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Aliases & Descriptions for C1orf38
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ICB-1 1 , 2 OTTHUMP00000003850 2 OTTHUMP00000003991 2 OTTHUMP00000003993 2
Descriptions Protein ICB-1 3 basement membrane-induced gene 2 chromosome 1 open reading frame 38 2
Search outside databases for aliases for C1orf38 genePrevious GC identifers: GC01M027189 GC01P027432 GC01P027803 GC01P027810 GC01P027883
Summaries for C1orf38 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Location for C1orf38
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the C1orf38 gene Entrez Gene cytogenetic band: 1p35.3 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35.2 C1orf38 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P028071:
(about GC identifiers )
Start:
28,071,642 bp from pter
End:
28,085,783 bp from pter
Size:
14,142 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_004610.18 Proteins for C1orf38
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ICB1_HUMAN, Q5TEJ8 (See
protein sequence )Recommended Name: Induced by contact to basement membrane 1 protein Size : 643 amino acids; 72049 Da
Sequence caution : Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532;Sequence=CAI21769.1; Type=Erroneous gene model prediction; Sequence=CAI21771.1; Type=Erroneousgene model prediction; Sequence=CAI21773.1; Type=Erroneous gene model prediction;
Secondary accessions : A2RTZ3 O60560 Q5TEJ1 Q5TEJ9 Q5TEK1 Q68DP4 Q9BYB6 Q9NS90Alternative splicing : 4 isoforms : Q5TEJ8-1 Q5TEJ8-2 Q5TEJ8-3 Q5TEJ8-4
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001034566.1 NP_001099026.1 NP_004839.2 ENSEMBL proteins: ENSP00000363037 ENSP00000363031 ENSP00000363029 ENSP00000363035 ENSP00000329862 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: C1orf38 Antibodies for C1orf38: Assays for C1orf38:
Protein
Domains/ Families for C1orf38(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q5TEJ8
Gene Function for C1orf38
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_004848 Applied Biosystems Silencer ® siRNAs for C1orf38 Sigma-Aldrich siRNA for C1orf38 Browse shRNA at Sigma-Aldrich Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001039477                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001039477                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001039477  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001105556 UniProtKB/Swiss-Prot: ICB1_HUMAN, Q5TEJ8 Induction : By contact to a reconstituted basement membrane
Pathways & Interactions for C1orf38
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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--1 Gene Ontology (GO) biological process term (links to tree view) :
About this table
Drugs & Compounds for C1orf38 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for C1orf38
Transcripts for C1orf38(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_004848 Sigma-Aldrich siRNA for C1orf38 Browse shRNA at Sigma-Aldrich Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001039477 NM_001105556 NM_004848
REFSEQ mRNAs for C1orf38 gene (3 alternative transcripts): NM_001039477.1 NM_001105556.1 NM_004848.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001039477 NM_001105556 NM_004848
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001039477                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001039477                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001039477  
Additional cDNA sequence: AB035482.1 AB050854.1 AF323721.1 AK303090.1 AK303141.1 AK309633.1 BC031655.1 BC132692.1 BC133049.1 CR604917.1 CR749321.1
10 DOTS entries : DT.100783005 DT.95110258 DT.95110255 DT.416836 DT.92066684 DT.100719017 DT.121404031 DT.100783006 DT.86847619 DT.91746611
24/181 AceView cDNA sequences (see all 181
):AA588624 BI521256 CB528870 AI866718 W63743 BP338649 BP339331 AI927451 AA575924 BM473038 AA455658 N33211 AA280149 CD365001 BV178317 AI570737 CR604917 AB035482 CA308421 BM708753 AA731736 AW193256 BI823781 AW518359
highest scoring ESTs for C1orf38 :AB035482 AB050854 AF044896 AJ712834 AL577281 AW129512 AW469341 BC031655 BF084335 BF849040
Unigene Cluster for C1orf38: Chromosome 1 open reading frame 38 Hs.10649 [show with all ESTs ] Unigene Representative Sequence: NM_001105556 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf38 (see all 10
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b SP1 :                   -   -   -     -         SP2 :                 -   -   -   -   -   -         SP3 :           -   -   -   -   -   -   -   -   -         SP4 :           -   -                       SP5 :                                  
About this scheme ECgene alternative splicing isoforms for C1orf38 5 Ensembl transcripts including schematic representations : ENST00000373927
ENST00000373921
ENST00000373919
ENST00000373925
ENST00000328928
Expression for C1orf38
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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C1orf38 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for C1orf38 1 / 2 / 3
5 probe-sets matching C1orf38 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GATTAATGTGSOURCE GeneReport for Unigene cluster: Hs.10649 Expression variation in blood from EXPOLDB for C1orf38
UniProtKB/Swiss-Prot: ICB1_HUMAN, Q5TEJ8 Tissue specificity : Expressed in different endometrial adenocarcinoma cell lines and various othercell lines aprat from the prostate cell line LNCAP and the ovarian cancer cell line BG-1
Orthologs for C1orf38
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for C1orf38 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for C1orf38 ENSEMBL Gene Tree for C1orf38 Paralogs for C1orf38 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for C1orf38 gene TSEPA 2
SNPs/Variants for C1orf38 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for C1orf38 (up to first 250kb)
Disorders & Mutations for C1orf38
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Human Genome Epidemiology Navigator: C1orf38 (1 document)
Medical News for C1orf38 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for C1orf38 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10 PubMed articles for C1orf38 gene : Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. (PubMed id 16219472) 1, 2, 3 Treeck O....Ortmann O. (2005) A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (PubMed id 9563507) 1, 3, 4 Treeck O.... Vollmer G. (1998) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation. (PubMed id 12191572) 1, 3 Treeck O....Vollmer G. (2002) Single Nucleotide Polymorphisms in Human Gene icb-1 and Breast Cancer Susceptibility. (PubMed id 19308812) 3 Springwald A....Treeck O. (2009) The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005) 4 Bechtel S....Schupp I. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Expression of differentiation-associated gene icb-1 is estrogen-responsive in ovarian and breast cancer cell lines. (PubMed id 18206364) 1 Bollmann J....Treeck O. (2008)
Search for C1orf38
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Genome Databases showing C1orf38
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing C1orf38
(According to HUGE )
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Specialized Databases showing C1orf38 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for C1orf38 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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