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Aliases for C1orf35 Gene

Aliases for C1orf35 Gene

  • Chromosome 1 Open Reading Frame 35 2 3 5
  • Multiple Myeloma Tumor-Associated Protein 2 2 3
  • Multiple Myeloma Transforming 2 3
  • HMMTAG2 4
  • MMTAG2 3

External Ids for C1orf35 Gene

Previous GeneCards Identifiers for C1orf35 Gene

  • GC01M226785
  • GC01M224027
  • GC01M224673
  • GC01M225263
  • GC01M224595
  • GC01M226355
  • GC01M228289
  • GC01M198804

Summaries for C1orf35 Gene

GeneCards Summary for C1orf35 Gene

C1orf35 (Chromosome 1 Open Reading Frame 35) is a Protein Coding gene. Diseases associated with C1orf35 include Multiple Myeloma. Among its related pathways are Innate Immune System. GO annotations related to this gene include poly(A) RNA binding.

Additional gene information for C1orf35 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf35 Gene

Genomics for C1orf35 Gene

Regulatory Elements for C1orf35 Gene

Enhancers for C1orf35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H228781 1.9 FANTOM5 Ensembl ENCODE dbSUPER 85.8 -677.7 -677652 3.7 FEZF1 ZNF2 ZNF302 ZNF416 FOS REST KAT8 MIER3 ZNF610 ZSCAN16 NUP133 CICP26 C1orf35 ENSG00000269890 HMGN2P19 HIST3H3 TAF5L ABCB10 PRSS38 URB2
GH01H227733 1.4 ENCODE dbSUPER 87.4 +370.3 370319 2.8 MLX ZFP64 FEZF1 DMAP1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC CICP26 ZNF678 C1orf35 ENSG00000269890 CDC42BPA HIST3H3 PRSS38 JMJD4 LOC100126822 SNAP47
GH01H227431 1.6 Ensembl ENCODE dbSUPER 67.8 +673.4 673364 1.5 PKNOX1 FOXA2 ARNT ZNF2 ZNF766 ZNF416 FOS MCM3 REST ZNF662 CICP26 ZNF678 C1orf35 ENSG00000269890 CDC42BPA HIST3H3 JMJD4 PSEN2 LINC01641 BTF3P9
GH01H228455 1.4 ENCODE dbSUPER 61.3 -352.5 -352479 4.1 HNRNPUL1 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF302 ZNF207 CICP26 C1orf35 ENSG00000269890 ZNF678 HIST3H3 PRSS38 LOC100421842 ENSG00000233920 LOC105373159 JMJD4
GH01H227562 1.5 FANTOM5 ENCODE 28.7 +541.5 541541 1.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF207 FOS C1orf35 HIST3H3 CICP26 ZNF678 IBA57 CDC42BPA SNAP47 MRPL57P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf35 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C1orf35 Gene

Genomic Locations for C1orf35 Gene
4,686 bases
Minus strand

Genomic View for C1orf35 Gene

Genes around C1orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf35 Gene

Proteins for C1orf35 Gene

  • Protein details for C1orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multiple myeloma tumor-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6P5Y0
    • Q6ZTZ6
    • Q6ZWA6
    • Q8IZH3

    Protein attributes for C1orf35 Gene

    263 amino acids
    Molecular mass:
    29412 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf35 Gene


neXtProt entry for C1orf35 Gene

Post-translational modifications for C1orf35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf35 Gene

Domains & Families for C1orf35 Gene

Gene Families for C1orf35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf35 Gene

Suggested Antigen Peptide Sequences for C1orf35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf35: view

No data available for UniProtKB/Swiss-Prot for C1orf35 Gene

Function for C1orf35 Gene

Phenotypes From GWAS Catalog for C1orf35 Gene

Gene Ontology (GO) - Molecular Function for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C1orf35: view
genes like me logo Genes that share phenotypes with C1orf35: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf35 Gene

Localization for C1orf35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf35 gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034774 secretory granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with C1orf35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf35 Gene

Pathways & Interactions for C1orf35 Gene

genes like me logo Genes that share pathways with C1orf35: view

Pathways by source for C1orf35 Gene

3 Reactome pathways for C1orf35 Gene

Gene Ontology (GO) - Biological Process for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with C1orf35: view

No data available for SIGNOR curated interactions for C1orf35 Gene

Drugs & Compounds for C1orf35 Gene

No Compound Related Data Available

Transcripts for C1orf35 Gene

Unigene Clusters for C1orf35 Gene

Chromosome 1 open reading frame 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP3: - -
SP4: -

Relevant External Links for C1orf35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf35 Gene

Protein differential expression in normal tissues from HIPED for C1orf35 Gene

This gene is overexpressed in Lung (19.6), Peripheral blood mononuclear cells (14.9), CD4 Tcells (6.9), and Pancreatic juice (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C1orf35 Gene

Protein tissue co-expression partners for C1orf35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf35 Gene:


SOURCE GeneReport for Unigene cluster for C1orf35 Gene:


Evidence on tissue expression from TISSUES for C1orf35 Gene

  • Blood(4.4)
  • Nervous system(4.3)
  • Lung(2.1)
  • Spleen(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with C1orf35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf35 Gene

Orthologs for C1orf35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1orf35 34
  • 97 (a)
C1H1orf35 33
  • 95.7 (n)
(Mus musculus)
Mammalia 2310033P09Rik 33 16 34
  • 81.14 (n)
(Rattus norvegicus)
Mammalia RGD1304587 33
  • 80.62 (n)
(Bos Taurus)
Mammalia C7H1orf35 33
  • 78.21 (n)
  • 77 (a)
(Canis familiaris)
Mammalia C14H1orf35 33
  • 74.74 (n)
C1orf35 34
  • 70 (a)
(Gallus gallus)
Aves C1orf35 34
  • 48 (a)
(Anolis carolinensis)
Reptilia C1orf35 34
  • 61 (a)
(Danio rerio)
Actinopterygii C2H1orf35 34
  • 42 (a)
zgc63882 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.843 33
Species where no ortholog for C1orf35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf35 Gene

Gene Tree for C1orf35 (if available)
Gene Tree for C1orf35 (if available)

Paralogs for C1orf35 Gene

No data available for Paralogs for C1orf35 Gene

Variants for C1orf35 Gene

Sequence variations from dbSNP and Humsavar for C1orf35 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000025404 -- 228,101,697(+) GCCCC(A/C)CCCCA intron-variant
rs1000288314 -- 228,105,379(+) GGCCA(C/T)AGGAG upstream-variant-2KB
rs1000621109 -- 228,103,802(+) AAAAA(C/T)AAGAA upstream-variant-2KB
rs1000703488 -- 228,102,474(+) CGCCC(A/G)CACCT intron-variant
rs1000756979 -- 228,104,119(+) AGCAC(G/T)GGTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf35 Gene

Variant ID Type Subtype PubMed ID
nsv952136 CNV deletion 24416366
nsv832803 CNV loss 17160897
nsv826908 CNV gain 20364138
nsv523935 CNV loss 19592680
nsv516409 CNV loss 19592680
nsv1160102 CNV deletion 26073780
esv32853 CNV gain 17666407

Variation tolerance for C1orf35 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf35 Gene

Disorders for C1orf35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1orf35 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multiple myeloma
  • plasma cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1orf35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C1orf35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf35 Gene

Publications for C1orf35 Gene

  1. Cloning and sequence analysis of tumor-associated gene hMMTAG2 from human multiple myeloma cell line ARH-77. (PMID: 12545221) Tian JY … Jiang YS (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for C1orf35 Gene

Sources for C1orf35 Gene

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