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Aliases for C1orf216 Gene

Aliases for C1orf216 Gene

  • Chromosome 1 Open Reading Frame 216 2 3 5

External Ids for C1orf216 Gene

Previous GeneCards Identifiers for C1orf216 Gene

  • GC01M035953
  • GC01M036179
  • GC01M034297

Summaries for C1orf216 Gene

GeneCards Summary for C1orf216 Gene

C1orf216 (Chromosome 1 Open Reading Frame 216) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf216 Gene

Genomics for C1orf216 Gene

Regulatory Elements for C1orf216 Gene

Enhancers for C1orf216 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C1orf216 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf216 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf216 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf216 Gene

Chromosome:
1
Start:
35,713,875 bp from pter
End:
35,719,472 bp from pter
Size:
5,598 bases
Orientation:
Minus strand

Genomic View for C1orf216 Gene

Genes around C1orf216 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf216 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf216 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf216 Gene

Proteins for C1orf216 Gene

  • Protein details for C1orf216 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAB5-CA216_HUMAN
    Recommended name:
    UPF0500 protein C1orf216
    Protein Accession:
    Q8TAB5
    Secondary Accessions:
    • D3DPS1
    • Q8N8N6

    Protein attributes for C1orf216 Gene

    Size:
    229 amino acids
    Molecular mass:
    24968 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04799.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C1orf216 Gene

Proteomics data for C1orf216 Gene at MOPED

Post-translational modifications for C1orf216 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf216 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf216 Gene

Domains & Families for C1orf216 Gene

Protein Domains for C1orf216 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf216 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAB5

UniProtKB/Swiss-Prot:

CA216_HUMAN :
  • Belongs to the UPF0500 family.
Family:
  • Belongs to the UPF0500 family.
genes like me logo Genes that share domains with C1orf216: view

No data available for Gene Families for C1orf216 Gene

Function for C1orf216 Gene

Phenotypes for C1orf216 Gene

genes like me logo Genes that share phenotypes with C1orf216: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf216 Gene

Localization for C1orf216 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf216 Gene COMPARTMENTS Subcellular localization image for C1orf216 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf216 Gene

Pathways & Interactions for C1orf216 Gene

SuperPathways for C1orf216 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf216 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf216 Gene

Drugs & Compounds for C1orf216 Gene

No Compound Related Data Available

Transcripts for C1orf216 Gene

mRNA/cDNA for C1orf216 Gene

Unigene Clusters for C1orf216 Gene

Chromosome 1 open reading frame 216:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf216 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for C1orf216 Gene

GeneLoc Exon Structure for
C1orf216
ECgene alternative splicing isoforms for
C1orf216

Expression for C1orf216 Gene

mRNA expression in normal human tissues for C1orf216 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf216 Gene

This gene is overexpressed in Brain - Cortex (x4.4) and Brain - Frontal Cortex (BA9) (x4.2).

SOURCE GeneReport for Unigene cluster for C1orf216 Gene Hs.112023

genes like me logo Genes that share expression patterns with C1orf216: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C1orf216 Gene

Orthologs for C1orf216 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf216 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C15H1orf216 35
  • 84.21 (n)
  • 84.65 (a)
C1orf216 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5730409E04Rik 35
  • 83.04 (n)
  • 83.33 (a)
5730409E04Rik 16
5730409E04Rik 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf216 35
  • 99.71 (n)
  • 99.13 (a)
C1orf216 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912566 35
  • 83.04 (n)
  • 82.14 (a)
cow
(Bos Taurus)
Mammalia C1orf216 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf216 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF216 35
  • 65.17 (n)
  • 58.5 (a)
C1orf216 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf216 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf216 35
  • 53.24 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii C1orf216 36
  • 22 (a)
OneToOne
Species with no ortholog for C1orf216:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf216 Gene

ENSEMBL:
Gene Tree for C1orf216 (if available)
TreeFam:
Gene Tree for C1orf216 (if available)

Paralogs for C1orf216 Gene

No data available for Paralogs for C1orf216 Gene

Variants for C1orf216 Gene

Sequence variations from dbSNP and Humsavar for C1orf216 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1053755 -- 35,713,992(-) ATCCA(A/G)AGAGT utr-variant-3-prime
rs3795501 -- 35,715,371(-) TGTGT(A/G)TGTAG utr-variant-3-prime
rs3179908 -- 35,713,876(-) AATTA(A/C)ATTTC utr-variant-3-prime
rs6694073 -- 35,719,954(+) AGGGT(A/C)TTGGG upstream-variant-2KB
rs6699375 -- 35,717,508(+) CAAAA(G/T)TAGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf216 Gene

Variant ID Type Subtype PubMed ID
nsv871396 CNV Gain 21882294
nsv834680 CNV Gain 17160897

Variation tolerance for C1orf216 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C1orf216 Gene

Disorders for C1orf216 Gene

Relevant External Links for C1orf216

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf216

No disorders were found for C1orf216 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf216 Gene

Publications for C1orf216 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for C1orf216 Gene

Sources for C1orf216 Gene

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