53.1) and Retina (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf43 Gene



Protein tissue co-expression partners for C1orf43 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf43 Gene:

C1orf43

SOURCE GeneReport for Unigene cluster for C1orf43 Gene:

Hs.287471
genes like me logo Genes that share expression patterns with C1orf43: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1orf43 Gene

Orthologs for C1orf43 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1orf43 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C3H1orf43 34
  • 93.28 (n)
  • 95.65 (a)
-- 35
  • 87 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C7H1orf43 34
  • 91.96 (n)
  • 96.05 (a)
C1orf43 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4933434E20Rik 34
  • 89.72 (n)
  • 95.65 (a)
4933434E20Rik 16
4933434E20Rik 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf43 34
  • 99.6 (n)
  • 99.21 (a)
C1orf43 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC361985 34
  • 88.79 (n)
  • 95.32 (a)
oppossum
(Monodelphis domestica)
Mammalia C1orf43 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf43 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves C25H1ORF43 34
  • 72.99 (n)
  • 85.31 (a)
C1orf43 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf43 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf43 34
  • 69.83 (n)
  • 73.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16623 34
zebrafish
(Danio rerio)
Actinopterygii zgc:123238 34
  • 63.65 (n)
  • 66.26 (a)
C16H1orf43 (1 of 2) 35
  • 63 (a)
OneToMany
C16H1orf43 (2 of 2) 35
  • 75 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004471 34
  • 50.77 (n)
  • 42.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6665 34
  • 47.62 (n)
  • 41.94 (a)
CG6665 35
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToOne
Species where no ortholog for C1orf43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf43 Gene

ENSEMBL:
Gene Tree for C1orf43 (if available)
TreeFam:
Gene Tree for C1orf43 (if available)

Paralogs for C1orf43 Gene

(1) SIMAP similar genes for C1orf43 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for C1orf43 Gene

genes like me logo Genes that share paralogs with C1orf43: view

No data available for Paralogs for C1orf43 Gene

Variants for C1orf43 Gene

Sequence variations from dbSNP and Humsavar for C1orf43 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4378197 -- 154,211,546(+) TGGCT(A/C)GGATG intron-variant, utr-variant-3-prime
rs4504882 -- 154,209,750(+) cccgg(A/C)taatt intron-variant
rs4845609 -- 154,209,478(+) tagag(G/T)gcagt intron-variant
rs7551128 -- 154,209,936(+) gccca(G/T)gttgg intron-variant
rs10908751 -- 154,214,829(+) CAGCA(C/T)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf43 Gene

Variant ID Type Subtype PubMed ID
nsv2954 CNV insertion 18451855

Variation tolerance for C1orf43 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf43 Gene

Disorders for C1orf43 Gene

Relevant External Links for C1orf43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf43

No disorders were found for C1orf43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf43 Gene

Publications for C1orf43 Gene

  1. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 2 3 4 65
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 65
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for C1orf43 Gene

Sources for C1orf43 Gene

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