C1orf228 Gene
protein-coding GIFtS: 36
GCID: GC01P045140
|
|
chromosome 1 open reading frame 228(Previous name: non-protein coding RNA 82 )
(Previous symbol: NCRNA00082)
| |
Aliases
for C1orf228 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 1 Open Reading Frame 2281 2 | | NCRNA000821 2 3 | | P401 | | MGC335561 | | Non-Protein Coding RNA 821 | | Uncharacterized Protein C1orf2282 |
Export aliases for C1orf228 gene to outside databasesPrevious GC identifers: GC01P044938 GC01P043255 |
Summaries
for C1orf228 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1orf228 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1orf228 gene promoter:
AML1a NF-AT NF-AT4 NF-AT2 NF-AT3 c-Myb Cart-1 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1orf228
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf228 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1C1orf228 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P045140: view genomic region
(about GC identifiers)
Start:
|
45,140,364 bp from pter |
End:
|
45,191,263 bp from pter |
Size:
|
50,900 bases |
Orientation:
|
plus strand |
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Proteins
for C1orf228 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CA228_HUMAN, Q6PIY5 (See
protein sequence)Recommended Name: Uncharacterized protein C1orf228 Size: 440 amino acids; 48855 Da
Secondary accessions: A1KXE5Alternative splicing: 2 isoforms: Q6PIY5-1 Q6PIY5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C1orf228: NX_Q6PIY5
C1orf228 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001139108.1
ENSEMBL proteins: ENSP00000417206 ENSP00000420358 ENSP00000420716 ENSP00000420664 ENSP00000417998 ENSP00000417538 ENSP00000420050 ENSP00000440524
Human Recombinant Protein Products for C1orf228:
C1orf228 Antibody Products:
Assay Products for C1orf228: |
Protein
Domains /
Families
for C1orf228 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C1orf228 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PIY5ProtoNet protein and cluster: Q6PIY5 |
Function
for C1orf228 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf228 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf228
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C1orf228 (NM_001145636) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf228 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf228 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf228 |
|
Pathways & Interactions
for C1orf228 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf228
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for C1orf228 (ENSP000004207164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C1orf228 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1orf228
Search CenterWatch for drugs/clinical trials and news about C1orf228 / CA228
|
Transcripts
for C1orf228 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1orf228 gene (2 alternative transcripts): NM_001004307.2 NM_001145636.1 Unigene Cluster for C1orf228: Chromosome 1 open reading frame 228 Hs.173679 [show with all ESTs]Unigene Representative Sequence: BC02611518/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000424484 ENST00000418644 ENST00000455805 ENST00000458657 ENST00000441519
ENST00000357508 ENST00000445071 ENST00000453711 ENST00000421398 ENST00000444751
ENST00000434068 ENST00000434520 ENST00000427321 ENST00000446792 ENST00000444525
ENST00000440383 ENST00000427336 ENST00000418779
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf228 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf228
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1orf228 (NM_001145636) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf228 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf228 |
Additional cDNA sequence: AY254217.1 BC026115.1 9 DOTS entries: DT.440764 DT.99977247 DT.422899 DT.100033575 DT.97786464 DT.75101509 DT.100013407 DT.91726761 DT.70104263 24/61 AceView cDNA sequences (see all 61): AI141011 AI436577 AW015512 BE674675 AI494416 AI760165 AL119896 BU949601 AI341569 BX098537 AW241888 AI356499 BM971816 BX112141 AI624778 BX093906 BI824371 AJ713037 BG719519 AI494564 BM564237 CB306179 AW511110 BU609011
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf228 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C1orf228
|
Expression
for C1orf228 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1orf228 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGCTCCTA
About this image
See C1orf228 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf228
SOURCE GeneReport for Unigene cluster: Hs.173679
SABiosciences Custom PCR Arrays for C1orf228
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf228
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1orf228 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf228 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf228 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf228 |
Orthologs
for C1orf228 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C1orf228 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gm16611 , 5 |
predicted gene 16611, 5 |
81.79(n)1
78.47(a)1 |
|
4 (53.43 cM)5
3815441 NM_001145637.11 NP_001139109.11
1172151935 |
chicken
(Gallus gallus) |
Aves |
C1orf2286 |
Uncharacterized protein |
60(a) |
1 ↔ 1 |
8(21450239-21454328) |
lizard
(Anolis carolinensis) |
Reptilia |
C1orf2286 |
-- |
69(a) |
1 ↔ 1 |
4(110029098-110043037) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.17492 |
Xenopus laevis transcribed sequences |
71.71(n) |
|
BJ622892.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.149412 |
Transcribed sequences |
73.19(n) |
|
BQ419924.1 |
ENSEMBL Gene Tree for C1orf228 (if available)
TreeFam Gene Tree for C1orf228 (if available) |
Paralogs
for C1orf228 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C1orf228 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1orf228 (45140364 - 45191263 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf228: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf228 |
|
Disorders
/ Diseases
for C1orf228 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C1orf228 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1orf228 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf228) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for C1orf228 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C1orf228 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1orf228 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1orf228 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1orf228 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1orf228 gene:
Search GeneIP for patents involving C1orf228
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1orf228 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C1orf228 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf228 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf228 | | | OriGene Protein Over-expression Lysate for C1orf228 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C1orf228 | | OriGene 3'-UTR Clone for C1orf228 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf228 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf228 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C1orf228 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C1orf228 | | OriGene Custom Protein Services for C1orf228 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf228 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf228 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf228 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf228 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf228 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf228 |
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 | | | C1orf228 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf228 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C1orf228 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf228 |
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