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Aliases for C1orf35 Gene

Aliases for C1orf35 Gene

  • Chromosome 1 Open Reading Frame 35 2 3 5
  • Multiple Myeloma Tumor-Associated Protein 2 2 3
  • Multiple Myeloma Transforming 2 3
  • HMMTAG2 4
  • MMTAG2 3

External Ids for C1orf35 Gene

Previous GeneCards Identifiers for C1orf35 Gene

  • GC01M226785
  • GC01M224027
  • GC01M224673
  • GC01M225263
  • GC01M224595
  • GC01M226355
  • GC01M228289
  • GC01M198804

Summaries for C1orf35 Gene

GeneCards Summary for C1orf35 Gene

C1orf35 (Chromosome 1 Open Reading Frame 35) is a Protein Coding gene. Diseases associated with C1orf35 include Multiple Myeloma. Among its related pathways are Immune System. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf35 Gene

Genomics for C1orf35 Gene

Regulatory Elements for C1orf35 Gene

Enhancers for C1orf35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F228646 1.6 FANTOM5 ENCODE 57.1 -542.6 -542627 2.8 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF207 FOS CICP26 NUP133 ENSG00000269890 C1orf35 HMGN2P19 HIST3H3 PRSS38 TAF5L ABCB10 LOC100421842
GH01F228781 1.7 FANTOM5 Ensembl ENCODE 46.9 -677.7 -677652 3.7 ARID4B FEZF1 ZNF2 ZNF302 ZNF416 FOS ZNF263 REST KAT8 MIER3 NUP133 CICP26 C1orf35 ENSG00000269890 PRSS38 TAF5L ABCB10 LOC100421842 ENSG00000233920 HMGB1P26
GH01F227733 1.2 ENCODE 50 +370.3 370319 2.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 CICP26 C1orf35 ENSG00000269890 PRSS38 LOC100126822 SNAP47 JMJD4 HIST3H3 ENSG00000234277 ENSG00000231563
GH01F227243 1.3 Ensembl ENCODE 33.1 +861.3 861311 2.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A YY1 ZNF766 ZNF416 FOS KLF13 C1orf35 CICP26 JMJD4 CDC42BPA LOC100418874 LOC100126822 GC01M227264
GH01F227431 1.3 Ensembl ENCODE 33.1 +673.4 673364 1.5 ATF1 ARNT CREB3L1 ZNF2 ZNF121 ZNF416 FOS MCM3 YY2 REST CICP26 ENSG00000269890 C1orf35 CDC42BPA JMJD4 ENSG00000234277 ENSG00000242757 BTF3P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf35 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf35 Gene

228,100,726 bp from pter
228,105,411 bp from pter
4,686 bases
Minus strand

Genomic View for C1orf35 Gene

Genes around C1orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf35 Gene

Proteins for C1orf35 Gene

  • Protein details for C1orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multiple myeloma tumor-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6P5Y0
    • Q6ZTZ6
    • Q6ZWA6
    • Q8IZH3

    Protein attributes for C1orf35 Gene

    263 amino acids
    Molecular mass:
    29412 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf35 Gene


neXtProt entry for C1orf35 Gene

Post-translational modifications for C1orf35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf35 Gene

Domains & Families for C1orf35 Gene

Protein Domains for C1orf35 Gene

Suggested Antigen Peptide Sequences for C1orf35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf35: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf35 Gene

Function for C1orf35 Gene

Gene Ontology (GO) - Molecular Function for C1orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C1orf35: view
genes like me logo Genes that share phenotypes with C1orf35: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf35 Gene

Localization for C1orf35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf35 gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf35 Gene

Pathways & Interactions for C1orf35 Gene

SuperPathways for C1orf35 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with C1orf35: view

Pathways by source for C1orf35 Gene

2 Reactome pathways for C1orf35 Gene

Gene Ontology (GO) - Biological Process for C1orf35 Gene


No data available for SIGNOR curated interactions for C1orf35 Gene

Transcripts for C1orf35 Gene

Unigene Clusters for C1orf35 Gene

Chromosome 1 open reading frame 35:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP3: - -
SP4: -

Relevant External Links for C1orf35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf35 Gene

Protein differential expression in normal tissues from HIPED for C1orf35 Gene

This gene is overexpressed in Lung (19.6), Peripheral blood mononuclear cells (14.9), CD4 Tcells (6.9), and Pancreatic juice (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C1orf35 Gene

Protein tissue co-expression partners for C1orf35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf35 Gene:


SOURCE GeneReport for Unigene cluster for C1orf35 Gene:

genes like me logo Genes that share expression patterns with C1orf35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1orf35 Gene

Orthologs for C1orf35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1orf35 35
  • 97 (a)
C1H1orf35 34
  • 95.7 (n)
(Mus musculus)
Mammalia 2310033P09Rik 34 16 35
  • 81.14 (n)
(Rattus norvegicus)
Mammalia RGD1304587 34
  • 80.62 (n)
(Bos Taurus)
Mammalia C7H1orf35 34
  • 78.21 (n)
  • 77 (a)
(Canis familiaris)
Mammalia C14H1orf35 34
  • 74.74 (n)
C1orf35 35
  • 70 (a)
(Gallus gallus)
Aves C1orf35 35
  • 48 (a)
(Anolis carolinensis)
Reptilia C1orf35 35
  • 61 (a)
(Danio rerio)
Actinopterygii C2H1orf35 35
  • 42 (a)
zgc63882 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.843 34
Species where no ortholog for C1orf35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf35 Gene

Gene Tree for C1orf35 (if available)
Gene Tree for C1orf35 (if available)

Paralogs for C1orf35 Gene

No data available for Paralogs for C1orf35 Gene

Variants for C1orf35 Gene

Sequence variations from dbSNP and Humsavar for C1orf35 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111267186 -- 228,105,460(+) ACAGT(A/G)GTGTC upstream-variant-2KB
rs112503713 -- 228,105,071(+) TGGCC(A/G)ACTCC upstream-variant-2KB
rs1128456 -- 228,102,142(-) GGCGG(A/G)CCCGG nc-transcript-variant, reference, synonymous-codon
rs112987398 -- 228,100,628(+) AAAAA(A/T)AAAAA downstream-variant-500B
rs115477247 -- 228,100,596(+) ACTCC(A/G)GCCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C1orf35 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1160102 CNV deletion 26073780
nsv516409 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv826908 CNV gain 20364138
nsv832803 CNV loss 17160897
nsv952136 CNV deletion 24416366

Variation tolerance for C1orf35 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf35 Gene

Disorders for C1orf35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1orf35 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multiple myeloma
  • myeloma, multiple amyloidosis, systemic, included
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1orf35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C1orf35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf35 Gene

Publications for C1orf35 Gene

  1. Cloning and sequence analysis of tumor-associated gene hMMTAG2 from human multiple myeloma cell line ARH-77. (PMID: 12545221) Tian J.Y. … Jiang Y.S. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64

Products for C1orf35 Gene

Sources for C1orf35 Gene

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