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Aliases for C1orf35 Gene

Aliases for C1orf35 Gene

  • Chromosome 1 Open Reading Frame 35 2 3 5
  • Multiple Myeloma Tumor-Associated Protein 2 2
  • Multiple Myeloma Transforming 2 3
  • HMMTAG2 4
  • MMTAG2 3

External Ids for C1orf35 Gene

Previous GeneCards Identifiers for C1orf35 Gene

  • GC01M226785
  • GC01M224027
  • GC01M224673
  • GC01M225263
  • GC01M224595
  • GC01M226355
  • GC01M228289
  • GC01M198804

Summaries for C1orf35 Gene

GeneCards Summary for C1orf35 Gene

C1orf35 (Chromosome 1 Open Reading Frame 35) is a Protein Coding gene. Diseases associated with C1orf35 include Multiple Myeloma and Myeloma. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf35 Gene

Genomics for C1orf35 Gene

Regulatory Elements for C1orf35 Gene

Enhancers for C1orf35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C1orf35 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf35 Gene

228,100,726 bp from pter
228,105,411 bp from pter
4,686 bases
Minus strand

Genomic View for C1orf35 Gene

Genes around C1orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf35 Gene

Proteins for C1orf35 Gene

  • Protein details for C1orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multiple myeloma tumor-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6P5Y0
    • Q6ZTZ6
    • Q6ZWA6
    • Q8IZH3

    Protein attributes for C1orf35 Gene

    263 amino acids
    Molecular mass:
    29412 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf35 Gene


neXtProt entry for C1orf35 Gene

Proteomics data for C1orf35 Gene at MOPED

Post-translational modifications for C1orf35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf35 Gene

Domains & Families for C1orf35 Gene

Protein Domains for C1orf35 Gene

Suggested Antigen Peptide Sequences for C1orf35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf35: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf35 Gene

Function for C1orf35 Gene

Gene Ontology (GO) - Molecular Function for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C1orf35: view

Phenotypes for C1orf35 Gene

genes like me logo Genes that share phenotypes with C1orf35: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf35 Gene

Localization for C1orf35 Gene

Subcellular locations from

Jensen Localization Image for C1orf35 Gene COMPARTMENTS Subcellular localization image for C1orf35 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf35 Gene

Pathways & Interactions for C1orf35 Gene

SuperPathways for C1orf35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf35 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf35 Gene

Drugs & Compounds for C1orf35 Gene

No Compound Related Data Available

Transcripts for C1orf35 Gene

Unigene Clusters for C1orf35 Gene

Chromosome 1 open reading frame 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP3: - -
SP4: -

Relevant External Links for C1orf35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf35 Gene

mRNA expression in normal human tissues for C1orf35 Gene

Protein differential expression in normal tissues from HIPED for C1orf35 Gene

This gene is overexpressed in Lung (19.6), Peripheral blood mononuclear cells (14.9), CD4 Tcells (6.9), and Pancreatic juice (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C1orf35 Gene

SOURCE GeneReport for Unigene cluster for C1orf35 Gene Hs.445952

genes like me logo Genes that share expression patterns with C1orf35: view

Protein tissue co-expression partners for C1orf35 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1orf35 Gene

Orthologs for C1orf35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C7H1orf35 35
  • 78.21 (n)
  • 79.22 (a)
  • 77 (a)
(Canis familiaris)
Mammalia C14H1orf35 35
  • 74.74 (n)
  • 70.93 (a)
C1orf35 36
  • 70 (a)
(Mus musculus)
Mammalia 2310033P09Rik 35
  • 81.14 (n)
  • 81.01 (a)
2310033P09Rik 16
2310033P09Rik 36
  • 78 (a)
(Pan troglodytes)
Mammalia C1H1orf35 35
  • 95.7 (n)
  • 94.9 (a)
C1orf35 36
  • 97 (a)
(Rattus norvegicus)
Mammalia RGD1304587 35
  • 80.62 (n)
  • 80.62 (a)
(Gallus gallus)
Aves C1orf35 36
  • 48 (a)
(Anolis carolinensis)
Reptilia C1orf35 36
  • 61 (a)
(Danio rerio)
Actinopterygii zgc63882 35
C2H1orf35 36
  • 42 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.843 35
Species with no ortholog for C1orf35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf35 Gene

Gene Tree for C1orf35 (if available)
Gene Tree for C1orf35 (if available)

Paralogs for C1orf35 Gene

No data available for Paralogs for C1orf35 Gene

Variants for C1orf35 Gene

Sequence variations from dbSNP and Humsavar for C1orf35 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs822731 -- 228,105,989(-) GGAGT(G/T)CCCGA upstream-variant-2KB
rs822739 -- 228,100,517(-) TGAGT(A/T)GCTGG downstream-variant-500B
rs849750 -- 228,105,634(-) GCTCA(A/G)TCCCT upstream-variant-2KB
rs1128456 -- 228,102,142(-) GGCGG(A/G)CCCGG nc-transcript-variant, reference, synonymous-codon
rs1745419 -- 228,103,769(-) caggc(A/G/T)ggagt upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C1orf35 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv516409 CNV Loss 19592680
nsv523935 CNV Loss 19592680
nsv832803 CNV Loss 17160897
nsv873252 CNV Loss 21882294
dgv537n71 CNV Loss 21882294
nsv873255 CNV Loss 21882294

Variation tolerance for C1orf35 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C1orf35 Gene

Disorders for C1orf35 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C1orf35 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multiple myeloma
  • plasma cell neoplasm
  • multiple myeloma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1orf35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C1orf35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf35 Gene

Publications for C1orf35 Gene

  1. Cloning and sequence analysis of tumor-associated gene hMMTAG2 from human multiple myeloma cell line ARH-77. (PMID: 12545221) Tian J.Y. … Jiang Y.S. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for C1orf35 Gene

Sources for C1orf35 Gene