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Aliases for C1orf27 Gene

Aliases for C1orf27 Gene

  • Chromosome 1 Open Reading Frame 27 2 3 5
  • Transactivated By Recombinant Transforming Growth Factor Beta 2 3
  • Transactivated By Transforming Growth Factor Beta Protein 1 3 4
  • LAG1-Interacting Protein 3 4
  • ODR4 3 4
  • TTG1 3 4
  • Odorant Response Abnormal 4 3
  • Protein Odr-4 Homolog 3
  • HODR-4 4
  • Odr-4 3
  • TTG1A 4

External Ids for C1orf27 Gene

Previous GeneCards Identifiers for C1orf27 Gene

  • GC01P183870
  • GC01P181772
  • GC01P182865
  • GC01P183584
  • GC01P183583
  • GC01P183076
  • GC01P184611
  • GC01P186344
  • GC01P157580

Summaries for C1orf27 Gene

GeneCards Summary for C1orf27 Gene

C1orf27 (Chromosome 1 Open Reading Frame 27) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for C1orf27 Gene

  • May play a role in the trafficking of a subset of G-protein coupled receptors.

Additional gene information for C1orf27 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf27 Gene

Genomics for C1orf27 Gene

Regulatory Elements for C1orf27 Gene

Enhancers for C1orf27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H186848 1.1 FANTOM5 Ensembl 22.6 +473.7 473655 1.8 FOXA2 ZSCAN4 BATF RELA EED FOS RUNX3 IKZF2 CREM NFE2L2 C1orf27 ENSG00000228238 PLA2G4A TPR PTGS2 GC01P187071
GH01H185438 1.6 FANTOM5 Ensembl ENCODE 11.6 -934.6 -934600 4.6 PKNOX1 ATF1 SIN3A GLIS2 ATF7 FOS SP3 TSHZ1 ZNF623 GLIS1 IVNS1ABP C1orf27 SWT1 RNF2 MCRIP2P2 ENSG00000279401
GH01H186081 1.6 FANTOM5 Ensembl ENCODE 11.3 -293.0 -292991 2 PKNOX1 FOXA2 ARNT FEZF1 ZNF766 CBX5 SP3 JUNB REST ZNF592 OCLM TPR C1orf27 HMCN1 PDC ENSG00000224691 GC01M185927
GH01H185374 1.4 FANTOM5 Ensembl ENCODE 11.3 -999.5 -999549 3.1 PKNOX1 STAT1 ZNF740 ETV1 TSC22D4 DPF2 ZNF354B GABPA BCL11A ZNF341 IVNS1ABP EDEM3 TPR RNU7-183P C1orf27 FAM129A SWT1 LOC100422414 RNF2 TRMT1L
GH01H186617 1.5 FANTOM5 Ensembl ENCODE 7.9 +242.7 242743 1.4 TBP CTCF MAX RAD21 BATF POLR3A POLR2A EED SMC3 ATF7 PTGS2 C1orf27 PACERR PLA2G4A GC01P186626 GC01P186627 LOC100131939
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf27 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000017237 -458 3001 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 GLIS1 NBN

Genomic Locations for C1orf27 Gene

Genomic Locations for C1orf27 Gene
chr1:186,375,758-186,421,378
(GRCh38/hg38)
Size:
45,621 bases
Orientation:
Plus strand
chr1:186,344,890-186,390,510
(GRCh37/hg19)

Genomic View for C1orf27 Gene

Genes around C1orf27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf27 Gene

Proteins for C1orf27 Gene

  • Protein details for C1orf27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SWX8-ODR4_HUMAN
    Recommended name:
    Protein odr-4 homolog
    Protein Accession:
    Q5SWX8
    Secondary Accessions:
    • B4DNY0
    • E9PFR7
    • Q19CC6
    • Q8WYB6
    • Q9BTS2
    • Q9H6A6
    • Q9NX06

    Protein attributes for C1orf27 Gene

    Size:
    454 amino acids
    Molecular mass:
    51103 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15356.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C1orf27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf27 Gene

Post-translational modifications for C1orf27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf27 Gene

No data available for DME Specific Peptides for C1orf27 Gene

Domains & Families for C1orf27 Gene

Gene Families for C1orf27 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C1orf27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf27 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SWX8

UniProtKB/Swiss-Prot:

ODR4_HUMAN :
  • Belongs to the ODR-4 family.
Family:
  • Belongs to the ODR-4 family.
genes like me logo Genes that share domains with C1orf27: view

Function for C1orf27 Gene

Molecular function for C1orf27 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the trafficking of a subset of G-protein coupled receptors.

Phenotypes From GWAS Catalog for C1orf27 Gene

genes like me logo Genes that share phenotypes with C1orf27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf27 Gene

Localization for C1orf27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf27 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf27 gene
Compartment Confidence
plasma membrane 4
nucleus 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf27: view

Pathways & Interactions for C1orf27 Gene

SuperPathways for C1orf27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf27 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf27 Gene

Drugs & Compounds for C1orf27 Gene

No Compound Related Data Available

Transcripts for C1orf27 Gene

Unigene Clusters for C1orf27 Gene

Chromosome 1 open reading frame 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf27 Gene

No ASD Table

Relevant External Links for C1orf27 Gene

GeneLoc Exon Structure for
C1orf27
ECgene alternative splicing isoforms for
C1orf27

Expression for C1orf27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf27 Gene

This gene is overexpressed in Breast (10.4), Islet of Langerhans (9.7), and Adrenal (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C1orf27 Gene



Protein tissue co-expression partners for C1orf27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf27 Gene:

C1orf27

SOURCE GeneReport for Unigene cluster for C1orf27 Gene:

Hs.371210

mRNA Expression by UniProt/SwissProt for C1orf27 Gene:

Q5SWX8-ODR4_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for C1orf27 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C1orf27: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf27 Gene

Orthologs for C1orf27 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1orf27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf27 34
  • 100 (a)
OneToOne
C1H1orf27 33
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia C16H1orf27 33
  • 90.82 (n)
C1orf27 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf27 33
  • 90.68 (n)
C1orf27 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC003331 33 16 34
  • 87.84 (n)
rat
(Rattus norvegicus)
Mammalia RGD1307830 33
  • 87.4 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf27 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf27 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8H1ORF27 33 34
  • 69.88 (n)
lizard
(Anolis carolinensis)
Reptilia C1orf27 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf27 33
  • 59.55 (n)
Str.15466 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10013 33
zebrafish
(Danio rerio)
Actinopterygii zgc:63674 33
  • 53.71 (n)
C2H1orf27 34
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006119 33
  • 41.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10616 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToOne
Species where no ortholog for C1orf27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf27 Gene

ENSEMBL:
Gene Tree for C1orf27 (if available)
TreeFam:
Gene Tree for C1orf27 (if available)

Paralogs for C1orf27 Gene

No data available for Paralogs for C1orf27 Gene

Variants for C1orf27 Gene

Sequence variations from dbSNP and Humsavar for C1orf27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000085484 -- 186,392,745(+) TGCCT(C/G)TAATC intron-variant
rs1000113607 -- 186,400,913(+) CAGCC(C/T)CATCT intron-variant, utr-variant-5-prime
rs1000116726 -- 186,392,972(+) TGCAC(C/T)CCAGC intron-variant
rs1000169648 -- 186,374,028(+) ACTCA(A/G)CTCTG intron-variant, upstream-variant-2KB
rs1000274946 -- 186,416,438(+) AGGCC(A/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf27 Gene

Variant ID Type Subtype PubMed ID
nsv548399 CNV loss 21841781
nsv1012164 CNV gain 25217958
esv3890826 CNV gain 25118596
esv3575361 CNV gain 25503493
esv2762201 CNV gain 21179565

Variation tolerance for C1orf27 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.53; 85.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf27 Gene

Disorders for C1orf27 Gene

Relevant External Links for C1orf27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf27

No disorders were found for C1orf27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf27 Gene

Publications for C1orf27 Gene

  1. Ubiquitously expressed GPCR membrane-trafficking orthologs. (PMID: 15718105) Lehman CW … Komives CF (Genomics 2005) 2 3 4 60
  2. An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. (PMID: 24603482) Chen C … de Bono M (PLoS genetics 2014) 2 3 60
  3. Protein expression, genomic structure, and polymorphisms of oculomedin. (PMID: 12868032) Fujiwara N … Ohtsuki H (Ophthalmic genetics 2003) 2 3 60
  4. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. (PMID: 28162770) Wang T … Sabatini DM (Cell 2017) 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for C1orf27 Gene

Sources for C1orf27 Gene

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