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Aliases for C1orf226 Gene

Aliases for C1orf226 Gene

  • Chromosome 1 Open Reading Frame 226 2 3 5

External Ids for C1orf226 Gene

Previous GeneCards Identifiers for C1orf226 Gene

  • GC01P160621
  • GC01P133593

Summaries for C1orf226 Gene

GeneCards Summary for C1orf226 Gene

C1orf226 (Chromosome 1 Open Reading Frame 226) is a Protein Coding gene.

Additional gene information for C1orf226 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf226 Gene

Genomics for C1orf226 Gene

Regulatory Elements for C1orf226 Gene

Enhancers for C1orf226 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H162151 1.3 ENCODE dbSUPER 17.2 -214.4 -214442 1 FOXA2 ATF1 MLX ARID4B SIN3A FEZF1 YY1 GLIS2 FOS ATF7 USP21 PPOX C1orf226 B4GALT3 ATF6 DUSP12 LOC148430 SPATA46 MIR4654 GC01M162031
GH01H162131 1.2 ENCODE dbSUPER 16.7 -234.8 -234834 1 FOXA2 MLX FEZF1 YY1 ZNF143 SP5 ZHX2 MXD4 REST PPARG C1orf226 OLFML2B SPATA46 MIR4654 GC01M162031
GH01H162380 1.1 Ensembl ENCODE 18.1 +15.2 15206 4 TBL1XR1 BRCA1 TCF12 GATA2 RCOR1 FOS DEK USF2 CEBPB ZEB2 C1orf226 SH2D1B UHMK1 RGS4 SPATA46
GH01H162206 1.4 Ensembl ENCODE dbSUPER 14 -159.6 -159620 2 FOXA2 INSM2 FEZF1 ZNF2 ZBTB40 RAD21 YY1 GLIS2 KLF7 EGR2 C1orf226 SPATA46 LOC105371475 ENSG00000227094
GH01H162143 1.2 ENCODE dbSUPER 16.2 -221.7 -221711 3 ELF3 ZFP64 ARID4B FEZF1 RAD21 RARA ZNF121 GLIS2 THAP11 CEBPB C1orf226 SPATA46 MIR4654 GC01M162031
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf226 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf226 Gene

Chromosome:
1
Start:
162,366,908 bp from pter
End:
162,386,818 bp from pter
Size:
19,911 bases
Orientation:
Plus strand

Genomic View for C1orf226 Gene

Genes around C1orf226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf226 Gene

Proteins for C1orf226 Gene

  • Protein details for C1orf226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L170-CA226_HUMAN
    Recommended name:
    Uncharacterized protein C1orf226
    Protein Accession:
    A1L170
    Secondary Accessions:
    • B4DF31

    Protein attributes for C1orf226 Gene

    Size:
    272 amino acids
    Molecular mass:
    29057 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf226 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf226 Gene

Post-translational modifications for C1orf226 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf226 Gene

No data available for DME Specific Peptides for C1orf226 Gene

Domains & Families for C1orf226 Gene

Gene Families for C1orf226 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf226 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf226: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf226 Gene

Function for C1orf226 Gene

Phenotypes From GWAS Catalog for C1orf226 Gene

Phenotypes for C1orf226 Gene

genes like me logo Genes that share phenotypes with C1orf226: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf226
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf226 Gene

Localization for C1orf226 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf226 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf226 Gene

Pathways & Interactions for C1orf226 Gene

SuperPathways for C1orf226 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf226 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf226 Gene

Drugs & Compounds for C1orf226 Gene

No Compound Related Data Available

Transcripts for C1orf226 Gene

Unigene Clusters for C1orf226 Gene

Chromosome 1 open reading frame 226:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf226
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf226 Gene

No ASD Table

Relevant External Links for C1orf226 Gene

GeneLoc Exon Structure for
C1orf226
ECgene alternative splicing isoforms for
C1orf226

Expression for C1orf226 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf226 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf226 Gene

This gene is overexpressed in Pituitary (x9.3).

Protein differential expression in normal tissues from HIPED for C1orf226 Gene

This gene is overexpressed in Fetal Liver (26.6), Blymphocyte (26.4), and Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1orf226 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1orf226 Gene:

C1orf226

SOURCE GeneReport for Unigene cluster for C1orf226 Gene:

Hs.447011
genes like me logo Genes that share expression patterns with C1orf226: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf226 Gene

Orthologs for C1orf226 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf226 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf226 33
  • 99.37 (n)
C1orf226 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf226 33
  • 85.35 (n)
mouse
(Mus musculus)
Mammalia Gm7694 33 16 34
  • 82.47 (n)
rat
(Rattus norvegicus)
Mammalia LOC100361087 33
  • 80.99 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883287 33
  • 55.28 (n)
Species where no ortholog for C1orf226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf226 Gene

ENSEMBL:
Gene Tree for C1orf226 (if available)
TreeFam:
Gene Tree for C1orf226 (if available)

Paralogs for C1orf226 Gene

No data available for Paralogs for C1orf226 Gene

Variants for C1orf226 Gene

Sequence variations from dbSNP and Humsavar for C1orf226 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000006801 -- 162,379,911(+) TTGGG(A/G)AGTGG intron-variant, upstream-variant-2KB
rs1000526612 -- 162,380,147(+) CCCTG(A/C)TTGCT intron-variant, upstream-variant-2KB
rs1001466080 -- 162,384,379(+) GGGTT(C/G)CCAAG utr-variant-3-prime
rs1001809097 -- 162,378,829(+) CTGAA(A/G)AGTTT upstream-variant-2KB
rs1002047169 -- 162,380,014(+) CAAAT(C/T)TTCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf226 Gene

Variant ID Type Subtype PubMed ID
esv2758973 CNV gain 17122850
esv34209 CNV gain 17911159
esv3587740 CNV gain 21293372
nsv516482 CNV gain+loss 19592680
nsv8513 CNV gain 18304495

Variation tolerance for C1orf226 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf226 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf226 Gene

Disorders for C1orf226 Gene

Relevant External Links for C1orf226

Genetic Association Database (GAD)
C1orf226
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf226

No disorders were found for C1orf226 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf226 Gene

Publications for C1orf226 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for C1orf226 Gene

Sources for C1orf226 Gene

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